def model individual_pCa_sarcolemmal as def import using "units_and_constants/units_BG.cellml" for unit mM using unit mM; unit fmol using unit fmol; unit per_fmol using unit per_fmol; unit J_per_mol using unit J_per_mol; unit fmol_per_sec using unit fmol_per_sec; unit C_per_mol using unit C_per_mol; unit J_per_C using unit J_per_C; unit microm3 using unit microm3; unit fF using unit fF; unit fC using unit fC; unit fA using unit fA; unit per_second using unit per_second; unit millivolt using unit millivolt; unit per_sec using unit per_sec; unit J_per_K_per_mol using unit J_per_K_per_mol; unit fmol_per_L using unit fmol_per_L; unit fmol_per_L_per_sec using unit fmol_per_L_per_sec; unit per_sec_per_fmol_per_L using unit per_sec_per_fmol_per_L; unit uM using unit uM; unit mM_per_sec using unit mM_per_sec; unit uM_per_sec using unit uM_per_sec; unit pL using unit pL; unit m_to_u using unit m_to_u; enddef; def import using "units_and_constants/constants_BG.cellml" for comp constants using comp constants; enddef; def comp environment as var time: second {pub: out}; // initial values var q_Ca_i: fmol {init: 1e-888, pub: out}; var q_Ca_o: fmol {init: 1e-888, pub: out}; var q_pCa: fmol {init: 1e-888, pub: out}; var q_pCa_Ca: fmol {init: 1e-888, pub: out}; // From submodule var v_pCa_R1: fmol_per_sec {pub: in}; var v_pCa_R2: fmol_per_sec {pub: in}; ode(q_Ca_i, time) = vvv; ode(q_Ca_o, time) = vvv; ode(q_pCa, time) = vvv; ode(q_pCa_Ca, time) = vvv; enddef; def comp pCa_sarcolemmal_parameters as var kappa_pCa_R1: fmol_per_sec {init: 161.883, pub: out}; var kappa_pCa_R2: fmol_per_sec {init: 161.883, pub: out}; var K_Ca_i: per_fmol {init: 84692.2, pub: out}; var K_Ca_o: per_fmol {init: 2.80997e-07, pub: out}; var K_pCa: per_fmol {init: 0.123323, pub: out}; var K_pCa_Ca: per_fmol {init: 179.573, pub: out}; enddef; def comp pCa_sarcolemmal as var time: second {pub: in}; var R: J_per_K_per_mol {pub: in}; var T: kelvin {pub: in}; // parameters var kappa_pCa_R1: fmol_per_sec {pub: in}; var kappa_pCa_R2: fmol_per_sec {pub: in}; var K_Ca_i: per_fmol {pub: in}; var K_Ca_o: per_fmol {pub: in}; var K_pCa: per_fmol {pub: in}; var K_pCa_Ca: per_fmol {pub: in}; // Input from global environment var q_Ca_i: fmol {pub: in}; var q_Ca_o: fmol {pub: in}; var q_pCa: fmol {pub: in}; var q_pCa_Ca: fmol {pub: in}; // Constitutive parameters var mu_Ca_i: J_per_mol; var mu_Ca_o: J_per_mol; var mu_pCa: J_per_mol; var mu_pCa_Ca: J_per_mol; var v_pCa_R1: fmol_per_sec {pub: out}; var v_pCa_R2: fmol_per_sec {pub: out}; mu_Ca_i = R*T*ln(K_Ca_i*q_Ca_i); mu_Ca_o = R*T*ln(K_Ca_o*q_Ca_o); mu_pCa = R*T*ln(K_pCa*q_pCa); mu_pCa_Ca = R*T*ln(K_pCa_Ca*q_pCa_Ca); v_pCa_R1 = ppp; v_pCa_R2 = ppp; enddef; def map between environment and pCa_sarcolemmal for vars time and time; vars q_Ca_i and q_Ca_i; vars q_Ca_o and q_Ca_o; vars q_pCa and q_pCa; vars q_pCa_Ca and q_pCa_Ca; vars v_pCa_R1 and v_pCa_R1; vars v_pCa_R2 and v_pCa_R2; enddef; def map between pCa_sarcolemmal and pCa_sarcolemmal_parameters for vars kappa_pCa_R1 and kappa_pCa_R1; vars kappa_pCa_R2 and kappa_pCa_R2; vars K_Ca_i and K_Ca_i; vars K_Ca_o and K_Ca_o; vars K_pCa and K_pCa; vars K_pCa_Ca and K_pCa_Ca; enddef; def map between constants and pCa_sarcolemmal for vars R and R; vars T and T; enddef; enddef;