<?xml version="1.0"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xml:base="" cmeta:id="cw59I0oG0ye" name="Baroreflex"><component name="Environmental"><variable name="Time" public_interface="out" units="second"/></component><component name="Parameters"><variable initial_value="480" name="S" public_interface="out" units="hertz"/><variable initial_value="1" name="Zeta" public_interface="out" units="dimensionless"/><variable initial_value="1.6" name="R0" public_interface="out" units="mm"/><variable initial_value="0.006" name="Cwall" public_interface="out" units="mm_per_mmHg"/><variable initial_value="1" name="Kne" public_interface="out" units="mmHg_per_mm"/><variable initial_value="1.5" name="K1" public_interface="out" units="mmHg_per_mm"/><variable initial_value="3.75" name="K2" public_interface="out" units="mmHg_per_mm"/><variable initial_value="1.05" name="K3" public_interface="out" units="mmHg_per_mm"/><variable initial_value="1" name="Bwall" public_interface="out" units="mmHg_s_per_sq_mm"/><variable initial_value="1" name="B1" public_interface="out" units="mmHg_s_per_mm"/><variable initial_value="10" name="B2" public_interface="out" units="mmHg_s_per_mm"/><variable initial_value="206.973" name="B3" public_interface="out" units="mmHg_s_per_mm"/><variable initial_value="4.12" name="Tsmax" public_interface="out" units="AU"/><variable initial_value="4.994" name="Tpmax" public_interface="out" units="AU"/><variable initial_value="0.5" name="Tsmin" public_interface="out" units="AU"/><variable initial_value="1.6" name="Tpmin" public_interface="out" units="AU"/><variable initial_value="1" name="Gcns" public_interface="out" units="dimensionless"/><variable initial_value="0.178" name="Gs" public_interface="out" units="per_Hertz"/><variable initial_value="0.492" name="Gp" public_interface="out" units="per_Hertz"/><variable initial_value="9.1" name="tau_nor" public_interface="out" units="second"/><variable initial_value="0.2" name="tau_ach" public_interface="out" units="second"/><variable initial_value="2.1" name="tau_HR_nor" public_interface="out" units="second"/><variable initial_value="2.5" name="tau_HR_ach" public_interface="out" units="second"/><variable initial_value="282.648" name="HRo" public_interface="out" units="Beats_per_min"/><variable initial_value="483.218" name="HRmax" public_interface="out" units="Beats_per_min"/><variable initial_value="226.238" name="HRmin" public_interface="out" units="Beats_per_min"/><variable initial_value="0.175" name="Beta" public_interface="out" units="dimensionless"/><variable initial_value="0" name="delta_th" public_interface="out" units="dimensionless"/><variable initial_value="0.1099" name="q_nor" public_interface="out" units="per_s"/><variable initial_value="5" name="q_ach" public_interface="out" units="per_s"/><variable initial_value="1.12" name="K_nor" public_interface="out" units="AU"/><variable initial_value="0.65" name="K_ach" public_interface="out" units="AU"/><variable initial_value="0.75" name="Gamma" public_interface="out" units="dimensionless"/></component><units base_units="yes" name="mmHg"/><units name="mm"><unit prefix="milli" units="meter"/></units><units name="mm_sq"><unit exponent="2" units="mm"/></units><units name="mm_per_mmHg"><unit units="mm"/><unit exponent="-1" units="mmHg"/></units><units name="mmHg_per_mm"><unit units="mmHg"/><unit exponent="-1" units="mm"/></units><units name="mmHg_s_per_mm"><unit units="mmHg"/><unit units="second"/><unit exponent="-1" units="mm"/></units><units base_units="yes" name="AU"/><units name="per_Hertz"><unit exponent="-1" units="hertz"/></units><units name="per_s"><unit exponent="-1" units="second"/></units><units base_units="yes" name="Beats"/><units