- Author:
- David Nickerson <david.nickerson@gmail.com>
- Date:
- 2021-09-16 00:41:19+12:00
- Desc:
- Updating Noble 1962 model:
* Exposing the membrane potential to the top-level model;
* adding SED-ML for the paced and pacemaker variants of the model.
Using OpenCOR Snapshot release 2021-09-14.
- Permanent Source URI:
- https://models.fieldml.org/workspace/a1/rawfile/f954e59183314cd37f86c8832dc81317d01c8ec5/models/1991_luo/experiments/generic.xml
<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" name="luo_rudy_I_model_1991_experiment_model" xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../luo_rudy_I_model_1991_variable_values_model.xml">
<component component_ref="parameters" name="parameters"/>
<component component_ref="initial_values" name="initial_values"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../luo_rudy_I_model_1991_interface_model.xml">
<component component_ref="luo_rudy_I_model_1991_interface_component" name="luo_rudy_I_model_1991_interface_component"/>
</import>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="parameters"/>
<map_variables variable_1="R" variable_2="R"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="F" variable_2="F"/>
<map_variables variable_1="C" variable_2="C"/>
<map_variables variable_1="g_Na" variable_2="g_Na"/>
<map_variables variable_1="E_Na" variable_2="E_Na"/>
<map_variables variable_1="g_si" variable_2="g_si"/>
<map_variables variable_1="g_K" variable_2="g_K"/>
<map_variables variable_1="PR_NaK" variable_2="PR_NaK"/>
<map_variables variable_1="g_K1" variable_2="g_K1"/>
<map_variables variable_1="g_Kp" variable_2="g_Kp"/>
<map_variables variable_1="E_b" variable_2="E_b"/>
<map_variables variable_1="g_b" variable_2="g_b"/>
<map_variables variable_1="Nao" variable_2="Nao"/>
<map_variables variable_1="Nai" variable_2="Nai"/>
<map_variables variable_1="Cao" variable_2="Cao"/>
<map_variables variable_1="Ki" variable_2="Ki"/>
</connection>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="initial_values"/>
<map_variables variable_1="V_initial" variable_2="V_initial"/>
<map_variables variable_1="m_initial" variable_2="m_initial"/>
<map_variables variable_1="h_initial" variable_2="h_initial"/>
<map_variables variable_1="j_initial" variable_2="j_initial"/>
<map_variables variable_1="d_initial" variable_2="d_initial"/>
<map_variables variable_1="f_initial" variable_2="f_initial"/>
<map_variables variable_1="X_initial" variable_2="X_initial"/>
<map_variables variable_1="Cai_initial" variable_2="Cai_initial"/>
</connection>
<component name="time" cmeta:id="time_component">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#time_component">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
The actual definition of the time variable.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable name="time" cmeta:id="time" initial_value="0.0" public_interface="out" units="ms"/>
</component>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="time"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../../protocols/single-pulse-IStim.xml">
<component name="stimulus_protocol" component_ref="stimulus_protocol"/>
</import>
<component name="stimulus_parameters" cmeta:id="stimulus_parameters">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#">
<rdf:Description rdf:about="#stimulus_parameters">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
Here we define the parameters for the standard stimulus protocol we import for this experiment.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<variable name="stimTime" initial_value="100" public_interface="out" units="ms"/>
<variable name="stimDuration" initial_value="1.0" public_interface="out" units="ms"/>
<variable name="stimCurrent" initial_value="100" public_interface="out" units="uA_per_mmcu"/>
<variable name="Am" initial_value="200" public_interface="out" units="per_mm"/>
</component>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="stimulus_protocol"/>
<map_variables variable_1="I_stim" variable_2="IStim"/>
</connection>
<connection>
<map_components component_1="time" component_2="stimulus_protocol"/>
<map_variables variable_1="time" variable_2="time"/>
</connection>
<connection>
<map_components component_1="stimulus_parameters" component_2="stimulus_protocol"/>
<map_variables variable_1="stimTime" variable_2="stimTime"/>
<map_variables variable_1="stimDuration" variable_2="stimDuration"/>
<map_variables variable_1="stimCurrent" variable_2="stimCurrent"/>
<map_variables variable_1="Am" variable_2="Am"/>
</connection>
<component name="interface">
<variable name="Ko" private_interface="out" public_interface="in" units="concentration_units"/>
</component>
<connection>
<map_components component_1="luo_rudy_I_model_1991_interface_component" component_2="interface"/>
<map_variables variable_1="Ko" variable_2="Ko"/>
</connection>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="interface">
<component_ref component="luo_rudy_I_model_1991_interface_component"/>
<component_ref component="time"/>
<component_ref component="parameters"/>
<component_ref component="initial_values"/>
<component_ref component="stimulus_protocol"/>
<component_ref component="stimulus_parameters"/>
</component_ref>
</group>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../luo_rudy_I_model_1991_units_model.xml">
<units name="ms" units_ref="ms"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="mV" units_ref="mV"/>
<units name="per_mV" units_ref="per_mV"/>
<units name="per_mV_ms" units_ref="per_mV_ms"/>
<units name="mS_per_mm2" units_ref="mS_per_mm2"/>
<units name="uF_per_mm2" units_ref="uF_per_mm2"/>
<units name="uA_per_mm2" units_ref="uA_per_mm2"/>
<units name="concentration_units" units_ref="concentration_units"/>
<units name="gas_constant_units" units_ref="gas_constant_units"/>
<units name="faradays_constant_units" units_ref="faradays_constant_units"/>
</import>
<import xmlns:xlink="http://www.w3.org/1999/xlink" xlink:href="../../common/units.xml">
<units name="per_mm" units_ref="per_mm"/>
<units name="uA_per_mmcu" units_ref="uA_per_mmcu"/>
</import>
</model>
