Current_Ikr.cellml

About this model

Original publication:
 Kernik et al. (2019): "A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
DOI:https://dx.doi.org/10.1113%2FJP277724

Figure 05

Rapid delayed rectifier potassium current (IKr) model

Current_Ikr.cellml is the main CellML file which contains the formulation for the rapid delayed rectifier potassium current. Its associated SED-ML file contains all the simulation settings.

To execute the code, all the files related to this channel need to be downloaded in a same folder:

  1. fig5_Kr.py
  2. Current_Ikr.cellml
  3. Current_Ikr.sedml
  4. parameter_Ikr.cellml
  5. parameter.cellml
  6. gating_Ikr.cellml
  7. unit.cellml

To reproduce Figure 5, save all the files to the same folder and execute the following script from the command line:

$ cd [PathToThisFile]

$ [PathToOpenCOR]/pythonshell fig5_Kr.py

Rapid delayed rectifier potassium current model

A, optimized activation with dataset-specific model fits. B, I-V curve, C, Time constant of IKr activation gate. D, Time constant of IKr inactivation gate.