base_units="no" name="Beats_per_min"><unit units="Beats"/><unit exponent="-1" multiplier="60" units="second"/></units><component name="Nervous_System"><variable name="alpha_cns" public_interface="out" units="hertz"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><ci>alpha_cns</ci><apply><times/><ci>Gcns</ci><ci>n</ci></apply></apply><apply><eq/><ci>n</ci><apply><times/><ci>S</ci><apply><minus/><ci>delta</ci><apply><times/><ci>Zeta</ci><ci>delta_th</ci></apply></apply></apply></apply></math><variable name="n" units="hertz"/><variable name="Gcns" public_interface="in" units="dimensionless"/><variable name="Gs" public_interface="in" units="per_Hertz"/><variable name="Gp" public_interface="in" units="per_Hertz"/><variable name="Zeta" public_interface="in" units="dimensionless"/><variable name="delta" public_interface="in" units="dimensionless"/><variable name="delta_th" public_interface="in" units="dimensionless"/><variable name="S" public_interface="in" units="hertz"/><variable initial_value="58.6" name="alpha_s0" public_interface="out" units="hertz"/><variable initial_value="76.019" name="alpha_p0" public_interface="out" units="hertz"/></component><component name="Aortic_Wall"><variable initial_value="15.20531" name="A" units="mm_sq"/><variable name="R0" public_interface="in" units="mm"/><variable name="Cwall" public_interface="in" units="mm_per_mmHg"/><variable name="P" units="mmHg"/><variable name="Bwall" public_interface="in" units="mmHg_s_per_sq_mm"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>A</ci></apply><apply><divide/><apply><plus/><apply><divide/><apply><minus/><apply><minus/><apply><root/><apply><divide/><ci>A</ci><pi/></apply></apply><ci>R0</ci></apply></apply><ci>Cwall</ci></apply><ci>P</ci></apply><ci>Bwall</ci></apply></apply><apply><eq/><ci>R</ci><apply><power/><apply><divide/><ci>A</ci><pi/></apply><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">0.5</cn></apply></apply><apply><eq/><ci>P</ci><apply><plus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="mmHg">100</cn><apply><times/><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" 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xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>Eps_1</ci></apply><apply><plus/><apply><divide/><apply><minus/><apply><times/><ci>Kne</ci><apply><minus/><ci>Eps_wall</ci><ci>Eps_1</ci></apply></apply><apply><times/><ci>K1</ci><apply><minus/><ci>Eps_1</ci><ci>Eps_2</ci></apply></apply></apply><ci>B1</ci></apply><apply><diff/><bvar><ci>t</ci></bvar><ci>Eps_2</ci></apply></apply></apply><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>Eps_2</ci></apply><apply><divide/><apply><plus/><apply><minus/><apply><times/><ci>K1</ci><apply><minus/><ci>Eps_1</ci><ci>Eps_2</ci></apply></apply><apply><times/><ci>K2</ci><apply><minus/><ci>Eps_2</ci><ci>Eps_3</ci></apply></apply></apply><apply><times/><ci>B1</ci><apply><diff/><bvar><ci>t</ci></bvar><ci>Eps_1</ci></apply></apply><apply><times/><ci>B2</ci><apply><diff/><bvar><ci>t</ci></bvar><ci>Eps_3</ci></apply></apply></apply><apply><plus/><ci>B1</ci><ci>B2</ci></apply></apply></apply><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>Eps_3</ci></apply><apply><divide/><apply><plus/><apply><minus/><apply><times/><ci>K2</ci><apply><minus/><ci>Eps_2</ci><ci>Eps_3</ci></apply></apply><apply><times/><ci>K3</ci><ci>Eps_3</ci></apply></apply><apply><times/><ci>B2</ci><apply><diff/><bvar><ci>t</ci></bvar><ci>Eps_2</ci></apply></apply></apply><apply><plus/><ci>B2</ci><ci>B3</ci></apply></apply></apply><apply><eq/><ci>Delta</ci><apply><minus/><ci>Eps_wall</ci><ci>Eps_1</ci></apply></apply><apply><eq/><ci>Eps_wall</ci><apply><divide/><apply><minus/><ci>R</ci><ci>R0</ci></apply><ci>R0</ci></apply></apply></math><variable