- Author:
- WeiweiAi <wai484@aucklanduni.ac.nz>
- Date:
- 2022-06-28 15:54:52+12:00
- Desc:
- Add Markov states
- Permanent Source URI:
- https://models.fieldml.org/workspace/6bc/rawfile/6dc0ec3b88004d6d2aff5ddf20061aa3cb35d7da/Protocols/X_clamp_protocol.cellml
<?xml version='1.0' encoding='UTF-8'?>
<model name="X_clamp_protocol" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<!-- clamp the concentration for the activation behaviour-->
<import xlink:href="../Components/units.cellml">
<units name="mM" units_ref="mM"/>
</import>
<component name="X_clamp_protocol">
<variable name="time" public_interface="in" units="second"/>
<variable cmeta:id="steady_state_time" name="t_ss" public_interface="in" units="second"/>
<variable cmeta:id="holding_concentration" name="X_Holding" public_interface="in" units="mM"/>
<variable cmeta:id="activation_duration" name="t_act" public_interface="in" units="second"/>
<variable cmeta:id="test_concentration" name="X_Test" public_interface="in" units="mM"/>
<variable name="X" public_interface="out" units="mM"/>
<!--get the model to steady state at the holding concentration.-->
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="concentration_clamping">
<eq/>
<ci>X</ci>
<piecewise>
<piece>
<ci>X_Holding</ci>
<apply>
<lt/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
</piece>
<piece>
<ci>X_Test</ci>
<apply>
<and/>
<apply>
<geq/>
<ci>time</ci>
<ci>t_ss</ci>
</apply>
<apply>
<lt/>
<ci>time</ci>
<apply>
<plus/>
<ci>t_act</ci>
<ci>t_ss</ci>
</apply>
</apply>
</apply>
</piece>
<otherwise>
<ci>X_Holding</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
</model>
