The Noble cardiac ventricular electrophysiology models in CellML

D. P. Nickerson, P. J. Hunter

A PDF of the this article is available: nickerson.pdf.

In our article we presented a review of the cardiac ventricular electrophysiology models developed by Prof. Denis Noble and colleagues. The CellML language was used to describe these models and we make available here the CellML models described in this review and the specific simulations performed. The simulations were all performed using the mozCellML extension for mozilla.

1. 1962 Noble
2. 1975 Hunter et al.
3. 1975 McAllister et al.
4. 1985 DiFrancesco & Noble
5. 1998 Noble et al.

1962 Noble

The CellML XML source files can be found here:

• the base model;
• the free running simulation; and
• the periodic stimulus simulation.

The results presented in Fig. 4 are the combination of these simulations, which can be run in mozCellML by clicking on the following links. In each case the parameters in the numerical integration tab of the model viewer window need to be altered: the time interval should be set to 0ms,10000ms; and the maximum step size needs to be 0.01.

• Free running pacemaker version of the model.
• Quiescent version of the model with a periodic stimulus applied. The stimPeriod variable can be used to control the period of the applied stimulus.

1975 Hunter et al.

The CellML XML source files can be found here:

• the base model;
• the voltage clamp simulation; and
• the current stimulus simulation.

The results presented in Fig. 5 are the combination of these simulations, which can be run in mozCellML by clicking on the link.

• Current response to a voltage clamp. For this simulation membrane potential varies linearly with time. The plot from Fig. 5(a) can be produced by setting the time interval to 0ms,100ms with a grid resolution of 0.1ms and a maximum time step of 0.01ms.
• Membrane potential response to a current injection. Need to set the final time to 50ms, the step size to 0.1ms and the maximum step size to 0.01ms.

1975 McAllister et al.

The CellML file can be obtained here as an XML file. This is a pure CellML 1.0 model containing all neccessary boundary and initial conditions.

The results presented in Fig. 6 include the following simulation, which can be run in mozCellML by clicking on the link.

• Pacemaker action potentials. The only setting needing to be changed for this simulation is to set the end of the time interval to 5000ms.

1985 DiFrancesco & Noble

The CellML file can be obtained here as an XML file. This is a pure CellML 1.0 model containing all neccessary boundary and initial conditions.

The results presented in Fig. 6 include the following simulation, which can be run in mozCellML by clicking on the link.

• Pacemaker action potentials. The only setting needing to be changed for this simulation is to set the end of the time interval to 5000ms.

1998 Noble et al.

The CellML file can be obtained here as an XML file. This is a pure CellML 1.0 model containing all neccessary boundary and initial conditions.

The results presented in Fig. 7 include the following simulation, which can be run in mozCellML by clicking on the link.

• Applied periodic stimulus current. The stimPeriod variable can be used to control the period of the applied stimulus and g_pna can be set to 0 to turn off the persistent sodium current.

1975 McAllister et al.

The CellML file can be obtained here as an XML file. This is a pure CellML 1.0 model containing all neccessary boundary and initial conditions.

The results presented in Fig. 6 include the following simulation, which can be run in mozCellML by clicking on the link.

• Pacemaker action potentials. The only setting needing to be changed for this simulation is to set the end of the time interval to 5000ms.

1985 DiFrancesco & Noble

The CellML file can be obtained here as an XML file. This is a pure CellML 1.0 model containing all neccessary boundary and initial conditions.

The results presented in Fig. 6 include the following simulation, which can be run in mozCellML by clicking on the link.

• Pacemaker action potentials. The only setting needing to be changed for this simulation is to set the end of the time interval to 5000ms.

1998 Noble et al.

The CellML file can be obtained here as an XML file. This is a pure CellML 1.0 model containing all neccessary boundary and initial conditions.

The results presented in Fig. 7 include the following simulation, which can be run in mozCellML by clicking on the link.

• Applied periodic stimulus current. The stimPeriod variable can be used to control the period of the applied stimulus and g_pna can be set to 0 to turn off the persistent sodium current.