- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2011-03-21 16:56:17+13:00
- Desc:
- updating the initial documentation to enable better navigation of a more complete exposure of the current state of the workspace.
- Permanent Source URI:
- https://models.fieldml.org/w/andre/cortassa-ECME-2006/rawfile/24ae0a590dc46cc7e4bfb1a017c61678ae6ca6b8/cellml/components/model.xml
<?xml version="1.0" encoding="iso-8859-1"?>
<model
name="cortassa_ECME_model_2006_model"
cmeta:id="model"
xmlns="http://www.cellml.org/cellml/1.1#"
xmlns:cellml="http://www.cellml.org/cellml/1.1#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:xlink="http://www.w3.org/1999/xlink">
<rdf:RDF
xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#"
xmlns:cmeta="http://www.cellml.org/metadata/1.0#"
xmlns:bqs="http://www.cellml.org/bqs/1.0#"
xmlns:dc="http://purl.org/dc/elements/1.1/"
xmlns:dcterms="http://purl.org/dc/terms/"
xmlns:vCard="http://www.w3.org/2001/vcard-rdf/3.0#"
xmlns:cs="http://www.cellml.org/metadata/simulation/1.0#"
xmlns:cg="http://www.cellml.org/metadata/graphs/1.0#">
<rdf:Description rdf:ID="andre">
<vCard:N rdf:parseType="Resource">
<vCard:Family>Nickerson</vCard:Family>
<vCard:Given>David</vCard:Given>
</vCard:N>
<vCard:EMAIL rdf:parseType="Resource">
<rdf:value>david.nickerson@nus.edu.sg</rdf:value>
<rdf:type rdf:resource="http://imc.org/vCard/3.0#internet"/>
</vCard:EMAIL>
<vCard:ORG rdf:parseType="Resource">
<vCard:Orgname>National University of Singapore</vCard:Orgname>
<vCard:Orgunit>Division of Bioengineering</vCard:Orgunit>
</vCard:ORG>
</rdf:Description>
<rdf:Description rdf:about="#model">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This is the main model component for the CellML encoding of the Cortassa et al (2006) Biophys J model.
</rdf:value>
</cmeta:comment>
<dc:creator rdf:resource="#andre"/>
<dcterms:created rdf:parseType="Resource">
<dcterms:W3CDTF>2008-06-11</dcterms:W3CDTF>
</dcterms:created>
<dc:publisher>
Division of Bioengineering, National University of Singapore
</dc:publisher>
<bqs:reference rdf:parseType="Resource">
<bqs:Pubmed_id>16679365</bqs:Pubmed_id>
</bqs:reference>
<cmeta:modification rdf:parseType="Resource">
<rdf:value>
Adding #clamp_ATPi and #clamp_ATPi_cyto variables to the model to allow the ATP concentration variables to be clamped in order to reproduce figure 6(a) from the original Cortassa et al (2006) Biophys J article.
</rdf:value>
<cmeta:modifier rdf:resource="#andre"/>
<dcterms:modified rdf:parseType="Resource">
<dcterms:W3CDTF>2009-01-06</dcterms:W3CDTF>
</dcterms:modified>
</cmeta:modification>
</rdf:Description>
<rdf:Description rdf:about="#clamp_ATPi">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This variable is used to clamp the value of [ATP]i at a constant value. The rate equation for [ATP]i is multiplied by the value (1-clamp_ATPi) - i.e., set clamp_ATPi = 1.0 in order to clamp the concentration.
</rdf:value>
</cmeta:comment>
</rdf:Description>
<rdf:Description rdf:about="#clamp_ATPi_cyto">
<cmeta:comment rdf:parseType="Resource">
<rdf:value>
This variable is used to clamp the value of [ATP]ic at a constant value. The rate equation for [ATP]ic is multiplied by the value (1-clamp_ATPi_cyto) - i.e., set clamp_ATPi_cyto = 1.0 in order to clamp the concentration.
</rdf:value>
</cmeta:comment>
</rdf:Description>
</rdf:RDF>
<import xlink:href="units.xml">
<units name="cm_per_ms" units_ref="cm_per_ms"/>
<units name="per_mV" units_ref="per_mV"/>
<units name="cm2_per_uF" units_ref="cm2_per_uF"/>
<units name="mM" units_ref="mM"/>
<units name="per_mM" units_ref="per_mM"/>
<units name="C_per_mol" units_ref="C_per_mol"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="per_mM3_per_ms" units_ref="per_mM3_per_ms"/>
<units name="mV" units_ref="mV"/>
<units name="mM_per_ms4" units_ref="mM_per_ms4"/>
<units name="mM3_cm2_per_uA" units_ref="mM3_cm2_per_uA"/>
<units name="uA_per_cm2" units_ref="uA_per_cm2"/>
<units name="mM3" units_ref="mM3"/>
<units name="per_mM4_per_ms" units_ref="per_mM4_per_ms"/>
<units name="mV_per_mM" units_ref="mV_per_mM"/>
<units name="mM_per_ms_per_mV" units_ref="mM_per_ms_per_mV"/>
<units name="mM_per_ms" units_ref="mM_per_ms"/>
<units name="mM2" units_ref="mM2"/>
<units name="mmol_per_C_per_cm" units_ref="mmol_per_C_per_cm"/>
<units name="per_mM_per_ms" units_ref="per_mM_per_ms"/>
<units name="N_per_mm2" units_ref="N_per_mm2"/>
<units name="cm2_per_uA" units_ref="cm2_per_uA"/>
<units name="mS_per_cm2" units_ref="mS_per_cm2"/>
<units name="cm_per_s" units_ref="cm_per_s"/>
<units name="C_cm_per_s_per_mol" units_ref="C_cm_per_s_per_mol"/>
<units name="TODO" units_ref="TODO"/>
</import>
<component name="model">
<variable name="ADP" cmeta:id="ADP" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ATPi" initial_value="ATPi_initial" cmeta:id="ATPi" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ATPi_initial" cmeta:id="ATPi_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="clamp_ATPi" cmeta:id="clamp_ATPi" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="inv_ATPi" cmeta:id="inv_ATPi" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VF_over_RT" cmeta:id="VF_over_RT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="V" initial_value="V_initial" cmeta:id="V" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="V_initial" cmeta:id="V_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="exp_VF_over_RT" cmeta:id="exp_VF_over_RT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VFsq_over_RT" cmeta:id="VFsq_over_RT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="exp2VFRT" cmeta:id="exp2VFRT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="O1_RyR" cmeta:id="O1_RyR" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C1_RyR" initial_value="C1_RyR_initial" cmeta:id="C1_RyR" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C1_RyR_initial" cmeta:id="C1_RyR_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="C2_RyR" initial_value="C2_RyR_initial" cmeta:id="C2_RyR" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C2_RyR_initial" cmeta:id="C2_RyR_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="O2_RyR" initial_value="O2_RyR_initial" cmeta:id="O2_RyR" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="O2_RyR_initial" cmeta:id="O2_RyR_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="V_30" cmeta:id="V_30" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="V_E_K" cmeta:id="V_E_K" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="INa" cmeta:id="INa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="mNa" initial_value="mNa_initial" cmeta:id="mNa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="mNa_initial" cmeta:id="mNa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="hNa" initial_value="hNa_initial" cmeta:id="hNa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="hNa_initial" cmeta:id="hNa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="jNa" initial_value="jNa_initial" cmeta:id="jNa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="jNa_initial" cmeta:id="jNa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="IKs" cmeta:id="IKs" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="xKs" initial_value="xKs_initial" cmeta:id="xKs" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="xKs_initial" cmeta:id="xKs_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="K1Alpha" cmeta:id="K1Alpha" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="K1Beta" cmeta:id="K1Beta" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="K1_inf" cmeta:id="K1_inf" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="IK1" cmeta:id="IK1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="INab" cmeta:id="INab" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="IKp" cmeta:id="IKp" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ICamax" cmeta:id="ICamax" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ICaK" cmeta:id="ICaK" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Open" initial_value="Open_initial" cmeta:id="Open" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Open_initial" cmeta:id="Open_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="OCa" initial_value="OCa_initial" cmeta:id="OCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="OCa_initial" cmeta:id="OCa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="yCa" initial_value="yCa_initial" cmeta:id="yCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="yCa_initial" cmeta:id="yCa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Ki" initial_value="Ki_initial" cmeta:id="Ki" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Ki_initial" cmeta:id="Ki_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="ICa" cmeta:id="ICa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="NaiP1p5" cmeta:id="NaiP1p5" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Nai" initial_value="Nai_initial" cmeta:id="Nai" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Nai_initial" cmeta:id="Nai_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="INaK" cmeta:id="INaK" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="exp_eta_VF_over_RT" cmeta:id="exp_eta_VF_over_RT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="exp_eta1_VF_over_RT" cmeta:id="exp_eta1_VF_over_RT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="INaCa" cmeta:id="INaCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Cai" initial_value="Cai_initial" cmeta:id="Cai" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Cai_initial" cmeta:id="Cai_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="ICab" cmeta:id="ICab" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="IpCa" cmeta:id="IpCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CaiP3" cmeta:id="CaiP3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="common" cmeta:id="common" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="InsNa" cmeta:id="InsNa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="InsK" cmeta:id="InsK" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="InsCa" cmeta:id="InsCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="V_AM" cmeta:id="V_AM" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ATPm" cmeta:id="ATPm" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ADPm" initial_value="ADPm_initial" cmeta:id="ADPm" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ADPm_initial" cmeta:id="ADPm_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="DmuH" cmeta:id="DmuH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Dpsi" initial_value="Dpsi_initial" cmeta:id="Dpsi" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Dpsi_initial" cmeta:id="Dpsi_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="NAD" cmeta:id="NAD" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="NADH" initial_value="NADH_initial" cmeta:id="NADH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="NADH_initial" cmeta:id="NADH_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="KmIDNAD_NAD" cmeta:id="KmIDNAD_NAD" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="exp_FRT_6_g_DmuH" cmeta:id="exp_FRT_6_g_DmuH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="FRT2_Dpsi" cmeta:id="FRT2_Dpsi" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VCS" cmeta:id="VCS" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Oaa" initial_value="Oaa_initial" cmeta:id="Oaa