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C C There are a total of 54 entries in the algebraic variable array. C There are a total of 7 entries in each of the rate and state variable arrays. C There are a total of 46 entries in the constant variable array. C C C VOI is t in component params_BG (second). C CONSTS(1) is R in component params_BG (J_per_K_mol). C CONSTS(2) is T in component params_BG (kelvin). C CONSTS(3) is F in component params_BG (C_per_mol). C CONSTS(4) is K_Nai in component params_BG (per_fmol). C CONSTS(39) is q_Nai in component params_BG (fmol). C CONSTS(5) is K_Nao in component params_BG (per_fmol). C CONSTS(41) is q_Nao in component params_BG (fmol). C CONSTS(6) is K_Glci in component params_BG (per_fmol). C CONSTS(43) is q_Glci in component params_BG (fmol). C CONSTS(7) is K_Glco in component params_BG (per_fmol). C CONSTS(45) is q_Glco in component params_BG (fmol). C CONSTS(8) is K_1 in component params_BG (per_fmol). C CONSTS(9) is q_init_1 in component params_BG (fmol). C CONSTS(10) is K_2 in component params_BG (per_fmol). C CONSTS(11) is q_init_2 in component params_BG (fmol). C CONSTS(12) is K_3 in component params_BG (per_fmol). C CONSTS(13) is q_init_3 in component params_BG (fmol). C CONSTS(14) is K_4 in component params_BG (per_fmol). C CONSTS(15) is q_init_4 in component params_BG (fmol). C CONSTS(16) is K_5 in component params_BG (per_fmol). C CONSTS(17) is q_init_5 in component params_BG (fmol). C CONSTS(18) is K_6 in component params_BG (per_fmol). C CONSTS(19) is q_init_6 in component params_BG (fmol). C ALGBRC(25) is V0_Vm in component params_BG (volt). C CONSTS(20) is z_zf1 in component params_BG (dimensionless). C CONSTS(21) is z_zr1 in component params_BG (dimensionless). C CONSTS(22) is z_zf6 in component params_BG (dimensionless). C CONSTS(23) is z_zr6 in component params_BG (dimensionless). C CONSTS(24) is kappa_r1 in component params_BG (fmol_per_s). C CONSTS(25) is kappa_r2 in component params_BG (fmol_per_s). C CONSTS(26) is kappa_r3 in component params_BG (fmol_per_s). C CONSTS(27) is kappa_r4 in component params_BG (fmol_per_s). C CONSTS(28) is kappa_r5 in component params_BG (fmol_per_s). C CONSTS(29) is kappa_r6 in component params_BG (fmol_per_s). C CONSTS(30) is kappa_r7 in component params_BG (fmol_per_s). C CONSTS(40) is mu_Nai in component SGLT1_BG (J_per_mol). C CONSTS(42) is mu_Nao in component SGLT1_BG (J_per_mol). C CONSTS(44) is mu_Glci in component SGLT1_BG (J_per_mol). C CONSTS(46) is mu_Glco in component SGLT1_BG (J_per_mol). C ALGBRC(1) is mu_1 in component SGLT1_BG (J_per_mol). C ALGBRC(47) is v_1 in component SGLT1_BG (fmol_per_s). C ALGBRC(3) is mu_2 in component SGLT1_BG (J_per_mol). C ALGBRC(39) is v_2 in component