- Author:
- jlaw060 <jlaw060@bioeng203.bioeng.auckland.ac.nz>
- Date:
- 2009-06-22 17:07:25+12:00
- Desc:
- removed .doc file
- Permanent Source URI:
- https://models.fieldml.org/workspace/li_smith_2009/rawfile/4c6874b14fc66049e1e6dd8e325adb98511664e6/C57BL7_WT_model_version1.cellml
<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 19/06/2009 at 09:10:40 using:
COR (0.9.31.813)
Copyright 2002-2009 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk
CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->
<model name="MyModel_2006" cmeta:id="MyModel_2006" xmlns="http://www.cellml.org/cellml/1.0#" xmlns:cellml="http://www.cellml.org/cellml/1.0#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<units name="millisecond">
<unit units="second" prefix="milli"/>
</units>
<units name="per_millisecond">
<unit units="second" prefix="milli" exponent="-1"/>
</units>
<units name="micromolar_per_millisecond">
<unit units="micromolar"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="per_micromolar_millisecond">
<unit units="micromolar" exponent="-1"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="micromolar3_per_millisecond">
<unit units="micromolar" exponent="-3"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="micromolar4_per_millisecond">
<unit units="micromolar" exponent="-4"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="millivolt">
<unit units="volt" prefix="milli"/>
</units>
<units name="per_millivolt">
<unit units="volt" prefix="milli" exponent="-1"/>
</units>
<units name="millivolt2">
<unit units="volt" prefix="milli" exponent="2"/>
</units>
<units name="per_millivolt_millisecond">
<unit units="millivolt" exponent="-1"/>
<unit units="millisecond" exponent="-1"/>
</units>
<units name="milliS_per_microF">
<unit units="siemens" prefix="milli"/>
<unit units="farad" prefix="micro" exponent="-1"/>
</units>
<units name="picoF">
<unit units="farad" prefix="pico"/>
</units>
<units name="per_picoF">
<unit units="picoF" exponent="-1"/>
</units>
<units name="microF_per_cm2">
<unit units="farad" prefix="micro"/>
<unit units="metre" prefix="centi" exponent="-2"/>
</units>
<units name="picoA_per_picoF">
<unit units="ampere" prefix="pico"/>
<unit units="farad" prefix="pico" exponent="-1"/>
</units>
<units name="micromolar">
<unit units="mole" prefix="micro"/>
<unit units="litre" exponent="-1"/>
</units>
<units name="joule_per_mole_kelvin">
<unit units="joule"/>
<unit units="mole" exponent="-1"/>
<unit units="kelvin" exponent="-1"/>
</units>
<units name="coulomb_per_millimole">
<unit units="coulomb"/>
<unit units="mole" prefix="milli" exponent="-1"/>
</units>
<units name="cm2">
<unit units="metre" prefix="centi" exponent="2"/>
</units>
<units name="microlitre">
<unit units="litre" prefix="micro"/>
</units>
<component name="environment">
<variable name="time" units="millisecond" public_interface="out"/>
</component>
<component name="membrane">
<variable name="V" units="millivolt" initial_value="-85.64004" public_interface="out"/>
<variable name="Cm" units="microF_per_cm2" initial_value="1" public_interface="out"/>
<variable name="Vmyo" units="microlitre" initial_value="2.2e-5" public_interface="out"/>
<variable name="VJSR" units="microlitre" initial_value="1.022e-7" public_interface="out"/>
<variable name="VNSR" units="microlitre" initial_value="1.786e-6" public_interface="out"/>
<variable name="Vss" units="microlitre" initial_value="1.264e-9" public_interface="out"/>
<variable name="Acap" units="cm2" initial_value="0.00013866" public_interface="out"/>
<variable name="Ko" units="micromolar" initial_value="5400" public_interface="out"/>
<variable name="Nao" units="micromolar" initial_value="134000" public_interface="out"/>
<variable name="Cao" units="micromolar" initial_value="1400" public_interface="out"/>
<variable name="R" units="joule_per_mole_kelvin" initial_value="8.314" public_interface="out"/>
<variable name="T" units="kelvin" initial_value="308" public_interface="out"/>
<variable name="F" units="coulomb_per_millimole" initial_value="96.5" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="i_CaL" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_pCa" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_NaCa" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Cab" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Na" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Nab" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_NaK" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kto_f" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kto_s" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_K1" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Ks" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kur" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kss" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_ClCa" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kr" units="picoA_per_picoF" public_interface="in"/>
<variable name="stim_offset" units="millisecond" initial_value="100"/>
<variable name="stim_period" units="millisecond" initial_value="333.3333333"/>
<variable name="stim_duration" units="millisecond" initial_value="3"/>
<variable name="stim_amplitude" units="picoA_per_picoF" initial_value="-15"/>
<variable name="i_Stim" units="picoA_per_picoF" public_interface="out"/>
<variable name="past" units="millisecond"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>past</ci>
<apply>
<times/>
<apply>
<floor/>
<apply>
<divide/>
<ci>time</ci>
<ci>stim_period</ci>
</apply>
</apply>
<ci>stim_period</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_Stim</ci>
<piecewise>
<piece>
<ci>stim_amplitude</ci>
<apply>
<and/>
<apply>
<geq/>
<apply>
<minus/>
<ci>time</ci>
<ci>past</ci>
</apply>
<ci>stim_offset</ci>
</apply>
<apply>
<leq/>
<apply>
<minus/>
<ci>time</ci>
<ci>past</ci>
</apply>
<apply>
<plus/>
<ci>stim_offset</ci>
<ci>stim_duration</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<cn cellml:units="picoA_per_picoF">0</cn>
</otherwise>
</piecewise>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_CaL</ci>
<ci>i_pCa</ci>
<ci>i_NaCa</ci>
<ci>i_Cab</ci>
<ci>i_Na</ci>
<ci>i_Nab</ci>
<ci>i_NaK</ci>
<ci>i_Kto_f</ci>
<ci>i_Kto_s</ci>
<ci>i_K1</ci>
<ci>i_Ks</ci>
<ci>i_Kur</ci>
<ci>i_Kss</ci>
<ci>i_Kr</ci>
<ci>i_ClCa</ci>
<ci>i_Stim</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_concentration">
<variable name="Cai" units="micromolar" initial_value="0.1040595" public_interface="out"/>
<variable name="Cass" units="micromolar" initial_value="0.1043777" public_interface="out"/>
<variable name="CaJSR" units="micromolar" initial_value="730.0589" public_interface="out"/>
<variable name="CaNSR" units="micromolar" initial_value="841.106" public_interface="out"/>
<variable name="Bi" units="dimensionless"/>
<variable name="Bss" units="dimensionless"/>
<variable name="BJSR" units="dimensionless"/>
<variable name="Bmax" units="micromolar" initial_value="109"/>
<variable name="CSQN_tot" units="micromolar" initial_value="15000"/>
<variable name="Kd" units="micromolar" initial_value="0.6"/>
<variable name="Km_CSQN" units="micromolar" initial_value="800"/>
<variable name="Acap" units="cm2" public_interface="in"/>
<variable name="Vmyo" units="microlitre" public_interface="in"/>
<variable name="VJSR" units="microlitre" public_interface="in"/>
<variable name="Vss" units="microlitre" public_interface="in"/>
<variable name="VNSR" units="microlitre" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Cm" units="microF_per_cm2" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="i_Cab" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_CaL" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_NaCa" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_pCa" units="picoA_per_picoF" public_interface="in"/>
<variable name="J_leak" units="micromolar_per_millisecond" public_interface="in"/>
<variable name="J_rel" units="micromolar_per_millisecond" public_interface="in"/>
<variable name="J_serca" units="micromolar_per_millisecond" public_interface="in"/>
<variable name="J_tr" units="micromolar_per_millisecond" public_interface="in"/>
<variable name="J_xfer" units="micromolar_per_millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<ci>Bi</ci>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>J_leak</ci>
