Location: Notch signaling pathway @ 6136675c8b0b / Notch_1_Wang.cellml

Author:
Nazanin ebrahimi <nebr002@aucklanduni.ac.nz>
Date:
2014-10-31 10:01:43+13:00
Desc:
Notch pathway figure
Permanent Source URI:
https://models.fieldml.org/workspace/1cd/rawfile/6136675c8b0b07fd2765bb78b53004cc5f03da2f/Notch_1_Wang.cellml

<?xml version="1.0" encoding="UTF-8"?>

<model  name="NotchPathway_Wang_Annotated"
		cmeta:id="Notch"
		xmlns="http://www.cellml.org/cellml/1.1#" 
		xmlns:cmeta="http://www.cellml.org/metadata/1.0#" 
		xmlns:xlink="http://www.w3.org/1999/xlink" 
		xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" 
		xmlns:bqbiol="http://biomodels.net/biology-qualifiers/" 
		xmlns:semsim="http://www.bhi.washington.edu/SemSim#" 
		xmlns:dcterms="http://purl.org/dc/terms/" 
		xmlns:foaf="http://xmlns.com/foaf/0.1/"
		>	
		
  
  <units name="per_nM_per_min">
    <unit exponent="-1.0" units="nM"/>
    <unit exponent="-1.0" units="min"/>
  </units>
  <units name="nM_per_min">
    <unit units="nM" />
    <unit exponent="-1.0" units="min"/>
  </units>
  <units name="per_min">
    <unit exponent="-1.0" units="min"/>
  </units>
  <units name="nM">
    <unit prefix="nano" units="mole"/>
    <unit exponent="-1.0" units="liter"/>
  </units>
  <units name="min">
    <unit units="second"/>
  </units>
 
  <component name="wholecell" cmeta:id="c0">
    <rdf:RDF>
      <rdf:Description rdf:ID="c0">
        <bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/UBERON_0003059"/>
      </rdf:Description>
    </rdf:RDF>
    <variable cmeta:id="v22" initial_value="0.073" name="mLfng_n" units="nM"/>
    <variable cmeta:id="v29" initial_value="2" name="h2" units="dimensionless">
      <rdf:RDF>
        <rdf:Description rdf:ID="v29">
          <dcterms:description>Hill coefficient of transcription of Hes7 induced by the complex of NICD and RBP-j</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v57" initial_value="0.2" name="V_sDll1" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v57">
          <dcterms:description>Dll1 synthesis rate</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v48" initial_value="0.635" name="V_MdmHes7_c" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v48">
          <dcterms:description>Maximum rate of degradation of Hes7 mRNA in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v19" initial_value="0.001" name="K_dNICD_n" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v19">
          <dcterms:description>Michaelis constant for degradation of NICD in the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v59" initial_value="2" name="h_HIH" units="dimensionless">
      <rdf:RDF>
        <rdf:Description rdf:ID="v59">
          <dcterms:description>Hill coefficient of inhibition by Hes7 protein of Hes7 gene transcription</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v26" initial_value="0.2" name="K_HIH" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v26">
          <dcterms:description>Constant of inhibition by Hes7 protein of Hes7 gene transcription in the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v15" initial_value="0.043" name="mLfng_c" units="nM" />
    <variable cmeta:id="v39" initial_value="1.035" name="K_c" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v39">
          <dcterms:description>Apparent first-order rate constant for Notch cleavage into NICD</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v46" initial_value="0.385" name="V_MdDll1" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v46">
          <dcterms:description>Maximum rate of degradation of Dll1</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v53" initial_value="0.1" name="V_MdHes7_c" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v53">
          <dcterms:description>Maximum rate of degradation of Hes7 protein in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v41" initial_value="1.5" name="EX_mHes7_n" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v41">
          <dcterms:description>Apparent first-order rate constant for Hes7 mRNA exit from the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v20" initial_value="0.15" name="K_ILfng" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v20">
          <dcterms:description>Constant of inhibition by Lfng of Notch cleavage into NICD</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v40" initial_value="0.117" name="V_MdLfng" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v40">
          <dcterms:description>Maximum rate of degradation of Lfng protein</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v24" initial_value="0.042" name="mHes7_c" units="nM" />
    <variable cmeta:id="v38" initial_value="0.01" name="EX_Hes7_n" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v38">
          <dcterms:description>Apparent first-order rate constant for Hes7 protein exit from the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v58" initial_value="0.03" name="V_mLfng" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v58">
          <dcterms:description>Basal rate of transcription of the Lfng gene</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v35" initial_value="0.01" name="IM_Hes7_c" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v35">
          <dcterms:description>First-order rate constant for Hes7 protein entry into nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v0" initial_value="0.768" name="K_dmLfng_c" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v0">
          <dcterms:description>Michaelis constant for degradation of Lfng mRNA in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v30" initial_value="1.24" name="V_MsmHes7" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v30">
          <dcterms:description>Maximum rate of transcription of Hes7 gene induced by the complex of NICD and RBP-j in nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v3" name="RBPj" units="nM" />
    <variable cmeta:id="v8" initial_value="0.041" name="K_smHes7" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v8">
          <dcterms:description>Threshold constant for induction by the complex of NICD and RBP-j in nucleus of Hes7 transcription</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v17" initial_value="0.37" name="K_dLfng" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v17">
          <dcterms:description>Michaelis constant for degradation of Lfng protein</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v6" initial_value="1.584" name="K_dDll1" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v6">
