Location: Faber, Rudy, 2000 @ 6f3b07858927 / faber_rudy_modified_version_2000.cellml

Author:
Catherine Lloyd <c.lloyd@auckland.ac.nz>
Date:
2009-12-16 12:49:12+13:00
Desc:
merge
Permanent Source URI:
https://models.fieldml.org/workspace/faber_rudy_2000/rawfile/6f3b07858927d97e55aedbc8bad0b89699e036d2/faber_rudy_modified_version_2000.cellml

<?xml version='1.0' encoding='utf-8'?>
<!--
This CellML file was generated on 31/07/2008 at 3:02:14 at p.m. using:

COR (0.9.31.915)
Copyright 2002-2008 Dr Alan Garny
http://COR.physiol.ox.ac.uk/ - COR@physiol.ox.ac.uk

CellML 1.0 was used to generate this cellular model
http://www.CellML.org/
-->

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<documentation xmlns="http://cellml.org/tmp-documentation">
<article>
  <articleinfo>
  <title>Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study</title>
  <author>
    <firstname>Catherine</firstname>
          <surname>Lloyd</surname>
    <affiliation>
      <shortaffil>Auckland Bioengineering Institute</shortaffil>
    </affiliation>
  </author>
</articleinfo>
  <section id="sec_status">
    <title>Model Status</title>
    <para>
            This model has been curated and is known to run in PCEnv and COR to recreate the published results.  The units have been checked and are known to be consistent.  The CellML model has been based on a translation of the LRd07 Matlab code which can be downloaded from the Rudy lab website.  It is basically the Faber and Rudy 2000 model with the addition of a transient potassium current (Ito) and an updated Irel current.
          </para>
  </section>
  <sect1 id="sec_structure">
<title>Model Structure</title>

<para>ABSTRACT:  Sodium overload of cardiac cells can accompany various pathologies and induce fatal cardiac arrhythmias. We investigate effects of elevated intracellular sodium on the cardiac action potential (AP) and on intracellular calcium using the Luo-Rudy model of a mammalian ventricular myocyte. The results are: 1) During rapid pacing, AP duration (APD) shortens in two phases, a rapid phase without Na(+) accumulation and a slower phase that depends on [Na(+)](i). 2) The rapid APD shortening is due to incomplete deactivation (accumulation) of I(Ks). 3) The slow phase is due to increased repolarizing currents I(NaK) and reverse-mode I(NaCa), secondary to elevated [Na(+)](i). 4) Na(+)-overload slows the rate of AP depolarization, allowing time for greater I(Ca(L)) activation; it also enhances reverse-mode I(NaCa). The resulting increased Ca(2+) influx triggers a greater [Ca(2+)](i) transient. 5) Reverse-mode I(NaCa) alone can trigger Ca(2+) release in a voltage and [Na(+)](i)-dependent manner. 6) During I(NaK) block, Na(+) and Ca(2+) accumulate and APD shortens due to enhanced reverse-mode I(NaCa); contribution of I(K(Na)) to APD shortening is negligible. By slowing AP depolarization (hence velocity) and shortening APD, Na(+)-overload acts to enhance inducibility of reentrant arrhythmias. Shortened APD with elevated [Ca(2+)](i) (secondary to Na(+)-overload) also predisposes the myocardium to arrhythmogenic delayed afterdepolarizations.
</para>

<para>
The complete original paper reference is cited below (but again please note that this CellML model is not the exact Faber-Rudy model, instead it is based on a translation of the LRd07 Matlab code which can be downloaded from the Rudy lab website.  It is similar to the Faber and Rudy 2000 model with the addition of a transient potassium current (Ito) and an updated Irel current.):
</para>

<para>
Action potential and contractility changes in [Na(+)](i) overloaded cardiac myocytes: a simulation study, Gregory M. Faber and Yoram Rudy, 2000, Biophysical Journal, 78, 2392-2404.  <ulink url="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&amp;db=PubMed&amp;list_uids=10777735&amp;dopt=Abstract">PubMed ID: 10777735</ulink>
</para>

<informalfigure float="0" id="fig_cell_diagram_faber">
<mediaobject>
  <imageobject>
    <objectinfo>
      <title>cell diagram of the shaw and viswanathan models showing ionic currents, pumps and exchangers within the sarcolemma and the sarcoplasmic reticulum</title>
    </objectinfo>
    <imagedata fileref="faber_2000.png"/>
  </imageobject>
</mediaobject>
<caption>A schematic diagram of the Faber and Rudy 2000 cardiac myocyte model.</caption>
</informalfigure>

</sect1>
</article>
</documentation>

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                  <cn cellml:units="per_ms">0</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <ci>beta_j</ci>
            <piecewise>
               <piece>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_ms">0.1212</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.01052</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.1378</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">40.14</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <lt/>
                     <ci>V</ci>
                     <apply>
                        <minus/>
                        <cn cellml:units="millivolt">40</cn>
                     </apply>
                  </apply>
               </piece>
               <otherwise>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_ms">0.3</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt" type="e-notation">2.535<sep/>-7</cn>
                              </apply>
                              <ci>V</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.1</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">32</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>j</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_j</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>j</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_j</ci>
                  <ci>j</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel">
      <variable units="microA_per_microF" public_interface="out" name="i_Ca_L"/>
      <variable units="microA_per_microF" public_interface="out" name="i_CaCa"/>
      <variable units="microA_per_microF" public_interface="out" name="i_CaK"/>
      <variable units="microA_per_microF" public_interface="out" name="i_CaNa"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Nai" initial_value="0.75"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Nao" initial_value="0.75"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Ki" initial_value="0.75"/>
      <variable units="dimensionless" public_interface="out" name="gamma_Ko" initial_value="0.75"/>
      <variable units="dimensionless" name="gamma_Cai" initial_value="1"/>
      <variable units="dimensionless" name="gamma_Cao" initial_value="0.341"/>
      <variable units="microA_per_microF" name="I_CaCa"/>
      <variable units="microA_per_microF" name="I_CaK"/>
      <variable units="microA_per_microF" name="I_CaNa"/>
      <variable units="litre_per_farad_millisecond" name="P_Ca" initial_value="0.00054"/>
      <variable units="litre_per_farad_millisecond" name="P_Na" initial_value="6.75e-7"/>
      <variable units="litre_per_farad_millisecond" name="P_K" initial_value="1.93e-7"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="millimolar" public_interface="in" private_interface="out" name="Cai"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="dimensionless" private_interface="in" name="d"/>
      <variable units="dimensionless" private_interface="in" name="f"/>
      <variable units="dimensionless" private_interface="in" name="f_Ca"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>I_CaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Ca</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">2</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Cai</ci>
                        <ci>Cai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">2</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Cao</ci>
                        <ci>Cao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">2</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaNa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_Na</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_CaK</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_K</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaCa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaCa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaNa</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaNa</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_CaK</ci>
            <apply>
               <times/>
               <ci>d</ci>
               <ci>f</ci>
               <ci>f_Ca</ci>
               <ci>I_CaK</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_L</ci>
            <apply>
               <plus/>
               <ci>i_CaCa</ci>
               <ci>i_CaK</ci>
               <ci>i_CaNa</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_d_gate">
      <variable units="dimensionless" public_interface="out" name="d" initial_value="0.000005906564"/>
      <variable units="per_ms" name="alpha_d"/>
      <variable units="per_ms" name="beta_d"/>
      <variable units="dimensionless" name="d_infinity"/>
      <variable units="ms" name="tau_d"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="millivolt" name="E0_d"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E0_d</ci>
            <apply>
               <plus/>
               <ci>V</ci>
               <cn cellml:units="millivolt">10</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>d_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>E0_d</ci>
                        </apply>
                        <cn cellml:units="millivolt">6.24</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_d</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="ms">1</cn>
                  <ci>d_infinity</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <ci>E0_d</ci>
                           </apply>
                           <cn cellml:units="millivolt">6.24</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <cn cellml:units="per_millivolt">0.035</cn>
                  <ci>E0_d</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_d</ci>
            <apply>
