- Author:
- Weiwei Ai <wai484@aucklanduni.ac.nz>
- Date:
- 2024-10-21 14:11:01+13:00
- Desc:
- Modify SGLT1_BG_fast.cellml to allow users to modify test_volt and Glco in the simulation tab.
- Permanent Source URI:
- https://models.fieldml.org/workspace/b65/rawfile/65898d4880efb52227f2860ddafb4c8cde585d47/doc/README.rst
Energy-based bond graph models of glucose transport with SLC transporters
===========================================================================
We present the parameterized bond graph models for facilitated diffusion with
SLC2A2 (GLUT2)
and electrogenic cotransport with SLC5A1 (SGLT1) transporters. The bond graph models
are placed in the folders <Facilitated transporter>
and <Electrogenic cotransporter>, respectively.
Facilitated transporter
===========================
The main CellML_ files are:
- The bond graph model *GLUT2_BG.cellml* parameterized to the kinetic data in `Lowe and Walmsley (1986)`_,
- The steady-state model derived from the bond graph with the variation of intracellular concentration of glucose *GLUT2_ss_io.cellml*,
- The steady-state model derived from the bond graph with the variation of extracellular concentration of glucose *GLUT2_ss_oi.cellml*,
- The steady-state kinetic models *GLUT2_kinetic.cellml* defined in `Lowe and Walmsley (1986)`_,
- The parameter file for the bond graph *params_BG.cellml*,
- The unit definition file *units.cellml*.
Electrogenic cotransporter
===========================
The main CellML_ files are:
- The bond graph model *SGLT1_BG.cellml* parameterized to the kinetic data in `Parent et al (1992)`_,
- The bond graph model with fast binding/unbinding parameters *SGLT1_BG_fast.cellml*,
- The steady-state model derived from the bond graph *SGLT1_ss.cellml*,
- The steady-state model with fast binding/unbinding parameters *SGLT1_ss_fast.cellml*,
- The parameter file for the bond graph model *params_BG.cellml*,
- The parameter file for the bond graph model with fast binding/unbinding parameters *params_BG_fast.cellml*,
- The unit definition file *units.cellml*.
The corresponding SED-ML_ files can be used to run simulations in OpenCOR_.
.. _CellML: https://www.cellml.org/
.. _OpenCOR: https://opencor.ws/
.. _SED-ML: https://sed-ml.org
.. _`Lowe and Walmsley (1986)`: https://doi.org/10.1016/0005-2736(86)90342-1
.. _`Parent et al (1992)`: https://doi.org/10.1007/BF00235798
