- Author:
- AnandR <a.rampadarath@auckland.ac.nz>
- Date:
- 2019-09-11 12:58:46+12:00
- Desc:
- Added .omex file
- Permanent Source URI:
- https://models.fieldml.org/workspace/599/rawfile/62e2b7dada2321b97f9c2d6a4deaea19b3b36d6c/model/hinch_greenstein_tanskanen_xu_winslow_2004.rdf
<rdf:RDF
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:semsim="http://www.bhi.washington.edu/SemSim#"
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xmlns:bqmodel="http://biomodels.net/model-qualifiers/"
xmlns:bqbiol="http://biomodels.net/biology-qualifiers/"
xmlns:ro="http://www.obofoundry.org/ro/ro.owl#" >
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</rdf:Description>
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</rdf:Description>
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</rdf:Description>
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<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
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</rdf:Description>
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<dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
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<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.mu_mcc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.alpha_p">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_12">
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<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.alpha_m">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
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<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_1">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_2"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_66836"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_oc">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.mu_poc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.N">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_17"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01001"/>
<dcterms:description>Number of calcium release units</dcterms:description>
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<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Sarcolemmal_Ca_pump.g_pCa">
<dcterms:description>Maximum pump rate of sarcolemmal pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU.FVRT_Ca">
<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Sarcolemmal_Ca_pump.K_mpCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Half saturation of sarcolemmal pump</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.phi_L">
<dcterms:description>Proportion of time closed in open mode for L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.r_3">
<dcterms:description>Rate constant for transition of calcium release unit from state 3 to state 4</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Concentration of calcium (2+) in dyadic space when L-type calcium channel state is closed and when ryanodine receptor state is open</dcterms:description>
</rdf:Description>
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<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.g_D">
<dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_67225"/>
</rdf:Description>
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<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_14067"/>
</rdf:Description>
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<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations.I_CaB">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_4"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.epsilon_pco">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#SR_Ca_leak_current.g_SRl">
<dcterms:description>Maximum pump rate of calcium (2+) leak current from the sarcoplasmic reticulum to the bulk myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.V_L">
<dcterms:description>Potential when half LCC open</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current_I_LCC">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#troponin_Ca_buffer.B_TRPN">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Total cytosolic troponin concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.epsilon_m">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Na_Ca_Exchanger.eta">
<dcterms:description>Voltage dependence of sodium-calcium exchanger control</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.r_2">
<dcterms:description>Rate constant for transition of calcium release unit from state 2 to state 1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.expVL">
<dcterms:description>Convenience variable that is equal to exp((V-V_L)/del_VL)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.Ca_o">
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.beta_pcc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_3">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_4"/>
<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
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<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_14">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_9"/>
<bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/PR_B0LPN4"/>
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<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_1">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_7"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.beta_m">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
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<dcterms:description>Intracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#calmodulin_Ca_buffer.k_CMDN">
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<dcterms:description>Inactivation time for ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_and_RyR_fluxes.J_Loc">
<dcterms:description>Current through the L-type calcium channel when L-type calcium channel state is open and ryanodine receptor state is closed</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.mu_mcc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_ci">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the inactivated state</dcterms:description>
</rdf:Description>
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<dcterms:description>Sarcolemmal calcium-ATPase flow</dcterms:description>
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<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
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<dcterms:description>Calcium (2+) leak from the sarcoplasmic reticulum to the bulk myoplasm</dcterms:description>
</rdf:Description>
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<dcterms:description>State 2 of calcium release channel: z2 = yoi union yci</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
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<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#SERCA.g_SERCA">
<dcterms:description>Maximum pump rate of sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.C_co">
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<dcterms:description>Concentration of calcium (2+) in dyadic space when L-type calcium channel state is closed and when ryanodine receptor state is open</dcterms:description>
</rdf:Description>
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</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.theta_R">
<dcterms:description>Reciprocal of proportion of time inactivated (closed) in open mode for ryanodine receptors</dcterms:description>
</rdf:Description>
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<semsim:hasCellMLdocumentation><documentation xmlns="http://cellml.org/tmp-documentation">
<article>
<section id="sec_status">
<title>Model Status</title>
<para>This model is known to run in OpenCell and COR to reproduce the output shown in the publication.</para>
</section>
<sect1 id="sec_structure">
<title>Model Structure</title>
<para>ABSTRACT: Calcium (Ca2+)-induced Ca2+ release (CICR) in cardiac myocytes exhibits high gain and is graded. These properties result from local control of Ca2+ release. Existing local control models of Ca2+ release in which interactions between L-Type Ca2+ channels (LCCs) and ryanodine-sensitive Ca2+ release channels (RyRs) are simulated stochastically are able to reconstruct these properties, but only at high computational cost. Here we present a general analytical approach for deriving simplified models of local control of CICR, consisting of low-dimensional systems of coupled ordinary differential equations, from these more complex local control models in which LCC-RyR interactions are simulated stochastically. The resulting model, referred to as the coupled LCC-RyR gating model, successfully reproduces a range of experimental data, including L-Type Ca2+ current in response to voltage-clamp stimuli, inactivation of LCC current with and without Ca2+ release from the sarcoplasmic reticulum, voltage-dependence of excitation-contraction coupling gain, graded release, and the force-frequency relationship. The model does so with low computational cost.</para>
