- Author:
- Nima <nafs080@aucklanduni.ac.nz>
- Date:
- 2019-10-13 11:55:52+13:00
- Desc:
- Add ODE for basolateral concentration (theta is usually equal to zero in this model)
- Permanent Source URI:
- https://models.fieldml.org/workspace/572/rawfile/a77158a9f8eb7d4b899aa4edc908c9c770ed9ac0/SGLT1_Rate_Constants.cellml
<?xml version='1.0'?>
<!--Link in Exposure : https://models.physiomeproject.org/exposure/4f0e5558031705df771326fb9bd90c28
Original Paper: Xing-Zhen Chen, Michael J Coady, Francis Jackson, Alfred Berteloot, and Jean-Yves Lapointe. Thermodynamic determination of the Na+: glucose coupling ratio for the human sglt1 cotransporter. -->
<model name="SGLT1_Rate_Constants" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="SGLT1_rate_constants">
<variable name="Na_i" public_interface="in" units="M"/>
<variable name="Na_m" public_interface="in" units="M"/>
<variable name="glucose_i" public_interface="in" units="M"/>
<variable name="glucose_m" public_interface="in" units="M"/>
<variable name="k_12" public_interface="out" units="per_second"/>
<variable name="ks_12" public_interface="out" units="per_M2_per_second"/>
<variable name="k_21" public_interface="out" units="per_second"/>
<variable name="k_32" public_interface="out" units="per_second"/>
<variable name="k_25" public_interface="out" units="per_second"/>
<variable name="k_52" public_interface="out" units="per_second"/>
<variable name="k_34" public_interface="out" units="per_second"/>
<variable name="k_43" public_interface="out" units="per_second"/>
<variable name="k_45" public_interface="out" units="per_second"/>
<variable name="k_54" public_interface="out" units="per_second"/>
<variable name="k_56" public_interface="out" units="per_second"/>
<variable name="k_65" public_interface="out" units="per_second"/>
<variable name="k_61" public_interface="out" units="per_second"/>
<variable name="k_16" public_interface="out" units="per_second"/>
<variable name="k0_12" public_interface="in" units="per_M2_per_second"/>
<variable name="k0_21" public_interface="in" units="per_second"/>
<variable name="k0_32" public_interface="in" units="per_second"/>
<variable name="k0_25" public_interface="in" units="per_second"/>
<variable name="k0_52" public_interface="in" units="per_second"/>
<variable name="k0_34" public_interface="in" units="per_second"/>
<variable name="k0_43" public_interface="in" units="per_second"/>
<variable name="k0_45" public_interface="in" units="per_second"/>
<variable name="k0_54" public_interface="in" units="per_M_per_second"/>
<variable name="k0_56" public_interface="in" units="per_second"/>
<variable name="k0_65" public_interface="in" units="per_M2_per_second"/>
<variable name="k0_61" public_interface="in" units="per_second"/>
<variable name="k0_16" public_interface="in" units="per_second"/>
<variable name="delta" public_interface="in" units="dimensionless"/>
<variable name="n" public_interface="in" units="dimensionless"/>
<variable name="z_c" public_interface="in" units="dimensionless"/>
<variable name="z_Na" public_interface="in" units="dimensionless"/>
<variable name="alpha_p" public_interface="in" units="dimensionless"/>
<variable name="mu" public_interface="in" units="dimensionless"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>ks_12</ci>
<apply>
<times/>
<ci>k0_12</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>n</ci>
</apply>
<ci>alpha_p</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_12</ci>
<apply>
<times/>
<ci>k0_12</ci>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<ci>alpha_p</ci>
</apply>
<ci>mu</ci>
</apply>
</apply>
<apply>
<power/>
<ci>Na_m</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_21</ci>
<apply>
<times/>
<ci>k0_21</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>n</ci>
<ci>z_Na</ci>
<ci>alpha_p</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_32</ci>
<ci>k0_32</ci>
</apply>
<apply>
<eq/>
<ci>k_34</ci>
<ci>k0_34</ci>
</apply>
<apply>
<eq/>
<ci>k_43</ci>
<ci>k0_43</ci>
</apply>
<apply>
<eq/>
<ci>k_45</ci>
<ci>k0_45</ci>
</apply>
<apply>
<eq/>
<ci>k_54</ci>
<apply>
<times/>
<ci>k0_54</ci>
<ci>glucose_i</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>k_25</ci>
<ci>k0_25</ci>
</apply>
<apply>
<eq/>
<ci>k_56</ci>
<ci>k0_56</ci>
</apply>
<apply>
<eq/>
<ci>k_65</ci>
<apply>
<times/>
<ci>k0_65</ci>
<apply>
<power/>
<ci>Na_i</ci>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_61</ci>
<apply>
<times/>
<ci>k0_61</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<ci>z_c</ci>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_16</ci>
<apply>
<times/>
<ci>k0_16</ci>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<times/>
<apply>
<minus/>
<ci>z_c</ci>
</apply>
<ci>delta</ci>
<ci>mu</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>k_52</ci>
<ci>k0_52</ci>
</apply>
</math>
</component>
</model>
