def model individual_AE as
 def import using "units_and_constants/units_BG.cellml" for
        unit mM using unit mM;
        unit fmol using unit fmol;
        unit per_fmol using unit per_fmol;
        unit J_per_mol using unit J_per_mol;
        unit fmol_per_sec using unit fmol_per_sec;
        unit C_per_mol using unit C_per_mol;
        unit fF using unit fF;
        unit fC using unit fC;
        unit per_second using unit per_second;
        unit per_sec using unit per_sec;
        unit J_per_K_per_mol using unit J_per_K_per_mol;
        unit fmol_per_L using unit fmol_per_L;
        unit pL using unit pL;
   enddef;
def import using "units_and_constants/constants_BG.cellml" for
            comp constants using comp constants;
enddef;

    def comp environment as
    var time: second {pub: out};
    // initial values
var q_HCO3_i: fmol {init: 1e-888, pub: out};
var q_HCO3_o: fmol {init: 1e-888, pub: out};
var q_Cl_i: fmol {init: 1e-888, pub: out};
var q_Cl_o: fmol {init: 1e-888, pub: out};
var q_S1_AE: fmol {init: 1e-888, pub: out};
var q_S2_AE: fmol {init: 1e-888, pub: out};
var q_S3_AE: fmol {init: 1e-888, pub: out};
var q_S4_AE: fmol {init: 1e-888, pub: out};
var q_S5_AE: fmol {init: 1e-888, pub: out};
var q_S6_AE: fmol {init: 1e-888, pub: out};
var q_H_i: fmol {init: 1e-888, pub: out};
var q_H_o: fmol {init: 1e-888, pub: out};
// From submodule
var v_R61_AE: fmol_per_sec {pub: in};
var v_R12_AE: fmol_per_sec {pub: in};
var v_R23_AE: fmol_per_sec {pub: in};
var v_R34_AE: fmol_per_sec {pub: in};
var v_R45_AE: fmol_per_sec {pub: in};
var v_R56_AE: fmol_per_sec {pub: in};
var v_R61_pHi_AE: fmol_per_sec {pub: in};
var v_R12_pHi_AE: fmol_per_sec {pub: in};
var v_R23_pHi_AE: fmol_per_sec {pub: in};
var v_R34_pHi_AE: fmol_per_sec {pub: in};
var v_R45_pHi_AE: fmol_per_sec {pub: in};
var v_R56_pHi_AE: fmol_per_sec {pub: in};
var v_R61_pHo_AE: fmol_per_sec {pub: in};
var v_R12_pHo_AE: fmol_per_sec {pub: in};
var v_R23_pHo_AE: fmol_per_sec {pub: in};
var v_R34_pHo_AE: fmol_per_sec {pub: in};
var v_R45_pHo_AE: fmol_per_sec {pub: in};
var v_R56_pHo_AE: fmol_per_sec {pub: in};
ode(q_HCO3_i, time) = vvv;
ode(q_HCO3_o, time) = vvv;
ode(q_Cl_i, time) = vvv;
ode(q_Cl_o, time) = vvv;
ode(q_S1_AE, time) = vvv;
ode(q_S2_AE, time) = vvv;
ode(q_S3_AE, time) = vvv;
ode(q_S4_AE, time) = vvv;
ode(q_S5_AE, time) = vvv;
ode(q_S6_AE, time) = vvv;
ode(q_H_i, time) = vvv;
ode(q_H_o, time) = vvv;
enddef;

def comp AE_parameters as
var kappa_R61_AE: fmol_per_sec {init: 2.36097e+07, pub: out};
var kappa_R12_AE: fmol_per_sec {init: 7.51684e+13, pub: out};