name="Delta" public_interface="out" units="dimensionless"/><variable name="R0" public_interface="in" units="mm"/></component><connection><map_components component_1="Aortic_Wall" component_2="Coupling_Dynamics"/><map_variables variable_1="R" variable_2="R"/></connection><connection><map_components component_1="Environmental" component_2="Coupling_Dynamics"/><map_variables variable_1="Time" variable_2="t"/></connection><connection><map_components component_1="Environmental" component_2="Aortic_Wall"/><map_variables variable_1="Time" variable_2="t"/></connection><connection><map_components component_1="Parameters" component_2="Coupling_Dynamics"/><map_variables variable_1="Kne" variable_2="Kne"/><map_variables variable_1="K1" variable_2="K1"/><map_variables variable_1="K2" variable_2="K2"/><map_variables variable_1="K3" variable_2="K3"/><map_variables variable_1="B1" variable_2="B1"/><map_variables variable_1="B2" variable_2="B2"/><map_variables variable_1="B3" variable_2="B3"/><map_variables variable_1="R0" variable_2="R0"/></connection><connection><map_components component_1="Coupling_Dynamics" component_2="Nervous_System"/><map_variables variable_1="Delta" variable_2="delta"/></connection><connection><map_components component_1="Parameters" component_2="Nervous_System"/><map_variables variable_1="delta_th" variable_2="delta_th"/><map_variables variable_1="Gcns" variable_2="Gcns"/><map_variables variable_1="Gs" variable_2="Gs"/><map_variables variable_1="Gp" variable_2="Gp"/><map_variables variable_1="Zeta" variable_2="Zeta"/><map_variables variable_1="S" variable_2="S"/></connection><component name="PNS_tones"><variable name="Ts" public_interface="out" units="AU"/><variable name="Tp" public_interface="out" units="AU"/><variable name="Ts_min" public_interface="in" units="AU"/><variable name="Tp_min" public_interface="in" units="AU"/><variable name="Ts_max" public_interface="in" units="AU"/><variable name="Tp_max" public_interface="in" units="AU"/><variable name="Gs" public_interface="in" units="per_Hertz"/><variable name="Gp" public_interface="in" units="per_Hertz"/><variable name="alpha_cns" public_interface="in" units="hertz"/><variable name="alpha_s0" public_interface="in" units="hertz"/><variable name="alpha_p0" public_interface="in" units="hertz"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><ci>Ts</ci><apply><plus/><ci>Ts_min</ci><apply><divide/><apply><minus/><ci>Ts_max</ci><ci>Ts_min</ci></apply><apply><plus/><apply><exp/><apply><times/><ci>Gs</ci><apply><minus/><ci>alpha_cns</ci><ci>alpha_s0</ci></apply></apply></apply><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn></apply></apply></apply></apply><apply><eq/><ci>Tp</ci><apply><plus/><ci>Tp_min</ci><apply><divide/><apply><minus/><ci>Tp_max</ci><ci>Tp_min</ci></apply><apply><plus/><apply><exp/><apply><times/><apply><minus/><ci>Gp</ci></apply><apply><minus/><ci>alpha_cns</ci><ci>alpha_p0</ci></apply></apply></apply><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn></apply></apply></apply></apply></math></component><connection><map_components component_1="Parameters" component_2="PNS_tones"/><map_variables variable_1="Tsmax" variable_2="Ts_max"/><map_variables variable_1="Tpmax" variable_2="Tp_max"/><map_variables variable_1="Tsmin" variable_2="Ts_min"/><map_variables variable_1="Tpmin" variable_2="Tp_min"/><map_variables variable_1="Gs" variable_2="Gs"/><map_variables variable_1="Gp" variable_2="Gp"/></connection><connection><map_components component_1="Nervous_System" component_2="PNS_tones"/><map_variables variable_1="alpha_cns" variable_2="alpha_cns"/><map_variables variable_1="alpha_s0" variable_2="alpha_s0"/><map_variables