          <dcterms:description>Michaelis constant for degradation of Dll1</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v18" initial_value="1.4" name="K_dNotch" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v18">
          <dcterms:description>Michaelis constant for degradation of Notch</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v42" initial_value="0.05" name="K_mHes7" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v42">
          <dcterms:description>Apparent first-order rate constant for synthesis of Hes7 protein</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v36" initial_value="0.003" name="V_MdNICD_n" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v36">
          <dcterms:description>Maximum rate of degradation of NICD in the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v50" initial_value="0.09" name="K_mLfng" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v50">
          <dcterms:description>Apparent first-order rate constant for synthesis of Lfng protein</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v54" name="t" units="min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v54">
          <dcterms:description>time</dcterms:description>
          <bqbiol:is rdf:resource="http://purl.obolibrary.org/obo/SBO_0000345" />
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v28" initial_value="0.001" name="K_dNICD_c" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v28">
          <dcterms:description>Michaelis constant for degradation of NICD in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v34" initial_value="0.01" name="V_mHes7" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v34">
          <dcterms:description>Basal rate of transcription of the Hes7 gene</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v52" initial_value="0.5" name="EX_mLfng_n" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v52">
          <dcterms:description>Apparent first-order rate constant for Lfng mRNA exit from the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v5" initial_value="0.35" name="RBPj_t" units="nM" />
    <variable cmeta:id="v10" initial_value="0.1" name="K_dHes7_c" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v10">
          <dcterms:description>Michaelis constant for degradation of Hes7 protein in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v43" initial_value="0.7" name="V_MdmLfng_c" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v43">
          <dcterms:description>Maximum rate of degradation of Lfng mRNA in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v32" initial_value="0.069" name="V_sNotch" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v32">
          <dcterms:description>Notch synthesis rate</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v27" initial_value="0.05" name="K_smLfng" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v27">
          <dcterms:description>Threshold constant for induction by the complex of NICD and RBP-j in nucleus of Lfng transcription</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v14" initial_value="1" name="K_dmHes7_c" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v14">
          <dcterms:description>Michaelis constant for degradation of Hes7 mRNA in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v56" initial_value="0.846" name="V_MdNotch" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v56">
          <dcterms:description>Maximum rate of degradation of Notch</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v47" initial_value="0.9" name="V_MsmLfng" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v47">
          <dcterms:description>Maximum rate of transcription of Lfng gene induced by the complex of NICD and RBP-j in nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v25" initial_value="0.009" name="NICD_n" units="nM" />
    <variable cmeta:id="v49" initial_value="0.03" name="IM_NICD_c" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v49">
          <dcterms:description>Apparent first-order rate constant for NICD entry into nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v21" initial_value="2.72" name="Lfng" units="nM" />
    <variable cmeta:id="v4" initial_value="0.1" name="K_dHes7_n" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v4">
          <dcterms:description>Michaelis constant for degradation of Hes7 protein in the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v2" initial_value="0" name="NICD_c" units="nM" />
    <variable cmeta:id="v11" initial_value="0.026" name="NR" units="nM" />
    <variable cmeta:id="v23" initial_value="0.013" name="mHes7_n" units="nM" />
    <variable cmeta:id="v45" initial_value="0.01" name="V_MdNICD_c" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v45">
          <dcterms:description>Maximum rate of degradation of NICD in the cytoplasm</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v1" initial_value="1.71" name="Dll1" units="nM" />
    <variable cmeta:id="v31" initial_value="1" name="d_NR" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v31">
          <dcterms:description>Bimolecular rate constant for degradation of the complex of NICD and RBP-j</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v51" initial_value="8" name="a_NR" units="per_nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v51">
          <dcterms:description>Bimolecular rate constant for binding of NICD to RBP-j</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v16" initial_value="0.12" name="Notch" units="nM" />
    <variable cmeta:id="v55" initial_value="2" name="n" units="dimensionless">
      <rdf:RDF>
        <rdf:Description rdf:ID="v55">
          <dcterms:description>Hill coefficient of inhibition by Lfng of Notch cleavage into NICD</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v13" initial_value="10.66" name="Hes7_c" units="nM" />
    <variable cmeta:id="v12" initial_value="1" name="K_Dll1" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v12">
          <dcterms:description>Michaelis constant for Notch cleavage into NICD by Dll1</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v7" initial_value="1.24" name="Hes7_n" units="nM" />
    <variable cmeta:id="v37" initial_value="2" name="h_HIL" units="dimensionless">
      <rdf:RDF>
        <rdf:Description rdf:ID="v37">
          <dcterms:description>Hill coefficient of inhibition by Hes7 protein of Lfng gene transcription</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v44" initial_value="2" name="h1" units="dimensionless">