var kappa_R23_AE: fmol_per_sec {init: 6.66566e+14, pub: out};
var kappa_R34_AE: fmol_per_sec {init: 2.41161e+07, pub: out};
var kappa_R45_AE: fmol_per_sec {init: 6.62911e+14, pub: out};
var kappa_R56_AE: fmol_per_sec {init: 7.4803e+13, pub: out};
var kappa_R61_pHi_AE: fmol_per_sec {init: 2.06816e-28, pub: out};
var kappa_R12_pHi_AE: fmol_per_sec {init: 2.07337e-28, pub: out};
var kappa_R23_pHi_AE: fmol_per_sec {init: 2.07369e-28, pub: out};
var kappa_R34_pHi_AE: fmol_per_sec {init: 2.06816e-28, pub: out};
var kappa_R45_pHi_AE: fmol_per_sec {init: 2.06264e-28, pub: out};
var kappa_R56_pHi_AE: fmol_per_sec {init: 2.06296e-28, pub: out};
var kappa_R61_pHo_AE: fmol_per_sec {init: 6.75544e+10, pub: out};
var kappa_R12_pHo_AE: fmol_per_sec {init: 6.77245e+10, pub: out};
var kappa_R23_pHo_AE: fmol_per_sec {init: 6.77351e+10, pub: out};
var kappa_R34_pHo_AE: fmol_per_sec {init: 6.75544e+10, pub: out};
var kappa_R45_pHo_AE: fmol_per_sec {init: 6.73743e+10, pub: out};
var kappa_R56_pHo_AE: fmol_per_sec {init: 6.73848e+10, pub: out};
var K_HCO3_i: per_fmol {init: 2.37042e-05, pub: out};
var K_HCO3_o: per_fmol {init: 0.000173879, pub: out};
var K_Cl_i: per_fmol {init: 2.67479e-06, pub: out};
var K_Cl_o: per_fmol {init: 1.96083e-05, pub: out};
var K_S1_AE: per_fmol {init: 3.88601e-07, pub: out};
var K_S2_AE: per_fmol {init: 3.88541e-07, pub: out};
var K_S3_AE: per_fmol {init: 3.8848e-07, pub: out};
var K_S4_AE: per_fmol {init: 3.90622e-07, pub: out};
var K_S5_AE: per_fmol {init: 3.90561e-07, pub: out};
var K_S6_AE: per_fmol {init: 3.905e-07, pub: out};
var K_H_i: per_fmol {init: 906184, pub: out};
var K_H_o: per_fmol {init: 618732, pub: out};
enddef;
def comp AE as
        var time: second {pub: in};
        var R: J_per_K_per_mol {pub: in};
        var T: kelvin {pub: in};
        // parameters
var kappa_R61_AE: fmol_per_sec {pub: in};
var kappa_R12_AE: fmol_per_sec {pub: in};
var kappa_R23_AE: fmol_per_sec {pub: in};
var kappa_R34_AE: fmol_per_sec {pub: in};
var kappa_R45_AE: fmol_per_sec {pub: in};
var kappa_R56_AE: fmol_per_sec {pub: in};
var kappa_R61_pHi_AE: fmol_per_sec {pub: in};
var kappa_R12_pHi_AE: fmol_per_sec {pub: in};
var kappa_R23_pHi_AE: fmol_per_sec {pub: in};
var kappa_R34_pHi_AE: fmol_per_sec {pub: in};
var kappa_R45_pHi_AE: fmol_per_sec {pub: in};
var kappa_R56_pHi_AE: fmol_per_sec {pub: in};
var kappa_R61_pHo_AE: fmol_per_sec {pub: in};
var kappa_R12_pHo_AE: fmol_per_sec {pub: in};
var kappa_R23_pHo_AE: fmol_per_sec {pub: in};
var kappa_R34_pHo_AE: fmol_per_sec {pub: in};
var kappa_R45_pHo_AE: fmol_per_sec {pub: in};