SGLT1_BG (fmol_per_s). C ALGBRC(4) is mu_3 in component SGLT1_BG (J_per_mol). C ALGBRC(14) is v_3 in component SGLT1_BG (fmol_per_s). C ALGBRC(5) is mu_4 in component SGLT1_BG (J_per_mol). C ALGBRC(18) is v_4 in component SGLT1_BG (fmol_per_s). C ALGBRC(6) is mu_5 in component SGLT1_BG (J_per_mol). C ALGBRC(26) is v_5 in component SGLT1_BG (fmol_per_s). C ALGBRC(7) is mu_6 in component SGLT1_BG (J_per_mol). C ALGBRC(48) is v_6 in component SGLT1_BG (fmol_per_s). C ALGBRC(27) is V_Vm in component SGLT1_BG (volt). C ALGBRC(28) is V_zf1 in component SGLT1_BG (volt). C ALGBRC(41) is I_zf1 in component SGLT1_BG (fA). C ALGBRC(29) is mu_zf1 in component SGLT1_BG (J_per_mol). C ALGBRC(40) is v_zf1 in component SGLT1_BG (fmol_per_s). C ALGBRC(30) is V_zr1 in component SGLT1_BG (volt). C ALGBRC(43) is I_zr1 in component SGLT1_BG (fA). C ALGBRC(31) is mu_zr1 in component SGLT1_BG (J_per_mol). C ALGBRC(42) is v_zr1 in component SGLT1_BG (fmol_per_s). C ALGBRC(32) is V_zf6 in component SGLT1_BG (volt). C ALGBRC(51) is I_zf6 in component SGLT1_BG (fA). C ALGBRC(33) is mu_zf6 in component SGLT1_BG (J_per_mol). C ALGBRC(49) is v_zf6 in component SGLT1_BG (fmol_per_s). C ALGBRC(34) is V_zr6 in component SGLT1_BG (volt). C ALGBRC(53) is I_zr6 in component SGLT1_BG (fA). C ALGBRC(35) is mu_zr6 in component SGLT1_BG (J_per_mol). C ALGBRC(52) is v_zr6 in component SGLT1_BG (fmol_per_s). C ALGBRC(36) is A_f_r1 in component SGLT1_BG (J_per_mol). C ALGBRC(38) is v_r1 in component SGLT1_BG (fmol_per_s). C ALGBRC(37) is A_r_r1 in component SGLT1_BG (J_per_mol). C ALGBRC(8) is A_f_r2 in component SGLT1_BG (J_per_mol). C ALGBRC(10) is v_r2 in component SGLT1_BG (fmol_per_s). C ALGBRC(9) is A_r_r2 in component SGLT1_BG (J_per_mol). C ALGBRC(11) is A_f_r3 in component SGLT1_BG (J_per_mol). C ALGBRC(13) is v_r3 in component SGLT1_BG (fmol_per_s). C ALGBRC(12) is A_r_r3 in component SGLT1_BG (J_per_mol). C ALGBRC(15) is A_f_r4 in component SGLT1_BG (J_per_mol). C ALGBRC(17) is v_r4 in component SGLT1_BG (fmol_per_s). C ALGBRC(16) is A_r_r4 in component SGLT1_BG (J_per_mol). C ALGBRC(19) is A_f_r5 in component SGLT1_BG (J_per_mol). C ALGBRC(21) is v_r5 in component SGLT1_BG (fmol_per_s). C ALGBRC(20) is A_r_r5 in component SGLT1_BG (J_per_mol). C ALGBRC(44) is A_f_r6 in component SGLT1_BG (J_per_mol). C ALGBRC(46) is v_r6 in component SGLT1_BG (fmol_per_s). C ALGBRC(45) is A_r_r6 in component SGLT1_BG (J_per_mol). C ALGBRC(22) is A_f_r7 in component SGLT1_BG (J_per_mol). C ALGBRC(24) is v_r7 in component SGLT1_BG (fmol_per_s). C ALGBRC(23) is A_r_r7 in component SGLT1_BG (J_per_mol). C STATES(1) is q_1 in component SGLT1_BG (fmol). C STATES(2) is q_2 in component SGLT1_BG (fmol). C STATES(3) is q_3 in component SGLT1_BG (fmol). C