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Oaa_initial" cmeta:id="Oaa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="VACO" cmeta:id="VACO" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="AKG" initial_value="AKG_initial" cmeta:id="AKG" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="AKG_initial" cmeta:id="AKG_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="SCoA" initial_value="SCoA_initial" cmeta:id="SCoA" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="SCoA_initial" cmeta:id="SCoA_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Succ" initial_value="Succ_initial" cmeta:id="Succ" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Succ_initial" cmeta:id="Succ_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="FUM" initial_value="FUM_initial" cmeta:id="FUM" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="FUM_initial" cmeta:id="FUM_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="MAL" initial_value="MAL_initial" cmeta:id="MAL" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="MAL_initial" cmeta:id="MAL_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="ISOC" initial_value="ISOC_initial" cmeta:id="ISOC" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ISOC_initial" cmeta:id="ISOC_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Fa" cmeta:id="Fa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Cam" initial_value="Cam_initial" cmeta:id="Cam" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Cam_initial" cmeta:id="Cam_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Fi" cmeta:id="Fi" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VIDH" cmeta:id="VIDH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="a__1" cmeta:id="a__1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VKGDH" cmeta:id="VKGDH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VSL" cmeta:id="VSL" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VSDH" cmeta:id="VSDH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VFH" cmeta:id="VFH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VMDH" cmeta:id="VMDH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VAAT" cmeta:id="VAAT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="AREN" cmeta:id="AREN" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="denominator1" cmeta:id="denominator1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="denominator2" cmeta:id="denominator2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="denominator3" cmeta:id="denominator3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VNO" cmeta:id="VNO" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VHNe" cmeta:id="VHNe" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VHFe" cmeta:id="VHFe" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="exp_3FRT_DmuH" cmeta:id="exp_3FRT_DmuH" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="AF1" cmeta:id="AF1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VATPase" cmeta:id="VATPase" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Vhu" cmeta:id="Vhu" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ATPi_ADP" cmeta:id="ATPi_ADP" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ADPm_ATPm" cmeta:id="ADPm_ATPm" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VANT" cmeta:id="VANT" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Vhleak" cmeta:id="Vhleak" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="MAlpha" cmeta:id="MAlpha" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="MBeta" cmeta:id="MBeta" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="inv_MBeta_MAlpha" cmeta:id="inv_MBeta_MAlpha" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="tmNa" cmeta:id="tmNa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="HAlpha" cmeta:id="HAlpha" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="HBeta" cmeta:id="HBeta" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="JAlpha" cmeta:id="JAlpha" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="JBeta" cmeta:id="JBeta" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="fb" cmeta:id="fb" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="rb" cmeta:id="rb" public_interface="out" private_interface="out" units="per_ms"/>
<variable name="CaNSR" initial_value="CaNSR_initial" cmeta:id="CaNSR" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CaNSR_initial" cmeta:id="CaNSR_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Jup" cmeta:id="Jup" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Jrel" cmeta:id="Jrel" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CaJSR" initial_value="CaJSR_initial" cmeta:id="CaJSR" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CaJSR_initial" cmeta:id="CaJSR_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="CaSS" initial_value="CaSS_initial" cmeta:id="CaSS" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CaSS_initial" cmeta:id="CaSS_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Jtr" cmeta:id="Jtr" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Jxfer" cmeta:id="Jxfer" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P1_N1_P2_P3" cmeta:id="P1_N1_P2_P3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="N1" initial_value="N1_initial" cmeta:id="N1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="N1_initial" cmeta:id="N1_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="P0" initial_value="P0_initial" cmeta:id="P0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P0_initial" cmeta:id="P0_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="P1" initial_value="P1_initial" cmeta:id="P1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P1_initial" cmeta:id="P1_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="P2" initial_value="P2_initial" cmeta:id="P2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P2_initial" cmeta:id="P2_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="P3" initial_value="P3_initial" cmeta:id="P3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P3_initial" cmeta:id="P3_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="N1_differential" cmeta:id="N1_differential" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P0_differential" cmeta:id="P0_differential" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P1_differential" cmeta:id="P1_differential" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P2_differential" cmeta:id="P2_differential" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="P3_differential" cmeta:id="P3_differential" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="FN_Ca" cmeta:id="FN_Ca" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="force_norm" cmeta:id="force_norm" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="force" cmeta:id="force" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="kTrop_np" cmeta:id="kTrop_np" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="LTRPNCa" initial_value="LTRPNCa_initial" cmeta:id="LTRPNCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="LTRPNCa_initial" cmeta:id="LTRPNCa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="HTRPNCa" initial_value="HTRPNCa_initial" cmeta:id="HTRPNCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="HTRPNCa_initial" cmeta:id="HTRPNCa_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="LTRPNCa_differential" cmeta:id="LTRPNCa_differential" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="HTRPNCa_differential" cmeta:id="HTRPNCa_differential" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Jtrpn" cmeta:id="Jtrpn" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="beta_SS" cmeta:id="beta_SS" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="beta_JSR" cmeta:id="beta_JSR" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="beta_i" cmeta:id="beta_i" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Cai_ktrans_plus1" cmeta:id="Cai_ktrans_plus1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Cai_ktrans_plus1_p3" cmeta:id="Cai_ktrans_plus1_p3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="Vuni" cmeta:id="Vuni" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="VnaCa" cmeta:id="VnaCa" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="alpha" cmeta:id="alpha" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="beta" cmeta:id="beta" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="alpha_prime" cmeta:id="alpha_prime" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="beta_prime" cmeta:id="beta_prime" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C0_to_C1" cmeta:id="C0_to_C1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C1_to_C2" cmeta:id="C1_to_C2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C2_to_C3" cmeta:id="C2_to_C3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C3_to_C4" cmeta:id="C3_to_C4" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa0_to_CCa1" cmeta:id="CCa0_to_CCa1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa1_to_CCa2" cmeta:id="CCa1_to_CCa2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa2_to_CCa3" cmeta:id="CCa2_to_CCa3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa3_to_CCa4" cmeta:id="CCa3_to_CCa4" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C1_to_C0" cmeta:id="C1_to_C0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C2_to_C1" cmeta:id="C2_to_C1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C3_to_C2" cmeta:id="C3_to_C2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C4_to_C3" cmeta:id="C4_to_C3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa1_to_CCa0" cmeta:id="CCa1_to_CCa0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa2_to_CCa1" cmeta:id="CCa2_to_CCa1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa3_to_CCa2" cmeta:id="CCa3_to_CCa2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa4_to_CCa3" cmeta:id="CCa4_to_CCa3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="gamma" cmeta:id="gamma" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C0_to_CCa0" cmeta:id="C0_to_CCa0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C1_to_CCa1" cmeta:id="C1_to_CCa1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C2_to_CCa2" cmeta:id="C2_to_CCa2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C3_to_CCa3" cmeta:id="C3_to_CCa3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C4_to_CCa4" cmeta:id="C4_to_CCa4" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa0_to_C0" cmeta:id="CCa0_to_C0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa1_to_C1" cmeta:id="CCa1_to_C1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa2_to_C2" cmeta:id="CCa2_to_C2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa3_to_C3" cmeta:id="CCa3_to_C3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa4_to_C4" cmeta:id="CCa4_to_C4" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C1" initial_value="C1_initial" cmeta:id="C1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C1_initial" cmeta:id="C1_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="CCa0" initial_value="CCa0_initial" cmeta:id="CCa0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa0_initial" cmeta:id="CCa0_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="C0" initial_value="C0_initial" cmeta:id="C0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C0_initial" cmeta:id="C0_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="C2" initial_value