Location: Eskandari, Wright, Loo 2005 @ da6a796f479f / experiments / figure-04.xml

Author:
David Nickerson <nickerso@users.sourceforge.net>
Date:
2015-10-01 16:26:31+13:00
Desc:
fix up time variable defintion so that model runs in newer versions of OpenCOR.
Permanent Source URI:
https://models.fieldml.org/workspace/eskandari_wright_loo_2005/rawfile/da6a796f479f57e9aa57eb3e21de465989753978/experiments/figure-04.xml

<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" name="figure_04"
	xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
	<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
		xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:bqs="http://www.cellml.org/bqs/1.0#"
		xmlns:dc="http://purl.org/dc/elements/1.1/" xmlns:dcterms="http://purl.org/dc/terms/"
		xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#" xmlns:cs="http://www.cellml.org/metadata/simulation/1.0#"
		xmlns:cg="http://www.cellml.org/metadata/graphs/1.0#" xmlns:csim="http://cellml.sourceforge.net/CellMLSimulator/#">
		<rdf:Description rdf:ID="andre">
			<vCard:N rdf:parseType="Resource">
				<vCard:Family>Nickerson</vCard:Family>
				<vCard:Given>David</vCard:Given>
			</vCard:N>
			<vCard:EMAIL rdf:parseType="Resource">
				<rdf:value>d.nickerson@auckland.ac.nz</rdf:value>
				<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
			</vCard:EMAIL>
			<vCard:ORG rdf:parseType="Resource">
				<vCard:Orgname>The University of Auckland</vCard:Orgname>
				<vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
			</vCard:ORG>
		</rdf:Description>
		<rdf:Description rdf:ID="jonna">
			<vCard:N rdf:parseType="Resource">
				<vCard:Family>Terkildsen</vCard:Family>
				<vCard:Given>Jonna</vCard:Given>
			</vCard:N>
			<vCard:EMAIL rdf:parseType="Resource">
				<rdf:value>j.terkildsen@auckland.ac.nz</rdf:value>
				<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
			</vCard:EMAIL>
			<vCard:ORG rdf:parseType="Resource">
				<vCard:Orgname>The University of Auckland</vCard:Orgname>
				<vCard:Orgunit>Auckland Bioengineering Institute</vCard:Orgunit>
			</vCard:ORG>
		</rdf:Description>
		<rdf:Description rdf:about="">
		    <dc:creator rdf:resource="#andre" />
			<dcterms:created rdf:parseType="Resource">
				<dcterms:W3CDTF>2010-04-22</dcterms:W3CDTF>
			</dcterms:created>
			<dc:publisher>
				Auckland Bioengineering Institute, The University of Auckland.
			</dc:publisher>
		</rdf:Description>
		<rdf:Description rdf:about="#figure_04">
			<cs:simulation>
				<rdf:Description rdf:ID="simulation">
					<cs:multistepMethod>bdf</cs:multistepMethod>
					<cs:iterationMethod>newton</cs:iterationMethod>
					<cs:linearSolver>dense</cs:linearSolver>
					<cs:boundIntervals rdf:parseType="Collection">
						<rdf:Description>
							<cs:boundVariable>
								<rdf:Description rdf:about="#time" />
							</cs:boundVariable>
							<cs:maximumStepSize rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
								0.1
							</cs:maximumStepSize>
							<cs:tabulationStepSize rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
								1
							</cs:tabulationStepSize>
							<cs:startingValue rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
								0
							</cs:startingValue>
							<cs:endingValue rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
								500
							</cs:endingValue>
						</rdf:Description>
					</cs:boundIntervals>
				</rdf:Description>
			</cs:simulation>
		</rdf:Description>
		<rdf:Description>
			<cg:graph>
				<rdf:Description rdf:ID="SGLT1-figure-04">
					<cg:title>Figure 4</cg:title>
					<dcterms:description rdf:parseType="Resource">
						<rdf:value>
							Reproduction of figure 4 from Eskandari et al (2005).