<ci>J_xfer</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Cab</ci>
<ci>i_pCa</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
<ci>J_serca</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Cass</ci>
</apply>
<apply>
<times/>
<ci>Bss</ci>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_rel</ci>
<ci>VJSR</ci>
</apply>
<ci>Vss</ci>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<ci>J_xfer</ci>
<ci>Vmyo</ci>
</apply>
<ci>Vss</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>i_CaL</ci>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vss</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaJSR</ci>
</apply>
<apply>
<times/>
<ci>BJSR</ci>
<apply>
<minus/>
<ci>J_tr</ci>
<ci>J_rel</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaNSR</ci>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>J_serca</ci>
<ci>J_leak</ci>
</apply>
<ci>Vmyo</ci>
</apply>
<ci>VNSR</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<ci>J_tr</ci>
<ci>VJSR</ci>
</apply>
<ci>VNSR</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Bi</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax</ci>
<ci>Kd</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Kd</ci>
<ci>Cai</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>Bss</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>Bmax</ci>
<ci>Kd</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Kd</ci>
<ci>Cass</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>BJSR</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<apply>
<times/>
<ci>CSQN_tot</ci>
<ci>Km_CSQN</ci>
</apply>
<apply>
<power/>
<apply>
<plus/>
<ci>Km_CSQN</ci>
<ci>CaJSR</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_fluxes">
<variable name="J_leak" units="micromolar_per_millisecond" public_interface="out"/>
<variable name="J_rel" units="micromolar_per_millisecond" public_interface="out"/>
<variable name="J_serca" units="micromolar_per_millisecond" public_interface="out"/>
<variable name="J_tr" units="micromolar_per_millisecond" public_interface="out"/>
<variable name="J_xfer" units="micromolar_per_millisecond" public_interface="out"/>
<variable name="P_RyR" units="dimensionless" initial_value="2.290355e-9"/>
<variable name="v1" units="per_millisecond" initial_value="4.5"/>
<variable name="tau_tr" units="millisecond" initial_value="20"/>
<variable name="v2" units="per_millisecond" initial_value="1e-5"/>
<variable name="tau_xfer" units="millisecond" initial_value="8"/>
<variable name="CaMKb" units="dimensionless"/>
<variable name="CaMKt" units="dimensionless" initial_value="0.08989079"/>
<variable name="CaMKa" units="dimensionless"/>
<variable name="on_rate" units="per_millisecond" initial_value="0.05"/>
<variable name="off_rate" units="per_millisecond" initial_value="0.00068"/>
<variable name="vmup" units="micromolar_per_millisecond"/>
<variable name="Km_up" units="micromolar" initial_value="0.412"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="i_CaL_max" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_CaL" units="picoA_per_picoF" public_interface="in"/>
<variable name="Cai" units="micromolar" public_interface="in"/>
<variable name="Cass" units="micromolar" public_interface="in"/>
<variable name="CaJSR" units="micromolar" public_interface="in"/>
<variable name="CaNSR" units="micromolar" public_interface="in"/>
<variable name="P_O1" units="dimensionless" public_interface="in"/>
<variable name="P_O2" units="dimensionless" public_interface="in"/>
<variable name="vmup_init" units="micromolar_per_millisecond" initial_value="0.3158"/>
<variable name="P_ryr_const1" units="per_millisecond" initial_value="-0.09"/>
<variable name="P_ryr_const2" units="per_millisecond" initial_value="-0.225"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>J_rel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<ci>CaJSR</ci>
<ci>Cass</ci>
</apply>
<ci>P_RyR</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_tr</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>CaJSR</ci>
</apply>
<ci>tau_tr</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_xfer</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>Cass</ci>
<ci>Cai</ci>
</apply>
<ci>tau_xfer</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_leak</ci>
<apply>
<times/>
<ci>v2</ci>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaMKb</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.05</cn>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>CaMKt</ci>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<divide/>
<cn cellml:units="micromolar">0.7</cn>
<ci>Cass</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>CaMKt</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>on_rate</ci>
<ci>CaMKb</ci>
<apply>
<plus/>
<ci>CaMKb</ci>
<ci>CaMKt</ci>
</apply>
</apply>
<apply>
<times/>
<ci>off_rate</ci>
<ci>CaMKt</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CaMKa</ci>
<apply>
<plus/>
<ci>CaMKb</ci>
<ci>CaMKt</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>vmup</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless">3.1512</cn>
<apply>
<power/>
<ci>CaMKa</ci>
<cn cellml:units="dimensionless">2.2062</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<cn cellml:units="dimensionless">0.1588</cn>
<cn cellml:units="dimensionless">2.2062</cn>
</apply>
<apply>
<power/>
<ci>CaMKa</ci>
<cn cellml:units="dimensionless">2.2062</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>vmup_init</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_serca</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>vmup</ci>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Km_up</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_RyR</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>P_ryr_const1</ci>
<ci>P_RyR</ci>
</apply>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>P_ryr_const2</ci>
<ci>i_CaL</ci>
</apply>
<ci>i_CaL_max</ci>
</apply>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<power/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<cn cellml:units="millivolt2">648</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ryanodine_receptors">
<variable name="P_O1" units="dimensionless" initial_value="0.003825599" public_interface="out"/>
<variable name="P_O2" units="dimensionless" initial_value="1.835831e-8" public_interface="out"/>
<variable name="P_C1" units="dimensionless" public_interface="out"/>
<variable name="P_C2" units="dimensionless" initial_value="0.3797679" public_interface="out"/>
<variable name="k_plus_a" units="micromolar4_per_millisecond" initial_value="0.006075"/>
<variable name="k_minus_a" units="per_millisecond" initial_value="0.07125"/>
<variable name="k_plus_b" units="micromolar3_per_millisecond" initial_value="0.00405"/>
<variable name="k_minus_b" units="per_millisecond" initial_value="0.965"/>
<variable name="k_plus_c" units="per_millisecond" initial_value="0.009"/>
<variable name="k_minus_c" units="per_millisecond" initial_value="0.0008"/>
<variable name="m" units="dimensionless" initial_value="3"/>
<variable name="n" units="dimensionless" initial_value="4"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Cass" units="micromolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>k_plus_a</ci>
<apply>
<power/>
<ci>Cass</ci>
<ci>n</ci>
</apply>
<ci>P_C1</ci>
</apply>
<apply>
<times/>
<ci>k_minus_b</ci>
<ci>P_O2</ci>
</apply>
<apply>
<times/>
<ci>k_minus_c</ci>
<ci>P_C2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>k_minus_a</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_plus_b</ci>
<apply>
<power/>
<ci>Cass</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_plus_c</ci>
<ci>P_O1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>P_C1</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>P_C2</ci>
<ci>P_O1</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_O2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_plus_b</ci>
<apply>
<power/>
<ci>Cass</ci>
<ci>m</ci>
</apply>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_minus_b</ci>
<ci>P_O2</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>P_C2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>k_plus_c</ci>
<ci>P_O1</ci>
</apply>
<apply>
<times/>
<ci>k_minus_c</ci>