      <rdf:RDF>
        <rdf:Description rdf:ID="v44">
          <dcterms:description>Hill coefficient of transcription of Lfng induced by the complex of NICD and RBP-j</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v60" initial_value="0.03" name="EX_NICD_n" units="per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v60">
          <dcterms:description>Apparent first-order rate constant for NICD exit from nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v33" initial_value="0.1" name="V_MdHes7_n" units="nM_per_min">
      <rdf:RDF>
        <rdf:Description rdf:ID="v33">
          <dcterms:description>Maximum rate of degradation of Hes7 protein in the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <variable cmeta:id="v9" initial_value="0.2" name="K_HIL" units="nM">
      <rdf:RDF>
        <rdf:Description rdf:ID="v9">
          <dcterms:description>Constant of inhibition by Hes7 protein of Lfng transcription in the nucleus</dcterms:description>
        </rdf:Description>
      </rdf:RDF>
    </variable>
    <math xmlns="http://www.w3.org/1998/Math/MathML" cmeta:id="eq_1">
      <apply id="eq_1">
        <eq />
        <ci>RBPj</ci>
        <apply>
          <minus />
          <ci>RBPj_t</ci>
          <ci>NR</ci>
        </apply>
      </apply>
    </math>
    <math xmlns="http://www.w3.org/1998/Math/MathML">
      <apply>
        <eq />
        <ci>RBPj</ci>
        <apply>
          <minus />
          <ci>RBPj_t</ci>
          <ci>NR</ci>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>Dll1</ci>
        </apply>
        <apply>
          <minus />
          <ci>V_sDll1</ci>
          <apply>
            <times />
            <ci>V_MdDll1</ci>
            <apply>
              <divide />
              <ci>Dll1</ci>
              <apply>
                <plus />
                <ci>K_dDll1</ci>
                <ci>Dll1</ci>
              </apply>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>Notch</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <minus />
            <ci>V_sNotch</ci>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <ci>K_c</ci>
                    <ci>Notch</ci>
                    <ci>Dll1</ci>
                  </apply>
                  <apply>
                    <plus />
                    <ci>K_Dll1</ci>
                    <ci>Dll1</ci>
                  </apply>
                </apply>
                <apply>
                  <power />
                  <ci>K_ILfng</ci>
                  <ci>n</ci>
                </apply>
              </apply>
              <apply>
                <plus />
                <apply>
                  <power />
                  <ci>K_ILfng</ci>
                  <ci>n</ci>
                </apply>
                <apply>
                  <power />
                  <ci>Lfng</ci>
                  <ci>n</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdNotch</ci>
              <ci>Notch</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dNotch</ci>
              <ci>Notch</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>NICD_c</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <minus />
            <apply>
              <plus />
              <apply>
                <divide />
                <apply>
                  <times />
                  <apply>
                    <divide />
                    <apply>
                      <times />
                      <ci>K_c</ci>
                      <ci>Notch</ci>
                      <ci>Dll1</ci>
                    </apply>
                    <apply>
                      <plus />
                      <ci>K_Dll1</ci>
                      <ci>Dll1</ci>
                    </apply>
                  </apply>
                  <apply>
                    <power />
                    <ci>K_ILfng</ci>
                    <ci>n</ci>
                  </apply>
                </apply>
                <apply>
                  <plus />
                  <apply>
                    <power />
                    <ci>K_ILfng</ci>
                    <ci>n</ci>
                  </apply>
                  <apply>
                    <power />
                    <ci>Lfng</ci>
                    <ci>n</ci>
                  </apply>
                </apply>
              </apply>
              <apply>
                <times />
                <ci>EX_NICD_n</ci>
                <ci>NICD_n</ci>
              </apply>
            </apply>
            <apply>
              <times />
              <ci>IM_NICD_c</ci>
              <ci>NICD_c</ci>
            </apply>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdNICD_c</ci>
              <ci>NICD_c</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dNICD_c</ci>
              <ci>NICD_c</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>Lfng</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <times />
            <ci>K_mLfng</ci>
            <ci>mLfng_c</ci>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdLfng</ci>
              <ci>Lfng</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dLfng</ci>
              <ci>Lfng</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>mLfng_c</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <times />
            <ci>EX_mLfng_n</ci>
            <ci>mLfng_n</ci>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdmLfng_c</ci>
              <ci>mLfng_c</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dmLfng_c</ci>
              <ci>mLfng_c</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>Hes7_c</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <minus />
            <apply>
              <plus />
              <apply>
                <times />
                <ci>K_mHes7</ci>
                <ci>mHes7_c</ci>
              </apply>
              <apply>
                <times />
                <ci>EX_Hes7_n</ci>
                <ci>Hes7_n</ci>
              </apply>
            </apply>
            <apply>
              <times />
              <ci>IM_Hes7_c</ci>
              <ci>Hes7_c</ci>
            </apply>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdHes7_c</ci>
              <ci>Hes7_c</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dHes7_c</ci>
              <ci>Hes7_c</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>mHes7_c</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <times />
            <ci>EX_mHes7_n</ci>
            <ci>mHes7_n</ci>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdmHes7_c</ci>
