Switching from Simple to Complex Oscillations in Calcium Signaling

Model Status

This CellML model runs in OpenCell and COR, and reproduces Figures 3, 6 and 7 from the published paper.

Model Structure

We present a new model for calcium oscillations based on experiments in hepatocytes. The model considers feedback inhibition on the initial agonist receptor complex by calcium and activated phospholipase C, as well as receptor type-dependent self-enhanced behavior of the activated G(alpha) subunit. It is able to show simple periodic oscillations and periodic bursting, and it is the first model to display chaotic bursting in response to agonist stimulations. Moreover, our model offers a possible explanation for the differences in dynamic behavior observed in response to different agonists in hepatocytes.

The original paper reference is cited below:

Switching from Simple to Complex Oscillations in Calcium Signaling, Kummer, U., Olsen, L.F, Dixon, C.J., Green, A.K, Bornberg-Bauer, E., Baier, G., 2000Biophysical Journal, 79, 1188-1195. PubMed ID: 10968983