Location: A Biophysically Based Mathematical Model of Unitary Potential Activity @ afe0649a295b / Common / generator.cellml
- Author:
- Leyla <lnor300>
- Date:
- 2022-09-28 14:18:41+13:00
- Desc:
- ..
- Permanent Source URI:
- https://models.fieldml.org/workspace/916/rawfile/afe0649a295b268b0f453c56ea726d6a4019a340/Common/generator.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="generator" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="../common/units.cellml">
<units name="flux" units_ref="flux"/>
<units name="micromolar" units_ref="micromolar"/>
<units name="picoampere" units_ref="picoampere"/>
<units name="millivolt" units_ref="millivolt"/>
<units name="first_order_rate_constant" units_ref="first_order_rate_constant"/>
</import>
<!-- def import using "../common/environment.cellml" for
comp environment using comp environment;
enddef;-->
<!-- def map between experiment and environment for
vars time and time;
enddef;-->
<component name="experiment">
<variable name="time" public_interface="in" units="second"/>
<variable name="Vm" private_interface="out" public_interface="out" units="millivolt"/>
<variable name="I_iCa" private_interface="out" public_interface="out" units="picoampere"/>
<variable name="I_iNa" private_interface="out" public_interface="out" units="picoampere"/>
<variable name="I_Ca" private_interface="out" public_interface="out" units="picoampere"/>
<variable name="I_Na" private_interface="out" public_interface="out" units="picoampere"/>
<variable name="I_NSCC_Ca" private_interface="out" public_interface="out" units="picoampere"/>
<variable name="I_NSCC_Na" private_interface="out" public_interface="out" units="picoampere"/>
<variable name="I_PM" private_interface="out" public_interface="out" units="picoampere"/>
<variable name="CER" private_interface="out" public_interface="out" units="micromolar"/>
<variable name="NS1" private_interface="out" public_interface="out" units="micromolar"/>
<variable name="CMT" private_interface="out" public_interface="out" units="micromolar"/>
<variable name="CS1" private_interface="out" public_interface="out" units="micromolar"/>
<variable name="CS2" private_interface="out" public_interface="out" units="micromolar"/>
<variable name="JMCU" private_interface="out" public_interface="out" units="flux"/>
<variable name="JNCX" private_interface="out" public_interface="out" units="flux"/>
<variable name="JS1S2" private_interface="out" public_interface="out" units="flux"/>
<variable name="JSERCA" private_interface="out" public_interface="out" units="flux"/>
<variable name="JIPR" private_interface="out" public_interface="out" units="flux"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>Vm</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">50</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="millivolt">1</cn>
<apply>
<times/>
<cn cellml:units="millivolt">1</cn>
<apply>
<sin/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">3.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>JNCX</ci>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.025</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="flux">0.25</cn>
<apply>
<times/>
<cn cellml:units="flux">1</cn>
<apply>
<sin/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">3.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>JIPR</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">0.011</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="flux">0.25</cn>
<apply>
<times/>
<cn cellml:units="flux">1</cn>
<apply>
<sin/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">3.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>JSERCA</ci>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.001</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="flux">0.25</cn>
<apply>
<sin/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">14.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>JS1S2</ci>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.0096</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="flux">0.1</cn>
<apply>
<sin/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">7.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>JMCU</ci>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.0025</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="flux">0.25</cn>
<apply>
<times/>
<cn cellml:units="flux">1</cn>
<apply>
<sin/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">5.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_iNa</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="picoampere">500</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.4</cn>
<apply>
<cos/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">14.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_iCa</ci>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="picoampere">3.50</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.4</cn>
<apply>
<cos/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">14.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Na</ci>
<apply>
<times/>
<cn cellml:units="picoampere">500</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<cos/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">14.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_Ca</ci>
<apply>
<times/>
<cn cellml:units="picoampere">50</cn>
<apply>
<plus/>
<cn cellml:units="dimensionless">0.4</cn>
<apply>
<cos/>
<apply>
<divide/>
<ci>time</ci>
<cn cellml:units="first_order_rate_constant">14.0096</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NSCC_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="picoampere">50</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.5</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">50</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NSCC_Ca</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="picoampere">50</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.5</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">50</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>I_PM</ci>
<apply>
<plus/>
<apply>
<minus/>
<cn cellml:units="picoampere">50</cn>
</apply>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="picoampere">50</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="first_order_rate_constant">0.5</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CER</ci>
<apply>
<plus/>
<cn cellml:units="micromolar">0.0003</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="micromolar">0.0096</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="rate_constants_units">0.5</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>NS1</ci>
<apply>
<plus/>
<cn cellml:units="micromolar">0.0001</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="micromolar">0.0096</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="rate_constants_units">0.5</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CMT</ci>
<apply>
<plus/>
<cn cellml:units="micromolar">0.0003</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="micromolar">0.0096</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="rate_constants_units">0.5</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CS1</ci>
<apply>
<plus/>
<cn cellml:units="micromolar">0.01</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="micromolar">0.009</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="rate_constants_units">0.3</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>CS2</ci>
<apply>
<plus/>
<cn cellml:units="micromolar">0.001</cn>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="micromolar">0.0096</cn>
<cn cellml:units="dimensionless">1</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="dimensionless">1</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="rate_constants_units">0.5</cn>
<ci>time</ci>
</apply>
<cn cellml:units="dimensionless">100</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<variable initial_value="0" name="m" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<apply>
<diff/>
<bvar>
<ci>time</ci>
</bvar>
<ci>m</ci>
</apply>
<cn cellml:units="first_order_rate_constant">1</cn>
</apply>
</math>
</component>
</model>