- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-20 13:59:48+12:00
- Desc:
- Change png to jpg
- Permanent Source URI:
- https://models.fieldml.org/workspace/b8b/rawfile/998d4148804e5dc45aa6da92077fc96868983a70/exposure/exposure_frontpage.rst
About
====================
Landing page for the pacemaker channel **HCN** (potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel). This channel creates the pacemaker current, also known as the **funny** current.
The HCN group is highly expressed in cardiac myocytes in order to generate action potentials for establishing heart beats. It is permeable to both potassium and sodium ions, with preference for potassium.
HCN is thought to be a homotetramer, where the channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. It is activated by membrane hyperpolarisation, and all subfamilies except HCN3 are also activated by cAMP binding to their cyclic nucleotide binding domain.
Pictures
===================
.. figure:: exposure/5u6p2.jpg
:width: 50%
:align: center
:alt: hcn_pic
Fig. 1. Rendered image of the HCN1 tetramer
Subfamilies
===================
The following is a list of all known subfamilies of the HCN channel.
.. csv-table:: Variants within the human species
:header: "Channel name", Gene, Structure
:widths: 7,7,7
HCN1, `Uniprot 1 <https://www.uniprot.org/uniprotkb/O60741/entry>`_, `PDB 1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/5U6O>`_
HCN2, `Uniprot 2 <https://www.uniprot.org/uniprotkb/Q9UL51/entry>`_, `PDB 2 <https://www.ebi.ac.uk/pdbe-srv/view/entry/2MPF>`_
HCN3, `Uniprot 3 <https://www.uniprot.org/uniprotkb/Q9P1Z3/entry>`_, `PDB 3 <https://www.ebi.ac.uk/pdbe-srv/view/entry/8INZ>`_
HCN4, `Uniprot 4 <https://www.uniprot.org/uniprotkb/Q9Y3Q4/entry>`_, `PDB 4 <https://www.ebi.ac.uk/pdbe-srv/view/entry/2MNG>`_
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_funny <https://models.physiomeproject.org/workspace/838>`_", "S Fong"
"`IPSC-model <https://github.com/ClancyLabUCD/IPSC-model>`_", "Kernik et al."
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 17, 15
"HCN channel complex", "`Gene Ontology Complex <https://www.ebi.ac.uk/QuickGO/term/GO:0098855>`_"