               <divide/>
               <ci>d_infinity</ci>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_d</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>d_infinity</ci>
               </apply>
               <ci>tau_d</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>d</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_d</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>d</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_d</ci>
                  <ci>d</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_gate">
      <variable units="dimensionless" public_interface="out" name="f" initial_value="0.999390880784"/>
      <variable units="per_ms" name="alpha_f"/>
      <variable units="per_ms" name="beta_f"/>
      <variable units="dimensionless" name="f_infinity"/>
      <variable units="ms" name="tau_f"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_infinity</ci>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">32</cn>
                           </apply>
                           <cn cellml:units="millivolt">8</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">0.6</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <minus/>
                              <cn cellml:units="millivolt">50</cn>
                              <ci>V</ci>
                           </apply>
                           <cn cellml:units="millivolt">20</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_f</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0197</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <minus/>
                           <apply>
                              <power/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="per_millivolt">0.0337</cn>
                                 <apply>
                                    <plus/>
                                    <ci>V</ci>
                                    <cn cellml:units="millivolt">10</cn>
                                 </apply>
                              </apply>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">0.02</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>alpha_f</ci>
            <apply>
               <divide/>
               <ci>f_infinity</ci>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_f</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <ci>f_infinity</ci>
               </apply>
               <ci>tau_f</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>f</ci>
            </apply>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <ci>alpha_f</ci>
                  <apply>
                     <minus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <ci>f</ci>
                  </apply>
               </apply>
               <apply>
                  <times/>
                  <ci>beta_f</ci>
                  <ci>f</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="L_type_Ca_channel_f_Ca_gate">
      <variable units="dimensionless" public_interface="out" name="f_Ca"/>
      <variable units="millimolar" name="Km_Ca" initial_value="0.0006"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>f_Ca</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>Cai</ci>
                     <ci>Km_Ca</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel">
      <variable units="microA_per_microF" public_interface="out" name="i_Ca_T"/>
      <variable units="milliS_per_microF" name="g_CaT" initial_value="0.05"/>
      <variable units="millivolt" public_interface="in" name="E_Ca"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="dimensionless" private_interface="in" name="b"/>
      <variable units="dimensionless" private_interface="in" name="g"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Ca_T</ci>
            <apply>
               <times/>
               <ci>g_CaT</ci>
               <ci>b</ci>
               <ci>b</ci>
               <ci>g</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_b_gate">
      <variable units="dimensionless" public_interface="out" name="b" initial_value="0.001378275288"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="dimensionless" name="b_inf"/>
      <variable units="ms" name="tau_b"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>b_inf</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">14</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">10.8</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_b</ci>
            <apply>
               <plus/>
               <cn cellml:units="ms">3.7</cn>
               <apply>
                  <divide/>
                  <cn cellml:units="ms">6.1</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">25</cn>
                           </apply>
                           <cn cellml:units="millivolt">4.5</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>b</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>b_inf</ci>
                  <ci>b</ci>
               </apply>
               <ci>tau_b</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="T_type_Ca_channel_g_gate">
      <variable units="dimensionless" public_interface="out" name="g" initial_value="0.988597502434"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="dimensionless" name="g_inf"/>
      <variable units="ms" name="tau_g"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_inf</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">60</cn>
                        </apply>
                        <cn cellml:units="millivolt">5.6</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_g</ci>
            <piecewise>
               <piece>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="ms_per_millivolt">0.875</cn>
                        </apply>
                        <ci>V</ci>
                     </apply>
                     <cn cellml:units="ms">12</cn>
                  </apply>
                  <apply>
                     <leq/>
                     <ci>V</ci>
                     <cn cellml:units="millivolt">0</cn>
                  </apply>
               </piece>
               <otherwise>
                  <cn cellml:units="ms">12</cn>
               </otherwise>
            </piecewise>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>g</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>g_inf</ci>
                  <ci>g</ci>
               </apply>
               <ci>tau_g</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Kr"/>
      <variable units="milliS_per_microF" name="g_Kr"/>
      <variable units="milliS_per_microF" name="G_Kr" initial_value="0.02614"/>
      <variable units="dimensionless" name="Rect"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="dimensionless" private_interface="in" name="xr"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_Kr</ci>
            <apply>
               <times/>
               <ci>G_Kr</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Rect</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">9</cn>
                        </apply>
                        <cn cellml:units="millivolt">22.4</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kr</ci>
            <apply>
               <times/>
               <ci>g_Kr</ci>
               <ci>xr</ci>
               <ci>Rect</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="rapid_delayed_rectifier_potassium_current_xr_gate">
      <variable units="dimensionless" public_interface="out" name="xr" initial_value="0.000207067204"/>
      <variable units="dimensionless" name="xr_infinity"/>
      <variable units="ms" name="tau_xr"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xr_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">21.5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">7.5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xr</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.00138</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">14.2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.123</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">14.2</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.00061</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">38.9</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.145</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">38.9</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xr</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xr_infinity</ci>
                  <ci>xr</ci>
               </apply>
               <ci>tau_xr</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Ks"/>
      <variable units="milliS_per_microF" name="g_Ks"/>
      <variable units="milliS_per_microF" name="G_Ks" initial_value="0.433"/>
      <variable units="millivolt" name="E_Ks"/>
      <variable units="dimensionless" name="PNaK" initial_value="0.01833"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="dimensionless" private_interface="in" name="xs1"/>
      <variable units="dimensionless" private_interface="in" name="xs2"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ks</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <apply>
                        <plus/>
                        <ci>Ko</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nao</ci>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <ci>Ki</ci>
                        <apply>
                           <times/>
                           <ci>PNaK</ci>
                           <ci>Nai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>g_Ks</ci>
            <apply>
               <times/>
               <ci>G_Ks</ci>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">0.6</cn>
                     <apply>
                        <plus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <power/>
                           <apply>
                              <divide/>
                              <cn cellml:units="millimolar" type="e-notation">3.8<sep/>-5</cn>
                              <ci>Cai</ci>
                           </apply>
                           <cn cellml:units="dimensionless">1.4</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ks</ci>
            <apply>
