Computer model of action potential of mouse ventricular myocytes
Noble
Penny
Oxford University
Model Status
This CellML model runs in both OpenCell and COR to reproduce the the action potential traces from Figure 16 of the publication. This model represents the APICAL CELL variant as described in Bondarenko et al.'s 2004 paper.
Model Structure
ABSTRACT: We have developed a mathematical model of the mouse ventricular myocyte action potential (AP) from voltage-clamp data of the underlying currents and Ca2+ transients. Wherever possible, we used Markov models to represent the molecular structure and function of ion channels. The model includes detailed intracellular Ca2+ dynamics, with simulations of localized events such as sarcoplasmic Ca2+ release into a small intracellular volume bounded by the sarcolemma and sarcoplasmic reticulum. Transporter-mediated Ca2+ fluxes from the bulk cytosol are closely matched to the experimentally reported values and predict stimulation rate-dependent changes in Ca2+ transients. Our model reproduces the properties of cardiac myocytes from two different regions of the heart: the apex and the septum. The septum has a relatively prolonged AP, which reflects a relatively small contribution from the rapid transient outward K+ current in the septum. The attribution of putative molecular bases for several of the component currents enables our mouse model to be used to simulate the behavior of genetically modified transgenic mice.
The original paper reference is cited below:
Computer model of action potential of mouse ventricular myocytes, Vladimir E. Bondarenko, Gyula P. Szigeti, Glenna C. L. Bett, Song-Jung Kim, and Randall L. Rasmusson, 2004,
American Journal of Physiology, 287, H1378-H1403.
PubMed ID: 15142845
cell diagram
Schematic diagram of the mouse model ionic currents and calcium fluxes.
reaction diagram
State diagram of the Markov model for the sodium channel. CNa
denotes a closed channel state, ONa
is the open state, IFNa
represents the fast, inactivated state, I1Na
and I2Na
are the intermediate inactivated states, and IC2Na
and IC3Na
are the closed-inactivation states.
Penny
Noble
J
Computer model of action potential of mouse ventricular myocytes (Apical Cell Description)
Department of Physiology, Anatomy & Genetics, University of Oxford
Added cmeta:id's to variables
Added cmeta:id's to several variables to allow creation of a session file.
American Journal of Physiology Heart and Circulatory Physiology
penny.noble@dpag.ox.ac.uk
Catherine Lloyd
G
Bett
C
2008-06-20T15:07:36+12:00
B
Bondarenko
E
2007-06-19T13:05:22+12:00
500
10000
0.01
This file contains a CellML description of Bondarenko et al.'s 2004 mathematical model of the action potential of mouse ventricular myocytes
This model represents the APICAL CELL variant as described in Bondarenko et al.'s 2004 paper and is known to run in COR and PCEnv. This model . Version 05 (this version) was created from version 04 by adding a stimulus protocol component to allow simulation of trains of action potentials.
Fixed error in IKs formulation
Computer model of action potential of mouse ventricular myocytes
287
H1378
H1403
James
Lawson
Richard
R
Rasmusson
L
G
Szigeti
P
S
Kim
J
Oxford University
Department of Physiology, Anatomy & Genetics
2007-06-14T12:42:22+12:00
Penny
Noble
J
2004-09-01
2008-06-16T11:07:04+12:00
James
Lawson
Richard
2007-11-27T15:26:19+13:00
2009-05-28T15:39:04+12:00
2007-12-05T14:40:24+13:00
James
Lawson
Richard
James Lawson
Penny
Noble
J
2006-01-01T00:00:00+00:00
Changed stimulus protocol stim length from 70 to 500ms
James
Lawson
Richard
Penny's file was modified to add a stimulus protocol component, which allows the model to produce a train of action potentials. The values for duration (0.5ms) and amplitute (-80 picoA_per_picoF) were used. A period of 200ms was used to represent the high heart beat rate of mice.
unknown
keyword
ventricular
cardiac action potential
Ventricular Myocyte
cardiac electrophysiology
calcium dynamics
ventricular myocyte
electrophysiology
cardiac
myocyte
mouse
Fixed e-notation error, updated curation status.
15142845
1000
1000000
0.01
James
Lawson
Richard
1000
10000
0.1
Units checked, curated.