STATES(4) is q_4 in component SGLT1_BG (fmol). C STATES(5) is q_5 in component SGLT1_BG (fmol). C STATES(6) is q_6 in component SGLT1_BG (fmol). C ALGBRC(54) is Ii in component SGLT1_BG (fA). C ALGBRC(50) is I_ss in component SGLT1_BG (fA). C CONSTS(31) is Nai in component params_BG (mM). C CONSTS(32) is Nao in component params_BG (mM). C CONSTS(33) is Glci in component params_BG (mM). C CONSTS(34) is Glco in component params_BG (mM). C CONSTS(35) is V_i in component params_BG (pL). C CONSTS(36) is V_o in component params_BG (pL). C STATES(7) is V_E in component params_BG (volt). C CONSTS(37) is test_volt in component params_BG (volt). C ALGBRC(2) is rate_VE in component params_BG (volt_per_s). C CONSTS(38) is dt in component params_BG (second). C RATES(1) is d/dt q_1 in component SGLT1_BG (fmol). C RATES(2) is d/dt q_2 in component SGLT1_BG (fmol). C RATES(3) is d/dt q_3 in component SGLT1_BG (fmol). C RATES(4) is d/dt q_4 in component SGLT1_BG (fmol). C RATES(5) is d/dt q_5 in component SGLT1_BG (fmol). C RATES(6) is d/dt q_6 in component SGLT1_BG (fmol). C RATES(7) is d/dt V_E in component params_BG (volt). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 8.31 CONSTS(2) = 293 CONSTS(3) = 96485 CONSTS(4) = 3.216e-08 CONSTS(5) = 3.216e-08 CONSTS(6) = 4.848e-06 CONSTS(7) = 4.848e-06 CONSTS(8) = 2.235 CONSTS(9) = 13.7727015449461 CONSTS(10) = 10.437 CONSTS(11) = 72.295598813025 CONSTS(12) = 8.602 CONSTS(13) = 0.16701061319503 CONSTS(14) = 8.602 CONSTS(15) = 0.233806833618937 CONSTS(16) = 28.628 CONSTS(17) = 1.73527350102727 CONSTS(18) = 0.192 CONSTS(19) = 11.4302815603453 CONSTS(20) = 0.3 CONSTS(21) = 0.3 CONSTS(22) = 0.7 CONSTS(23) = 0.7 CONSTS(24) = 47.905 CONSTS(25) = 2.325 CONSTS(26) = 5.812 CONSTS(27) = 92.998 CONSTS(28) = 0.349 CONSTS(29) = 15.661 CONSTS(30) = 0.029 CONSTS(31) = 20 CONSTS(32) = 100 CONSTS(33) = 10e-3 CONSTS(34) = 1e-12 CONSTS(35) = 8.5e5 CONSTS(36) = 8.5e5 STATES(7) = -0.05 CONSTS(37) = 0 CONSTS(38) = 1e-3 CONSTS(39) = CONSTS(31)*CONSTS(35) CONSTS(40) = CONSTS(1)*CONSTS(2)*log( CONSTS(4)*CONSTS(39)) CONSTS(41) = CONSTS(32)*CONSTS(36) CONSTS(42) = CONSTS(1)*CONSTS(2)*log( CONSTS(5)*CONSTS(41)) CONSTS(43) = CONSTS(33)*CONSTS(35) CONSTS(44) = CONSTS(1)*CONSTS(2)*log( CONSTS(6)*CONSTS(43)) CONSTS(45) = CONSTS(34)*CONSTS(36) CONSTS(46) = CONSTS(1)*CONSTS(2)*log( CONSTS(7)*CONSTS(45)) STATES(1) = CONSTS(9) STATES(2) = CONSTS(11) STATES(3) = CONSTS(13) STATES(4) = CONSTS(15) STATES(5) = CONSTS(17) STATES(6) = CONSTS(19) RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = TERNRY(VOI.LT.1.20475, 0.00000, TERNRY(VOI.GE.1.20475.AND.VOI.LT.1.20475+CONSTS(38), (CONSTS(37)+0.0500000)/CONSTS(38), TERNRY(VOI.GE.1.20475+CONSTS(38).AND.VOI.LT.2.98475, 