- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-08-08 16:59:54+12:00
- Desc:
- adding table template
- Permanent Source URI:
- https://models.fieldml.org/workspace/b80/rawfile/9c2ca00eabdf0bdc36a9b39e1ff1dc482815c4b2/exposure/exposure_frontpage.rst
About
====================
Landing page for the delayed rectifier potassium channel, of both rapid (Kr) and slow (Ks) variants (**Kr** and **Ks**).
Other name for this protein: **Kv**, **KCNx** (x denotes letter from A to H)
Kv is thought to be tetrameric - made of four units of the pore-forming, alpha subunit protein. This is assembled with one or more units of the regulatory beta subunit. There may be other subunits that control channel gating.
Pictures
===================
.. figure:: exposure/K_channel_wikipedia.png
:width: 100%
:align: center
:alt: Kr_pic
Fig. 1. Schematic of delayed rectifier potassium channel action (purple channel), transferring potassium ions (purple triangles) from the extracellular fluid into the cell cytosol.
Subfamilies
===================
The following list contains a portion of all 12 subfamilies that fall under the Kv group. This portion pertains to the delayed rectifier current only.
.. csv-table:: Variants within the human species
:header: "Name", "Alias", "x", "Subunit", "Associates with", "Participants in", "Gene", "Structure"
:widths: 7, 15, 7, 7, 10, 10, 7, 7
"Kv1.x", "KCNAx", "1", "alpha", " ", " ", " ", " "
" ", " ", "2 ", "alpha", " ", "Kr", " ", " "
" ", " ", "3 ", "alpha", " ", " ", " ", " "
" ", " ", "5 ", "alpha", " ", " ", " ", " "
" ", " ", "6 ", "alpha", " ", " ", " ", " "
" ", " ", "7 ", "alpha", " ", " ", " ", " "
" ", " ", "8 ", "alpha", " ", " ", " ", " "
"Kv2.x", "KCNBx", "1", "alpha", " ", "Ks", " ", " "
" ", " ", "2 ", "alpha ", " ", " ", " ", " "
"Kv3.x", "KCNCx", "1", alpha" ", " ", " ", " ", " "
" ", " ", "2", "alpha", " ", " ", " ", " "
" ", " ", "3", "alpha", " ", " ", " ", " "
" ", " ", "4", "alpha", " ", " ", " ", " "
"Kv6.x", "KCNGx", "1", alpha" ", " ", "Ks", " ", " "
" ", " ", "2", "alpha ", " ", "Ks", " ", " "
" ", " ", "3", "alpha ", " ", "Ks", " ", " "
" ", " ", "4", "alpha ", " ", "Ks", " ", " "
"Kv9.x", "KCNSx", "1", alpha" ", " ", "Ks", " ", " "
" ", " ", "2", "alpha", " ", "Ks", " ", " "
" ", " ", "3", "alpha", " ", "Ks", " ", " "
"Kv7.x", "KCNQx", "1", "alpha", " ", "Ks", " ", " "
" ", " ", "2", "alpha", " ", " ", " ", " "
" ", " ", "3", "alpha", " ", " ", " ", " "
" ", " ", "4", "alpha", " ", " ", " ", " "
" ", " ", "5", "alpha", " ", " ", " ", " "
"Kv10.x", "KCNHx", "1", "alpha", " ", " ", " ", " "
" ", " ", "2", "alpha", " ", "Kr", " ", " "
" ", "KCNEx", "1", "beta", KCNQ1", "Ks", " ", " "
" ", " ", "2", "beta", " ", "Kr", " ", " "
" ", " ", "3", "beta", "KCNB1", "Ks", " ", " "
Known associates of Kr: KCNA2, KCNH2, KCNE2
Known associates of Ks: KCNB1, KCNE1 (with KCNQ1), KCNE3 (with KCNB1), KCNG1-4 (Kv6.x), KCNS1-3, KCIP4 (with KCND2)
Literature
===================
.. csv-table:: For further reading
:header: "Title", "Author"
:widths: 30, 15
"`A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources <https://doi.org/10.1113/JP278739>`_", "Kernik et al."
Existing models
===================
.. csv-table:: Link to other PMR workspaces or exposures
:header: "Title", "Author"
:widths: 30, 15
"`BG_Kr <https://models.physiomeproject.org/workspace/82c>`_", "S Fong"
"`BG_Ks <https://models.physiomeproject.org/workspace/82d>`_", "S Fong"
"`Cellular consequences of HERG mutations in the long QT syndrome: precursors to sudden cardiac death*^ <https://models.physiomeproject.org/e/514>`_", "C Clancy and Y Rudy"
"`Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states^ <https://github.com/uomsystemsbiology/bond_graph_cardiac_AP>`_", "M Pan et al."
"`A Model of the Ventricular Cardiac Action Potential - Depolarisation, Repolarisation and Their Interaction*^ <https://models.physiomeproject.org/exposure/2d2ce7737b42a4f72d6bf8b67f6eb5a2>`_", "C Luo and Y Rudy"
Models denoted by [*] are not in bond graph form.
Models denoted by [^] are part of a whole cell model.
Other annotations
===================
.. csv-table::
:header: "Item", "Database"
:widths: 30, 15
"KCNE1 structure", "`PDB <https://www.rcsb.org/structure/2K21>`_"
"KCNE2 structure", "`PDB <https://www.rcsb.org/structure/2M0Q>`_"
"KCNE3 structure", "`PDB <https://www.rcsb.org/structure/2NDJ>`_"
"KCNE1 protein", "`Uniprot 1 <https://www.uniprot.org/uniprotkb/P15382/entry>`_"
"KCNE2 protein", "`Uniprot 2 <https://www.uniprot.org/uniprotkb/Q9Y6J6/entry>`_"
"KCNE3 protein", "`Uniprot 3 <https://www.uniprot.org/uniprotkb/Q9Y6H6/entry>`_"
"m", "n"
"Voltage gated potassium channel subunits Kv1-12", "Reactome <https://reactome.org/content/detail/R-HSA-1296098>`_" "Protein activity", "`Gene ontology <https://www.ebi.ac.uk/QuickGO/term/GO:0005251>`_"
"Hierarchy of Kv channels", "`Interpro <https://www.ebi.ac.uk/interpro/entry/InterPro/IPR003968/>`_"
