Location: A review of cardiac cellular electrophysiology models @ faec014e4ba6 / models / 1962_noble / experiments / free-running.xml

Author:
David Nickerson <david.nickerson@gmail.com>
Date:
2021-09-15 23:47:07+12:00
Desc:
Updating BR model with SED-ML for the default periodic stimulus simulation experinment
Permanent Source URI:
https://models.fieldml.org/workspace/a1/rawfile/faec014e4ba6524541fe8093d6bf343861caacfd/models/1962_noble/experiments/free-running.xml

<?xml version="1.0" encoding="iso-8859-1"?>

<model
    name="1962_noble_freeRunning"
    cmeta:id="1962_noble_freeRunning"
    xmlns="http://www.cellml.org/cellml/1.1#"
    xmlns:cellml="http://www.cellml.org/cellml/1.1#"
    xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
    xmlns:xlink="http://www.w3.org/1999/xlink">
  <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
      xmlns:bqs="http://www.cellml.org/bqs/1.0#"
      xmlns:dc="http://purl.org/dc/elements/1.1/"
      xmlns:dcterms="http://purl.org/dc/terms/"
      xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"
      xmlns:cs="http://www.cellml.org/metadata/simulation/1.0#">
    <rdf:Description rdf:about="">
      <dc:creator rdf:parseType="Resource">
        <vCard:N rdf:parseType="Resource">
          <vCard:Family>Nickerson</vCard:Family>
          <vCard:Given>David</vCard:Given>
        </vCard:N>
        <vCard:EMAIL rdf:parseType="Resource">
          <rdf:value>d.nickerson@auckland.ac.nz</rdf:value>
          <rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
        </vCard:EMAIL>
        <vCard:ORG rdf:parseType="Resource">
          <vCard:Orgname>The University of Auckland</vCard:Orgname>
          <vCard:Orgunit>Bioengineering Institute</vCard:Orgunit>
        </vCard:ORG>
      </dc:creator>
      <dcterms:created rdf:parseType="Resource">
        <dcterms:W3CDTF>2004-12-21</dcterms:W3CDTF>
      </dcterms:created>
      <dc:publisher>
        Bioengineering Institute, The University of Auckland.
      </dc:publisher>
    </rdf:Description>
    <rdf:Description rdf:about="#1962_noble_freeRunning">
      <dc:title>
        Free running version of Noble (1962) Purkinje fibre model
      </dc:title>
      <cmeta:comment rdf:parseType="Resource">
        <rdf:value>
          This CellML file describes the boundary conditions used with the
          Noble (1962) cardiac Purkinje fibre electrophysiology model to
          produce a free running (pacemaker) version of the model.
        </rdf:value>
        <dc:creator rdf:parseType="Resource">
          <vCard:FN>David Nickerson</vCard:FN>
        </dc:creator>
      </cmeta:comment>
      <cs:simulation>
        <rdf:Description rdf:ID="simulation">
          <cs:multistepMethod>bdf</cs:multistepMethod>
          <cs:iterationMethod>functional</cs:iterationMethod>
          <cs:boundIntervals rdf:parseType="Collection">
            <rdf:Description>
              <cs:boundVariable>
                <rdf:Description rdf:about="#time"/>
              </cs:boundVariable>
              <cs:maximumStepSize rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
                0.01
              </cs:maximumStepSize>
              <cs:tabulationStepSize rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
                1.0
              </cs:tabulationStepSize>
              <cs:startingValue rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
                0
              </cs:startingValue>
              <cs:endingValue rdf:datatype="http://www.w3.org/2001/XMLSchema#double">
                3000
              </cs:endingValue>
            </rdf:Description>
          </cs:boundIntervals>
        </rdf:Description>
      </cs:simulation>
    </rdf:Description>
  </rdf:RDF>

  <import xlink:href="../../common/units.xml">
    <units name="ms" units_ref="ms"/>
    <units name="uA_per_mmsq" units_ref="uA_per_mmsq"/>
    <units name="uA_per_mmcu" units_ref="uA_per_mmcu"/>
    <units name="mV" units_ref="mV"/>
    <units name="mS_per_mmsq" units_ref="mS_per_mmsq"/>
    <units name="per_mm" units_ref="per_mm"/>
  </import>
  <import xlink:href="../1962_noble.xml">
    <component name="model" component_ref="interface"/>
  </import>
  
  <component name="time" cmeta:id="time_component">
    <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
      <rdf:Description rdf:about="#time_component">
        <cmeta:comment rdf:parseType="Resource">
          <rdf:value>
            The actual definition of the time variable.
          </rdf:value>
        </cmeta:comment>
      </rdf:Description>
    </rdf:RDF>
    <variable name="time" cmeta:id="time" initial_value="0.0" public_interface="out" units="ms"/>
  </component>
  <connection>
    <map_components component_1="model" component_2="time"/>
    <map_variables variable_1="time" variable_2="time"/>
  </connection>
  
  <component name="stimulus_protocol" cmeta:id="stimulus_protocol">
    <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
      <rdf:Description rdf:about="#stimulus_protocol">
        <cmeta:comment rdf:parseType="Resource">
          <rdf:value>
            Here we define the stimulus protocol for the simulation.
            In this case there is no stimulus applied.
          </rdf:value>
        </cmeta:comment>
      </rdf:Description>
    </rdf:RDF>
    <variable name="IStim" initial_value="0.0" public_interface="out" units="uA_per_mmsq"/>
  </component>
  <connection>
    <map_components component_1="model" component_2="stimulus_protocol"/>
    <map_variables variable_1="I_stim" variable_2="IStim"/>
  </connection>
    
  <component name="parameters" cmeta:id="parameters">
    <rdf:RDF
      xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
      xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
      <rdf:Description rdf:about="#parameters">
        <cmeta:comment rdf:parseType="Resource">
          <rdf:value>
            Here we define the parameter values for this simulation. g_K_add
            is set to zero to allow the free running (self-activating) version
            of the model.
          </rdf:value>
        </cmeta:comment>
      </rdf:Description>
    </rdf:RDF>
    <variable name="g_K_add" initial_value="0.0" public_interface="out" units="mS_per_mmsq"/>
  </component>
  <connection>
    <map_components component_1="model" component_2="parameters"/>
    <map_variables variable_1="g_K_add" variable_2="g_K_add"/>
  </connection>
  
</model>