               <times/>
               <ci>g_Ks</ci>
               <ci>xs1</ci>
               <ci>xs2</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ks</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs1_gate">
      <variable units="dimensionless" public_interface="out" name="xs1" initial_value="0.007136102382"/>
      <variable units="dimensionless" name="xs1_infinity"/>
      <variable units="ms" name="tau_xs1"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs1_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs1</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">1</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt" type="e-notation">7.19<sep/>-5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs1</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs1_infinity</ci>
                  <ci>xs1</ci>
               </apply>
               <ci>tau_xs1</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="slow_delayed_rectifier_potassium_current_xs2_gate">
      <variable units="dimensionless" public_interface="out" name="xs2" initial_value="0.039518996812"/>
      <variable units="dimensionless" name="xs2_infinity"/>
      <variable units="ms" name="tau_xs2"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>xs2_infinity</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">1.5</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">16.7</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_xs2</ci>
            <apply>
               <divide/>
               <cn cellml:units="ms">4</cn>
               <apply>
                  <plus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt" type="e-notation">7.19<sep/>-5</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <cn cellml:units="dimensionless">1</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="per_millivolt">0.148</cn>
                              </apply>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.000131</cn>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">30</cn>
                        </apply>
                     </apply>
                     <apply>
                        <minus/>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.0687</cn>
                              <apply>
                                 <plus/>
                                 <ci>V</ci>
                                 <cn cellml:units="millivolt">30</cn>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">1</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>xs2</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>xs2_infinity</ci>
                  <ci>xs2</ci>
               </apply>
               <ci>tau_xs2</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ATP_sensitive_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_K_ATP"/>
      <variable units="milliS_per_microF" name="g_K_ATP"/>
      <variable units="dimensionless" name="i_K_ATP_on" initial_value="1"/>
      <variable units="dimensionless" name="nATP" initial_value="0.24"/>
      <variable units="dimensionless" name="nicholsarea" initial_value="5e-5"/>
      <variable units="millimolar" name="ATPi" initial_value="3"/>
      <variable units="dimensionless" name="hATP" initial_value="2"/>
      <variable units="millimolar" name="kATP" initial_value="0.00025"/>
      <variable units="dimensionless" name="pATP"/>
      <variable units="milliS_per_microF" name="GKbaraATP"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K_ATP</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_K_ATP_on</ci>
                  <cn cellml:units="milliS_per_microF">0.000193</cn>
               </apply>
               <ci>nicholsarea</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pATP</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>ATPi</ci>
                        <ci>kATP</ci>
                     </apply>
                     <ci>hATP</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>GKbaraATP</ci>
            <apply>
               <times/>
               <ci>g_K_ATP</ci>
               <ci>pATP</ci>
               <apply>
                  <power/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="millimolar">4</cn>
                  </apply>
                  <ci>nATP</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_ATP</ci>
            <apply>
               <times/>
               <ci>GKbaraATP</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current">
      <variable units="microA_per_microF" public_interface="out" name="i_to"/>
      <variable units="milliS_per_microF" name="g_to"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="ms" public_interface="in" private_interface="out" name="time"/>
      <variable units="dimensionless" name="rvdv"/>
      <variable units="dimensionless" private_interface="in" name="zdv"/>
      <variable units="dimensionless" private_interface="in" name="ydv"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_to</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0</cn>
               <cn cellml:units="milliS_per_microF">0.5</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>rvdv</ci>
            <apply>
               <exp/>
               <apply>
                  <divide/>
                  <ci>V</ci>
                  <cn cellml:units="millivolt">100</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_to</ci>
            <apply>
               <times/>
               <ci>g_to</ci>
               <apply>
                  <power/>
                  <ci>zdv</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
               <ci>ydv</ci>
               <ci>rvdv</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_zdv_gate">
      <variable units="dimensionless" public_interface="out" name="zdv" initial_value="0.014537782303"/>
      <variable units="per_ms" name="alpha_zdv"/>
      <variable units="per_ms" name="beta_zdv"/>
      <variable units="ms" name="tau_zdv"/>
      <variable units="dimensionless" name="zdv_ss"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">40</cn>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">40</cn>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_zdv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">10</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">90</cn>
                           </apply>
                        </apply>
                        <cn cellml:units="millivolt">25</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_zdv</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>zdv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_zdv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_zdv</ci>
                  <ci>beta_zdv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>zdv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>zdv_ss</ci>
                  <ci>zdv</ci>
               </apply>
               <ci>tau_zdv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transient_outward_current_ydv_gate">
      <variable units="dimensionless" public_interface="out" name="ydv" initial_value="0.99993940527"/>
      <variable units="per_ms" name="alpha_ydv"/>
      <variable units="per_ms" name="beta_ydv"/>
      <variable units="ms" name="tau_ydv"/>
      <variable units="dimensionless" name="ydv_ss"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_ydv</ci>
            <apply>
               <divide/>
               <cn cellml:units="per_ms">0.015</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">60</cn>
                        </apply>
                        <cn cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_ydv</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">0.1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">25</cn>
                        </apply>
                        <cn cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <plus/>
                           <ci>V</ci>
                           <cn cellml:units="millivolt">25</cn>
                        </apply>
                        <cn cellml:units="millivolt">5</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_ydv</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>ydv_ss</ci>
            <apply>
               <divide/>
               <ci>alpha_ydv</ci>
               <apply>
                  <plus/>
                  <ci>alpha_ydv</ci>
                  <ci>beta_ydv</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>ydv</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>ydv_ss</ci>
                  <ci>ydv</ci>
               </apply>
               <ci>tau_ydv</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_K1"/>
      <variable units="millivolt" public_interface="out" private_interface="out" name="E_K"/>
      <variable units="milliS_per_microF" name="g_K1"/>
      <variable units="milliS_per_microF" name="G_K1" initial_value="0.75"/>
      <variable units="millivolt" public_interface="in" private_interface="out" name="V"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="dimensionless" private_interface="in" name="K1_infinity"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>g_K1</ci>
            <apply>
               <times/>
               <ci>G_K1</ci>
               <apply>
                  <root/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <cn cellml:units="millimolar">5.4</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>E_K</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <ci>F</ci>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Ko</ci>
                     <ci>Ki</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K1</ci>
            <apply>
               <times/>
               <ci>g_K1</ci>
               <ci>K1_infinity</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="time_independent_potassium_current_K1_gate">
      <variable units="dimensionless" public_interface="out" name="K1_infinity"/>
      <variable units="per_ms" name="alpha_K1"/>
      <variable units="per_ms" name="beta_K1"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_K1</ci>
            <apply>
               <divide/>