						</rdf:value>
					</dcterms:description>
					<csim:citation rdf:parseType="Resource">
						<csim:authors>
							<rdf:Seq>
								<rdf:li rdf:parseType="Resource">
									<dc:creator rdf:resource="#andre" />
								</rdf:li>
								<rdf:li rdf:parseType="Resource">
									<dc:creator rdf:resource="#jonna" />
								</rdf:li>
							</rdf:Seq>
						</csim:authors>
						<dc:title>
							An example validation study using annotated CellML models
						</dc:title>
						<dcterms:issued>2010-04-22</dcterms:issued>
						<dcterms:bibliographicCitation>Demonstration for Experimental Biology</dcterms:bibliographicCitation>
					</csim:citation>
					<cg:x-label>Na_i (M)</cg:x-label>
					<cg:y-label>I_out (norm)</cg:y-label>
					<cg:background-colour>#ffffff</cg:background-colour>
					<cg:traces rdf:parseType="Collection">
						<rdf:Description>
							<cg:type rdf:resource="http://www.cellml.org/metadata/graphs/1.0#line" />
							<cg:colour>#ff0000</cg:colour>
							<cg:label>I_out</cg:label>
							<cg:x-variable rdf:parseType="Resource">
								<cs:simulation rdf:resource="#simulation" />
								<cg:variable rdf:resource="#Na_i" />
							</cg:x-variable>
							<cg:y-variable rdf:parseType="Resource">
								<cs:simulation rdf:resource="#simulation" />
								<cg:variable rdf:resource="#I_NaGl_SS_normalised" />
							</cg:y-variable>
						</rdf:Description>
					</cg:traces>
				</rdf:Description>
			</cg:graph>
		</rdf:Description>
	</rdf:RDF>
	<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="base.xml">
		<component component_ref="variables" name="model" />
	</import>
	<import xmlns:xlink="http://www.w3.org/1999/xlink"
		xlink:href="../decomposed-model/eskandari_2005_units_model.xml">
		<units name="M" units_ref="M" />
		<units name="volt" units_ref="volt" />
		<units name="volt_per_second" units_ref="volt_per_second" />
		<units name="second" units_ref="second" />
		<units name="uA" units_ref="uA" />
		<units name="M_per_second" units_ref="M_per_second"/>
	</import>
	<component name="Na_i" cmeta:id="Na_i_component">
		<variable cmeta:id="Na_i" name="Na_i" units="M" public_interface="out" initial_value="0" />
		<variable cmeta:id="I_NaGl_SS_normalised" name="I_norm" public_interface="out" units="dimensionless"/>
		<variable cmeta:id="I_NaGl_SS" name="I_NaGl_SS" public_interface="in" units="uA" />
		<variable name="time" units="second" public_interface="in" />
		<math xmlns="http://www.w3.org/1998/Math/MathML">
			<apply><eq/>
				<apply><diff/>
					<bvar><ci>time</ci></bvar>
					<ci>Na_i</ci>
				</apply>
				<cn cellml:units="M_per_second">1.0e-3</cn>
			</apply>
			<apply><eq/>
				<ci>I_norm</ci>
				<apply><divide/>
					<ci>I_NaGl_SS</ci>
					<cn cellml:units="uA">6.29510065e-06</cn>
				</apply>
			</apply>
		</math>
	</component>
	<component name="variables" cmeta:id="variables">
		<variable cmeta:id="N_C" name="N_C" units="dimensionless"
			public_interface="out" initial_value="3.4e6" />
		<variable cmeta:id="Na_o" name="Na_o" units="M"
			public_interface="out" initial_value="10e-3" />
		<variable cmeta:id="glucose_i" name="glucose_i" units="M"
			public_interface="out" initial_value="100e-3" />
		<variable cmeta:id="glucose_o" name="glucose_o" units="M"
			public_interface="out" initial_value="0.0" />
		<variable cmeta:id="V_initial" name="V_initial" units="volt"
			public_interface="out" initial_value="0" />
		<variable cmeta:id="V_dot" name="V_dot" units="volt_per_second"
			public_interface="out" initial_value="0" />
		<variable cmeta:id="time" name="time" units="second"
			public_interface="in" />
		<variable cmeta:id="V" name="V" units="volt"
			public_interface="in" />
	</component>
	<connection>
		<map_components component_1="Na_i" component_2="model" />
		<map_variables variable_1="Na_i" variable_2="Na_i" />
		<map_variables variable_1="time" variable_2="time" />
		<map_variables variable_1="I_NaGl_SS" variable_2="I_NaGl_SS" />
	</connection>
	<connection>
		<map_components component_1="variables" component_2="model" />
		<map_variables variable_1="N_C" variable_2="N_C" />
		<map_variables variable_1="Na_o" variable_2="Na_o" />
		<map_variables variable_1="glucose_i" variable_2="glucose_i" />
		<map_variables variable_1="glucose_o" variable_2="glucose_o" />
		<map_variables variable_1="V_initial" variable_2="V_initial" />
		<map_variables variable_1="V_dot" variable_2="V_dot" />
		<map_variables variable_1="V" variable_2="V" />
		<map_variables variable_1="time" variable_2="time" />
	</connection>
</model>