Location: Glucose Uptake in Enterocyte @ 5e09ad349add / GLUT2_flux.cellml

Author:
nima <nafs080@aucklanduni.ac.nz>
Date:
2020-07-17 14:13:02+12:00
Desc:
test
Permanent Source URI:
https://models.fieldml.org/workspace/572/rawfile/5e09ad349add8687582de44b8fbc16f8c07e3801/GLUT2_flux.cellml

<?xml version='1.0'?>
<model name="GLUT2_flux" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#">
    <component name="GLUT2">
        <variable initial_value="1000" name="K_12" public_interface="out" units="per_M_per_second"/>
        <variable initial_value="12.6" name="K_21" public_interface="out" units="per_second"/>
        <variable initial_value="1350" name="K_23" public_interface="out" units="per_second"/>
        <variable initial_value="90" name="K_32" public_interface="out" units="per_second"/>
        <variable initial_value="12.6" name="K_34" public_interface="out" units="per_second"/>
        <variable initial_value="1000" name="K_43" public_interface="out" units="per_M_per_second"/>
        <variable initial_value="0.8" name="K_41" public_interface="out" units="per_second"/>
        <variable initial_value="12" name="K_14" public_interface="out" units="per_second"/>
        <variable name="glucose_i" public_interface="in" units="M"/>
        <variable name="glucose_s" public_interface="in" units="M"/>
        <variable name="K_S" public_interface="out" units="M"/>
        <variable name="J_GLUT" public_interface="out" units="umol_per_s"/>
        <variable name="C_tot" public_interface="out" units="umol"/>
        <variable initial_value="140000000" name="n_GLUT" public_interface="out" units="dimensionless"/>
        <variable name="D" public_interface="out" units="per_second"/>
        <variable name="v_cell" public_interface="in" units="m3"/>
        <math xmlns="http://www.w3.org/1998/Math/MathML">
            <apply>
                <eq/>
                <ci>C_tot</ci>
                <apply>
                    <divide/>
                    <ci>n_GLUT</ci>
                    <cn cellml:units="per_umole" type="e-notation">6.022<sep/>17</cn>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>K_S</ci>
                <apply>
                    <divide/>
                    <ci>K_21</ci>
                    <ci>K_12</ci>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>J_GLUT</ci>
                <apply>
                    <times/>
                    <apply>
                        <divide/>
                        <ci>C_tot</ci>
                        <ci>D</ci>
                    </apply>
                    <apply>
                        <minus/>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>K_23</ci>
                                <ci>K_41</ci>
                                <ci>glucose_i</ci>
                            </apply>
                            <ci>K_S</ci>
                        </apply>
                        <apply>
                            <divide/>
                            <apply>
                                <times/>
                                <ci>K_32</ci>
                                <ci>K_14</ci>
                                <ci>glucose_s</ci>
                            </apply>
                            <ci>K_S</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
            <apply>
                <eq/>
                <ci>D</ci>
                <apply>
                    <plus/>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <ci>glucose_i</ci>
                                <ci>K_S</ci>
                            </apply>
                        </apply>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>K_32</ci>
                                    <ci>glucose_s</ci>
                                </apply>
                                <ci>K_S</ci>
                            </apply>
                            <ci>K_41</ci>
                        </apply>
                    </apply>
                    <apply>
                        <times/>
                        <apply>
                            <plus/>
                            <cn cellml:units="dimensionless">1</cn>
                            <apply>
                                <divide/>
                                <ci>glucose_s</ci>
                                <ci>K_S</ci>
                            </apply>
                        </apply>
                        <apply>
                            <plus/>
                            <apply>
                                <divide/>
                                <apply>
                                    <times/>
                                    <ci>K_23</ci>
                                    <ci>glucose_i</ci>
                                </apply>
                                <ci>K_S</ci>
                            </apply>
                            <ci>K_14</ci>
                        </apply>
                    </apply>
                </apply>
            </apply>
        </math>
    </component>
</model>