variable_1="alpha_p0" variable_2="alpha_p0"/></connection><component name="Norepinephrine"><variable name="q_nor" public_interface="in" units="per_s"/><variable name="Ts" public_interface="in" units="AU"/><variable name="t" public_interface="in" units="second"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>c_nor</ci></apply><apply><plus/><apply><minus/><apply><divide/><ci>c_nor</ci><ci>tau_nor</ci></apply></apply><apply><times/><ci>q_nor</ci><ci>Ts</ci></apply></apply></apply></math><variable initial_value="1.441" name="c_nor" public_interface="out" units="AU"/><variable name="tau_nor" public_interface="in" units="second"/></component><connection><map_components component_1="Environmental" component_2="Norepinephrine"/><map_variables variable_1="Time" variable_2="t"/></connection><connection><map_components component_1="Parameters" component_2="Norepinephrine"/><map_variables variable_1="q_nor" variable_2="q_nor"/><map_variables variable_1="tau_nor" variable_2="tau_nor"/></connection><connection><map_components component_1="PNS_tones" component_2="Norepinephrine"/><map_variables variable_1="Ts" variable_2="Ts"/></connection><component name="Acetylcholine"><variable initial_value="1.0" name="C_ach" public_interface="out" units="AU"/><variable name="Tau_ach" public_interface="in" units="second"/><variable name="q_ach" public_interface="in" units="per_s"/><variable name="Tp" public_interface="in" units="AU"/><variable name="t" public_interface="in" units="second"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>C_ach</ci></apply><apply><plus/><apply><minus/><apply><divide/><ci>C_ach</ci><ci>Tau_ach</ci></apply></apply><apply><times/><ci>q_ach</ci><ci>Tp</ci></apply></apply></apply></math></component><connection><map_components component_1="Environmental" component_2="Acetylcholine"/><map_variables variable_1="Time" variable_2="t"/></connection><connection><map_components component_1="Parameters" component_2="Acetylcholine"/><map_variables variable_1="tau_ach" variable_2="Tau_ach"/><map_variables variable_1="q_ach" variable_2="q_ach"/></connection><connection><map_components component_1="PNS_tones" component_2="Acetylcholine"/><map_variables variable_1="Tp" variable_2="Tp"/></connection><component name="Heart_Response_Nor"><variable name="delta_HR_ss" units="Beats_per_min"/><variable name="delta_HR_smax" units="Beats_per_min"/><variable name="HR_max" public_interface="in" units="Beats_per_min"/><variable name="C_nor" public_interface="in" units="AU"/><variable name="K_nor" public_interface="in" units="AU"/><variable name="HR0" public_interface="in" units="Beats_per_min"/><variable initial_value="0" name="delta_HR_s" public_interface="out" units="Beats_per_min"/><variable name="Tau_HR_nor" public_interface="in" units="second"/><variable name="t" public_interface="in" units="second"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><ci>delta_HR_ss</ci><apply><divide/><apply><times/><ci>delta_HR_smax</ci><apply><power/><ci>C_nor</ci><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn></apply></apply><apply><plus/><apply><power/><ci>K_nor</ci><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn></apply><apply><power/><ci>C_nor</ci><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn></apply></apply></apply></apply><apply><eq/><ci>delta_HR_smax</ci><apply><minus/><ci>HR_max</ci><ci>HR0</ci></apply></apply><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>delta_HR_s</ci></apply><apply><divide/><apply><plus/><apply><minus/><ci>delta_HR_s</ci></apply><ci>delta_HR_ss</ci></apply><ci>Tau_HR_nor</ci></apply></apply></math></component><connection><map_components component_1="Environmental" component_2="Heart_Response_Nor"/><map_variables