Computer model of action potential of mouse ventricular myocytes
Noble
Penny
Oxford University
Model Status
This CellML model runs in both OpenCell and COR to reproduce the the action potential traces from Figure 16 of the publication. This model represents the SEPTAL CELL variant as described in Bondarenko et al.'s 2004 paper.
Model Structure
ABSTRACT: We have developed a mathematical model of the mouse ventricular myocyte action potential (AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever possible, we used Markov models to represent the molecular structure and function of ion channels. The model includes detailed intracellular Ca2+ dynamics, with simulations of localized events such as sarcoplasmic Ca2+ release into a small intracellular volume bounded by the sarcolemma and sarcoplasmic reticulum. Transporter-mediated Ca2+ fluxes from the bulk cytosol are closely matched to the experimentally reported values and predict stimulation rate-dependent changes in Ca2+ transients. Our model reproduces the properties of cardiac myocytes from two different regions of the heart: the apex and the septum. The septum has a relatively prolonged AP, which reflects a relatively small contribution from the rapid transient outward K+ current in the septum. The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice.
The original paper reference is cited below:
Computer model of action potential of mouse ventricular myocytes, Vladimir E. Bondarenko, Gyula P. Szigeti, Glenna C. L. Bett, Song-Jung Kim, and Randall L. Rasmusson, 2004,
American Journal of Physiology, 287, H1378-H1403.
PubMed ID: 15142845
cell diagram
Schematic diagram of the mouse model ionic currents and calcium fluxes.
reaction diagram
State diagram of the Markov model for the sodium channel. CNa
denotes a closed channel state, ONa
is the open state, IFNa
represents the fast, inactivated state, I1Na
and I2Na
are the intermediate inactivated states, and IC2Na
and IC3Na
are the closed-inactivation states.
2007-06-14T00:00:00+00:00
2007-06-19T13:05:22+12:00
Version 04 was created by Penny Noble of Oxford University and is known to run in COR and PCEnv. This model represents the SEPTAL CELL variant as described in Bondarenko et al.'s 2004 paper. Version 05 (this version) was created from version 04 by adding a stimulus protocol component to allow simulation of trains of action potentials.
Fixed error in IKs formulation
American Journal of Physiology Heart and Circulatory Physiology
Added cmeta:id's to several variables to allow creation of a session file.
Computer model of action potential of mouse ventricular myocytes (Septal Cell Description)
Department of Physiology, Anatomy & Genetics, University of Oxford
2004-09-01
Penny
Noble
J
70
10000
0.01
G
Bett
C
This file contains a CellML description of Bondarenko et al.'s 2004 mathematical model of the action potential of mouse ventricular myocytes
Catherine Lloyd
James
Lawson
Richard
15142845
Penny
Noble
J
S
Kim
J
2007-11-27T15:33:53+13:00
2007-12-05T14:41:33+13:00
James
Lawson
Richard
2006-01-01
Oxford University
Department of Physiology, Anatomy & Genetics
2007-06-14T12:42:22+12:00
R
Rasmusson
L
James Lawson
B
Bondarenko
E
unknown
unknown
unknown
penny.noble@dpag.ox.ac.uk
A Computer Model for the Action Potential of Mouse Ventricular Myocytes
287 3
1378
1403
Penny's file was modified to add a stimulus protocol component, which allows the model to produce a train of action potentials. The values for duration (0.5ms) and amplitute (-80 picoA_per_picoF) were used. A period of 200ms was used to represent the high heart beat rate of mice.
Units checked, curated.
Penny
Noble
J
keyword
ventricular
cardiac action potential
Ventricular Myocyte
cardiac electrophysiology
calcium dynamics
ventricular myocyte
electrophysiology
cardiac
myocyte
mouse
unknown
2009-05-28T15:40:33+12:00
unknown
Fixed e-notation issue, updated curation status
1000
1000000
0.01
James
Lawson
Richard
G
Szigeti
P
unknown
unknown
1000
10000
0.1