Mitochondrial Modulation of Intracellular Ca2+ Signalling

Model Status

This is the original unchecked version of the model imported from the previous CellML model repository, 24-Jan-2006.

Model Structure

In 2001 Christopher Fall and Joel Keizer published a detailed mathematical model to describe mitochondrial function and mitochondrial Ca²⁺ handling coupled to endoplasmic reticulum (ER) based IP3-dependent Ca²⁺ release. Their aim was to create a biologically realistic model of the influence of mitochondria on IP3-mediated Ca²⁺ signaling. They aimed to integrate the separate IP3 receptor/channel (DeYoung-Keizer 1992) and mitochondrial Ca²⁺ handling (Magnus-Keizer 1997, 1998) models into a single, common framework (see the figure below).

The complete original paper reference is cited below:

Mitochondrial Modulation of Intracellular Ca²⁺ Signaling, Christopher P. Fall and Joel E. Keizer, 2001, J. theor. Biol. , 210, 151-165. (A full text (html) and PDF versions of the article are available to subscribers on the Science Direct website.) PubMed ID: 11371172

The raw CellML description of the mitochondria and Ca²⁺ signaling model can be downloaded in various formats as described in . For an example of a more complete documentation for an electrophysiological model, see The Hodgkin-Huxley Squid Axon Model, 1952.

Key components of the IP3-mediated intracellular Ca²⁺ signaling diagram shows endoplasmic reticulum based Ca²⁺ release and uptake mechanisms, mitochondrial Ca²⁺ release and uptake mechanisms, in addition to other components which are not included in the mathematical model.

The network defined in the CellML description of the mitochondria and Ca²⁺ signaling model.