Location: Activation of the Liver Glycogen Phosphorylase by Ca2+ Oscillations: a Theoretical Study @ 81df4382cc0a / gall_2000b.cellml

Author:
Hanne Nielsen <hnie010@aucklanduni.ac.nz>
Date:
2011-08-08 16:02:18+12:00
Desc:
Added images in ai svg and png format. CellML files based on equations 1-3 (a) and 4-8 (b). HTML file also added. Does not reproduce published figure ut does run in OpenCell.
Permanent Source URI:
https://models.fieldml.org/workspace/35d/rawfile/81df4382cc0a0cd3cc05a97b6dd94d87f9226895/gall_2000b.cellml

<?xml version="1.0" encoding="utf-8"?>
<!--
This CellML file was generated on 8/8/2011 at 3:46:11 at PM using:

COR (0.9.31.1409)
Copyright 2002-2011 Dr Alan Garny
http://cor.physiol.ox.ac.uk/ - cor@physiol.ox.ac.uk

CellML 1.0 was used to generate this model
http://www.cellml.org/
-->
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      <unit units="second" multiplier="60"/>
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   <units name="per_minute">
      <unit units="minute" exponent="-1"/>
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   <units name="millimole">
      <unit units="mole" prefix="milli"/>
   </units>
   <units name="micromole">
      <unit units="mole" prefix="micro"/>
   </units>
   <units name="micromolar">
      <unit units="micromole"/>
      <unit units="litre" exponent="-1"/>
   </units>
   <units name="micromolar_per_minute">
      <unit units="micromolar"/>
      <unit units="minute" exponent="-1"/>
   </units>
   <units name="millimolar">
      <unit units="millimole"/>
      <unit units="litre" exponent="-1"/>
   </units>
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      <variable name="time" units="minute" initial_value="0" public_interface="out"/>
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      <variable name="V_in" units="dimensionless" public_interface="in"/>
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                     <ci>V_2i</ci>
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                  <ci>V_3i</ci>
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                     <times/>
                     <ci>k_f</ci>
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      </math>
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      <variable name="Y" units="dimensionless" initial_value="0.00122" public_interface="out"/>
      <variable name="V_2i" units="dimensionless" public_interface="in"/>
      <variable name="V_3i" units="dimensionless" public_interface="in"/>
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      <variable name="time" units="minute" public_interface="in"/>
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      </math>
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      <variable name="v_0" units="micromolar_per_minute" initial_value="1"/>
      <variable name="v_1" units="micromolar_per_minute" initial_value="5.7"/>
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      </math>
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      <variable name="V_2i" units="dimensionless" public_interface="out"/>
      <variable name="v_M2i" units="micromolar_per_minute" initial_value="30"/>
      <variable name="Z" units="dimensionless" public_interface="in"/>
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      <variable name="Y" units="dimensionless" public_interface="in"/>
      <variable name="m" units="dimensionless" initial_value="4"/>
      <variable name="n" units="dimensionless" public_interface="in"/>
      <variable name="K_Ri" units="micromolar" initial_value="1.7"/>
      <variable name="K_Ai" units="micromolar" initial_value="0.46"/>
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   <connection>
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   <connection>
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      <map_variables variable_1="n" variable_2="n"/>
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   <connection>
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      <map_variables variable_1="Y" variable_2="Y"/>
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   <connection>
      <map_components component_1="V_2i" component_2="Y"/>
      <map_variables variable_1="V_2i" variable_2="V_2i"/>
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      <map_variables variable_1="Z" variable_2="Z"/>
      <map_variables variable_1="V_3i" variable_2="V_3i"/>
   </connection>
   <connection>
      <map_components component_1="V_2i" component_2="Z"/>
      <map_variables variable_1="Z" variable_2="Z"/>
      <map_variables variable_1="V_2i" variable_2="V_2i"/>
   </connection>
   <connection>
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      <map_variables variable_1="V_in" variable_2="V_in"/>
   </connection>
   <connection>
      <map_components component_1="Y" component_2="Z"/>
      <map_variables variable_1="Y" variable_2="Y"/>
   </connection>
</model>