var kappa_R56_pHo_AE: fmol_per_sec {pub: in};
var K_HCO3_i: per_fmol {pub: in};
var K_HCO3_o: per_fmol {pub: in};
var K_Cl_i: per_fmol {pub: in};
var K_Cl_o: per_fmol {pub: in};
var K_S1_AE: per_fmol {pub: in};
var K_S2_AE: per_fmol {pub: in};
var K_S3_AE: per_fmol {pub: in};
var K_S4_AE: per_fmol {pub: in};
var K_S5_AE: per_fmol {pub: in};
var K_S6_AE: per_fmol {pub: in};
var K_H_i: per_fmol {pub: in};
var K_H_o: per_fmol {pub: in};
// Input from global environment
var q_HCO3_i: fmol {pub: in};
var q_HCO3_o: fmol {pub: in};
var q_Cl_i: fmol {pub: in};
var q_Cl_o: fmol {pub: in};
var q_S1_AE: fmol {pub: in};
var q_S2_AE: fmol {pub: in};
var q_S3_AE: fmol {pub: in};
var q_S4_AE: fmol {pub: in};
var q_S5_AE: fmol {pub: in};
var q_S6_AE: fmol {pub: in};
var q_H_i: fmol {pub: in};
var q_H_o: fmol {pub: in};
// Constitutive parameters
var mu_HCO3_i: J_per_mol;
var mu_HCO3_o: J_per_mol;
var mu_Cl_i: J_per_mol;
var mu_Cl_o: J_per_mol;
var mu_S1_AE: J_per_mol;
var mu_S2_AE: J_per_mol;
var mu_S3_AE: J_per_mol;
var mu_S4_AE: J_per_mol;
var mu_S5_AE: J_per_mol;
var mu_S6_AE: J_per_mol;
var mu_H_i: J_per_mol;
var mu_H_o: J_per_mol;
var v_R61_AE: fmol_per_sec {pub: out};
var v_R12_AE: fmol_per_sec {pub: out};
var v_R23_AE: fmol_per_sec {pub: out};
var v_R34_AE: fmol_per_sec {pub: out};
var v_R45_AE: fmol_per_sec {pub: out};
var v_R56_AE: fmol_per_sec {pub: out};
var v_R61_pHi_AE: fmol_per_sec {pub: out};
var v_R12_pHi_AE: fmol_per_sec {pub: out};
var v_R23_pHi_AE: fmol_per_sec {pub: out};
var v_R34_pHi_AE: fmol_per_sec {pub: out};
var v_R45_pHi_AE: fmol_per_sec {pub: out};
var v_R56_pHi_AE: fmol_per_sec {pub: out};
var v_R61_pHo_AE: fmol_per_sec {pub: out};
var v_R12_pHo_AE: fmol_per_sec {pub: out};
var v_R23_pHo_AE: fmol_per_sec {pub: out};
var v_R34_pHo_AE: fmol_per_sec {pub: out};
var v_R45_pHo_AE: fmol_per_sec {pub: out};
var v_R56_pHo_AE: fmol_per_sec {pub: out};
mu_HCO3_i = R*T*ln(K_HCO3_i*q_HCO3_i);
mu_HCO3_o = R*T*ln(K_HCO3_o*q_HCO3_o);
mu_Cl_i = R*T*ln(K_Cl_i*q_Cl_i);
mu_Cl_o = R*T*ln(K_Cl_o*q_Cl_o);
mu_S1_AE = R*T*ln(K_S1_AE*q_S1_AE);
mu_S2_AE = R*T*ln(K_S2_AE*q_S2_AE);
mu_S3_AE = R*T*ln(K_S3_AE*q_S3_AE);
mu_S4_AE = R*T*ln(K_S4_AE*q_S4_AE);
mu_S5_AE = R*T*ln(K_S5_AE*q_S5_AE);
mu_S6_AE = R*T*ln(K_S6_AE*q_S6_AE);
mu_H_i = R*T*ln(K_H_i*q_H_i);
mu_H_o = R*T*ln(K_H_o*q_H_o);
v_R61_AE = kappa_R61_AE*(ppp);
v_R12_AE = kappa_R12_AE*(ppp);
v_R23_AE = kappa_R23_AE*(ppp);
v_R34_AE = kappa_R34_AE*(ppp);
v_R45_AE = kappa_R45_AE*(ppp);
v_R56_AE = kappa_R56_AE*(ppp);
v_R61_pHi_AE = kappa_R61_pHi_AE*(ppp);
