Model Mathematics

v_42 = eps (\frac{K1 {(\frac{CYCB}{J1})}^{2}}{{(\frac{CYCB}{J1})}^{2} + 1} + K1a) v_19 = V_2 CYCB v_21 = \frac{V_4 Cdh1}{J4 + Cdh1} v_20 = \frac{(K3a + K3 Cdc20) (1 - Cdh1)}{(J3 - Cdh1) + 1} V_2 = K2aa Cdc20 + K2a (1 - Cdh1) + K2 Cdh1 V_4 = K4 (GA CYCA + GB CYCB + GE CYCE) \frac{d}{d time} (Cdh1) = v_20 - v_21 \frac{d}{d time} (CYCB) = v_42 - v_19

v_39 = eps K9 DRG v_41 = eps (\frac{k17 {(\frac{DRG}{J17})}^{2}}{{(\frac{DRG}{J17})}^{2} + 1} + k17a ERG) v_2 = k18 DRG v_34 = \frac{eps k15}{{(\frac{DRG}{J15})}^{2} + 1} v_1 = k16 ERG \frac{d}{d time} (DRG) = v_41 - v_2 \frac{d}{d time} (ERG) = v_34 - v_1

PP1A = \frac{PP1T}{K21 FE (CYCA + CYCE + FB CYCB) + 1} v_29 = E2FRb K20 (CYCDT LD + LA CYCA + LB CYCB + LE CYCE) v_30 = PE2FRb K20 (CYCDT LD + LA CYCA + LB CYCB + LE CYCE) v_43 = Rb K20 (CYCDT LD + LA CYCA + LB CYCB + LE CYCE) v_44 = PPRb (K19a (PP1T - PP1A) + K19 PP1A) v_45 = E2FRb K26R v_46 = E2F (K23a + K23 (CYCA + CYCB)) v_47 = PE2F K22 v_48 = E2F Rb K26 v_49 = PE2FRb K26R v_50 = Rb PE2F K26 v_51 = PE2FRb K22 v_52 = E2FRb (K23a + K23 (CYCA + CYCB)) \frac{d}{d time} (PPRb) = v_29 + v_30 + v_43 - v_44 \frac{d}{d time} (E2F) = v_29 + v_45 + v_47 - v_46 - v_48 \frac{d}{d time} (PE2F) = v_30 + v_49 + v_46 - v_47 - v_50 \frac{d}{d time} (Rb) = v_44 + v_45 + v_49 - v_48 - v_50 - v_43 \frac{d}{d time} (E2FRb) = v_51 + v_48 - v_52 - v_29 - v_45 \frac{d}{d time} (PE2FRb) = v_52 + v_50 - v_51 - v_30 - v_49

V_6 = K6a + K6 (HA CYCA + HB CYCB + HE CYCE) V_8 = \frac{K8 (YE (CYCA + CYCE) + YB CYCB)}{CYCET + J8} + K8a v_3 = K10 CD v_4 = K10 CYCD v_5 = K25 p27 CYCE v_6 = K25 p27 CYCA v_7 = k24 p27 CYCD v_8 = k24r CD v_9 = K30 Cdc20 CYCA v_10 = K30 Cdc20 CA v_11 = K25R CE v_12 = K25R CA v_13 = V_8 CE v_14 = V_8 CYCE v_15 = V_6 p27 v_16 = V_6 CE v_17 = V_6 CD v_18 = V_6 CA v_36 = eps K29 E2F MASS v_38 = eps (K7a + K7 E2F) v_40 = eps K5 \frac{d}{d time} (CA) = v_6 - v_12 - v_18 - v_10 \frac{d}{d time} (CD) = v_7 - v_8 - v_17 - v_3 \frac{d}{d time} (CE) = v_5 - v_11 - v_13 - v_16 \frac{d}{d time} (CYCA) = (v_36 - v_9 - v_6) + v_12 + v_18 \frac{d}{d time} (CYCD) = v_39 + v_17 + v_8 - v_7 - v_4 \frac{d}{d time} (CYCE) = (v_38 - v_14 - v_5) + v_11 + v_16 \frac{d}{d time} (p27) = (v_40 + v_3 + v_8 - v_15 - v_5 - v_6 - v_7) + v_11 + v_12 + v_13 + v_10

v_31 = K27 MASS r31switch v_32 = K28 GM v_33 = eps MU GM \frac{d}{d time} (GM) = v_31 - v_32 \frac{d}{d time} (MASS) = v_33

v_22 = K34 PPX v_23 = \frac{K31 CYCB (1 - IEP)}{(J31 - IEP) + 1} v_24 = \frac{K32 PPX IEP}{J32 + IEP} v_25 = K12 Cdc20T v_26 = \frac{K13 IEP (Cdc20T - Cdc20)}{(J13 - Cdc20) + Cdc20T} v_27 = \frac{K14 Cdc20}{J14 + Cdc20} v_28 = K12 Cdc20 v_35 = eps K11a + K11 CYCB v_37 = eps K33 \frac{d}{d time} (Cdc20T) = v_35 - v_25 \frac{d}{d time} (IEP) = v_23 - v_24 \frac{d}{d time} (PPX) = v_37 - v_22