="C2_initial" cmeta:id="C2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C2_initial" cmeta:id="C2_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="CCa1" initial_value="CCa1_initial" cmeta:id="CCa1" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa1_initial" cmeta:id="CCa1_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="C3" initial_value="C3_initial" cmeta:id="C3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C3_initial" cmeta:id="C3_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="CCa2" initial_value="CCa2_initial" cmeta:id="CCa2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa2_initial" cmeta:id="CCa2_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="C4" initial_value="C4_initial" cmeta:id="C4" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="C4_initial" cmeta:id="C4_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="CCa3" initial_value="CCa3_initial" cmeta:id="CCa3" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa3_initial" cmeta:id="CCa3_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="CCa4" initial_value="CCa4_initial" cmeta:id="CCa4" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CCa4_initial" cmeta:id="CCa4_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Vt_CRP2" cmeta:id="Vt_CRP2" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CrPi_mito" initial_value="CrPi_mito_initial" cmeta:id="CrPi_mito" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CrPi_mito_initial" cmeta:id="CrPi_mito_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="CrPi_cyto" initial_value="CrPi_cyto_initial" cmeta:id="CrPi_cyto" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="CrPi_cyto_initial" cmeta:id="CrPi_cyto_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="VCK_cyto" cmeta:id="VCK_cyto" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ATPi_cyto" initial_value="ATPi_cyto_initial" cmeta:id="ATPi_cyto" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ATPi_cyto_initial" cmeta:id="ATPi_cyto_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="clamp_ATPi_cyto" cmeta:id="clamp_ATPi_cyto" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="VCK_mito" cmeta:id="VCK_mito" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ASP" initial_value="ASP_initial" cmeta:id="ASP" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="ASP_initial" cmeta:id="ASP_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="N0" initial_value="N0_initial" cmeta:id="N0" public_interface="out" private_interface="out" units="dimensionless"/>
<variable name="N0_initial" cmeta:id="N0_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="Istim" cmeta:id="Istim" public_interface="in" units="dimensionless"/>
<variable name="LHospitalThreshold" cmeta:id="LHospitalThreshold" public_interface="in" units="mV"/>
<variable name="F_over_RT" cmeta:id="F_over_RT" public_interface="in" units="per_mV"/>
<variable name="FaradayE3" cmeta:id="FaradayE3" public_interface="in" units="C_per_mol"/>
<variable name="time" cmeta:id="time" public_interface="in" units="dimensionless"/>
<variable name="E_K" cmeta:id="E_K" public_interface="in" units="dimensionless"/>
<variable name="G_Na" cmeta:id="G_Na" public_interface="in" units="mS_per_cm2"/>
<variable name="E_Na" cmeta:id="E_Na" public_interface="in" units="dimensionless"/>
<variable name="G_Ks" cmeta:id="G_Ks" public_interface="in" units="mS_per_cm2"/>
<variable name="E_Ks" cmeta:id="E_Ks" public_interface="in" units="dimensionless"/>
<variable name="G_K1" cmeta:id="G_K1" public_interface="in" units="mS_per_cm2"/>
<variable name="G_Nab" cmeta:id="G_Nab" public_interface="in" units="mS_per_cm2"/>
<variable name="G_Kp" cmeta:id="G_Kp" public_interface="in" units="mS_per_cm2"/>
<variable name="inv_5p98" cmeta:id="inv_5p98" public_interface="in" units="dimensionless"/>
<variable name="Pca_4En3" cmeta:id="Pca_4En3" public_interface="in" units="cm_per_ms"/>
<variable name="Cao_341" cmeta:id="Cao_341" public_interface="in" units="mM"/>
<variable name="PKFe3" cmeta:id="PKFe3" public_interface="in" units="C_cm_per_s_per_mol"/>
<variable name="Ko" cmeta:id="Ko" public_interface="in" units="mM"/>
<variable name="inv_ICahalf" cmeta:id="inv_ICahalf" public_interface="in" units="cm2_per_uA"/>
<variable name="INaKmax_Ko_Ko_KmKo" cmeta:id="INaKmax_Ko_Ko_KmKo" public_interface="in" units="uA_per_cm2"/>
<variable name="sigma" cmeta:id="sigma" public_interface="in" units="dimensionless"/>
<variable name="Km1AT_NaK" cmeta:id="Km1AT_NaK" public_interface="in" units="mM"/>
<variable name="inv_Ki1AD_NaK" cmeta:id="inv_Ki1AD_NaK" public_interface="in" units="per_mM"/>
<variable name="eta" cmeta:id="eta" public_interface="in" units="dimensionless"/>
<variable name="Nao_p3" cmeta:id="Nao_p3" public_interface="in" units="mM2"/>
<variable name="KmCa_Cao" cmeta:id="KmCa_Cao" public_interface="in" units="mM3_cm2_per_uA"/>
<variable name="KmCa_Cao_ksat" cmeta:id="KmCa_Cao_ksat" public_interface="in" units="mM3_cm2_per_uA"/>
<variable name="G_Cab" cmeta:id="G_Cab" public_interface="in" units="mS_per_cm2"/>
<variable name="E_Ca" cmeta:id="E_Ca" public_interface="in" units="dimensionless"/>
<variable name="IpCamax" cmeta:id="IpCamax" public_interface="in" units="uA_per_cm2"/>
<variable name="KmpCa" cmeta:id="KmpCa" public_interface="in" units="mM"/>
<variable name="Km1ATP_CaP" cmeta:id="Km1ATP_CaP" public_interface="in" units="mM"/>
<variable name="inv_KiADP_CaP" cmeta:id="inv_KiADP_CaP" public_interface="in" units="mM"/>
<variable name="Km2ATP_CaP" cmeta:id="Km2ATP_CaP" public_interface="in" units="mM"/>
<variable name="KmnsCa_p3" cmeta:id="KmnsCa_p3" public_interface="in" units="mM3"/>
