Model Mathematics

Component: environment

t_modulo=timemod1000

Component: general_parameters

Component: action_potential

V=rest+A1--t_modulot1p-t_modulot21-t_modulo10A110+t_modulo10

Component: calcium_input

tcalcium=0ift_modulo-1.20t_modulo-1.2otherwise Ca_input=Ca_amp1--tcalciumCa_tau1Ca_pow-tcalciumCa_tau2

Component: NCX_current

INaCa=kNaCaKmNa3+Na_o3KmCa+Ca_o1+ksateta-1VFRTetaVFRTNa_i3Ca_o-eta-1VFRTNa_o3Ca_cyt

Component: serca_parameters

EC_50_fwd=Kmf_PLBKO+Kmf_PLBPSRPLB_dephosph11+0.27CaMKII_reg EC_50_rev=Kmr_PLBKO-Kmr_PLBPSRPLB_dephosph1

Component: transition_parameters

br_cyt_serca=1000br_serca_sr k_cyt_serca=br_cyt_serca1+0.7CaMKII_reg k_serca_cyt=EC_50_fwd2br_cyt_serca k_serca_sr=br_serca_sr1+0.7CaMKII_reg k_sr_serca=br_serca_srEC_50_rev2

Component: calcium_fluxes

J_cyt_serca=k_cyt_sercaCa_cyt2SERCA_TOT-Ca_serca-k_serca_cytCa_serca J_serca_sr=k_serca_srCa_serca-k_sr_sercaCa_NSR2SERCA_TOT-Ca_serca J_up=J_cyt_serca-J_serca_sr

Component: calcium_buffering

B_i=1+CaM_totKm_CaMKm_CaM+Ca_cyt2-1 J_LTRPN=kltrpn_posCa_cytLTRPN_tot-LTRPN-kltrpn_negLTRPN

Component: differential_equations

ddtimeCa_cyt=B_iINaCaAcapC_m2V_myoF-J_cyt_serca+J_leak+Ca_input-J_LTRPN ddtimeLTRPN=kltrpn_posCa_cytLTRPN_tot-LTRPN-kltrpn_negLTRPN ddtimePLB_dephosph=kplb_posPLB_tot-PLB_dephosph-kplb_negCaMKII_reg+PKA_reg2PLB_dephosph ddtimeCa_serca=J_cyt_serca-J_serca_sr