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Model Mathematics

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Component: environment

Component: cytosolic_Ca_uptake

J_L1 = k_L1 (Ca_i - Ca_o) K_L1 = \frac{k_L1}{v_i}

Component: cytosolic_Ca_release

J_P1 = k_P1 Ca_i K_P1 = \frac{k_P1}{v_i}

Component: internal_store_Ca_release

J_L2 = k_L2 (Ca_i - Ca_s) K_L2 = \frac{K_L2_0 + K_L2_1}{1.0 + {(\frac{Kd_Ca}{Ca_i})}^{n}}

Component: internal_store_Ca_uptake

J_P2 = k_P2 Ca_i K_P2 = \frac{k_P2}{v_s}

Component: cytosolic_calcium

\frac{d}{d time} (Ca_i) = (- (K_L1 + K_P1 + gamma (K_L2 + K_P2))) Ca_i + gamma K_L2 Ca_s + K_L1 Ca_o Ca_i_ss = \frac{Ca_o}{\frac{1.0 + K_P1}{K_L1}} gamma = \frac{v_i}{v_s}

Component: internal_store_calcium

\frac{d}{d time} (Ca_s) = (K_L2 + K_P2) Ca_i - (K_L2 Ca_s) Ca_s_ss = \frac{Ca_i_ss}{\frac{1.0 + K_P2}{K_L2}}

Source: Derived from workspace Friel, 1995 at changeset 8c93002fa303.; This exposure was expired. A more up-to-date exposure is available, or view related resources.

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[Ca2+]i oscillations in sympathetic neurons: an experimental test of a theoretical model