- Author:
- Soroush Safaei <ssaf006@aucklanduni.ac.nz>
- Date:
- 2016-04-01 20:00:08+13:00
- Desc:
- fix a bug
- Permanent Source URI:
- https://models.fieldml.org/workspace/295/rawfile/e0e2e54caca7290cc323f314bc4401cb3431b8aa/Oyehaug_2009_NBC.cellml
<?xml version='1.0'?>
<!-- This CellML file was generated from:
Østby, Ivar, et al. "Astrocytic mechanisms explaining neural-activity-induced shrinkage of extraneuronal space." PLoS Comput Biol 5.1 (2009): e1000272.-->
<model cmeta:id="Oyehaug_2009_NBC" name="Oyehaug_2009_NBC" xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#" xmlns:dc="http://purl.org/dc/elements/1.1/">
<rdf:Description rdf:about="">
<dc:title>A kinetic model of Na+/HCO3- cotransporter (NBC)</dc:title>
</rdf:Description>
<rdf:Description rdf:about="#Oyehaug_2009_NBC">
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>protein module</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<import xlink:href="Units/Units.cellml">
<units name="mM" units_ref="mM"/>
<units name="mM_per_s" units_ref="mM_per_s"/>
<units name="joule_per_mmole_kelvin" units_ref="joule_per_mmole_kelvin"/>
<units name="coulomb_per_mmole" units_ref="coulomb_per_mmole"/>
<units name="mS_per_cm2" units_ref="mS_per_cm2"/>
</import>
<component name="NBC">
<variable name="V_m" public_interface="in" units="volt"/>
<variable name="Na_int" public_interface="in" units="mM"/>
<variable name="Na_ext" public_interface="in" units="mM"/>
<variable name="HCO3_int" public_interface="in" units="mM"/>
<variable name="HCO3_ext" public_interface="in" units="mM"/>
<variable initial_value="0.08" name="g_NBC" public_interface="out" units="mS_per_cm2"/>
<variable initial_value="96.5" name="F" units="coulomb_per_mmole"/>
<variable initial_value="0.008315" name="R" units="joule_per_mmole_kelvin"/>
<variable initial_value="300" name="T" units="kelvin"/>
<variable initial_value="2" name="n" units="dimensionless"/>
<variable name="E_NBC" public_interface="out" units="volt"/>
<variable name="J_NBC_Na" public_interface="out" units="mM_per_s"/>
<variable name="J_NBC_HCO3" public_interface="out" units="mM_per_s"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>E_NBC</ci>
<apply>
<times/>
<apply>
<divide/>
<apply>
<times/>
<ci>R</ci>
<ci>T</ci>
</apply>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="dimensionless">1</cn>
<ci>n</ci>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<ln/>
<apply>
<times/>
<apply>
<divide/>
<ci>Na_ext</ci>
<ci>Na_int</ci>
</apply>
<apply>
<power/>
<apply>
<divide/>
<ci>HCO3_ext</ci>
<ci>HCO3_int</ci>
</apply>
<cn cellml:units="dimensionless">2</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_Na</ci>
<apply>
<divide/>
<apply>
<times/>
<ci>g_NBC</ci>
<apply>
<minus/>
<ci>E_NBC</ci>
<ci>V_m</ci>
</apply>
</apply>
<ci>F</ci>
</apply>
</apply>
<apply>
<eq/>
<ci>J_NBC_HCO3</ci>
<apply>
<times/>
<cn cellml:units="dimensionless">3.0</cn>
<ci>J_NBC_Na</ci>
</apply>
</apply>
</math>
</component>
</model>