<variable name="PnsNa" cmeta:id="PnsNa" public_interface="in" units="cm_per_s"/>
<variable name="Nao" cmeta:id="Nao" public_interface="in" units="mM"/>
<variable name="PnsK" cmeta:id="PnsK" public_interface="in" units="cm_per_s"/>
<variable name="V_AM_scaler_max_1_f_01_12_23" cmeta:id="V_AM_scaler_max_1_f_01_12_23" public_interface="in" units="mM_per_ms4"/>
<variable name="f_01" cmeta:id="f_01" public_interface="in" units="per_ms"/>
<variable name="f_12" cmeta:id="f_12" public_interface="in" units="per_ms"/>
<variable name="f_23" cmeta:id="f_23" public_interface="in" units="per_ms"/>
<variable name="KmATP_AM" cmeta:id="KmATP_AM" public_interface="in" units="mM"/>
<variable name="KmATP_AM_Ki_AM" cmeta:id="KmATP_AM_Ki_AM" public_interface="in" units="dimensionless"/>
<variable name="Cm" cmeta:id="Cm" public_interface="in" units="mM"/>
<variable name="DmuH_Constant" cmeta:id="DmuH_Constant" public_interface="in" units="mV"/>
<variable name="CPN" cmeta:id="CPN" public_interface="in" units="mM"/>
<variable name="KmIDNAD" cmeta:id="KmIDNAD" public_interface="in" units="mM"/>
<variable name="FRT_6_g" cmeta:id="FRT_6_g" public_interface="in" units="per_mV"/>
<variable name="FRT2" cmeta:id="FRT2" public_interface="in" units="per_mV"/>
<variable name="VCS_C1" cmeta:id="VCS_C1" public_interface="in" units="mM_per_ms"/>
<variable name="KmOaa" cmeta:id="KmOaa" public_interface="in" units="mM"/>
<variable name="kfACO" cmeta:id="kfACO" public_interface="in" units="per_ms"/>
<variable name="CIK" cmeta:id="CIK" public_interface="in" units="mM"/>
<variable name="one_inv_KACOeq" cmeta:id="one_inv_KACOeq" public_interface="in" units="dimensionless"/>
<variable name="inv_KADP" cmeta:id="inv_KADP" public_interface="in" units="per_mM"/>
<variable name="inv_KaCa" cmeta:id="inv_KaCa" public_interface="in" units="per_mM"/>
<variable name="inv_KidhNADH" cmeta:id="inv_KidhNADH" public_interface="in" units="per_mM"/>
<variable name="kIDH_EtID" cmeta:id="kIDH_EtID" public_interface="in" units="mM_per_ms"/>
<variable name="VIDH_Constant" cmeta:id="VIDH_Constant" public_interface="in" units="dimensionless"/>
<variable name="Kmiso" cmeta:id="Kmiso" public_interface="in" units="mM"/>
<variable name="nID" cmeta:id="nID" public_interface="in" units="dimensionless"/>
<variable name="Mg_Kmg_1" cmeta:id="Mg_Kmg_1" public_interface="in" units="dimensionless"/>
<variable name="Mg_Kmg_1_Kca" cmeta:id="Mg_Kmg_1_Kca" public_interface="in" units="mM"/>
<variable name="kKGDH_EtKG" cmeta:id="kKGDH_EtKG" public_interface="in" units="mM_per_ms"/>
<variable name="KmKG" cmeta:id="KmKG" public_interface="in" units="mM"/>
<variable name="nKG" cmeta:id="nKG" public_interface="in" units="dimensionless"/>
<variable name="KmKGNAD_KmIDNAD" cmeta:id="KmKGNAD_KmIDNAD" public_interface="in" units="dimensionless"/>
<variable name="kfSL" cmeta:id="kfSL" public_interface="in" units="per_mM_per_ms"/>
<variable name="CoA_KSLeq" cmeta:id="CoA_KSLeq" public_interface="in" units="mM"/>
<variable name="kSDH_EtSDH" cmeta:id="kSDH_EtSDH" public_interface="in" units="mM_per_ms"/>
<variable name="KmSucc" cmeta:id="KmSucc" public_interface="in" units="mM"/>
<variable name="KmSucc_KiFUM" cmeta:id="KmSucc_KiFUM" public_interface="in" units="dimensionless"/>
<variable name="inv_KiOxaa" cmeta:id="inv_KiOxaa" public_interface="in" units="per_mM"/>
<variable name="kfFH" cmeta:id="kfFH" public_interface="in" units="per_ms"/>
<variable name="kfFH_KFHeq" cmeta:id="kfFH_KFHeq" public_interface="in" units="per_ms"/>
<variable name="kMDH_Fh_EtMD" cmeta:id="kMDH_Fh_EtMD" public_interface="in" units="mM_per_ms"/>
<variable name="Kmal" cmeta:id="Kmal" public_interface="in" units="mM"/>
<variable name="Kmal_Kioaa" cmeta:id="Kmal_Kioaa" public_interface="in" units="dimensionless"/>
<variable name="KmmNAD" cmeta:id="KmmNAD" public_interface="in" units="mM"/>
<variable name="VAAT_Constant" cmeta:id="VAAT_Constant" public_interface="in" units="mM_per_ms"/>
<variable name="kcnsASP_KAATeq_kfAAT" cmeta:id="kcnsASP_KAATeq_kfAAT" public_interface="in" units="dimensionless"/>
<variable name="kres_sq_KmIDNAD" cmeta:id="kres_sq_KmIDNAD" public_interface="in" units="per_mM"/>
<variable name="exp_6_FRT_Dpsio" cmeta:id="exp_6_FRT_Dpsio" public_interface="in" units="dimensionless"/>
<variable name="r1_exp_6_FRT_Dpsio" cmeta:id="r1_exp_6_FRT_Dpsio" public_interface="in" units="dimensionless"/>
<variable name="r2" cmeta:id="r2" public_interface="in" units="dimensionless"/>
<variable name="r3" cmeta:id="r3" public_interface="in" units="dimensionless"/>
<variable name="rhoREN_ra_rc1_exp_6_FRT_Dpsio" cmeta:id="rhoREN_ra_rc1_exp_6_FRT_Dpsio" public_interface="in" units="mM_per_ms"/>
<variable name="rhoREN_rc2" cmeta:id="rhoREN_rc2" public_interface="in" units="mM_per_ms"/>
<variable name="rhoREN_ra" cmeta:id="rhoREN_ra" public_interface="in" units="mM_per_ms"/>
<variable name="rhoRen_6_ra" cmeta:id="rhoRen_6_ra" public_interface="in" units="mM_per_ms"/>
<variable name="rhoRen_6_ra_rb" cmeta:id="rhoRen_6_ra_rb" public_interface="in" units="mM_per_ms"/>
<variable name="rhoREF" cmeta:id="rhoREF" public_interface="in" units="mM"/>
<variable name="VFO_VHFe_C1" cmeta:id="VFO_VHFe_C1" public_interface="in" units="per_ms"/>
<variable name="r2_r3_exp_AREF_FRT" cmeta:id="r2_r3_exp_AREF_FRT" public_interface="in" units="dimensionless"/>
<variable name="ra_exp_AREF_FRT" cmeta:id="ra_exp_AREF_FRT" public_interface="in" units="per_ms"/>
<variable name="ra_rb" cmeta:id="ra_rb" public_interface="in" units="per_ms"/>
<variable name="FRT_3" cmeta:id="FRT_3" public_interface="in" units="per_mV"/>
<variable name="kf1_Pi" cmeta:id="kf1_Pi" public_interface="in" units="mM"/>
<variable name="rhoF1" cmeta:id="rhoF1" public_interface="in" units="mM"/>