variable_1="Time" variable_2="t"/></connection><connection><map_components component_1="Parameters" component_2="Heart_Response_Nor"/><map_variables variable_1="HRmax" variable_2="HR_max"/><map_variables variable_1="K_nor" variable_2="K_nor"/><map_variables variable_1="tau_HR_nor" variable_2="Tau_HR_nor"/><map_variables variable_1="HRo" variable_2="HR0"/></connection><connection><map_components component_1="Norepinephrine" component_2="Heart_Response_Nor"/><map_variables variable_1="c_nor" variable_2="C_nor"/></connection><component name="HR_ach"><variable name="delta_HR_ps" units="Beats_per_min"/><variable name="delta_HR_pmax" units="Beats_per_min"/><variable name="C_ach" public_interface="in" units="AU"/><variable name="K_ach" public_interface="in" units="AU"/><variable name="HR0" public_interface="in" units="Beats_per_min"/><variable name="HR_min" public_interface="in" units="Beats_per_min"/><variable name="t" public_interface="in" units="second"/><variable name="delta_HR_pfast" units="Beats_per_min"/><variable initial_value="0" name="delta_HR_pslow" units="Beats_per_min"/><variable name="delta_HR_p" public_interface="out" units="Beats_per_min"/><variable name="Gamma" public_interface="in" units="dimensionless"/><math xmlns="http://www.w3.org/1998/Math/MathML"><apply><eq/><ci>delta_HR_ps</ci><apply><divide/><apply><times/><ci>delta_HR_pmax</ci><apply><power/><ci>C_ach</ci><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn></apply></apply><apply><plus/><apply><power/><ci>K_ach</ci><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn></apply><apply><power/><ci>C_ach</ci><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">2</cn></apply></apply></apply></apply><apply><eq/><ci>delta_HR_pmax</ci><apply><minus/><ci>HR0</ci><ci>HR_min</ci></apply></apply><apply><eq/><ci>delta_HR_pfast</ci><apply><times/><ci>Gamma</ci><ci>delta_HR_ps</ci></apply></apply><apply><eq/><apply><diff/><bvar><ci>t</ci></bvar><ci>delta_HR_pslow</ci></apply><apply><divide/><apply><plus/><apply><minus/><ci>delta_HR_pslow</ci></apply><apply><times/><apply><minus/><cn xmlns:cellml="http://www.cellml.org/cellml/1.1#" cellml:units="dimensionless">1</cn><ci>Gamma</ci></apply><ci>delta_HR_ps</ci></apply></apply><ci>tau_HR_ach</ci></apply></apply><apply><eq/><ci>delta_HR_p</ci><apply><plus/><ci>delta_HR_pfast</ci><ci>delta_HR_pslow</ci></apply></apply></math><variable name="tau_HR_ach" public_interface="in" units="second"/></component><connection><map_components component_1="Environmental" component_2="HR_ach"/><map_variables variable_1="Time" variable_2="t"/></connection><connection><map_components component_1="Parameters" component_2="HR_ach"/><map_variables variable_1="K_ach" variable_2="K_ach"/><map_variables variable_1="Gamma" variable_2="Gamma"/><map_variables variable_1="HRo" variable_2="HR0"/><map_variables variable_1="HRmin" variable_2="HR_min"/><map_variables variable_1="tau_HR_ach" variable_2="tau_HR_ach"/></connection><connection><map_components component_1="Acetylcholine" component_2="HR_ach"/><map_variables variable_1="C_ach" variable_2="C_ach"/></connection><component name="HR_Combined"><variable name="HR" units="Beats_per_min"/><variable name="HR_p" units="Beats_per_min"/><variable name="HR_s" units="Beats_per_min"/><variable name="HR0" public_interface="in" units="Beats_per_min"/><variable name="HR_min" public_interface="in" units="Beats_per_min"/><variable name="Beta" public_interface="in" units="dimensionless"/><variable name="delta_HR_s" public_interface="in" units="Beats_per_min"/><variable name="delta_HR_p" public_interface="in" units="Beats_per_min"/><math 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