<ci>P_C2</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="L_type_calcium_current">
<variable name="i_CaL" units="picoA_per_picoF" public_interface="out"/>
<variable name="i_CaL_max" units="picoA_per_picoF" initial_value="4" public_interface="out"/>
<variable name="P_CaL" units="per_millisecond" initial_value="19.1078"/>
<variable name="O" units="dimensionless" initial_value="4.373318e-6"/>
<variable name="C" units="dimensionless"/>
<variable name="I" units="dimensionless" initial_value="0.009171979"/>
<variable name="y_gate" units="dimensionless" initial_value="0.8876797"/>
<variable name="y_gate_inf" units="dimensionless"/>
<variable name="y_gate_tau" units="millisecond"/>
<variable name="Cass" units="micromolar" public_interface="in"/>
<variable name="alpha_p" units="per_millisecond"/>
<variable name="alpha_m" units="per_millisecond"/>
<variable name="epsilon_p" units="per_micromolar_millisecond"/>
<variable name="epsilon_m" units="per_millisecond"/>
<variable name="V_L" units="millivolt" initial_value="-2"/>
<variable name="delta_V_L" units="millivolt" initial_value="7.0671"/>
<variable name="t_L" units="millisecond" initial_value="1.1683"/>
<variable name="phi_L" units="dimensionless" initial_value="1.6411"/>
<variable name="a" units="dimensionless" initial_value="0.07"/>
<variable name="b" units="dimensionless" initial_value="14"/>
<variable name="tau_L" units="millisecond" initial_value="972.9715"/>
<variable name="K_L" units="micromolar" initial_value="0.0964"/>
<variable name="expVL" units="dimensionless"/>
<variable name="FVRT" units="dimensionless"/>
<variable name="FVRT_Ca" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="Cao" units="micromolar" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="Acap" units="cm2" public_interface="in"/>
<variable name="Vss" units="microlitre" public_interface="in"/>
<variable name="Cm" units="microF_per_cm2" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="const5" units="millivolt" initial_value="6.6755"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>FVRT</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>F</ci>
<ci>V</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>FVRT_Ca</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>FVRT</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>expVL</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<ci>V_L</ci>
</apply>
<ci>delta_V_L</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_p</ci>
<apply>
<divide/>
<ci>expVL</ci>
<apply>
<times/>
<ci>t_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_m</ci>
<apply>
<divide/>
<ci>phi_L</ci>
<ci>t_L</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_p</ci>
<apply>
<divide/>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a</ci>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<ci>K_L</ci>
<apply>
<plus/>
<ci>expVL</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>epsilon_m</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>b</ci>
<apply>
<plus/>
<ci>expVL</ci>
<ci>a</ci>
</apply>
</apply>
<apply>
<times/>
<ci>tau_L</ci>
<apply>
<plus/>
<apply>
<times/>
<ci>b</ci>
<ci>expVL</ci>
</apply>
<ci>a</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_gate_inf</ci>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">16.6577</cn>
</apply>
<ci>const5</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<cn cellml:units="millivolt">40</cn>
</apply>
<cn cellml:units="millivolt">6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>y_gate_tau</ci>
<apply>
<plus/>
<cn cellml:units="millisecond">20</cn>
<apply>
<divide/>
<cn cellml:units="millisecond">600</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">30</cn>
</apply>
<cn cellml:units="millivolt">9.6</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C</ci>
<apply>
<minus/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>O</ci>
</apply>
<ci>I</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_p</ci>
<ci>C</ci>
</apply>
<apply>
<times/>
<ci>alpha_m</ci>
<ci>O</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>epsilon_p</ci>
<ci>Cass</ci>
<ci>C</ci>
</apply>
<apply>
<times/>
<ci>epsilon_m</ci>
<ci>I</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>y_gate</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>y_gate_inf</ci>
<ci>y_gate</ci>
</apply>
<ci>y_gate_tau</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>i_CaL</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>P_CaL</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
<ci>Vss</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
</apply>
<ci>O</ci>
<ci>y_gate</ci>
<ci>FVRT_Ca</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<minus/>
<ci>FVRT_Ca</ci>
</apply>
</apply>
</apply>
<ci>Cass</ci>
</apply>
</apply>
<apply>
<gt/>
<apply>
<abs/>
<ci>FVRT_Ca</ci>
</apply>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>P_CaL</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
<ci>Vss</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
</apply>
<ci>O</ci>
<ci>y_gate</ci>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Cao</ci>
<apply>
<exp/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.00001</cn>
</apply>
</apply>
</apply>
<ci>Cass</ci>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<component name="calcium_pump_current">
<variable name="i_pCa" units="picoA_per_picoF" public_interface="out"/>
<variable name="i_pCa_max" units="picoA_per_picoF" initial_value="0.9"/>
<variable name="Km_pCa" units="micromolar" initial_value="0.4"/>
<variable name="Cai" units="micromolar" public_interface="in"/>
<variable name="J_pCa" units="micromolar_per_millisecond" public_interface="out"/>
<variable name="Vmyo" units="microlitre" public_interface="in"/>
<variable name="Acap" units="cm2" public_interface="in"/>
<variable name="Cm" units="microF_per_cm2" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_pCa</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_pCa_max</ci>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>Km_pCa</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<power/>
<ci>Cai</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_pCa</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>i_pCa</ci>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_calcium_exchange_current">
<variable name="J_ncx" units="micromolar_per_millisecond"/>
<variable name="i_NaCa" units="picoA_per_picoF" public_interface="out"/>
<variable name="k_NaCa" units="picoA_per_picoF" initial_value="772.8991"/>
<variable name="K_mNa" units="micromolar" initial_value="86500"/>
<variable name="K_mCa" units="micromolar" initial_value="1380"/>
<variable name="k_sat" units="dimensionless" initial_value="0.1"/>
<variable name="eta" units="dimensionless" initial_value="0.35"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nai" units="micromolar" public_interface="in"/>
<variable name="Nao" units="micromolar" public_interface="in"/>
<variable name="Cai" units="micromolar" public_interface="in"/>
<variable name="Cao" units="micromolar" public_interface="in"/>
<variable name="Vmyo" units="microlitre" public_interface="in"/>
<variable name="Acap" units="cm2" public_interface="in"/>
<variable name="Cm" units="microF_per_cm2" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>k_NaCa</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<apply>
<power/>
<ci>K_mNa</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<ci>K_mCa</ci>
<ci>Cao</ci>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<ci>k_sat</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>eta</ci>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nai</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cao</ci>
</apply>
<apply>
<times/>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>eta</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
<apply>
<power/>
<ci>Nao</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_ncx</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaCa</ci>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_background_current">
<variable name="i_Cab" units="picoA_per_picoF" public_interface="out"/>
<variable name="g_Cab" units="milliS_per_microF" initial_value="0.00088"/>