0.00000, TERNRY(VOI.GE.2.98475.AND.VOI.LT.2.98475+CONSTS(38), - (CONSTS(37)+0.0500000)/CONSTS(38), 0.00000) RATES(7) = ALGBRC(2) ALGBRC(3) = CONSTS(1)*CONSTS(2)*log( CONSTS(10)*STATES(2)) ALGBRC(8) = CONSTS(46)+ALGBRC(3) ALGBRC(4) = CONSTS(1)*CONSTS(2)*log( CONSTS(12)*STATES(3)) ALGBRC(9) = ALGBRC(4) ALGBRC(10) = CONSTS(25)*(EXP(ALGBRC(8)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(9)/( CONSTS(1)*CONSTS(2)))) ALGBRC(11) = ALGBRC(4) ALGBRC(5) = CONSTS(1)*CONSTS(2)*log( CONSTS(14)*STATES(4)) ALGBRC(12) = ALGBRC(5) ALGBRC(13) = CONSTS(26)*(EXP(ALGBRC(11)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(12)/( CONSTS(1)*CONSTS(2)))) ALGBRC(14) = ALGBRC(10) - ALGBRC(13) RATES(3) = ALGBRC(14) ALGBRC(15) = ALGBRC(5) ALGBRC(6) = CONSTS(1)*CONSTS(2)*log( CONSTS(16)*STATES(5)) ALGBRC(16) = CONSTS(44)+ALGBRC(6) ALGBRC(17) = CONSTS(27)*(EXP(ALGBRC(15)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(16)/( CONSTS(1)*CONSTS(2)))) ALGBRC(18) = ALGBRC(13) - ALGBRC(17) RATES(4) = ALGBRC(18) ALGBRC(19) = ALGBRC(6) ALGBRC(7) = CONSTS(1)*CONSTS(2)*log( CONSTS(18)*STATES(6)) ALGBRC(20) = 2.00000*CONSTS(40)+ALGBRC(7) ALGBRC(21) = CONSTS(28)*(EXP(ALGBRC(19)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(20)/( CONSTS(1)*CONSTS(2)))) ALGBRC(22) = ALGBRC(3) ALGBRC(23) = ALGBRC(6) ALGBRC(24) = CONSTS(30)*(EXP(ALGBRC(22)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(23)/( CONSTS(1)*CONSTS(2)))) ALGBRC(26) = (ALGBRC(17) - ALGBRC(21))+ALGBRC(24) RATES(5) = ALGBRC(26) ALGBRC(1) = CONSTS(1)*CONSTS(2)*log( CONSTS(8)*STATES(1)) ALGBRC(25) = STATES(7) ALGBRC(27) = ALGBRC(25) ALGBRC(28) = ALGBRC(27) ALGBRC(29) = CONSTS(20)*CONSTS(3)*ALGBRC(28) ALGBRC(36) = ( 2.00000*CONSTS(42)+ALGBRC(1)) - ALGBRC(29) ALGBRC(30) = ALGBRC(27) ALGBRC(31) = CONSTS(21)*CONSTS(3)*ALGBRC(30) ALGBRC(37) = ALGBRC(3)+ALGBRC(31) ALGBRC(38) = CONSTS(24)*(EXP(ALGBRC(36)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(37)/( CONSTS(1)*CONSTS(2)))) ALGBRC(39) = (ALGBRC(38) - ALGBRC(10)) - ALGBRC(24) RATES(2) = ALGBRC(39) ALGBRC(32) = ALGBRC(27) ALGBRC(33) = CONSTS(22)*CONSTS(3)*ALGBRC(32) ALGBRC(44) = ALGBRC(7) - ALGBRC(33) ALGBRC(34) = ALGBRC(27) ALGBRC(35) = CONSTS(23)*CONSTS(3)*ALGBRC(34) ALGBRC(45) = ALGBRC(1)+ALGBRC(35) ALGBRC(46) = CONSTS(29)*(EXP(ALGBRC(44)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(45)/( CONSTS(1)*CONSTS(2)))) ALGBRC(47) = - ALGBRC(38)+ALGBRC(46) RATES(1) = ALGBRC(47) ALGBRC(48) = ALGBRC(21) - ALGBRC(46) RATES(6) = ALGBRC(48) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(2) = TERNRY(VOI.LT.1.20475, 0.00000, TERNRY(VOI.GE.1.20475.AND.VOI.LT.1.20475+CONSTS(38), (CONSTS(37)+0.0500000)/CONSTS(38), TERNRY(VOI.GE.1.20475+CONSTS(38).AND.VOI.LT.2.98475, 0.00000, TERNRY(VOI.GE.2.98475.AND.VOI.LT.2.98475+CONSTS(38), - (CONSTS(37)+0.0500000)/CONSTS(38), 