Shear-induced nitric oxide production by endothelial cells

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Description

This model simulates how endothelial cells convert the mechanical stimulus of shear stress applied to the single-cell endothelial layer into chemical responses, including the generation of nitric oxide (NO). Subsequently, the shear-induced NO diffuses into the adjacent arterial layer, the smooth muscle layer, initiating a cell signalling pathway that modulates the vasoactivity of smooth muscle cells. Reference: Sriram, K., Laughlin, J. G., Rangamani, P., & Tartakovsky, D. M. (2016). Shear-induced nitric oxide production by endothelial cells. Biophysical journal, 111(1), 208-221.

Owner

Fariba Bahadori <fbir042@aucklanduni.ac.nz>

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https://models.fieldml.org/workspace/b34

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