- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-27 14:26:17+12:00
- Desc:
- Updating captions
- Permanent Source URI:
- https://models.fieldml.org/workspace/702/rawfile/013a1f6b66817f0be90630420f0c7fd83618cd18/RST/Fig4_CaL.rst
About this model
====================
:Original publication: `Kernik et al. (2019)`_:
"A computational model of induced pluripotent stem-cell derived cardiomyocytes \
incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
:DOI: https://dx.doi.org/10.1113%2FJP277724
.. _`Kernik et al. (2019)`: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767694/
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Figure 04
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Calcium current model
*************************************
`Current_Ica.cellml`_ is the main CellML files which contains the formulation for L-type calcium current.
Its associated SED-ML file contains all the simulation settings.
To execute the code, all the files related to this channel need to be downloaded in a same folder:
1. Fig4_CaL.py
2. Current_Ica.cellml
3. Current_Ica.sedml
4. parameter_Ica.cellml
5. parameter.cellml
6. gating_Ica.cellml
7. unit.cellml
To reproduce Figure 4, save all the files to the same folder and
execute the following script from the command line:
``$ cd [PathToThisFile]``
``$ [PathToOpenCOR]/pythonshell Fig4_CaL.py``
.. figure:: figures/Figure4_CaL.png
:width: 85%
:align: center
:alt: Calcium current model
A, L-type calcium current (ICaL) steady-state inactivation and activation
curves with dataset-specific model optimized to experimental data. The L-type calcium
model used in the baseline cellular model is shown in black.
B, I-V curves for ICaL, C, time constants of ICaL activation gate. D, time
constants of ICaL inactivation gate.
.. _`Current_Ica.cellml`: https://models.physiomeproject.org/workspace/702/file/98f5f62a7e8d3e057f3d24027e38ed91a2a185ed/Current_Ica.cellml
.. _`fig4_CaL.py`: https://models.physiomeproject.org/workspace/702/file/98f5f62a7e8d3e057f3d24027e38ed91a2a185ed/fig4_CaL.py
