- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-20 11:47:58+12:00
- Desc:
- Add caption
- Permanent Source URI:
- https://models.fieldml.org/workspace/baf/rawfile/971509f7aa9f3895aa5107709198dd77737b7877/exposure/exposure_frontpage.rst
About
====================
Landing page for the plasma membrane calcium-transporting ATPase (**PMCA**).
Other name for these proteins: Ca\ :math:`{^2}`:math:`{^+}`\ **pump**
Its major function is to catalyze the hydrolysis of ATP coupled with the extrusion of calcium from the cytoplasm to the extracellular space.
Pictures
===================
.. figure:: exposure/Calcium_atpase.png
:width: 50%
:align: center
:alt: pmca_pic
Fig. 1. Rendered image of the PMCA
Subfamilies
===================
The following list contains the known isoforms of PMCA.
.. csv-table:: Variants within the human species
:header: "Channel name", "Alias", Gene, Structure
:widths: 7,7,7,7
PMCA1, ATP2B1, `Uniprot 1 <https://www.uniprot.org/uniprotkb/P20020/entry>`_, `PDB 1 <https://www.ebi.ac.uk/pdbe-srv/view/entry/6A69>`_
PMCA2, ATP2B2, `Uniprot 2 <https://www.uniprot.org/uniprotkb/Q01814/entry>`_, `SMR 2 <https://swissmodel.expasy.org/repository/uniprot/Q01814?csm=7F10221B7B9AC3A2>`_
PMCA3, ATP2B3, `Uniprot 3 <https://www.uniprot.org/uniprotkb/Q16720/entry>`_, `SMR 3 <https://swissmodel.expasy.org/repository/uniprot/Q16720?csm=03B2BA8A0A33B193>`_
PMCA4, ATP2B4, `Uniprot 4 <https://www.uniprot.org/uniprotkb/P23634/entry>`_, `PDB 4 <https://www.ebi.ac.uk/pdbe-srv/view/entry/1CFF>`_
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes <http://www.ncbi.nlm.nih.gov/pubmed/7514509>`_", "Luo and Rudy"
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_pCa <https://models.physiomeproject.org/workspace/833>`_", "S Fong"
"`A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes*^ <https://models.physiomeproject.org/exposure/8f2ba36d47893780d4a1b41ae1b1a959>`_", "Luo and Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
..
Other annotations
..
===================