0.00000) ALGBRC(3) = CONSTS(1)*CONSTS(2)*log( CONSTS(10)*STATES(2)) ALGBRC(8) = CONSTS(46)+ALGBRC(3) ALGBRC(4) = CONSTS(1)*CONSTS(2)*log( CONSTS(12)*STATES(3)) ALGBRC(9) = ALGBRC(4) ALGBRC(10) = CONSTS(25)*(EXP(ALGBRC(8)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(9)/( CONSTS(1)*CONSTS(2)))) ALGBRC(11) = ALGBRC(4) ALGBRC(5) = CONSTS(1)*CONSTS(2)*log( CONSTS(14)*STATES(4)) ALGBRC(12) = ALGBRC(5) ALGBRC(13) = CONSTS(26)*(EXP(ALGBRC(11)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(12)/( CONSTS(1)*CONSTS(2)))) ALGBRC(14) = ALGBRC(10) - ALGBRC(13) ALGBRC(15) = ALGBRC(5) ALGBRC(6) = CONSTS(1)*CONSTS(2)*log( CONSTS(16)*STATES(5)) ALGBRC(16) = CONSTS(44)+ALGBRC(6) ALGBRC(17) = CONSTS(27)*(EXP(ALGBRC(15)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(16)/( CONSTS(1)*CONSTS(2)))) ALGBRC(18) = ALGBRC(13) - ALGBRC(17) ALGBRC(19) = ALGBRC(6) ALGBRC(7) = CONSTS(1)*CONSTS(2)*log( CONSTS(18)*STATES(6)) ALGBRC(20) = 2.00000*CONSTS(40)+ALGBRC(7) ALGBRC(21) = CONSTS(28)*(EXP(ALGBRC(19)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(20)/( CONSTS(1)*CONSTS(2)))) ALGBRC(22) = ALGBRC(3) ALGBRC(23) = ALGBRC(6) ALGBRC(24) = CONSTS(30)*(EXP(ALGBRC(22)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(23)/( CONSTS(1)*CONSTS(2)))) ALGBRC(26) = (ALGBRC(17) - ALGBRC(21))+ALGBRC(24) ALGBRC(1) = CONSTS(1)*CONSTS(2)*log( CONSTS(8)*STATES(1)) ALGBRC(25) = STATES(7) ALGBRC(27) = ALGBRC(25) ALGBRC(28) = ALGBRC(27) ALGBRC(29) = CONSTS(20)*CONSTS(3)*ALGBRC(28) ALGBRC(36) = ( 2.00000*CONSTS(42)+ALGBRC(1)) - ALGBRC(29) ALGBRC(30) = ALGBRC(27) ALGBRC(31) = CONSTS(21)*CONSTS(3)*ALGBRC(30) ALGBRC(37) = ALGBRC(3)+ALGBRC(31) ALGBRC(38) = CONSTS(24)*(EXP(ALGBRC(36)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(37)/( CONSTS(1)*CONSTS(2)))) ALGBRC(39) = (ALGBRC(38) - ALGBRC(10)) - ALGBRC(24) ALGBRC(32) = ALGBRC(27) ALGBRC(33) = CONSTS(22)*CONSTS(3)*ALGBRC(32) ALGBRC(44) = ALGBRC(7) - ALGBRC(33) ALGBRC(34) = ALGBRC(27) ALGBRC(35) = CONSTS(23)*CONSTS(3)*ALGBRC(34) ALGBRC(45) = ALGBRC(1)+ALGBRC(35) ALGBRC(46) = CONSTS(29)*(EXP(ALGBRC(44)/( CONSTS(1)*CONSTS(2))) - EXP(ALGBRC(45)/( CONSTS(1)*CONSTS(2)))) ALGBRC(47) = - ALGBRC(38)+ALGBRC(46) ALGBRC(48) = ALGBRC(21) - ALGBRC(46) ALGBRC(40) = ALGBRC(38) ALGBRC(41) = CONSTS(20)*CONSTS(3)*ALGBRC(40) ALGBRC(42) = ALGBRC(38) ALGBRC(43) = CONSTS(21)*CONSTS(3)*ALGBRC(42) ALGBRC(49) = ALGBRC(46) ALGBRC(50) = 2.00000*CONSTS(3)*- ALGBRC(46) ALGBRC(51) = CONSTS(22)*CONSTS(3)*ALGBRC(49) ALGBRC(52) = ALGBRC(46) ALGBRC(53) = CONSTS(23)*CONSTS(3)*ALGBRC(52) ALGBRC(54) = ALGBRC(41)+ALGBRC(43)+ALGBRC(51)+ALGBRC(53) RETURN END REAL FUNCTION TERNRY(TEST, VALA, VALB) LOGICAL TEST REAL VALA, VALB IF (TEST) THEN TERNRY = VALA ELSE TERNRY = VALB ENDIF RETURN END