Location: A review of cardiac cellular electrophysiology models @ faebb18f1db5 / sed-ml / BR-INa-variants.xml

Author:
David Nickerson <david.nickerson@gmail.com>
Date:
2021-09-16 01:07:43+12:00
Desc:
adding BR variant comparison to jupyter notebook
Permanent Source URI:
https://models.fieldml.org/workspace/a1/rawfile/faebb18f1db53a7d1f8f4e7fc588d660d45744c0/sed-ml/BR-INa-variants.xml

<?xml version="1.0" encoding="utf-8"?>

<sedML xmlns="http://www.biomodels.net/sed-ml">
	<listOfSimulations>
		<uniformTimeCourse id="simulation"
			algorithm="KISAO:0000019"
			initialTime="0"
			outputStartTime="0"
			outputEndTime="1500"
			numberOfPoints="1500" />
		<!-- 
		FIXME: need to reference IVOI - can't go here though...
		-->
	</listOfSimulations>
	<listOfModels>
		<model id="BR"
			type="CellML"
			source="../models/1977_beeler/experiments/periodic_stimulus.xml" />
		<model id="BREJ"
			type="CellML"
			source="../models/1977_beeler/experiments/1980_ebihara_johnson.xml" />
		<model id="BRDR"
			type="CellML"
			source="../models/1977_beeler/experiments/1987_drouhard_roberge.xml" />
	</listOfModels>
	<listOfTasks>
		<task id="BR-task" modelReference="BR" simulationReference="simulation" />
		<task id="BREJ-task" modelReference="BREJ" simulationReference="simulation" />
		<task id="BRDR-task" modelReference="BRDR" simulationReference="simulation" />
	</listOfTasks>
	<listOfDataGenerators>
		<dataGenerator id="BR-time" name="BR time">
			<listOfVariables>
				<variable id="BR-time" taskReference="BR-task" target="/cellml:model/cellml:component[@name='time']/cellml:variable[@name='time']" />
			</listOfVariables>
			<math xmlns="http://www.w3.org/1998/Math/MathML">
				<ci> BR-time </ci>
			</math>
		</dataGenerator>
		<dataGenerator id="BR-Vm" name="BR Vm">
			<listOfVariables>
				<variable id="BR-Vm" taskReference="BR-task"
					target="/cellml:model/cellml:component[@name='exposed_variables']/cellml:variable[@name='Vm']" />
			</listOfVariables>
			<math xmlns="http://www.w3.org/1998/Math/MathML">
				<ci> BR-Vm </ci>
			</math>
		</dataGenerator>
		<dataGenerator id="BREJ-time" name="BREJ time">
			<listOfVariables>
				<variable id="BREJ-time" taskReference="BREJ-task" target="/cellml:model/cellml:component[@name='time']/cellml:variable[@name='time']" />
			</listOfVariables>
			<math xmlns="http://www.w3.org/1998/Math/MathML">
				<ci> BREJ-time </ci>
			</math>
		</dataGenerator>
		<dataGenerator id="BREJ-Vm" name="BREJ Vm">
			<listOfVariables>
				<variable id="BREJ-Vm" taskReference="BREJ-task"
					target="/cellml:model/cellml:component[@name='fast_sodium_current']/cellml:variable[@name='V']" />
			</listOfVariables>
			<math xmlns="http://www.w3.org/1998/Math/MathML">
				<ci> BREJ-Vm </ci>
			</math>
		</dataGenerator>
		<dataGenerator id="BRDR-time" name="BRDR time">
			<listOfVariables>
				<variable id="BRDR-time" taskReference="BRDR-task" target="/cellml:model/cellml:component[@name='time']/cellml:variable[@name='time']" />
			</listOfVariables>
			<math xmlns="http://www.w3.org/1998/Math/MathML">
				<ci> BRDR-time </ci>
			</math>
		</dataGenerator>
		<dataGenerator id="BRDR-Vm" name="BRDR Vm">
			<listOfVariables>
				<variable id="BRDR-Vm" taskReference="BRDR-task"
					target="/cellml:model/cellml:component[@name='fast_sodium_current']/cellml:variable[@name='V']" />
			</listOfVariables>
			<math xmlns="http://www.w3.org/1998/Math/MathML">
				<ci> BRDR-Vm </ci>
			</math>
		</dataGenerator>
	</listOfDataGenerators>
	<listOfOutputs>
		<plot2D id="plot1" name="Action Potentials" logX="false" logY="false">
			<listOfCurves>
				<curve xDataReference="BR-time" yDataReference="BR-Vm" />
				<curve xDataReference="BREJ-time" yDataReference="BREJ-Vm" />
				<curve xDataReference="BRDR-time" yDataReference="BRDR-Vm" />
			</listOfCurves>
		</plot2D>
	</listOfOutputs>
</sedML>