              <ci>mHes7_c</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dmHes7_c</ci>
              <ci>mHes7_c</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>NICD_n</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <minus />
            <apply>
              <minus />
              <apply>
                <plus />
                <apply>
                  <times />
                  <ci>IM_NICD_c</ci>
                  <ci>NICD_c</ci>
                </apply>
                <apply>
                  <times />
                  <ci>d_NR</ci>
                  <ci>NR</ci>
                </apply>
              </apply>
              <apply>
                <times />
                <ci>EX_NICD_n</ci>
                <ci>NICD_n</ci>
              </apply>
            </apply>
            <apply>
              <times />
              <ci>a_NR</ci>
              <ci>NICD_n</ci>
              <ci>RBPj</ci>
            </apply>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdNICD_n</ci>
              <ci>NICD_n</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dNICD_n</ci>
              <ci>NICD_n</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>NR</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <times />
            <ci>a_NR</ci>
            <ci>NICD_n</ci>
            <ci>RBPj</ci>
          </apply>
          <apply>
            <times />
            <ci>d_NR</ci>
            <ci>NR</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>Hes7_n</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <minus />
            <apply>
              <times />
              <ci>IM_Hes7_c</ci>
              <ci>Hes7_c</ci>
            </apply>
            <apply>
              <times />
              <ci>EX_Hes7_n</ci>
              <ci>Hes7_n</ci>
            </apply>
          </apply>
          <apply>
            <divide />
            <apply>
              <times />
              <ci>V_MdHes7_n</ci>
              <ci>Hes7_n</ci>
            </apply>
            <apply>
              <plus />
              <ci>K_dHes7_n</ci>
              <ci>Hes7_n</ci>
            </apply>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>mLfng_n</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <plus />
            <ci>V_mLfng</ci>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <ci>V_MsmLfng</ci>
                    <apply>
                      <power />
                      <ci>NR</ci>
                      <ci>h1</ci>
                    </apply>
                  </apply>
                  <apply>
                    <plus />
                    <apply>
                      <power />
                      <ci>K_smLfng</ci>
                      <ci>h1</ci>
                    </apply>
                    <apply>
                      <power />
                      <ci>NR</ci>
                      <ci>h1</ci>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <power />
                  <ci>K_HIL</ci>
                  <ci>h_HIL</ci>
                </apply>
              </apply>
              <apply>
                <plus />
                <apply>
                  <power />
                  <ci>K_HIL</ci>
                  <ci>h_HIL</ci>
                </apply>
                <apply>
                  <power />
                  <ci>Hes7_n</ci>
                  <ci>h_HIL</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>EX_mLfng_n</ci>
            <ci>mLfng_n</ci>
          </apply>
        </apply>
      </apply>
      <apply>
        <eq />
        <apply>
          <diff />
          <bvar>
            <ci>t</ci>
          </bvar>
          <ci>mHes7_n</ci>
        </apply>
        <apply>
          <minus />
          <apply>
            <plus />
            <ci>V_mHes7</ci>
            <apply>
              <divide />
              <apply>
                <times />
                <apply>
                  <divide />
                  <apply>
                    <times />
                    <ci>V_MsmHes7</ci>
                    <apply>
                      <power />
                      <ci>NR</ci>
                      <ci>h2</ci>
                    </apply>
                  </apply>
                  <apply>
                    <plus />
                    <apply>
                      <power />
                      <ci>K_smHes7</ci>
                      <ci>h2</ci>
                    </apply>
                    <apply>
                      <power />
                      <ci>NR</ci>
                      <ci>h2</ci>
                    </apply>
                  </apply>
                </apply>
                <apply>
                  <power />
                  <ci>K_HIH</ci>
                  <ci>h_HIH</ci>
                </apply>
              </apply>
              <apply>
                <plus />
                <apply>
                  <power />
                  <ci>K_HIH</ci>
                  <ci>h_HIH</ci>
                </apply>
                <apply>
                  <power />
                  <ci>Hes7_n</ci>
                  <ci>h_HIH</ci>
                </apply>
              </apply>
            </apply>
          </apply>
          <apply>
            <times />
            <ci>EX_mHes7_n</ci>
            <ci>mHes7_n</ci>
          </apply>
        </apply>
      </apply>
    </math>
  </component>
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    <rdf:Description rdf:ID="v0">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_6">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v25">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_17">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_10">
              <ro:part_of>
                <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_11">
                  <ro:contained_in>
                    <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_2">
                      <semsim:refersTo rdf:resource="http://identifiers.org/go/GO:0005634" />
                    </rdf:Description>
                  </ro:contained_in>
                  <semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q01705" />
                </rdf:Description>
              </ro:part_of>
              <dcterms:description />
              <semsim:name>Notch 1 intracellular domain (NICD)</semsim:name>
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v6">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_10">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v11">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_21">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_15">
