- Author:
- Shelley Fong <sfon036@UoA.auckland.ac.nz>
- Date:
- 2024-09-27 14:26:17+12:00
- Desc:
- Updating captions
- Permanent Source URI:
- https://models.fieldml.org/workspace/702/rawfile/013a1f6b66817f0be90630420f0c7fd83618cd18/RST/Fig10_Ca.rst
About this model
====================
:Original publication: `Kernik et al. (2019)`_:
"A computational model of induced pluripotent stem-cell derived cardiomyocytes
incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
:DOI: https://dx.doi.org/10.1113%2FJP277724
.. _`Kernik et al. (2019)`: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6767694/
************
Figure 10
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Calcium handling in the iPSC-CM model
****************************************
`Channels.cellml`_ is the main CellML file which incorporates the handling of calcium within the cell. Its associated SED-ML file contains all the simulation settings.
To execute the code, all the files related to this channel need to be downloaded in a same folder:
1. fig10_Ca.py
2. Channels.cellml
3. Channels.sedml
4. parameter.cellml
5. unit.cellml
To reproduce Figure 10, save all the files to the same folder and
execute the following script from the command line:
``$ cd [PathToThisFile]``
``$ [PathToOpenCOR]/pythonshell fig10_Ca.py``
.. figure:: figures/Figure10_Ca.png
:width: 85%
:align: center
A, baseline model the calcium transient. B, relative contribution of calcium from :math:`I_{SERCA}`, :math:`I_{NCX}` and :math:`I_{PMCA}` to the calcium transient during a single AP in the baseline mode. (Blue: 62% SERCA, Red: 31% NCX, Yellow: 7% non-NCX (SL-pump))
.. _`Channels.cellml`: https://models.physiomeproject.org/workspace/702/file/98f5f62a7e8d3e057f3d24027e38ed91a2a185ed/Channels.cellml
.. _`fig10_Ca.py`: https://models.physiomeproject.org/workspace/702/file/98f5f62a7e8d3e057f3d24027e38ed91a2a185ed/fig10_Ca.py