<variable name="exp_3_FRT_Dpsio" cmeta:id="exp_3_FRT_Dpsio" public_interface="in" units="dimensionless"/>
<variable name="p1_exp_3_FRT_Dpsio" cmeta:id="p1_exp_3_FRT_Dpsio" public_interface="in" units="dimensionless"/>
<variable name="p2" cmeta:id="p2" public_interface="in" units="dimensionless"/>
<variable name="p3" cmeta:id="p3" public_interface="in" units="dimensionless"/>
<variable name="VATPase_C1" cmeta:id="VATPase_C1" public_interface="in" units="per_ms"/>
<variable name="pc2" cmeta:id="pc2" public_interface="in" units="per_ms"/>
<variable name="pa" cmeta:id="pa" public_interface="in" units="per_ms"/>
<variable name="pa_300" cmeta:id="pa_300" public_interface="in" units="per_ms"/>
<variable name="pa_pb_3" cmeta:id="pa_pb_3" public_interface="in" units="per_ms"/>
<variable name="VmDT_75" cmeta:id="VmDT_75" public_interface="in" units="mM_per_ms"/>
<variable name="VmDT_20" cmeta:id="VmDT_20" public_interface="in" units="mM_per_ms"/>
<variable name="hm_F_over_RT" cmeta:id="hm_F_over_RT" public_interface="in" units="per_mV"/>
<variable name="gh" cmeta:id="gh" public_interface="in" units="mM_per_ms_per_mV"/>
<variable name="inv_Kfb" cmeta:id="inv_Kfb" public_interface="in" units="per_mM"/>
<variable name="Nfb" cmeta:id="Nfb" public_interface="in" units="dimensionless"/>
<variable name="inv_Krb" cmeta:id="inv_Krb" public_interface="in" units="per_mM"/>
<variable name="Nrb" cmeta:id="Nrb" public_interface="in" units="dimensionless"/>
<variable name="KSR" cmeta:id="KSR" public_interface="in" units="dimensionless"/>
<variable name="vmaxf" cmeta:id="vmaxf" public_interface="in" units="per_ms"/>
<variable name="vmaxr" cmeta:id="vmaxr" public_interface="in" units="per_ms"/>
<variable name="KmATP_SR" cmeta:id="KmATP_SR" public_interface="in" units="mM"/>
<variable name="KmATP_SR_Ki_SR" cmeta:id="KmATP_SR_Ki_SR" public_interface="in" units="dimensionless"/>
<variable name="inv_Ki_prime_SR" cmeta:id="inv_Ki_prime_SR" public_interface="in" units="per_mM"/>
<variable name="v1" cmeta:id="v1" public_interface="in" units="per_ms"/>
<variable name="inv_tautr" cmeta:id="inv_tautr" public_interface="in" units="per_ms"/>
<variable name="inv_tauxfer" cmeta:id="inv_tauxfer" public_interface="in" units="per_ms"/>
<variable name="alpha_SL_fnormmax2" cmeta:id="alpha_SL_fnormmax2" public_interface="in" units="dimensionless"/>
<variable name="alpha_SL_fnormmax" cmeta:id="alpha_SL_fnormmax" public_interface="in" units="dimensionless"/>
<variable name="zeta_alpha_SL_fnormmax" cmeta:id="zeta_alpha_SL_fnormmax" public_interface="in" units="N_per_mm2"/>
<variable name="kTrop_pn" cmeta:id="kTrop_pn" public_interface="in" units="per_ms"/>
<variable name="inv_LTRPNtot_Ktrop_half" cmeta:id="inv_LTRPNtot_Ktrop_half" public_interface="in" units="per_mM"/>
<variable name="Ntrop" cmeta:id="Ntrop" public_interface="in" units="dimensionless"/>
<variable name="kTrop_pn_f_01" cmeta:id="kTrop_pn_f_01" public_interface="in" units="per_ms"/>
<variable name="g_01_mod" cmeta:id="g_01_mod" public_interface="in" units="per_ms"/>
<variable name="kTrop_pn_f_12_g_01_mod" cmeta:id="kTrop_pn_f_12_g_01_mod" public_interface="in" units="per_ms"/>
<variable name="g_12_mod" cmeta:id="g_12_mod" public_interface="in" units="per_ms"/>
<variable name="f_23_g_12_mod" cmeta:id="f_23_g_12_mod" public_interface="in" units="per_ms"/>
<variable name="g_23_mod" cmeta:id="g_23_mod" public_interface="in" units="per_ms"/>
<variable name="g_01_off_mod" cmeta:id="g_01_off_mod" public_interface="in" units="per_ms"/>
<variable name="kltrpn_plus" cmeta:id="kltrpn_plus" public_interface="in" units="per_mM_per_ms"/>
<variable name="LTRPNtot" cmeta:id="LTRPNtot" public_interface="in" units="mM"/>
<variable name="kltrpn_minus" cmeta:id="kltrpn_minus" public_interface="in" units="per_ms"/>
<variable name="khtrpn_plus" cmeta:id="khtrpn_plus" public_interface="in" units="per_mM_per_ms"/>
<variable name="HTRPNtot" cmeta:id="HTRPNtot" public_interface="in" units="mM"/>
<variable name="khtrpn_minus" cmeta:id="khtrpn_minus" public_interface="in" units="per_ms"/>
<variable name="CMDNtot_KmCMDN" cmeta:id="CMDNtot_KmCMDN" public_interface="in" units="mM2"/>
<variable name="KmCMDN" cmeta:id="KmCMDN" public_interface="in" units="mM"/>
<variable name="CSQNtot_KmCSQN" cmeta:id="CSQNtot_KmCSQN" public_interface="in" units="mM2"/>
<variable name="KmCSQN" cmeta:id="KmCSQN" public_interface="in" units="mM"/>
<variable name="inv_ktrans" cmeta:id="inv_ktrans" public_interface="in" units="per_mM"/>
<variable name="Vmuni_ktrans" cmeta:id="Vmuni_ktrans" public_interface="in" units="per_ms"/>
<variable name="L" cmeta:id="L" public_interface="in" units="dimensionless"/>
<variable name="inv_kact" cmeta:id="inv_kact" public_interface="in" units="per_mM"/>
<variable name="na" cmeta:id="na" public_interface="in" units="dimensionless"/>
<variable name="VmNC" cmeta:id="VmNC" public_interface="in" units="mM_per_ms"/>
<variable name="b_05" cmeta:id="b_05" public_interface="in" units="dimensionless"/>
<variable name="Kna" cmeta:id="Kna" public_interface="in" units="mM"/>
<variable name="n" cmeta:id="n" public_interface="in" units="dimensionless"/>
<variable name="Knca" cmeta:id="Knca" public_interface="in" units="mM"/>
<variable name="Acap_Vmyo_F" cmeta:id="Acap_Vmyo_F" public_interface="in" units="mmol_per_C_per_cm"/>
<variable name="VJSR_VSS" cmeta:id="VJSR_VSS" public_interface="in" units="dimensionless"/>
<variable name="Vmyo_VSS" cmeta:id="Vmyo_VSS" public_interface="in" units="dimensionless"/>
<variable name="Acap_VSS_F" cmeta:id="Acap_VSS_F" public_interface="in" units="mmol_per_C_per_cm"/>
<variable name="Vmyo_VNSR" cmeta:id="Vmyo_VNSR" public_interface="in" units="dimensionless"/>