               <cn cellml:units="per_ms">1.02</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <cn cellml:units="per_millivolt">0.2385</cn>
                        <apply>
                           <minus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn cellml:units="millivolt">59.215</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>beta_K1</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <cn cellml:units="per_ms">1</cn>
                  <apply>
                     <plus/>
                     <apply>
                        <times/>
                        <cn cellml:units="dimensionless">0.49124</cn>
                        <apply>
                           <exp/>
                           <apply>
                              <times/>
                              <cn cellml:units="per_millivolt">0.08032</cn>
                              <apply>
                                 <plus/>
                                 <apply>
                                    <minus/>
                                    <ci>V</ci>
                                    <ci>E_K</ci>
                                 </apply>
                                 <cn cellml:units="millivolt">5.476</cn>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <exp/>
                        <apply>
                           <times/>
                           <cn cellml:units="per_millivolt">0.06175</cn>
                           <apply>
                              <minus/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                                 <ci>E_K</ci>
                              </apply>
                              <cn cellml:units="millivolt">594.31</cn>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <cn cellml:units="per_millivolt">0.5143</cn>
                        </apply>
                        <apply>
                           <plus/>
                           <apply>
                              <minus/>
                              <ci>V</ci>
                              <ci>E_K</ci>
                           </apply>
                           <cn cellml:units="millivolt">4.753</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K1_infinity</ci>
            <apply>
               <divide/>
               <ci>alpha_K1</ci>
               <apply>
                  <plus/>
                  <ci>alpha_K1</ci>
                  <ci>beta_K1</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="plateau_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Kp"/>
      <variable units="milliS_per_microF" name="g_Kp" initial_value="0.00552"/>
      <variable units="dimensionless" name="Kp"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>Kp</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <minus/>
                           <cn cellml:units="millivolt">7.488</cn>
                           <ci>V</ci>
                        </apply>
                        <cn cellml:units="millivolt">5.98</cn>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Kp</ci>
            <apply>
               <times/>
               <ci>g_Kp</ci>
               <ci>Kp</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_activated_potassium_current">
      <variable units="microA_per_microF" public_interface="out" name="i_K_Na"/>
      <variable units="milliS_per_microF" name="g_K_Na" initial_value="0.12848"/>
      <variable units="dimensionless" name="nKNa" initial_value="2.8"/>
      <variable units="dimensionless" name="pona"/>
      <variable units="dimensionless" name="pov"/>
      <variable units="millimolar" name="kdKNa" initial_value="66"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millivolt" public_interface="in" name="E_K"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>pona</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">0.85</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>kdKNa</ci>
                        <ci>Nai</ci>
                     </apply>
                     <ci>nKNa</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>pov</ci>
            <apply>
               <minus/>
               <cn cellml:units="dimensionless">0.8</cn>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">0.65</cn>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <plus/>
                              <ci>V</ci>
                              <cn cellml:units="millivolt">125</cn>
                           </apply>
                           <cn cellml:units="millivolt">15</cn>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_K_Na</ci>
            <apply>
               <times/>
               <ci>g_K_Na</ci>
               <ci>pona</ci>
               <ci>pov</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_K</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sarcolemmal_calcium_pump">
      <variable units="microA_per_microF" public_interface="out" name="i_p_Ca"/>
      <variable units="millimolar" name="K_mpCa" initial_value="0.0005"/>
      <variable units="microA_per_microF" name="I_pCa" initial_value="1.15"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_p_Ca</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_pCa</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>K_mpCa</ci>
                  <ci>Cai</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_background_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Na_b"/>
      <variable units="milliS_per_microF" name="g_Nab" initial_value="0.004"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="millivolt" public_interface="in" name="E_Na"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_Na_b</ci>
            <apply>
               <times/>
               <ci>g_Nab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Na</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_background_current">
      <variable units="microA_per_microF" public_interface="out" name="i_Ca_b"/>
      <variable units="milliS_per_microF" name="g_Cab" initial_value="0.003016"/>
      <variable units="millivolt" public_interface="out" name="E_Ca"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>E_Ca</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>R</ci>
                     <ci>T</ci>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <ln/>
                  <apply>
                     <divide/>
                     <ci>Cao</ci>
                     <ci>Cai</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_Ca_b</ci>
            <apply>
               <times/>
               <ci>g_Cab</ci>
               <apply>
                  <minus/>
                  <ci>V</ci>
                  <ci>E_Ca</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="sodium_potassium_pump">
      <variable units="microA_per_microF" public_interface="out" name="i_NaK"/>
      <variable units="microA_per_microF" name="I_NaK" initial_value="2.25"/>
      <variable units="dimensionless" name="f_NaK"/>
      <variable units="millimolar" name="K_mNai" initial_value="10"/>
      <variable units="millimolar" name="K_mKo" initial_value="1.5"/>
      <variable units="dimensionless" name="sigma"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>sigma</ci>
            <apply>
               <times/>
               <apply>
                  <divide/>
                  <cn cellml:units="dimensionless">1</cn>
                  <cn cellml:units="dimensionless">7</cn>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <ci>Nao</ci>
                        <cn cellml:units="millimolar">67.3</cn>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>f_NaK</ci>
            <apply>
               <divide/>
               <cn cellml:units="dimensionless">1</cn>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.1245</cn>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <cn cellml:units="dimensionless">0.1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">0.0365</cn>
                     <ci>sigma</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>V</ci>
                              </apply>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_NaK</ci>
            <apply>
               <divide/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>I_NaK</ci>
                     <ci>f_NaK</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <cn cellml:units="dimensionless">1</cn>
                     <apply>
                        <power/>
                        <apply>
                           <divide/>
                           <ci>K_mNai</ci>
                           <ci>Nai</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <ci>K_mKo</ci>
                     <ci>Ko</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="non_specific_calcium_activated_current">
      <variable units="microA_per_microF" public_interface="out" name="i_ns_Ca"/>
      <variable units="microA_per_microF" public_interface="out" name="i_ns_Na"/>
      <variable units="microA_per_microF" public_interface="out" name="i_ns_K"/>
      <variable units="litre_per_farad_millisecond" name="P_ns_Ca"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Nai"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Nao"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Ki"/>
      <variable units="dimensionless" public_interface="in" name="gamma_Ko"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Ko"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Ki"/>
      <variable units="microA_per_microF" name="I_ns_Na"/>
      <variable units="microA_per_microF" name="I_ns_K"/>
      <variable units="millimolar" name="K_m_ns_Ca" initial_value="0.0012"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>P_ns_Ca</ci>
            <cn cellml:units="litre_per_farad_millisecond" type="e-notation">1.75<sep/>-7</cn>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Nai</ci>
                        <ci>Nai</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Nao</ci>
                        <ci>Nao</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <ci>P_ns_Ca</ci>
                        <apply>
                           <power/>
                           <cn cellml:units="dimensionless">1</cn>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <ci>V</ci>