<variable name="E_CaN" units="millivolt"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Cai" units="micromolar" public_interface="in"/>
<variable name="Cao" units="micromolar" public_interface="in"/>
<variable name="J_Cab" units="micromolar_per_millisecond"/>
<variable name="Vmyo" units="microlitre" public_interface="in"/>
<variable name="Acap" units="cm2" public_interface="in"/>
<variable name="Cm" units="microF_per_cm2" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Cab</ci>
<apply>
<times/>
<ci>g_Cab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_CaN</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_CaN</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Cao</ci>
<ci>Cai</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_Cab</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>i_Cab</ci>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_concentration">
<variable name="Nai" units="micromolar" initial_value="16522.45" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Vmyo" units="microlitre" public_interface="in"/>
<variable name="Cm" units="microF_per_cm2" public_interface="in"/>
<variable name="Acap" units="cm2" public_interface="in"/>
<variable name="i_Na" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_NaCa" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_NaK" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Nab" units="picoA_per_picoF" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Nai</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Na</ci>
<ci>i_Nab</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaK</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">3</cn>
<ci>i_NaCa</ci>
</apply>
</apply>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_sodium_current">
<variable name="i_Na" units="picoA_per_picoF" public_interface="out"/>
<variable name="E_Na" units="millivolt" public_interface="out"/>
<variable name="g_Na" units="milliS_per_microF" initial_value="13"/>
<variable name="O_Na" units="dimensionless" initial_value="2.639399e-7"/>
<variable name="C_Na1" units="dimensionless" initial_value="0.0001581035"/>
<variable name="C_Na2" units="dimensionless" initial_value="0.01702105"/>
<variable name="C_Na3" units="dimensionless"/>
<variable name="I1_Na" units="dimensionless" initial_value="0.00001799179"/>
<variable name="I2_Na" units="dimensionless" initial_value="0.000005460299"/>
<variable name="IF_Na" units="dimensionless" initial_value="0.0000556206"/>
<variable name="IC_Na2" units="dimensionless" initial_value="0.005985434"/>
<variable name="IC_Na3" units="dimensionless" initial_value="0.2543133"/>
<variable name="alpha_Na11" units="per_millisecond"/>
<variable name="beta_Na11" units="per_millisecond"/>
<variable name="alpha_Na12" units="per_millisecond"/>
<variable name="beta_Na12" units="per_millisecond"/>
<variable name="alpha_Na13" units="per_millisecond"/>
<variable name="beta_Na13" units="per_millisecond"/>
<variable name="alpha_Na3" units="per_millisecond"/>
<variable name="beta_Na3" units="per_millisecond"/>
<variable name="alpha_Na2" units="per_millisecond"/>
<variable name="beta_Na2" units="per_millisecond"/>
<variable name="alpha_Na4" units="per_millisecond"/>
<variable name="beta_Na4" units="per_millisecond"/>
<variable name="alpha_Na5" units="per_millisecond"/>
<variable name="beta_Na5" units="per_millisecond"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nao" units="micromolar" public_interface="in"/>
<variable name="Nai" units="micromolar" public_interface="in"/>
<variable name="Ko" units="micromolar" public_interface="in"/>
<variable name="Ki" units="micromolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Na</ci>
<apply>
<times/>
<ci>g_Na</ci>
<ci>O_Na</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_Na</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.9</cn>
<ci>Nao</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<ci>Ko</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.9</cn>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1</cn>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>C_Na3</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<ci>O_Na</ci>
<ci>C_Na1</ci>
<ci>C_Na2</ci>
<ci>IF_Na</ci>
<ci>I1_Na</ci>
<ci>I2_Na</ci>
<ci>IC_Na2</ci>
<ci>IC_Na3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_Na2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_Na11</ci>
<ci>C_Na3</ci>
</apply>
<apply>
<times/>
<ci>beta_Na12</ci>
<ci>C_Na1</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na3</ci>
<ci>IC_Na2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_Na11</ci>
<ci>C_Na2</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na12</ci>
<ci>C_Na2</ci>
</apply>
<apply>
<times/>
<ci>beta_Na3</ci>
<ci>C_Na2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_Na1</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_Na12</ci>
<ci>C_Na2</ci>
</apply>
<apply>
<times/>
<ci>beta_Na13</ci>
<ci>O_Na</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na3</ci>
<ci>IF_Na</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_Na12</ci>
<ci>C_Na1</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na13</ci>
<ci>C_Na1</ci>
</apply>
<apply>
<times/>
<ci>beta_Na3</ci>
<ci>C_Na1</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_Na13</ci>
<ci>C_Na1</ci>
</apply>
<apply>
<times/>
<ci>beta_Na2</ci>
<ci>IF_Na</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_Na13</ci>
<ci>O_Na</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na2</ci>
<ci>O_Na</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IF_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_Na2</ci>
<ci>O_Na</ci>
</apply>
<apply>
<times/>
<ci>beta_Na3</ci>
<ci>C_Na1</ci>
</apply>
<apply>
<times/>
<ci>beta_Na4</ci>
<ci>I1_Na</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na12</ci>
<ci>IC_Na2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_Na2</ci>
<ci>IF_Na</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na3</ci>
<ci>IF_Na</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na4</ci>
<ci>IF_Na</ci>
</apply>
<apply>
<times/>
<ci>beta_Na12</ci>
<ci>IF_Na</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I1_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_Na4</ci>
<ci>IF_Na</ci>
</apply>
<apply>
<times/>
<ci>beta_Na5</ci>
<ci>I2_Na</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_Na4</ci>
<ci>I1_Na</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na5</ci>
<ci>I1_Na</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I2_Na</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_Na5</ci>
<ci>I1_Na</ci>
</apply>
<apply>
<times/>
<ci>beta_Na5</ci>
<ci>I2_Na</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IC_Na2</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_Na11</ci>
<ci>IC_Na3</ci>
</apply>
<apply>
<times/>
<ci>beta_Na12</ci>
<ci>IF_Na</ci>
</apply>
<apply>
<times/>
<ci>beta_Na3</ci>
<ci>IC_Na2</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_Na11</ci>
<ci>IC_Na2</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na12</ci>
<ci>IC_Na2</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na3</ci>
<ci>IC_Na2</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>IC_Na3</ci>
</apply>
<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>beta_Na11</ci>
<ci>IC_Na2</ci>
</apply>
<apply>
<times/>
<ci>beta_Na3</ci>
<ci>C_Na3</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_Na11</ci>
<ci>IC_Na3</ci>
</apply>
<apply>
<times/>
<ci>alpha_Na3</ci>
<ci>IC_Na3</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Na11</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">3.802</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">17</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">150</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Na12</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">3.802</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">15</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.23</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">150</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Na13</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">3.802</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1027</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">12</cn>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.25</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">150</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Na11</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.1917</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20.3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Na12</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.2</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">2.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20.3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Na13</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.22</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">7.5</cn>
