A Model For Circadian PER Oscillations In Drosophila
Catherine
Lloyd
Auckland Bioengineering Institute, The University of Auckland
Model Status
This CellML model runs in both OpenCell and COR to reproduce Figure 2 in the original published paper by Goldbeter in the 1995 model 'A Model For Circadian PER Oscillations In Drosophila', as referenced as the gerard_gonze_goldbeter_2009 model . The units have been checked and they are consistent.
Model Structure
ABSTRACT: The mechanism of circadian oscillations in the period protein (PER) in Drosophila is investigated by means of a theoretical model. Taking into account recent experimental observations, the model for the circadian clock is based on multiple phosphorylation of PER and on the negative feedback exerted by PER on the transcription of the period (per) gene. This minimal biochemical model provides a molecular basis for circadian oscillations of the limit cycle type. During oscillations, the peak in per mRNA precedes by several hours the peak in total PER protein. The results support the view that multiple PER phosphorylation introduces times delays which strengthen the capability of negative feedback to produce oscillations. The analysis shows that the rhythm only occurs in a range bounded by two critical values of the maximum rate of PER degradation. A similar result is obtained with respect to the rate of PER transport into the nucleus. The results suggest a tentative explanation for the altered period of per mutants, in terms of variations in the rate of PER degradation.
The original paper reference is cited below:
A Model for Circadian Oscillations in the Drosophila Period Protein (PER), Albert Goldbeter, 1995, Proceedings of the Royal Society of London, Series B, Biological Sciences, 261, 319-324. PubMed ID: 8587874
reaction diagram
Schematic diagram of the model for circadian oscillations in PER protein and per mRNA.
Auckland Bioengineering Institute, The University of AucklandFixed link to the correct figure diagram.Proceedings of the Royal Society of London series BAlbert Goldbeter's 1995 model for circadian oscillations in the
Drosophila period protein (PER).DrosophilaLloydCatherineMay85878740.016010000Pttotal PER proteinc.lloyd@auckland.ac.nzCatherine Lloydadded cmeta:id's to variables, changed documentationcell cycledrosophilacircadian rhythmsdrosophila period proteinMper mRNAP2bisphosphorylated PER protein1995-09-22keywordThis is the CellML description of Albert Goldbeter's 1995 model for circadian oscillations in the Drosophila period protein (PER).PNnuclear bisphosphorylated PER protein2008-08-29T15:07:19+12:00A model for circadian oscillations in the Drosophila period protein (PER)261319324LloydCatherineMayP0PER proteinGoldbeterAlbertP1phosphorylated PER protein2007-06-14T11:56:49+12:00The University of AucklandAuckland Bioengineering InstituteLawsonJamesRichard2003-10-30T00:00:00+00:00