<?xml version="1.0" encoding="utf-8"?>
<model
name="NFATMyocyte_DualProtocol"
cmeta:id="NFATMyocyte_DualProtocol"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<import xlink:href="calcium_DualProtocol.cellml">
<component name="calcium" component_ref="calcium" />
</import>
<import xlink:href="calcineurin_DualProtocol.cellml">
<component name="calcineurin" component_ref="calcineurin" />
</import>
<import xlink:href="NFATCycling_DualProtocol.cellml">
<component name="NFAT_Cycling" component_ref="NFAT_Cycling" />
</import>
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#">
<rdf:Description rdf:about="">
<dc:creator rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Cooling</vCard:Family>
<vCard:Given>Michael</vCard:Given>
</vCard:N>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
<vCard:Orgunit>University of Auckland</vCard:Orgunit>
</vCard:ORG>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>m.cooling@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet" />
</vCard:EMAIL>
</dc:creator>
<dc:title>Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes (Dual Calcium Protocol)</dc:title>
</rdf:Description>
<rdf:Description rdf:about="#NFATMyocyte_DualProtocol">
<bqs:reference rdf:parseType="Resource">
<bqs:JournalArticle rdf:parseType="Resource">
<dc:creator>
<rdf:Seq>
<rdf:li rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Cooling</vCard:Family>
<vCard:Given>Mike</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>m.cooling@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
<vCard:Orgunit>University of Auckland</vCard:Orgunit>
</vCard:ORG>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Hunter</vCard:Family>
<vCard:Given>Peter</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>p.hunter@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
<vCard:Orgunit>University of Auckland</vCard:Orgunit>
</vCard:ORG>
</rdf:li>
<rdf:li rdf:parseType="Resource">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Crampin</vCard:Family>
<vCard:Given>Edmund</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>e.crampin@auckland.ac.nz</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>Auckland Bioengineering Institute</vCard:Orgname>
<vCard:Orgunit>University of Auckland</vCard:Orgunit>
</vCard:ORG>
</rdf:li>
</rdf:Seq>
</dc:creator>
<dc:title>Sensitivity of NFAT Cycling to Cytosolic Calcium Concentration: Implications for Hypertrophic Signals in Cardiac Myocytes</dc:title>
<bqs:volume>96</bqs:volume>
<bqs:first_page>2095</bqs:first_page>
<bqs:last_page>2104</bqs:last_page>
<bqs:Journal rdf:parseType="Resource">
<dc:title>Biophysical Journal</dc:title>
</bqs:Journal>
<dcterms:issued rdf:parseType="Resource">
<dcterms:W3CDTF>2009-00-00 00:00</dcterms:W3CDTF>
</dcterms:issued>
</bqs:JournalArticle>
</bqs:reference>
<bqs:reference rdf:parseType="Resource">
<dc:subject rdf:parseType="Resource">
<bqs:subject_type>keyword</bqs:subject_type>
<rdf:value>
<rdf:Bag>
<rdf:li>Signal Transduction</rdf:li>
<rdf:li>Calcium Dynamics</rdf:li>
<rdf:li>Gene Regulation</rdf:li>
<rdf:li>Excitation-Transcription Coupling</rdf:li>
<rdf:li>NFAT</rdf:li>
</rdf:Bag>
</rdf:value>
</dc:subject>
</bqs:reference>
</rdf:Description>
</rdf:RDF>
<!--
*******************************************************
*** U N I T S ***
*******************************************************
-->
<units name="s">
<unit units="second"/>
</units>
<units xmlns="http://www.cellml.org/cellml/1.0#" name="nM">
<unit units="mole" prefix="nano"/>
<unit units="liter" exponent="-1"/>
</units>
<!--
*********************************************************
*** C O M P O N E N T S ***
*********************************************************
-->
<component name="environment">
<variable name="t" units="s" private_interface="out"/>
</component>
<component name="geometry">
<variable name="Ccn" units="dimensionless" initial_value="50" private_interface="out"/>
</component>
<component name="NFAT_Cycling_interface">
<variable name="nuclearNFAT" units="nM"/>
<variable name="NFATN_n" units="nM" public_interface="in"/>
<variable name="NFATp_n" units="nM" public_interface="in"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply>
<eq/>
<ci>nuclearNFAT</ci>
<apply>
<plus/>
<ci>NFATN_n</ci>
<ci>NFATp_n</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation" />
<component_ref component="environment">
<component_ref component="geometry">
<component_ref component="calcium"/>
<component_ref component="calcineurin"/>
<component_ref component="NFAT_Cycling"/>
<component_ref component="NFAT_Cycling_interface"/>
</component_ref>
</component_ref>
</group>
<connection>
<map_components
component_1="environment" component_2="calcium" />
<map_variables variable_1="t" variable_2="t" />
</connection>
<connection>
<map_components component_1="environment" component_2="calcineurin" />
<map_variables variable_1="t" variable_2="t" />
</connection>
<connection>
<map_components component_1="environment" component_2="NFAT_Cycling" />
<map_variables variable_1="t" variable_2="t" />
</connection>
<connection>
<map_components component_1="geometry" component_2="NFAT_Cycling" />
<map_variables variable_1="Ccn" variable_2="Ccn" />
</connection>
<connection>
<map_components component_1="calcium" component_2="calcineurin" />
<map_variables variable_1="Ca" variable_2="Ca" />
</connection>
<connection>
<map_components component_1="calcineurin" component_2="NFAT_Cycling" />
<map_variables variable_1="act_N" variable_2="act_N" />
<map_variables variable_1="Ntot" variable_2="Ntot" />
</connection>
<connection>
<map_components component_1="NFAT_Cycling_interface" component_2="NFAT_Cycling" />
<map_variables variable_1="NFATN_n" variable_2="NFATN_n" />
<map_variables variable_1="NFATp_n" variable_2="NFATp_n" />
</connection>
</model>