                        <apply>
                           <power/>
                           <ci>F</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>R</ci>
                        <ci>T</ci>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <ci>gamma_Ki</ci>
                        <ci>Ki</ci>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">1</cn>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <times/>
                        <ci>gamma_Ko</ci>
                        <ci>Ko</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <minus/>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">1</cn>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Na</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_Na</ci>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_K</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_ns_K</ci>
                  <cn cellml:units="dimensionless">1</cn>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_m_ns_Ca</ci>
                        <ci>Cai</ci>
                     </apply>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_ns_Ca</ci>
            <apply>
               <plus/>
               <ci>i_ns_Na</ci>
               <ci>i_ns_K</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="Na_Ca_exchanger">
      <variable units="microA_per_microF" public_interface="out" name="i_NaCa"/>
      <variable units="microA_per_microF" name="c1" initial_value="0.00025"/>
      <variable units="dimensionless" name="c2" initial_value="0.0001"/>
      <variable units="dimensionless" name="gamma" initial_value="0.15"/>
      <variable units="millivolt" public_interface="in" name="V"/>
      <variable units="joule_per_kilomole_kelvin" public_interface="in" name="R"/>
      <variable units="kelvin" public_interface="in" name="T"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="in" name="Nai"/>
      <variable units="millimolar" public_interface="in" name="Nao"/>
      <variable units="millimolar" public_interface="in" name="Cai"/>
      <variable units="millimolar" public_interface="in" name="Cao"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>i_NaCa</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>c1</ci>
                  <apply>
                     <exp/>
                     <apply>
                        <divide/>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <ci>gamma</ci>
                              <cn cellml:units="dimensionless">1</cn>
                           </apply>
                           <ci>V</ci>
                           <ci>F</ci>
                        </apply>
                        <apply>
                           <times/>
                           <ci>R</ci>
                           <ci>T</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <minus/>
                     <apply>
                        <times/>
                        <apply>
                           <exp/>
                           <apply>
                              <divide/>
                              <apply>
                                 <times/>
                                 <ci>V</ci>
                                 <ci>F</ci>
                              </apply>
                              <apply>
                                 <times/>
                                 <ci>R</ci>
                                 <ci>T</ci>
                              </apply>
                           </apply>
                        </apply>
                        <apply>
                           <power/>
                           <ci>Nai</ci>
                           <cn cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cao</ci>
                     </apply>
                     <apply>
                        <times/>
                        <apply>
                           <power/>
                           <ci>Nao</ci>
                           <cn cellml:units="dimensionless">3</cn>
                        </apply>
                        <ci>Cai</ci>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="millimolar4">1</cn>
                  <apply>
                     <times/>
                     <ci>c2</ci>
                     <apply>
                        <exp/>
                        <apply>
                           <divide/>
                           <apply>
                              <times/>
                              <apply>
                                 <minus/>
                                 <ci>gamma</ci>
                                 <cn cellml:units="dimensionless">1</cn>
                              </apply>
                              <ci>V</ci>
                              <ci>F</ci>
                           </apply>
                           <apply>
                              <times/>
                              <ci>R</ci>
                              <ci>T</ci>
                           </apply>
                        </apply>
                     </apply>
                     <apply>
                        <plus/>
                        <apply>
                           <times/>
                           <apply>
                              <exp/>
                              <apply>
                                 <divide/>
                                 <apply>
                                    <times/>
                                    <ci>V</ci>
                                    <ci>F</ci>
                                 </apply>
                                 <apply>
                                    <times/>
                                    <ci>R</ci>
                                    <ci>T</ci>
                                 </apply>
                              </apply>
                           </apply>
                           <apply>
                              <power/>
                              <ci>Nai</ci>
                              <cn cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cao</ci>
                        </apply>
                        <apply>
                           <times/>
                           <apply>
                              <power/>
                              <ci>Nao</ci>
                              <cn cellml:units="dimensionless">3</cn>
                           </apply>
                           <ci>Cai</ci>
                        </apply>
                     </apply>
                  </apply>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="calcium_dynamics">
      <variable units="millimolar_per_ms" public_interface="in" name="i_rel"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_up"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_leak"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_tr"/>
      <variable units="ms" name="tau_tr" initial_value="120"/>
      <variable units="millimolar" name="CSQN_max" initial_value="10"/>
      <variable units="millimolar" name="K_mCSQN" initial_value="0.8"/>
      <variable units="millimolar" name="K_mup" initial_value="0.00092"/>
      <variable units="per_ms" name="K_leak"/>
      <variable units="millimolar_per_ms" name="I_up" initial_value="0.00875"/>
      <variable units="millimolar" name="Ca_NSR_max" initial_value="15"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="millimolar" public_interface="out" name="CaT" initial_value="0.01544711"/>
      <variable units="millimolar" public_interface="out" name="Cao" initial_value="1.8"/>
      <variable units="millimolar" public_interface="out" name="Ca_JSR"/>
      <variable units="millimolar" public_interface="out" name="JSR" initial_value="8.290468"/>
      <variable units="millimolar" public_interface="out" name="NSR" initial_value="1.516756041281"/>
      <variable units="millimolar" public_interface="out" name="Cai"/>
      <variable units="millimolar" public_interface="out" name="bjsr"/>
      <variable units="millimolar2" public_interface="out" name="cjsr"/>
      <variable units="millimolar" public_interface="out" name="bmyo"/>
      <variable units="millimolar2" public_interface="out" name="cmyo"/>
      <variable units="millimolar3" public_interface="out" name="dmyo"/>
      <variable units="micro_litre" public_interface="in" name="V_myo"/>
      <variable units="cm2" public_interface="in" name="A_cap"/>
      <variable units="micro_litre" public_interface="in" name="V_JSR"/>
      <variable units="micro_litre" public_interface="in" name="V_NSR"/>
      <variable units="microA_per_microF" public_interface="in" name="i_NaCa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaCa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_p_Ca"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Ca_b"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Ca_T"/>
      <variable units="millimolar" name="K_mTRPN" initial_value="0.0005"/>
      <variable units="millimolar" name="K_mCMDN" initial_value="0.00238"/>
      <variable units="millimolar" name="TRPN_max" initial_value="0.07"/>
      <variable units="millimolar" name="CMDN_max" initial_value="0.05"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>bjsr</ci>
            <apply>
               <plus/>
               <ci>CSQN_max</ci>
               <ci>K_mCSQN</ci>
               <apply>
                  <minus/>
                  <ci>JSR</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>cjsr</ci>
            <apply>
               <times/>
               <ci>K_mCSQN</ci>
               <ci>JSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Ca_JSR</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <root/>
                     <apply>
                        <plus/>
                        <apply>
                           <power/>
                           <ci>bjsr</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">4</cn>
                           <ci>cjsr</ci>
                        </apply>
                     </apply>
                  </apply>
                  <ci>bjsr</ci>
               </apply>
               <cn cellml:units="dimensionless">2</cn>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>bmyo</ci>