</apply>
</apply>
<cn cellml:units="millivolt">20.3</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Na3</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">7e-7</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
<cn cellml:units="millivolt">7.7</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Na3</ci>
<apply>
<plus/>
<cn cellml:units="per_millisecond">0.0084</cn>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.00002</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Na2</ci>
<apply>
<divide/>
<cn cellml:units="per_millisecond">1</cn>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.188495</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">7</cn>
</apply>
</apply>
<cn cellml:units="millivolt">16.6</cn>
</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">0.393956</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Na2</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>alpha_Na13</ci>
<ci>alpha_Na2</ci>
<ci>alpha_Na3</ci>
</apply>
<apply>
<times/>
<ci>beta_Na13</ci>
<ci>beta_Na3</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_Na4</ci>
<apply>
<divide/>
<ci>alpha_Na2</ci>
<cn cellml:units="dimensionless">1000</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Na4</ci>
<ci>alpha_Na3</ci>
</apply>
<apply>
<eq/>
<ci>alpha_Na5</ci>
<apply>
<divide/>
<ci>alpha_Na2</ci>
<cn cellml:units="dimensionless">95000</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_Na5</ci>
<apply>
<divide/>
<ci>alpha_Na3</ci>
<cn cellml:units="dimensionless">50</cn>
</apply>
</apply>
</math>
</component>
<component name="sodium_background_current">
<variable name="i_Nab" units="picoA_per_picoF" public_interface="out"/>
<variable name="g_Nab" units="milliS_per_microF" initial_value="0.0026"/>
<variable name="E_Na" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Nab</ci>
<apply>
<times/>
<ci>g_Nab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="potassium_concentration">
<variable name="Ki" units="micromolar" initial_value="141474" public_interface="out"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Vmyo" units="microlitre" public_interface="in"/>
<variable name="Cm" units="microF_per_cm2" public_interface="in"/>
<variable name="Acap" units="cm2" public_interface="in"/>
<variable name="i_Kto_f" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kto_s" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_K1" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Ks" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kss" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kur" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Kr" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_NaK" units="picoA_per_picoF" public_interface="in"/>
<variable name="i_Stim" units="picoA_per_picoF" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>Ki</ci>
</apply>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<plus/>
<ci>i_Stim</ci>
<ci>i_Kto_f</ci>
<ci>i_Kto_s</ci>
<ci>i_K1</ci>
<ci>i_Ks</ci>
<ci>i_Kss</ci>
<ci>i_Kur</ci>
<ci>i_Kr</ci>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">2</cn>
<ci>i_NaK</ci>
</apply>
</apply>
</apply>
<ci>Acap</ci>
<ci>Cm</ci>
</apply>
<apply>
<times/>
<ci>Vmyo</ci>
<ci>F</ci>
</apply>
</apply>
</apply>
</math>
</component>
<component name="fast_transient_outward_K_I">
<variable name="i_Kto_f" units="picoA_per_picoF" public_interface="out"/>
<variable name="E_K" units="millivolt" public_interface="out"/>
<variable name="g_Kto_f" units="milliS_per_microF" initial_value="0.4067"/>
<variable name="ato_f" units="dimensionless" initial_value="0.001937245"/>
<variable name="ito_f" units="dimensionless" initial_value="0.9999985"/>
<variable name="alpha_a" units="per_millisecond"/>
<variable name="beta_a" units="per_millisecond"/>
<variable name="alpha_i" units="per_millisecond"/>
<variable name="beta_i" units="per_millisecond"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Ki" units="micromolar" public_interface="in"/>
<variable name="Ko" units="micromolar" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kto_f</ci>
<apply>
<times/>
<ci>g_Kto_f</ci>
<apply>
<power/>
<ci>ato_f</ci>
<cn cellml:units="dimensionless">3</cn>
</apply>
<ci>ito_f</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>E_K</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<ln/>
<apply>
<divide/>
<ci>Ko</ci>
<ci>Ki</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ato_f</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_a</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>ato_f</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_a</ci>
<ci>ato_f</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ito_f</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_i</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>ito_f</ci>
</apply>
</apply>
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<times/>
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<minus/>
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<plus/>
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</apply>
</apply>
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<eq/>
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<apply>
<divide/>
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<times/>
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<apply>
<exp/>
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<divide/>
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<minus/>
<apply>
<plus/>
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</apply>
</apply>
<cn cellml:units="millivolt">7</cn>
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<plus/>
<apply>
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<divide/>
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<minus/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
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<eq/>
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<divide/>
<apply>
<times/>
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<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
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<apply>
<exp/>
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<divide/>
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<plus/>
<ci>V</ci>
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</apply>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
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<variable name="ass" units="dimensionless" public_interface="out"/>
<variable name="iss" units="dimensionless" public_interface="out"/>
<variable name="g_Kto_s" units="milliS_per_microF" initial_value="0"/>
<variable name="ato_s" units="dimensionless" initial_value="0.02000568"/>
<variable name="ito_s" units="dimensionless" initial_value="0.9308568"/>
<variable name="tau_ta_s" units="millisecond"/>
<variable name="tau_ti_s" units="millisecond"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kto_s</ci>
<apply>
<times/>
<ci>g_Kto_s</ci>
<ci>ato_s</ci>
<ci>ito_s</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ato_s</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ass</ci>
<ci>ato_s</ci>
</apply>
<ci>tau_ta_s</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>ito_s</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>iss</ci>
<ci>ito_s</ci>
</apply>
<ci>tau_ti_s</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>ass</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
</apply>
<cn cellml:units="millivolt">7.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>iss</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
