- Author:
- Nima <nafs080@aucklanduni.ac.nz>
- Date:
- 2019-10-13 11:55:52+13:00
- Desc:
- Add ODE for basolateral concentration (theta is usually equal to zero in this model)
- Permanent Source URI:
- https://models.fieldml.org/workspace/572/rawfile/a77158a9f8eb7d4b899aa4edc908c9c770ed9ac0/NBC_flux.cellml
<?xml version='1.0'?>
<model name="NBC_flux" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
<component name="NBC">
<!--var time: second {pub: in};-->
<variable name="A_Apical" public_interface="in" units="m2"/>
<variable name="v_sc" public_interface="in" units="volt"/>
<variable name="v_cell" public_interface="in" units="m3"/>
<variable name="Na_i" public_interface="in" units="M"/>
<variable name="Na_s" public_interface="in" units="M"/>
<variable name="HCO3_i" public_interface="in" units="M"/>
<variable name="HCO3_s" public_interface="in" units="M"/>
<variable initial_value="0.08" name="g_NBC" public_interface="out" units="S_per_m2"/>
<variable name="F" public_interface="in" units="C_per_mol"/>
<variable name="R" public_interface="in" units="J_per_K_per_mol"/>
<variable name="T" public_interface="in" units="kelvin"/>
<!--kelvin {init: 300};-->
<variable initial_value="2" name="n" units="dimensionless"/>
<!--var eps: M {init: 1e-12};-->
<variable name="E_NBC" public_interface="out" units="volt"/>
<variable name="J_NBC_Na" public_interface="out" units="umol_per_s"/>
<variable name="J_NBC_HCO3" public_interface="out" units="umol_per_s"/>
<variable name="I_NBC_Na" public_interface="out" units="uA"/>
<variable name="I_NBC_HCO3" public_interface="out" units="uA"/>
<variable initial_value="1e-18" name="eps" units="M"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_NBC</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>n</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<times/>
<apply>
<divide/>
<ci>Na_s</ci>
<ci>Na_i</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>HCO3_s</ci>
<ci>HCO3_i</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<cn cellml:units="dimensionless" type="e-notation">1<sep/>6</cn>
<ci>g_NBC</ci>
<ci>A_Apical</ci>
<apply>
<minus/>
<ci>v_sc</ci>
<ci>E_NBC</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_HCO3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>J_NBC_Na</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NBC_Na</ci>
<apply>
<times/>
<ci>J_NBC_Na</ci>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>I_NBC_HCO3</ci>
<apply>
<times/>
<ci>J_NBC_HCO3</ci>
<ci>F</ci>
</apply>
</apply>
</math>
</component>
</model>