            <apply>
               <plus/>
               <ci>CMDN_max</ci>
               <ci>TRPN_max</ci>
               <ci>K_mCMDN</ci>
               <ci>K_mTRPN</ci>
               <apply>
                  <minus/>
                  <ci>CaT</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>cmyo</ci>
            <apply>
               <plus/>
               <apply>
                  <times/>
                  <ci>K_mCMDN</ci>
                  <ci>K_mTRPN</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>TRPN_max</ci>
                  <ci>K_mCMDN</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>CMDN_max</ci>
                  <ci>K_mTRPN</ci>
               </apply>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <ci>CaT</ci>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>K_mTRPN</ci>
                     <ci>K_mCMDN</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>dmyo</ci>
            <apply>
               <times/>
               <apply>
                  <minus/>
                  <ci>K_mTRPN</ci>
               </apply>
               <ci>K_mCMDN</ci>
               <ci>CaT</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>Cai</ci>
            <apply>
               <minus/>
               <apply>
                  <times/>
                  <apply>
                     <divide/>
                     <cn cellml:units="dimensionless">2</cn>
                     <cn cellml:units="dimensionless">3</cn>
                  </apply>
                  <apply>
                     <root/>
                     <apply>
                        <minus/>
                        <apply>
                           <power/>
                           <ci>bmyo</ci>
                           <cn cellml:units="dimensionless">2</cn>
                        </apply>
                        <apply>
                           <times/>
                           <cn cellml:units="dimensionless">3</cn>
                           <ci>cmyo</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <cos/>
                     <apply>
                        <divide/>
                        <apply>
                           <arccos/>
                           <apply>
                              <divide/>
                              <apply>
                                 <minus/>
                                 <apply>
                                    <times/>
                                    <cn cellml:units="dimensionless">9</cn>
                                    <ci>bmyo</ci>
                                    <ci>cmyo</ci>
                                 </apply>
                                 <apply>
                                    <plus/>
                                    <apply>
                                       <times/>
                                       <cn cellml:units="dimensionless">2</cn>
                                       <apply>
                                          <power/>
                                          <ci>bmyo</ci>
                                          <cn cellml:units="dimensionless">3</cn>
                                       </apply>
                                    </apply>
                                    <apply>
                                       <times/>
                                       <cn cellml:units="dimensionless">27</cn>
                                       <ci>dmyo</ci>
                                    </apply>
                                 </apply>
                              </apply>
                              <apply>
                                 <times/>
                                 <cn cellml:units="dimensionless">2</cn>
                                 <apply>
                                    <root/>
                                    <apply>
                                       <power/>
                                       <apply>
                                          <minus/>
                                          <apply>
                                             <power/>
                                             <ci>bmyo</ci>
                                             <cn cellml:units="dimensionless">2</cn>
                                          </apply>
                                          <apply>
                                             <times/>
                                             <cn cellml:units="dimensionless">3</cn>
                                             <ci>cmyo</ci>
                                          </apply>
                                       </apply>
                                       <cn cellml:units="dimensionless">3</cn>
                                    </apply>
                                 </apply>
                              </apply>
                           </apply>
                        </apply>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <ci>bmyo</ci>
                  <cn cellml:units="dimensionless">3</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_up</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>I_up</ci>
                  <ci>Cai</ci>
               </apply>
               <apply>
                  <plus/>
                  <ci>Cai</ci>
                  <ci>K_mup</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>K_leak</ci>
            <apply>
               <divide/>
               <ci>I_up</ci>
               <ci>Ca_NSR_max</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_leak</ci>
            <apply>
               <times/>
               <ci>K_leak</ci>
               <ci>NSR</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>i_tr</ci>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <ci>NSR</ci>
                  <ci>Ca_JSR</ci>
               </apply>
               <ci>tau_tr</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>JSR</ci>
            </apply>
            <apply>
               <minus/>
               <ci>i_tr</ci>
               <ci>i_rel</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>NSR</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <minus/>
                  <apply>
                     <divide/>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_tr</ci>
                        </apply>
                        <ci>V_JSR</ci>
                     </apply>
                     <ci>V_NSR</ci>
                  </apply>
                  <ci>i_leak</ci>
               </apply>
               <ci>i_up</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>CaT</ci>
            </apply>
            <apply>
               <plus/>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <cn cellml:units="microF_per_cm2">1</cn>
                     </apply>
                     <ci>A_cap</ci>
                     <apply>
                        <plus/>
                        <ci>i_CaCa</ci>
                        <ci>i_Ca_T</ci>
                        <ci>i_p_Ca</ci>
                        <ci>i_Ca_b</ci>
                        <apply>
                           <times/>
                           <apply>
                              <minus/>
                              <cn cellml:units="dimensionless">2</cn>
                           </apply>
                           <ci>i_NaCa</ci>
                        </apply>
                     </apply>
                  </apply>
                  <apply>
                     <times/>
                     <cn cellml:units="dimensionless">2</cn>
                     <ci>V_myo</ci>
                     <ci>F</ci>
                  </apply>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <ci>i_rel</ci>
                     <ci>V_JSR</ci>
                  </apply>
                  <ci>V_myo</ci>
               </apply>
               <apply>
                  <divide/>
                  <apply>
                     <times/>
                     <apply>
                        <minus/>
                        <ci>i_leak</ci>
                        <ci>i_up</ci>
                     </apply>
                     <ci>V_NSR</ci>
                  </apply>
                  <ci>V_myo</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="CICR_current">
      <variable units="mM_per_millivolt_ms" name="kappa" initial_value="0.125"/>
      <variable units="ms" name="tau" initial_value="4.75"/>
      <variable units="millimolar" name="K_relss" initial_value="1"/>
      <variable units="dimensionless" name="qn" initial_value="9"/>
      <variable units="millimolar_per_mV" public_interface="out" name="alpha_rel"/>
      <variable units="ms" public_interface="out" name="tau_rel"/>
      <variable units="millimolar_per_ms" public_interface="out" name="I_relss"/>
      <variable units="millimolar_per_ms" public_interface="out" name="i_rel" initial_value="-0.000000000000000000474565"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaCa"/>
      <variable units="millimolar" public_interface="in" name="Ca_JSR"/>
      <variable units="ms" public_interface="in" name="time"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>alpha_rel</ci>
            <apply>
               <times/>
               <ci>kappa</ci>
               <ci>tau</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>I_relss</ci>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <ci>i_CaCa</ci>
                  <ci>alpha_rel</ci>
               </apply>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <power/>
                     <apply>
                        <divide/>
                        <ci>K_relss</ci>
                        <ci>Ca_JSR</ci>
                     </apply>
                     <ci>qn</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>tau_rel</ci>
            <apply>
               <divide/>
               <ci>tau</ci>
               <apply>
                  <plus/>
                  <cn cellml:units="dimensionless">1</cn>
                  <apply>
                     <divide/>
                     <cn cellml:units="millimolar">0.0123</cn>