<cn cellml:units="millivolt">5.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_ta_s</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">0.493</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
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</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">2.058</cn>
</apply>
</apply>
<apply>
<eq/>
<ci>tau_ti_s</ci>
<apply>
<plus/>
<cn cellml:units="millisecond">270</cn>
<apply>
<divide/>
<cn cellml:units="millisecond">1050</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">45.2</cn>
</apply>
<cn cellml:units="millivolt">5.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="time_independent_K_I">
<variable name="i_K1" units="picoA_per_picoF" public_interface="out"/>
<variable name="Ko" units="micromolar" public_interface="in"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="g_K1" units="milliS_per_microF" initial_value="0.2938"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_K1</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_K1</ci>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<cn cellml:units="micromolar">210</cn>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.0896</cn>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
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<component name="slow_delayed_rectifier_K_I">
<variable name="i_Ks" units="picoA_per_picoF" public_interface="out"/>
<variable name="g_Ks" units="milliS_per_microF" initial_value="0.00575"/>
<variable name="nKs" units="dimensionless" initial_value="0.002206261"/>
<variable name="alpha_n" units="per_millisecond"/>
<variable name="beta_n" units="per_millisecond"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Ks</ci>
<apply>
<times/>
<ci>g_Ks</ci>
<apply>
<power/>
<ci>nKs</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
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</bvar>
<ci>nKs</ci>
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<apply>
<minus/>
<apply>
<times/>
<ci>alpha_n</ci>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>nKs</ci>
</apply>
</apply>
<apply>
<times/>
<ci>beta_n</ci>
<ci>nKs</ci>
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</apply>
<apply>
<eq/>
<ci>alpha_n</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="per_millivolt_millisecond">0.00000481333</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">26.5</cn>
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</apply>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
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</apply>
<apply>
<plus/>
<ci>V</ci>
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</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_n</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.0000953333</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.038</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
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</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="ultra_rapidly_activating_delayed_rectifier_K_I">
<variable name="i_Kur" units="picoA_per_picoF" public_interface="out"/>
<variable name="g_Kur" units="milliS_per_microF" initial_value="0.16"/>
<variable name="aur" units="dimensionless" initial_value="0.02000568"/>
<variable name="iur" units="dimensionless" initial_value="0.9822006"/>
<variable name="tau_aur" units="millisecond"/>
<variable name="tau_iur" units="millisecond"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="ass" units="dimensionless" public_interface="in"/>
<variable name="iss" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kur</ci>
<apply>
<times/>
<ci>g_Kur</ci>
<ci>aur</ci>
<ci>iur</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>aur</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>ass</ci>
<ci>aur</ci>
</apply>
<ci>tau_aur</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>iur</ci>
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<apply>
<divide/>
<apply>
<minus/>
<ci>iss</ci>
<ci>iur</ci>
</apply>
<ci>tau_iur</ci>
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<apply>
<eq/>
<ci>tau_aur</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">0.493</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
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</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
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</apply>
<apply>
<eq/>
<ci>tau_iur</ci>
<apply>
<minus/>
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<apply>
<divide/>
<cn cellml:units="millisecond">170</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
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</apply>
<cn cellml:units="millivolt">5.7</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="non_inactivating_steady_state_K_I">
<variable name="i_Kss" units="picoA_per_picoF" public_interface="out"/>
<variable name="g_Kss" units="milliS_per_microF" initial_value="0.05"/>
<variable name="aKss" units="dimensionless" initial_value="0.8883113"/>
<variable name="iKss" units="dimensionless" initial_value="1"/>
<variable name="tau_Kss" units="millisecond"/>
<variable name="E_K" units="millivolt" public_interface="in"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="time" units="millisecond" public_interface="in"/>
<variable name="ass" units="dimensionless" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_Kss</ci>
<apply>
<times/>
<ci>g_Kss</ci>
<ci>aKss</ci>
<ci>iKss</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>aKss</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<ci>ass</ci>
<ci>aKss</ci>
</apply>
<ci>tau_Kss</ci>
</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>iKss</ci>
</apply>
<cn cellml:units="per_millisecond">0</cn>
</apply>
<apply>
<eq/>
<ci>tau_Kss</ci>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="millisecond">39.3</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.0862</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
<cn cellml:units="millisecond">13.17</cn>
</apply>
</apply>
</math>
</component>
<component name="rapid_delayed_rectifier_K_I">
<variable name="i_Kr" units="picoA_per_picoF" public_interface="out"/>
<variable name="g_Kr" units="milliS_per_microF" initial_value="0.078"/>
<variable name="O_K" units="dimensionless" initial_value="0.0004858865"/>
<variable name="C_K1" units="dimensionless" initial_value="0.0007799137"/>
<variable name="C_K2" units="dimensionless" initial_value="0.0005301217"/>
<variable name="C_K0" units="dimensionless"/>
<variable name="I_K" units="dimensionless" initial_value="0.00007519518"/>
<variable name="alpha_a0" units="per_millisecond"/>
<variable name="beta_a0" units="per_millisecond"/>
<variable name="kb" units="per_millisecond" initial_value="0.036778"/>
<variable name="kf" units="per_millisecond" initial_value="0.023761"/>
<variable name="alpha_a1" units="per_millisecond"/>
<variable name="beta_a1" units="per_millisecond"/>
<variable name="alpha_i" units="per_millisecond"/>
<variable name="beta_i" units="per_millisecond"/>
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<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nao" units="micromolar" public_interface="in"/>
<variable name="Nai" units="micromolar" public_interface="in"/>
<variable name="Ko" units="micromolar" public_interface="in"/>
<variable name="Ki" units="micromolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
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<eq/>
<ci>i_Kr</ci>
<apply>
<times/>
<ci>g_Kr</ci>
<ci>O_K</ci>
<apply>
<minus/>
<ci>V</ci>
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<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
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<ci>F</ci>
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<apply>
<ln/>
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<divide/>
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<plus/>
<apply>
<times/>
<cn cellml:units="dimensionless">0.98</cn>
<ci>Ko</ci>
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<times/>
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<ci>Nao</ci>
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<plus/>
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<times/>
<cn cellml:units="dimensionless">0.98</cn>