<para>The original publication reference is cited below:</para>
<para>
A Simplified Local Control Model of Calcium-Induced Calcium Release in Cardiac Ventricular Myocytes, R. Hinch, J.R. Greenstein, A.J. Tanskanen, L. Xu, R.L. Winslow, 2004
<emphasis>Biophysical Journal</emphasis>
, 87, 3723-3736,
<ulink url="http://www.ncbi.nlm.nih.gov/pubmed/15465866">PubMed ID: 15465866</ulink>
</para>
<informalfigure float="0" id="cell_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>state diagram</title>
</objectinfo>
<imagedata fileref="hinch_2004.png" />
</imageobject>
</mediaobject>
<caption>Schematic diagram of the currents and the ion exchanges described by the cardiac ventricular myocyte model.</caption>
</informalfigure>
<informalfigure float="0" id="markov_diagram">
<mediaobject>
<imageobject>
<objectinfo>
<title>state diagram</title>
</objectinfo>
<imagedata fileref="hinch_2004b.png" />
</imageobject>
</mediaobject>
<caption>The nine-state Markov model of the calcium release unit (CaRU). In state yij, the LCC is in the state i and the RyR is in the state j.</caption>
</informalfigure>
</sect1>
</article>
</documentation></semsim:hasCellMLdocumentation>
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<semsim:modelName>Hinch_2004</semsim:modelName>
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<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_9462"/>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Half concentration of activation for ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_and_RyR_fluxes.J_Roo">
<dcterms:description>Current through the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.z_1">
<dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
</rdf:Description>
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<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current_I_RyR">
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<dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
</rdf:Description>
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<dcterms:description>Volume of sarcoplasmic reticulum</dcterms:description>
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<dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
</rdf:Description>
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<dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
</rdf:Description>
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<dcterms:description>Pump rate of sodium-calcium exchanger. Used to balance transmembrane flux of calcium(2+) over each cycle.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.mu_moc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_ic">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the inactivated state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_oo">
<dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
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<dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
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<dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is closed</dcterms:description>
</rdf:Description>
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<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
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<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
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<semsim:name>Calcium release unit</semsim:name>
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<dcterms:description>Calcium (2+) resequestering into the sarcoplasmic reticulum via the sarco/endoplasmic reticulum Ca2+ -ATPase (SERCA) pump</dcterms:description>
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<dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is closed</dcterms:description>
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<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
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</rdf:Description>
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<dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
</rdf:Description>
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<dcterms:description>Volume of myoplasm</dcterms:description>
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<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29108"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.y_oc">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU.N">
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<dcterms:description>Number of calcium release units</dcterms:description>
</rdf:Description>
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<dcterms:description>Convenience variable that is equal to F*V/(R*T)</dcterms:description>
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<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
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<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Total cytosolic calmodulin concentration</dcterms:description>
</rdf:Description>
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<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
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<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>Voltage across cell membrane</dcterms:description>
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<dcterms:description>Sarcolemmal calcium leak current</dcterms:description>
</rdf:Description>
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<dcterms:description>Transition rate for three-state model of the ryanodine receptor when L-type calcium channel is open and ryanodine receptor is closed</dcterms:description>
</rdf:Description>
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<bqbiol:is rdf:resource="https://identifiers.org/chebi/CHEBI:29101"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.z_3">
<dcterms:description>State 3 of calcium release unit: z3 = yic union yio</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_3">
<semsim:hasMediatorParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_3"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_4"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_4"/>
<semsim:name>Total calcium ion flow through L-type calcium channels</semsim:name>
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<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.N">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_17"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_01001"/>
<dcterms:description>Number of calcium release units</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Background_Ca_current.g_CaB">
<dcterms:description>Conductance of background calcium (2+) current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_and_RyR_fluxes.J_Loo">
<dcterms:description>Current through the L-type calcium channel when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_19">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_1"/>
<semsim:name>Total bound and unbound troponin</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.z_3">
<dcterms:description>State 3 of calcium release unit: z3 = yic union yio</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#calmodulin_Ca_buffer.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_8">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_9"/>
<bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/PR_Q01728"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_6">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Background_Ca_current.R">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410"/>
<dcterms:description>Universal gas constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#troponin_Ca_buffer.k_m_TRPN">
<dcterms:description>Dissociation rate of calcium (2+) from troponin</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.J_L2">
<dcterms:description>Convenience term for expressing equation for I_LCC?</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_4">
<semsim:hasMediatorParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_4"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_5"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_5"/>
<semsim:name>Sarcolemmal calcium leak flow</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#membrane.FVRT">