v_R12_pHi_AE = kappa_R12_pHi_AE*(ppp);
v_R23_pHi_AE = kappa_R23_pHi_AE*(ppp);
v_R34_pHi_AE = kappa_R34_pHi_AE*(ppp);
v_R45_pHi_AE = kappa_R45_pHi_AE*(ppp);
v_R56_pHi_AE = kappa_R56_pHi_AE*(ppp);
v_R61_pHo_AE = kappa_R61_pHo_AE*(ppp);
v_R12_pHo_AE = kappa_R12_pHo_AE*(ppp);
v_R23_pHo_AE = kappa_R23_pHo_AE*(ppp);
v_R34_pHo_AE = kappa_R34_pHo_AE*(ppp);
v_R45_pHo_AE = kappa_R45_pHo_AE*(ppp);
v_R56_pHo_AE = kappa_R56_pHo_AE*(ppp);
enddef;
def map between environment and AE for
vars time and time;
vars q_HCO3_i and q_HCO3_i;
vars q_HCO3_o and q_HCO3_o;
vars q_Cl_i and q_Cl_i;
vars q_Cl_o and q_Cl_o;
vars q_S1_AE and q_S1_AE;
vars q_S2_AE and q_S2_AE;
vars q_S3_AE and q_S3_AE;
vars q_S4_AE and q_S4_AE;
vars q_S5_AE and q_S5_AE;
vars q_S6_AE and q_S6_AE;
vars q_H_i and q_H_i;
vars q_H_o and q_H_o;
vars v_R61_AE and v_R61_AE;
vars v_R12_AE and v_R12_AE;
vars v_R23_AE and v_R23_AE;
vars v_R34_AE and v_R34_AE;
vars v_R45_AE and v_R45_AE;
vars v_R56_AE and v_R56_AE;
vars v_R61_pHi_AE and v_R61_pHi_AE;
vars v_R12_pHi_AE and v_R12_pHi_AE;
vars v_R23_pHi_AE and v_R23_pHi_AE;
vars v_R34_pHi_AE and v_R34_pHi_AE;
vars v_R45_pHi_AE and v_R45_pHi_AE;
vars v_R56_pHi_AE and v_R56_pHi_AE;
vars v_R61_pHo_AE and v_R61_pHo_AE;
vars v_R12_pHo_AE and v_R12_pHo_AE;
vars v_R23_pHo_AE and v_R23_pHo_AE;
vars v_R34_pHo_AE and v_R34_pHo_AE;
vars v_R45_pHo_AE and v_R45_pHo_AE;
vars v_R56_pHo_AE and v_R56_pHo_AE;
enddef;
def map between AE and AE_parameters for
vars kappa_R61_AE and kappa_R61_AE;
vars kappa_R12_AE and kappa_R12_AE;
vars kappa_R23_AE and kappa_R23_AE;
vars kappa_R34_AE and kappa_R34_AE;
vars kappa_R45_AE and kappa_R45_AE;
vars kappa_R56_AE and kappa_R56_AE;
vars kappa_R61_pHi_AE and kappa_R61_pHi_AE;
vars kappa_R12_pHi_AE and kappa_R12_pHi_AE;
vars kappa_R23_pHi_AE and kappa_R23_pHi_AE;
vars kappa_R34_pHi_AE and kappa_R34_pHi_AE;
vars kappa_R45_pHi_AE and kappa_R45_pHi_AE;
vars kappa_R56_pHi_AE and kappa_R56_pHi_AE;
vars kappa_R61_pHo_AE and kappa_R61_pHo_AE;
vars kappa_R12_pHo_AE and kappa_R12_pHo_AE;
vars kappa_R23_pHo_AE and kappa_R23_pHo_AE;
vars kappa_R34_pHo_AE and kappa_R34_pHo_AE;
vars kappa_R45_pHo_AE and kappa_R45_pHo_AE;
vars kappa_R56_pHo_AE and kappa_R56_pHo_AE;
vars K_HCO3_i and K_HCO3_i;
vars K_HCO3_o and K_HCO3_o;
vars K_Cl_i and K_Cl_i;
vars K_Cl_o and K_Cl_o;
vars K_S1_AE and K_S1_AE;
vars K_S2_AE and K_S2_AE;
vars K_S3_AE and K_S3_AE;
vars K_S4_AE and K_S4_AE;
vars K_S5_AE and K_S5_AE;
vars K_S6_AE and K_S6_AE;
vars K_H_i and K_H_i;
vars K_H_o and K_H_o;
enddef;
def map between constants and AE for
vars R and R;
 vars T and T;
enddef;
enddef;