<ci>Ki</ci>
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<times/>
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<ci>Nai</ci>
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</apply>
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</apply>
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<apply>
<eq/>
<ci>C_K0</ci>
<apply>
<minus/>
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<apply>
<plus/>
<ci>C_K1</ci>
<ci>C_K2</ci>
<ci>O_K</ci>
<ci>I_K</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>C_K2</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>kf</ci>
<ci>C_K1</ci>
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<apply>
<times/>
<ci>beta_a1</ci>
<ci>O_K</ci>
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<apply>
<plus/>
<apply>
<times/>
<ci>kb</ci>
<ci>C_K2</ci>
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<apply>
<times/>
<ci>alpha_a1</ci>
<ci>C_K2</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
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<ci>C_K1</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_a0</ci>
<ci>C_K0</ci>
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<apply>
<times/>
<ci>kb</ci>
<ci>C_K2</ci>
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<apply>
<plus/>
<apply>
<times/>
<ci>beta_a0</ci>
<ci>C_K1</ci>
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<apply>
<times/>
<ci>kf</ci>
<ci>C_K1</ci>
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<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>O_K</ci>
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<apply>
<minus/>
<apply>
<plus/>
<apply>
<times/>
<ci>alpha_a1</ci>
<ci>C_K2</ci>
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<apply>
<times/>
<ci>beta_i</ci>
<ci>I_K</ci>
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<apply>
<plus/>
<apply>
<times/>
<ci>beta_a1</ci>
<ci>O_K</ci>
</apply>
<apply>
<times/>
<ci>alpha_i</ci>
<ci>O_K</ci>
</apply>
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</apply>
</apply>
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>I_K</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>alpha_i</ci>
<ci>O_K</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<ci>I_K</ci>
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<apply>
<eq/>
<ci>alpha_a0</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.022348</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.01176</cn>
<ci>V</ci>
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<apply>
<eq/>
<ci>beta_a0</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.047002</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.0631</cn>
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<ci>V</ci>
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<apply>
<eq/>
<ci>alpha_a1</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.013733</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.038198</cn>
<ci>V</ci>
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</apply>
<apply>
<eq/>
<ci>beta_a1</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.0000689</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.04178</cn>
</apply>
<ci>V</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>alpha_i</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.090821</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="per_millivolt">0.023391</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>beta_i</ci>
<apply>
<times/>
<cn cellml:units="per_millisecond">0.006497</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="per_millivolt">0.03268</cn>
</apply>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="millivolt">5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="sodium_potassium_pump_current">
<variable name="i_NaK" units="picoA_per_picoF" public_interface="out"/>
<variable name="i_NaK_max" units="picoA_per_picoF" initial_value="1.66"/>
<variable name="Km_Nai" units="micromolar" initial_value="21000"/>
<variable name="Km_Ko" units="micromolar" initial_value="1500"/>
<variable name="f_NaK" units="dimensionless"/>
<variable name="sigma" units="dimensionless"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="R" units="joule_per_mole_kelvin" public_interface="in"/>
<variable name="T" units="kelvin" public_interface="in"/>
<variable name="F" units="coulomb_per_millimole" public_interface="in"/>
<variable name="Nai" units="micromolar" public_interface="in"/>
<variable name="Nao" units="micromolar" public_interface="in"/>
<variable name="Ko" units="micromolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_NaK</ci>
<apply>
<divide/>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>i_NaK_max</ci>
<ci>f_NaK</ci>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<power/>
<apply>
<divide/>
<ci>Km_Nai</ci>
<ci>Nai</ci>
</apply>
<cn cellml:units="dimensionless">1.5</cn>
</apply>
</apply>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<plus/>
<ci>Ko</ci>
<ci>Km_Ko</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>f_NaK</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<times/>
<cn cellml:units="dimensionless">0.1245</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.1</cn>
</apply>
<ci>V</ci>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<cn cellml:units="dimensionless">0.0365</cn>
<ci>sigma</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>V</ci>
</apply>
<ci>F</ci>
</apply>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>sigma</ci>
<apply>
<times/>
<apply>
<divide/>
<cn cellml:units="dimensionless">1</cn>
<cn cellml:units="dimensionless">7</cn>
</apply>
<apply>
<minus/>
<apply>
<exp/>
<apply>
<divide/>
<ci>Nao</ci>
<cn cellml:units="micromolar">67300</cn>
</apply>
</apply>
<cn cellml:units="dimensionless">1</cn>
</apply>
</apply>
</apply>
</math>
</component>
<component name="calcium_activated_chloride_current">
<variable name="i_ClCa" units="picoA_per_picoF" public_interface="out"/>
<variable name="g_ClCa" units="milliS_per_microF" initial_value="10"/>
<variable name="O_ClCa" units="dimensionless"/>
<variable name="E_Cl" units="millivolt" initial_value="-40"/>
<variable name="Km_Cl" units="micromolar" initial_value="10"/>
<variable name="V" units="millivolt" public_interface="in"/>
<variable name="Cai" units="micromolar" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>i_ClCa</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>g_ClCa</ci>
<ci>O_ClCa</ci>
<ci>Cai</ci>
</apply>
<apply>
<plus/>
<ci>Cai</ci>
<ci>Km_Cl</ci>
</apply>
</apply>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Cl</ci>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>O_ClCa</ci>
<apply>
<divide/>
<cn cellml:units="dimensionless">0.2</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="millivolt">46.7</cn>
</apply>
</apply>
<cn cellml:units="millivolt">7.8</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
</component>
<component name="transmembrane_currents"/>
<component name="intracellular_currents"/>
<component name="Ions_n_reversal_potentials"/>
<group>
<relationship_ref relationship="containment"/>
<component_ref component="membrane">
<component_ref component="transmembrane_currents">
<component_ref component="L_type_calcium_current"/>
<component_ref component="calcium_pump_current"/>
<component_ref component="sodium_calcium_exchange_current"/>
<component_ref component="calcium_background_current"/>
<component_ref component="fast_sodium_current"/>
<component_ref component="sodium_background_current"/>
<component_ref component="fast_transient_outward_K_I"/>
<component_ref component="slow_transient_outward_K_I"/>
<component_ref component="time_independent_K_I"/>
<component_ref component="slow_delayed_rectifier_K_I"/>
<component_ref component="ultra_rapidly_activating_delayed_rectifier_K_I"/>
<component_ref component="non_inactivating_steady_state_K_I"/>
<component_ref component="rapid_delayed_rectifier_K_I"/>
<component_ref component="sodium_potassium_pump_current"/>
<component_ref component="calcium_activated_chloride_current"/>
</component_ref>
<component_ref component="Ions_n_reversal_potentials">
<component_ref component="calcium_concentration"/>
<component_ref component="sodium_concentration"/>
<component_ref component="potassium_concentration"/>