              <ro:contained_in rdf:resource="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_2" />
              <dcterms:description />
              <semsim:name>The complex of NICD and RBP-j</semsim:name>
              <bqbiol:isVersionOf rdf:resource="http://identifiers.org/go/GO:0043234" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v21">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_18">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_12">
              <semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q924T4" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
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    </rdf:Description>
    <rdf:Description rdf:ID="v15">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_3">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_3">
              <ro:part_of>
                <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_4">
                  <ro:contained_in>
                    <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_5">
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                    </rdf:Description>
                  </ro:contained_in>
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                </rdf:Description>
              </ro:part_of>
              <semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:33699" />
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          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v20">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_4">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v19">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_1">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v26">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_2">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v12">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_26">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v5">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_13">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_9">
              <dcterms:description />
              <semsim:name>Total RBP-j concentration which is assumed to be constant</semsim:name>
              <bqbiol:isVersionOf rdf:resource="http://identifiers.org/uniprot/P31266" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v1">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_23">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_18">
              <semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q61483" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
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    </rdf:Description>
    <rdf:Description rdf:ID="v22">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_0">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_0">
              <ro:part_of>
                <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_1">
                  <ro:contained_in rdf:resource="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_2" />
                  <semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q924T4" />
                </rdf:Description>
              </ro:part_of>
              <semsim:refersTo rdf:resource="http://identifiers.org/chebi/CHEBI:33699" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v16">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_24">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_19">
              <semsim:refersTo rdf:resource="http://identifiers.org/uniprot/Q01705" />
            </rdf:Description>
          </semsim:physicalPropertyOf>
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
        </rdf:Description>
      </semsim:isComputationalComponentFor>
    </rdf:Description>
    <rdf:Description rdf:ID="v9">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_28">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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    </rdf:Description>
    <rdf:Description rdf:ID="v4">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_19">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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    </rdf:Description>
    <rdf:Description rdf:ID="v27">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_15">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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    </rdf:Description>
    <rdf:Description rdf:ID="v13">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_25">
          <semsim:physicalPropertyOf>
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    <rdf:Description rdf:ID="v8">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_8">
          <semsim:refersTo rdf:resource="http://identifiers.org/opb/OPB_00340" />
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    <rdf:Description rdf:ID="v23">
      <semsim:isComputationalComponentFor>
        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_22">
          <semsim:physicalPropertyOf>
            <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_16">
              <ro:part_of>
                <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_17">
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                </rdf:Description>
              </ro:part_of>
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            </rdf:Description>
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    <rdf:Description rdf:ID="v17">
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    <rdf:Description rdf:ID="v7">
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        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_12">
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    <rdf:Description rdf:ID="v14">
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        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_16">
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    <rdf:Description rdf:ID="v18">
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    <rdf:Description rdf:ID="v2">
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        <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#property_20">
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                <rdf:Description rdf:about="http://www.bhi.washington.edu/SemSim/28012014170904500p1300#entity_14">
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    </rdf:Description>
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</model>