<dcterms:description>Convenience variable that is equal to F*V/(R*T)</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Na_Ca_Exchanger.K_mCa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Calcium (2+) half saturation of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.J_Rco">
<dcterms:description>Current through the ryanodine receptor when L-type calcium channel state is closed and ryanodine receptor state is open</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.y_co">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.alpha_m">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_7">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.r_8">
<dcterms:description>Rate constant for transition of calcium release unit from state 4 to state 2</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations.beta_CMDN">
<dcterms:description>Rapid buffer coeffiecient in the cytoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.z_4">
<dcterms:description>State 4 of calcium release unit: z4 = yii</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.beta_m">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_3">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.t_L">
<dcterms:description>Time switching between closed and open states for L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.V_myo">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Na_Ca_Exchanger.Ca_o">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Extracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_and_RyR_fluxes.FVRT_Ca">
<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations.Ca_SR">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_12"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Background_Ca_current.E_Ca">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>Reversal potential for sarcolemmal leak current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#membrane.F">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089"/>
<dcterms:description>Faraday constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_9">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_2"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_63841"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_cc">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel and the ryanodine receptor are both in the closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.J_L1">
<dcterms:description>Convenience term for expressing equation for I_LCC?</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_5">
<semsim:hasMediatorParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_5"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_6"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_6"/>
<semsim:name>Calcium leak from sarcoplasmic reticulum to myoplasm</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_io">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the inactivated state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Na_Ca_Exchanger.Na_o">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Extracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.alpha_p">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_6">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_12"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_5">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_3"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_4">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.z_1">
<dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_6">
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_21"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.Ca_SR">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_12"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Calcium (2+) concentration in sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#membrane_V">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_11"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>Voltage across cell membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.J_R">
<dcterms:description>Permeability of a single ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.epsilon_pco">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.C_oo">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Concentration of calcium (2+) in the dyadic space when the L-type calcium channel state is open and the ryanodine receptor state is open</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations.I_NaCa">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_0"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>Sodium-calcium exchange current</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations_Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Background_Ca_current.T">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00293"/>
<dcterms:description>Ambient temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_6">
<semsim:hasMediatorParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_6"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_7"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_7"/>
<semsim:name>Calcium flow into the sarcoplasmic reticulum via SERCA pump</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.y_co">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.denom">
<dcterms:description>Convenience term for computing ycc, yco, yoc, and yoo variables</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations.V_SR">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_22"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>Volume of sarcoplasmic reticulum</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#environment_time">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
<dcterms:description>Simulation time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.z_2">
<dcterms:description>State 2 of calcium release channel: z2 = yoi union yci</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_4">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_3"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_and_RyR_fluxes.J_L">
<dcterms:description>Permeability of a single L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU.J_L">
<dcterms:description>Permeability of a single L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#cell_geometry.V_myo">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_5">
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_20"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations.I_LCC">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_3"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>Total whole-cell current through the L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.V_myo">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_16"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00154"/>
<dcterms:description>Volume of myoplasm</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Na_Ca_Exchanger.K_mNa">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Soldium (1+) half saturation of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.beta_poc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when L-type calcium channel is open and ryanodine receptor is closed</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_oi">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the inactivated state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.phi_R">
<dcterms:description>Proportion of time closed in open mode for L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#membrane.T">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_5"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00293"/>
<dcterms:description>Ambient temperature</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.b">
<dcterms:description>Biasing to make inactivation a function of membrane voltage</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.r_5">
<dcterms:description>Rate constant for transition of calcium release unit from state 1 to state 3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Sarcolemmal_Ca_pump.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.FVRT_Ca">
<dcterms:description>Convenience variable that is equal to (F*V/(R*T))*2. Also equivalent to [greek delta]*V in the source manuscript</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_3">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_12"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.J_R1">
<dcterms:description>Convenience term for expressing I_RyR equation?</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.alpha_p">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.y_oc">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the open state and the ryanodine receptor is in the closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.mu_moc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Background_Ca_current.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_4">