</component_ref>
<component_ref component="intracellular_currents">
<component_ref component="ryanodine_receptors"/>
<component_ref component="calcium_fluxes"/>
</component_ref>
</component_ref>
</group>
<connection>
<map_components component_1="membrane" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ryanodine_receptors" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="L_type_calcium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_K_I" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_transient_outward_K_I" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="slow_delayed_rectifier_K_I" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="time_independent_K_I" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="ultra_rapidly_activating_delayed_rectifier_K_I" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="non_inactivating_steady_state_K_I" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="rapid_delayed_rectifier_K_I" component_2="environment"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="L_type_calcium_current"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_pump_current"/>
<map_variables variable_1="i_pCa" variable_2="i_pCa"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_calcium_exchange_current"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_background_current"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_sodium_current"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_background_current"/>
<map_variables variable_1="i_Nab" variable_2="i_Nab"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_potassium_pump_current"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="fast_transient_outward_K_I"/>
<map_variables variable_1="i_Kto_f" variable_2="i_Kto_f"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_transient_outward_K_I"/>
<map_variables variable_1="i_Kto_s" variable_2="i_Kto_s"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="time_independent_K_I"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="slow_delayed_rectifier_K_I"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="ultra_rapidly_activating_delayed_rectifier_K_I"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="non_inactivating_steady_state_K_I"/>
<map_variables variable_1="i_Kss" variable_2="i_Kss"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="rapid_delayed_rectifier_K_I"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_activated_chloride_current"/>
<map_variables variable_1="i_ClCa" variable_2="i_ClCa"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_concentration"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="VNSR" variable_2="VNSR"/>
<map_variables variable_1="VJSR" variable_2="VJSR"/>
<map_variables variable_1="Vss" variable_2="Vss"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="calcium_fluxes"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="sodium_concentration"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="F" variable_2="F"/>
</connection>
<connection>
<map_components component_1="membrane" component_2="potassium_concentration"/>
<map_variables variable_1="Cm" variable_2="Cm"/>
<map_variables variable_1="Acap" variable_2="Acap"/>
<map_variables variable_1="Vmyo" variable_2="Vmyo"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="i_Stim" variable_2="i_Stim"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_fluxes"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
<map_variables variable_1="CaJSR" variable_2="CaJSR"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
<map_variables variable_1="CaNSR" variable_2="CaNSR"/>
<map_variables variable_1="J_rel" variable_2="J_rel"/>
<map_variables variable_1="J_tr" variable_2="J_tr"/>
<map_variables variable_1="J_xfer" variable_2="J_xfer"/>
<map_variables variable_1="J_leak" variable_2="J_leak"/>
<map_variables variable_1="J_serca" variable_2="J_serca"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="ryanodine_receptors"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="L_type_calcium_current"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
<map_variables variable_1="Cass" variable_2="Cass"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_pump_current"/>
<map_variables variable_1="i_pCa" variable_2="i_pCa"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="sodium_calcium_exchange_current"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_background_current"/>
<map_variables variable_1="i_Cab" variable_2="i_Cab"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_concentration" component_2="calcium_activated_chloride_current"/>
<map_variables variable_1="Cai" variable_2="Cai"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes" component_2="L_type_calcium_current"/>
<map_variables variable_1="i_CaL_max" variable_2="i_CaL_max"/>
<map_variables variable_1="i_CaL" variable_2="i_CaL"/>
</connection>
<connection>
<map_components component_1="calcium_fluxes" component_2="ryanodine_receptors"/>
<map_variables variable_1="P_O1" variable_2="P_O1"/>
<map_variables variable_1="P_O2" variable_2="P_O2"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="fast_sodium_current"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_Na" variable_2="i_Na"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="sodium_background_current"/>
<map_variables variable_1="i_Nab" variable_2="i_Nab"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="sodium_calcium_exchange_current"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaCa" variable_2="i_NaCa"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="sodium_potassium_pump_current"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="sodium_background_current"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
</connection>
<connection>
<map_components component_1="fast_sodium_current" component_2="potassium_concentration"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="fast_transient_outward_K_I"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
<map_variables variable_1="i_Kto_f" variable_2="i_Kto_f"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="slow_transient_outward_K_I"/>
<map_variables variable_1="i_Kto_s" variable_2="i_Kto_s"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="time_independent_K_I"/>
<map_variables variable_1="i_K1" variable_2="i_K1"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="slow_delayed_rectifier_K_I"/>
<map_variables variable_1="i_Ks" variable_2="i_Ks"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="rapid_delayed_rectifier_K_I"/>
<map_variables variable_1="i_Kr" variable_2="i_Kr"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="sodium_concentration" component_2="rapid_delayed_rectifier_K_I"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="ultra_rapidly_activating_delayed_rectifier_K_I"/>
<map_variables variable_1="i_Kur" variable_2="i_Kur"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="sodium_potassium_pump_current"/>
<map_variables variable_1="i_NaK" variable_2="i_NaK"/>
</connection>
<connection>
<map_components component_1="potassium_concentration" component_2="non_inactivating_steady_state_K_I"/>
<map_variables variable_1="i_Kss" variable_2="i_Kss"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_K_I" component_2="slow_transient_outward_K_I"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_K_I" component_2="time_independent_K_I"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_K_I" component_2="slow_delayed_rectifier_K_I"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_K_I" component_2="ultra_rapidly_activating_delayed_rectifier_K_I"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="fast_transient_outward_K_I" component_2="non_inactivating_steady_state_K_I"/>
<map_variables variable_1="E_K" variable_2="E_K"/>
</connection>
<connection>
<map_components component_1="slow_transient_outward_K_I" component_2="ultra_rapidly_activating_delayed_rectifier_K_I"/>
<map_variables variable_1="ass" variable_2="ass"/>
<map_variables variable_1="iss" variable_2="iss"/>
</connection>
<connection>
<map_components component_1="slow_transient_outward_K_I" component_2="non_inactivating_steady_state_K_I"/>
<map_variables variable_1="ass" variable_2="ass"/>
</connection>
</model>