                     <ci>Ca_JSR</ci>
                  </apply>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>i_rel</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <minus/>
                  <apply>
                     <plus/>
                     <ci>I_relss</ci>
                     <ci>i_rel</ci>
                  </apply>
               </apply>
               <ci>tau_rel</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="ionic_concentrations">
      <variable units="millimolar" public_interface="out" name="Nai" initial_value="10"/>
      <variable units="millimolar" public_interface="out" name="Nao" initial_value="140"/>
      <variable units="millimolar" public_interface="out" name="Ki" initial_value="144.473230653346"/>
      <variable units="millimolar" public_interface="out" name="Ko" initial_value="5.4"/>
      <variable units="cm2" public_interface="in" name="A_cap"/>
      <variable units="micro_litre" public_interface="in" name="V_myo"/>
      <variable units="ms" public_interface="in" name="time"/>
      <variable units="coulomb_per_mole" public_interface="in" name="F"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Na"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaNa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Na_b"/>
      <variable units="microA_per_microF" public_interface="in" name="i_ns_Na"/>
      <variable units="microA_per_microF" public_interface="in" name="i_NaCa"/>
      <variable units="microA_per_microF" public_interface="in" name="i_NaK"/>
      <variable units="microA_per_microF" public_interface="in" name="i_CaK"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Kr"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Ks"/>
      <variable units="microA_per_microF" public_interface="in" name="i_K1"/>
      <variable units="microA_per_microF" public_interface="in" name="i_Kp"/>
      <variable units="microA_per_microF" public_interface="in" name="i_K_Na"/>
      <variable units="microA_per_microF" public_interface="in" name="i_ns_K"/>
      <variable units="microA_per_microF" public_interface="in" name="I_st"/>
      <variable units="microA_per_microF" public_interface="in" name="i_K_ATP"/>
      <variable units="microA_per_microF" public_interface="in" name="i_to"/>
	  <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Nai</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>i_Na</ci>
                     <ci>i_CaNa</ci>
                     <ci>i_Na_b</ci>
                     <ci>i_ns_Na</ci>
                     <apply>
                        <times/>
                        <ci>i_NaCa</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                     <apply>
                        <times/>
                        <ci>i_NaK</ci>
                        <cn cellml:units="dimensionless">3</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <apply>
               <diff/>
               <bvar>
                  <ci>time</ci>
               </bvar>
               <ci>Ki</ci>
            </apply>
            <apply>
               <divide/>
               <apply>
                  <times/>
                  <apply>
                     <minus/>
                     <cn cellml:units="microF_per_cm2">1</cn>
                  </apply>
                  <apply>
                     <plus/>
                     <ci>I_st</ci>
                     <ci>i_CaK</ci>
                     <ci>i_Kr</ci>
                     <ci>i_Ks</ci>
                     <ci>i_K1</ci>
                     <ci>i_K_ATP</ci>
                     <ci>i_to</ci>
					 <ci>i_Kp</ci>
                     <ci>i_K_Na</ci>
                     <ci>i_ns_K</ci>
                     <apply>
                        <times/>
                        <apply>
                           <minus/>
                           <ci>i_NaK</ci>
                        </apply>
                        <cn cellml:units="dimensionless">2</cn>
                     </apply>
                  </apply>
                  <ci>A_cap</ci>
               </apply>
               <apply>
                  <times/>
                  <ci>V_myo</ci>
                  <ci>F</ci>
               </apply>
            </apply>
         </apply>
      </math>
   </component>
   <component name="geometry">
      <variable units="mm" name="preplength" initial_value="0.1"/>
      <variable units="mm" name="radius" initial_value="0.011"/>
      <variable units="micro_litre" name="volume"/>
      <variable units="micro_litre" public_interface="out" name="V_myo"/>
      <variable units="micro_litre" public_interface="out" name="V_JSR"/>
      <variable units="micro_litre" public_interface="out" name="V_NSR"/>
      <variable units="cm2" public_interface="out" name="A_cap" initial_value="1.534e-4"/>
      <math xmlns="http://www.w3.org/1998/Math/MathML">
         <apply>
            <eq/>
            <ci>volume</ci>
            <apply>
               <times/>
               <pi/>
               <ci>preplength</ci>
               <apply>
                  <power/>
                  <ci>radius</ci>
                  <cn cellml:units="dimensionless">2</cn>
               </apply>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_myo</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.68</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_JSR</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.0048</cn>
               <ci>volume</ci>
            </apply>
         </apply>
         <apply>
            <eq/>
            <ci>V_NSR</ci>
            <apply>
               <times/>
               <cn cellml:units="dimensionless">0.0552</cn>
               <ci>volume</ci>
            </apply>
         </apply>
      </math>
   </component>
   <component name="transmembrane_currents"/>
   <component name="intracellular_currents"/>
   <component name="Ions_n_reversal_potentials"/>
   <group>
      <relationship_ref relationship="containment"/>
      <component_ref component="cell">
         <component_ref component="geometry"/>
         <component_ref component="transmembrane_currents">
            <component_ref component="fast_sodium_current">
               <component_ref component="fast_sodium_current_m_gate"/>
               <component_ref component="fast_sodium_current_h_gate"/>
               <component_ref component="fast_sodium_current_j_gate"/>
            </component_ref>
            <component_ref component="L_type_Ca_channel">
               <component_ref component="L_type_Ca_channel_d_gate"/>
               <component_ref component="L_type_Ca_channel_f_gate"/>
               <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
            </component_ref>
            <component_ref component="T_type_Ca_channel">
               <component_ref component="T_type_Ca_channel_b_gate"/>
               <component_ref component="T_type_Ca_channel_g_gate"/>
            </component_ref>
            <component_ref component="rapid_delayed_rectifier_potassium_current">
               <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
            </component_ref>
            <component_ref component="slow_delayed_rectifier_potassium_current">
               <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
               <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
            </component_ref>
            <component_ref component="time_independent_potassium_current">
               <component_ref component="time_independent_potassium_current_K1_gate"/>
            </component_ref>
			<component_ref component="transient_outward_current">
               <component_ref component="transient_outward_current_zdv_gate"/>
               <component_ref component="transient_outward_current_ydv_gate"/>
            </component_ref>
            <component_ref component="Na_Ca_exchanger"/>
            <component_ref component="plateau_potassium_current"/>
            <component_ref component="sodium_activated_potassium_current"/>
            <component_ref component="ATP_sensitive_potassium_current"/>
			<component_ref component="sodium_background_current"/>
            <component_ref component="calcium_background_current"/>
            <component_ref component="sodium_potassium_pump"/>
            <component_ref component="non_specific_calcium_activated_current"/>
         </component_ref>
         <component_ref component="intracellular_currents">
            <component_ref component="sarcolemmal_calcium_pump"/>
         </component_ref>
         <component_ref component="Ions_n_reversal_potentials">
            <component_ref component="ionic_concentrations"/>
            <component_ref component="calcium_dynamics"/>
         </component_ref>
      </component_ref>
   </group>
   <group>
      <relationship_ref relationship="encapsulation"/>
      <component_ref component="fast_sodium_current">
         <component_ref component="fast_sodium_current_m_gate"/>
         <component_ref component="fast_sodium_current_h_gate"/>
         <component_ref component="fast_sodium_current_j_gate"/>
      </component_ref>
      <component_ref component="L_type_Ca_channel">
         <component_ref component="L_type_Ca_channel_d_gate"/>
         <component_ref component="L_type_Ca_channel_f_gate"/>
         <component_ref component="L_type_Ca_channel_f_Ca_gate"/>
      </component_ref>
      <component_ref component="T_type_Ca_channel">
         <component_ref component="T_type_Ca_channel_b_gate"/>
         <component_ref component="T_type_Ca_channel_g_gate"/>
      </component_ref>
      <component_ref component="rapid_delayed_rectifier_potassium_current">
         <component_ref component="rapid_delayed_rectifier_potassium_current_xr_gate"/>
      </component_ref>
      <component_ref component="slow_delayed_rectifier_potassium_current">
         <component_ref component="slow_delayed_rectifier_potassium_current_xs1_gate"/>
         <component_ref component="slow_delayed_rectifier_potassium_current_xs2_gate"/>
      </component_ref>
      <component_ref component="time_independent_potassium_current">
         <component_ref component="time_independent_potassium_current_K1_gate"/>
