About this model

Original publication:
 Kernik et al. (2019): "A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.

Figure 08

Inward rectifier potassium current (IK1) model optimization

The slow delayed rectifier potassium current was modeled here. experimental iPSC-CM data collected from Ma et al. (2011) , Kurokawa Lab (Li et al. (2017)), and the Jalife Lab (Herron et al. (2016)) in order to optimize data specific model.

Current_Ik1.cellml is the main CellML files which has all the formulation for Inward rectifier potassium current, Its associated Sedml file contains all the simulation settings.

All the CellML files and SED-ML files related to this channel need to be downloaded in a same folder (Current_Ik1, gating_Ik1, parameter_Ik1, parameter, unit) as well as python script ( In the python script, required Sedml file (Current_Ik1.sedml) is loaded into the script and by running the code following figure is reproduced.``_ is used to generate the simulation and reproduces the graph shown in Figure 9 in the original study. In order to reproduce Figure 9, once all the files are downloaded to the same folder, execute the following script from the command line (command prompt):

cd [PathToThisFile]


I-V curve with dataset-specific model fits. Different colour represent experimental iPSC-CM data from multiple laboratories