- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-08 14:28:03+12:00
- Desc:
- Fixing details of subfamilies and adding picture
- Permanent Source URI:
- https://models.fieldml.org/workspace/b80/rawfile/d55b019e0960fcddfba24ae1b1a289024ba0a6c2/exposure/exposure_frontpage.rst
About
====================
Landing page for the delayed rectifier potassium channel, of both rapid (Kr) and slow (Ks) variants (**Kr** and **Ks**).
Other name for this protein: **Kv**, **KCNx** (x denotes letter from A to H)
Kv is thought to be tetrameric - made of four units of the pore-forming, alpha subunit protein. This is assembled with one or more units of the regulatory beta subunit. There may be other subunits that control channel gating.
Pictures
===================
.. figure:: exposure/K_channel_wikipedia.png
:width: 100%
:align: center
:alt: Kr_pic
Fig. 1. Schematic of delayed rectifier potassium channel action (purple channel), transferring potassium ions (purple triangles) from the extracellular fluid into the cell cytosol.
Subfamilies
===================
alpha units from wiki:
Kvα1.x: Kv1.1 (KCNA1), Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv1.6 (KCNA6), Kv1.7 (KCNA7), Kv1.8 (KCNA10)
Kvα2.x: Kv2.1 (KCNB1), Kv2.2 (KCNB2)
Kvα3.x: Kv3.1 (KCNC1), Kv3.2 (KCNC2), Kv3.3 (KCNC3), Kv3.4 (KCNC4)
Kvα7.x: Kv7.1 (KCNQ1/KvLQT1), Kv7.2 (KCNQ2), Kv7.3 (KCNQ3), Kv7.4 (KCNQ4), Kv7.5 (KCNQ5)
Kvα10.x: Kv10.1 (KCNH1), Kv10.2 (KCNH2)
beta: KCNE
Known associates of Kr: KCNA2, KCNH2, KCNE2
Known associates of Ks: KCNB1, KCNE1 (with KCNQ1), KCNE3 (with KCNB1), KCNG1-4 (Kv6.x), KCNS1-3, KCIP4 (with KCND2)
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_Kr <https://models.physiomeproject.org/workspace/82c>`_", "S Fong"
"`Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death*^ <https://models.physiomeproject.org/e/514>`_", "C Clancy and Y Rudy"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
"`A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^ <https://models.physiomeproject.org/exposure/2d2ce7737b42a4f72d6bf8b67f6eb5a2>`_", "C Luo and Y Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 30, 15
"KCNE1 structure", "`PDB <https://www.rcsb.org/structure/2K21>`_"
"KCNE2 structure", "`PDB <https://www.rcsb.org/structure/2M0Q>`_"
"KCNE3 structure", "`PDB <https://www.rcsb.org/structure/2NDJ>`_"
"KCNE1 protein", "`Uniprot 1 <https://www.uniprot.org/uniprotkb/P15382/entry>`_"
"KCNE2 protein", "`Uniprot 2 <https://www.uniprot.org/uniprotkb/Q9Y6J6/entry>`_"
"KCNE3 protein", "`Uniprot 3 <https://www.uniprot.org/uniprotkb/Q9Y6H6/entry>`_"
"m", "n"
"Voltage gated potassium channel subunits Kv1-12", "Reactome <https://reactome.org/content/detail/R-HSA-1296098>`_" "Protein activity", "`Gene ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0005251>`_"
"Hierarchy of Kv channels", "`Interpro <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR003968/>`_"