      </component_ref>
	  <component_ref component="transient_outward_current">
         <component_ref component="transient_outward_current_zdv_gate"/>
         <component_ref component="transient_outward_current_ydv_gate"/>
      </component_ref>
   </group>
   <connection>
      <map_components component_2="environment" component_1="cell"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="fast_sodium_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="L_type_Ca_channel"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="T_type_Ca_channel"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="transient_outward_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="non_specific_calcium_activated_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="ionic_concentrations"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="calcium_dynamics"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="environment" component_1="CICR_current"/>
      <map_variables variable_2="time" variable_1="time"/>
   </connection>
   <connection>
      <map_components component_2="fast_sodium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Na" variable_1="i_Na"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="L_type_Ca_channel" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Ca_L" variable_1="i_Ca_L"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="T_type_Ca_channel" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Ca_T" variable_1="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_2="rapid_delayed_rectifier_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Kr" variable_1="i_Kr"/>
   </connection>
   <connection>
      <map_components component_2="ATP_sensitive_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_K_ATP" variable_1="i_K_ATP"/>
   </connection>
   <connection>
      <map_components component_2="transient_outward_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_to" variable_1="i_to"/>
   </connection>
   <connection>
      <map_components component_2="slow_delayed_rectifier_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Ks" variable_1="i_Ks"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="sodium_activated_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_K_Na" variable_1="i_K_Na"/>
   </connection>
   <connection>
      <map_components component_2="Na_Ca_exchanger" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="time_independent_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_K1" variable_1="i_K1"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="plateau_potassium_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Kp" variable_1="i_Kp"/>
   </connection>
   <connection>
      <map_components component_2="sarcolemmal_calcium_pump" component_1="cell"/>
      <map_variables variable_2="i_p_Ca" variable_1="i_p_Ca"/>
   </connection>
   <connection>
      <map_components component_2="sodium_background_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Na_b" variable_1="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_2="calcium_background_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_Ca_b" variable_1="i_Ca_b"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="sodium_potassium_pump" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="i_NaK" variable_1="i_NaK"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="non_specific_calcium_activated_current" component_1="cell"/>
      <map_variables variable_2="V" variable_1="V"/>
      <map_variables variable_2="R" variable_1="R"/>
      <map_variables variable_2="T" variable_1="T"/>
      <map_variables variable_2="F" variable_1="F"/>
      <map_variables variable_2="i_ns_Ca" variable_1="i_ns_Ca"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="cell"/>
      <map_variables variable_2="F" variable_1="F"/>
      <map_variables variable_2="I_st" variable_1="I_st"/>
   </connection>
   <connection>
      <map_components component_2="calcium_dynamics" component_1="cell"/>
      <map_variables variable_2="F" variable_1="F"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="fast_sodium_current"/>
      <map_variables variable_2="i_Na" variable_1="i_Na"/>
      <map_variables variable_2="Nao" variable_1="Nao"/>
      <map_variables variable_2="Nai" variable_1="Nai"/>
   </connection>
   <connection>
      <map_components component_2="sodium_background_current" component_1="fast_sodium_current"/>
      <map_variables variable_2="E_Na" variable_1="E_Na"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="L_type_Ca_channel"/>
      <map_variables variable_2="Nao" variable_1="Nao"/>
      <map_variables variable_2="Nai" variable_1="Nai"/>
      <map_variables variable_2="Ko" variable_1="Ko"/>
      <map_variables variable_2="Ki" variable_1="Ki"/>
      <map_variables variable_2="i_CaNa" variable_1="i_CaNa"/>
      <map_variables variable_2="i_CaK" variable_1="i_CaK"/>
   </connection>
   <connection>
      <map_components component_2="calcium_dynamics" component_1="L_type_Ca_channel"/>
      <map_variables variable_2="Cai" variable_1="Cai"/>
      <map_variables variable_2="Cao" variable_1="Cao"/>
      <map_variables variable_2="i_CaCa" variable_1="i_CaCa"/>
   </connection>
   <connection>
      <map_components component_2="calcium_dynamics" component_1="T_type_Ca_channel"/>
      <map_variables variable_2="i_Ca_T" variable_1="i_Ca_T"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="Ki" variable_1="Ki"/>
      <map_variables variable_2="Ko" variable_1="Ko"/>
      <map_variables variable_2="Nao" variable_1="Nao"/>
      <map_variables variable_2="Nai" variable_1="Nai"/>
      <map_variables variable_2="i_Ks" variable_1="i_Ks"/>
   </connection>
   <connection>
      <map_components component_2="calcium_dynamics" component_1="slow_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="Cai" variable_1="Cai"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="Ko" variable_1="Ko"/>
      <map_variables variable_2="i_Kr" variable_1="i_Kr"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="Na_Ca_exchanger"/>
      <map_variables variable_2="Nai" variable_1="Nai"/>
      <map_variables variable_2="Nao" variable_1="Nao"/>
      <map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_2="calcium_dynamics" component_1="Na_Ca_exchanger"/>
      <map_variables variable_2="Cai" variable_1="Cai"/>
      <map_variables variable_2="Cao" variable_1="Cao"/>
      <map_variables variable_2="i_NaCa" variable_1="i_NaCa"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="time_independent_potassium_current"/>
      <map_variables variable_2="Ki" variable_1="Ki"/>
      <map_variables variable_2="Ko" variable_1="Ko"/>
      <map_variables variable_2="i_K1" variable_1="i_K1"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="sodium_activated_potassium_current"/>
      <map_variables variable_2="Nai" variable_1="Nai"/>
      <map_variables variable_2="i_K_Na" variable_1="i_K_Na"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="transient_outward_current"/>
      <map_variables variable_2="i_to" variable_1="i_to"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="ATP_sensitive_potassium_current"/>
      <map_variables variable_2="Ko" variable_1="Ko"/>
      <map_variables variable_2="i_K_ATP" variable_1="i_K_ATP"/>
   </connection>
   <connection>
      <map_components component_2="time_independent_potassium_current" component_1="plateau_potassium_current"/>
      <map_variables variable_2="E_K" variable_1="E_K"/>
   </connection>
   <connection>
      <map_components component_2="time_independent_potassium_current" component_1="rapid_delayed_rectifier_potassium_current"/>
      <map_variables variable_2="E_K" variable_1="E_K"/>
   </connection>
   <connection>
      <map_components component_2="time_independent_potassium_current" component_1="sodium_activated_potassium_current"/>
      <map_variables variable_2="E_K" variable_1="E_K"/>
   </connection>
   <connection>
      <map_components component_2="time_independent_potassium_current" component_1="transient_outward_current"/>
      <map_variables variable_2="E_K" variable_1="E_K"/>
   </connection>
   <connection>
      <map_components component_2="time_independent_potassium_current" component_1="ATP_sensitive_potassium_current"/>
      <map_variables variable_2="E_K" variable_1="E_K"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="plateau_potassium_current"/>
      <map_variables variable_2="i_Kp" variable_1="i_Kp"/>
   </connection>
   <connection>
      <map_components component_2="calcium_dynamics" component_1="sarcolemmal_calcium_pump"/>
      <map_variables variable_2="i_p_Ca" variable_1="i_p_Ca"/>
      <map_variables variable_2="Cai" variable_1="Cai"/>
   </connection>
   <connection>
      <map_components component_2="calcium_background_current" component_1="T_type_Ca_channel"/>
      <map_variables variable_2="E_Ca" variable_1="E_Ca"/>
   </connection>
   <connection>
      <map_components component_2="ionic_concentrations" component_1="sodium_background_current"/>
      <map_variables variable_2="i_Na_b" variable_1="i_Na_b"/>
   </connection>
   <connection>
      <map_components component_2="calcium_dynamics" component_1="calcium_background_current"/>
      <map_variables variable_2="Cai" variable_1="Cai"/>
      <map_variables variable_2="Cao" variable_1="Cao"/>
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      <map_variables variable_2="Ko" variable_1="Ko"/>
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      <map_variables variable_2="Ko" variable_1="Ko"/>
      <map_variables variable_2="Ki" variable_1="Ki"/>
      <map_variables variable_2="i_ns_Na" variable_1="i_ns_Na"/>
      <map_variables variable_2="i_ns_K" variable_1="i_ns_K"/>
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      <map_variables variable_2="gamma_Ki" variable_1="gamma_Ki"/>
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   <connection>
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   <connection>
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   <connection>
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