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_11"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.J_Loc">
<dcterms:description>Current through the L-type calcium channel when L-type calcium channel state is open and ryanodine receptor state is closed</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.alpha_p">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU.time">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
<dcterms:description>Simulation time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Background_Ca_current.V">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_11"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00506"/>
<dcterms:description>Voltage across cell membrane</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_0">
<semsim:hasMediatorParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_0"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_1"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_0"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_1"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_0"/>
<semsim:name>Ionic flow through sodium-calcium exchanger</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.time">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
<dcterms:description>Simulation time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.a">
<dcterms:description>Biasing to make inactivation a function of membrane voltage</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Na_Ca_Exchanger.Ca_i">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Intracellular calcium (2+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.mu_pcc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.r_4">
<dcterms:description>Rate constant for transition of calcium release unit from state 4 to state 3</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Background_Ca_current.F">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00089"/>
<dcterms:description>Faraday constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#cell_geometry.A_cap">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00295"/>
<dcterms:description>Unknown. This is an orphan term in the model.</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#membrane.time">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
<dcterms:description>Simulation time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.tau_L">
<dcterms:description>Inactivation time for L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_2">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_6"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_20">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_2"/>
<bqbiol:is rdf:resource="http://identifiers.org/fma/FMA_80352"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU.g_D">
<dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_3">
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_15"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#intracellular_ion_concentrations.time">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_01023"/>
<dcterms:description>Simulation time domain</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.J_Roo">
<dcterms:description>Current through the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_and_RyR_fluxes.J_Rco">
<dcterms:description>Current through the ryanodine receptor when L-type calcium channel state is closed and ryanodine receptor state is open</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#extracellular_ion_concentrations.Na_o">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_7"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Extracellular sodium (1+) concentration</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_7">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_12"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.d">
<dcterms:description>Biasing to make inactivation a function of calcium 2+ in the dyadic space</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_current.y_oo">
<dcterms:description>The state of the calcium (2+) release unit when both the L-type calcium channel and the ryanodine receptor are in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_1">
<semsim:hasMediatorParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_1"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_2"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_2"/>
<semsim:name>Sarcolemmal calcium-ATPase flow</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#membrane.R">
<bqbiol:is rdf:resource="http://identifiers.org/opb/OPB_00410"/>
<dcterms:description>Universal gas constant</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.z_1">
<dcterms:description>State 1 of calcium release unit: z1 = ycc union yco union yoc union yoo</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.y_co">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel is in the closed state and the ryanodine receptor is in the open state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.r_7">
<dcterms:description>Rate constant for transition of calcium release unit from state 2 to state 4</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.mu_poc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.J_R3">
<dcterms:description>Convenience term for expressing I_RyR equation?</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_1">
<semsim:hasMultiplier>1.0</semsim:hasMultiplier>
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_3"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#RyR_current.beta_pcc">
<dcterms:description>Transition rate for three-state model of the ryanodine receptor when both the L-type calcium channel and ryanodine receptor are closed</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_21">
<bqbiol:isPartOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_20"/>
<bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/PR_P11507"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_2">
<semsim:hasPhysicalEntityReference rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#entity_14"/>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#Na_Ca_Exchanger.k_sat">
<dcterms:description>Low potential saturation factor of sodium-calcium exchanger</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU.I_RyR">
<bqbiol:isPropertyOf rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_2"/>
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00593"/>
<dcterms:description>Total whole-cell current through the ryanodine receptors</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.del_VL">
<dcterms:description>Width of opening potentials of L-type calcium channels</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#DS_Calcium_Concentrations.C_cc">
<bqbiol:isVersionOf rdf:resource="https://identifiers.org/opb/OPB_00340"/>
<dcterms:description>Concentration of calcium (2+) in dyadic space when both L-type calcium channel and ryanodine receptor states are closed</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#process_2">
<semsim:hasMediatorParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#mediator_2"/>
<semsim:hasSinkParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#sink_3"/>
<semsim:hasSourceParticipant rdf:resource="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#source_3"/>
<semsim:name>Total ionic flow through ryanodine receptor</semsim:name>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_states.alpha_m">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.epsilon_pcc">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_Transitions.c">
<dcterms:description>Biasing to make inactivation a function of calcium 2+ in the dyadic space</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.epsilon_pcc">
<dcterms:description>Transition rate for three-state model of the L-type calcium channel</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.y_cc">
<dcterms:description>The state of the calcium (2+) release unit when the L-type calcium channel and the ryanodine receptor are both in the closed state</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#CaRU_reduced_states.r_6">
<dcterms:description>Rate constant for transition of calcium release unit from state 3 to state 1</dcterms:description>
</rdf:Description>
<rdf:Description rdf:about="./hinch_greenstein_tanskanen_xu_winslow_2004.cellml#LCC_and_RyR_fluxes.g_D">
<dcterms:description>Calcium (2+) flux rate from dyadic space to cytosol</dcterms:description>
</rdf:Description>
</rdf:RDF>