<variable name="VJSR_VNSR" cmeta:id="VJSR_VNSR" public_interface="in" units="dimensionless"/>
<variable name="inv_C_m" cmeta:id="inv_C_m" public_interface="in" units="cm2_per_uF"/>
<variable name="kaplus" cmeta:id="kaplus" public_interface="in" units="per_mM4_per_ms"/>
<variable name="ncoop" cmeta:id="ncoop" public_interface="in" units="dimensionless"/>
<variable name="kaminus" cmeta:id="kaminus" public_interface="in" units="per_ms"/>
<variable name="kbplus" cmeta:id="kbplus" public_interface="in" units="per_mM3_per_ms"/>
<variable name="mcoop" cmeta:id="mcoop" public_interface="in" units="dimensionless"/>
<variable name="kbminus" cmeta:id="kbminus" public_interface="in" units="per_ms"/>
<variable name="kcplus" cmeta:id="kcplus" public_interface="in" units="per_ms"/>
<variable name="kcminus" cmeta:id="kcminus" public_interface="in" units="per_ms"/>
<variable name="aL" cmeta:id="aL" public_interface="in" units="dimensionless"/>
<variable name="inv_bL" cmeta:id="inv_bL" public_interface="in" units="dimensionless"/>
<variable name="omega" cmeta:id="omega" public_interface="in" units="per_ms"/>
<variable name="gL" cmeta:id="gL" public_interface="in" units="per_ms"/>
<variable name="fL" cmeta:id="fL" public_interface="in" units="per_ms"/>
<variable name="gprime" cmeta:id="gprime" public_interface="in" units="per_ms"/>
<variable name="fprime" cmeta:id="fprime" public_interface="in" units="per_ms"/>
<variable name="kt_2" cmeta:id="kt_2" public_interface="in" units="dimensionless"/>
<variable name="kf_2" cmeta:id="kf_2" public_interface="in" units="dimensionless"/>
<variable name="CRT_cyto" cmeta:id="CRT_cyto" public_interface="in" units="mM"/>
<variable name="inv_keq" cmeta:id="inv_keq" public_interface="in" units="dimensionless"/>
<variable name="kf_3" cmeta:id="kf_3" public_interface="in" units="dimensionless"/>
<variable name="CRT_mito" cmeta:id="CRT_mito" public_interface="in" units="mM"/>
<variable name="VATPase_cyto" cmeta:id="VATPase_cyto" public_interface="in" units="dimensionless"/>
<variable name="fm" cmeta:id="fm" public_interface="in" units="dimensionless"/>
<variable name="two_b" cmeta:id="two_b" public_interface="in" units="dimensionless"/>
<variable name="inv_Cmito" cmeta:id="inv_Cmito" public_interface="in" units="mV_per_mM"/>
<variable name="kcnsASP" cmeta:id="kcnsASP" public_interface="in" units="per_ms"/>
<variable name="KmNai" cmeta:id="KmNai" public_interface="in" units="mM"/>
<math id='math_0' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ADP</ci>
<apply>
<minus/>
<cn cellml:units="TODO">8.0</cn>
<ci>ATPi</ci>
</apply>
</apply>
</math>
<math id='math_1' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>inv_ATPi</ci>
<apply>
<divide/>
<cn cellml:units="TODO">1.0</cn>
<ci>ATPi</ci>
</apply>
</apply>
</math>
<math id='math_2' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VF_over_RT</ci>
<apply>
<times/>
<ci>V</ci>
<ci>F_over_RT</ci>
</apply>
</apply>
</math>
<math id='math_3' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>exp_VF_over_RT</ci>
<apply>
<exp/>
<ci>VF_over_RT</ci>
</apply>
</apply>
</math>
<math id='math_4' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<ci>FaradayE3</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
</math>
<math id='math_5' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>exp2VFRT</ci>
<apply>
<times/>
<ci>exp_VF_over_RT</ci>
<ci>exp_VF_over_RT</ci>
</apply>
</apply>
</math>
<math id='math_6' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>O1_RyR</ci>
<apply>
<minus/>
<cn cellml:units="TODO">1.0</cn>
<apply><plus/>
<ci>C1_RyR</ci>
<ci>C2_RyR</ci>
<ci>O2_RyR</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_7' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>V_30</ci>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="TODO">30.0</cn>
</apply>
</apply>
</math>
<math id='math_8' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>V_E_K</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
</apply>
</math>
<math id='math_9' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>INa</ci>
<apply>
<times/>
<ci>G_Na</ci>
<ci>mNa</ci>
<ci>mNa</ci>
<ci>mNa</ci>
<ci>hNa</ci>
<ci>jNa</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_10' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>IKs</ci>
<apply>
<times/>
<ci>G_Ks</ci>
<ci>xKs</ci>
<ci>xKs</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ks</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<divide/>
<apply>
<minus/>
<ci>V</ci>
<cn cellml:units="TODO">40.0</cn>
</apply>
<cn cellml:units="TODO">40.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_11' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>K1Alpha</ci>
<apply>
<divide/>
<cn cellml:units="TODO">1.02</cn>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="TODO">0.2385</cn>
<apply>
<minus/>
<ci>V_E_K</ci>
<cn cellml:units="TODO">59.215</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_12' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>K1Beta</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<cn cellml:units="TODO">0.4912</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="TODO">0.08032</cn>
<apply>
<plus/>
<ci>V_E_K</ci>
<cn cellml:units="TODO">5.476</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="TODO">0.06175</cn>
<apply>
<minus/>
<ci>V_E_K</ci>
<cn cellml:units="TODO">594.31</cn>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="TODO">-0.5143</cn>
<apply>
<plus/>
<apply>
<minus/>
<ci>V</ci>
<ci>E_K</ci>
</apply>
<cn cellml:units="TODO">4.753</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_13' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>K1_inf</ci>
<apply>
<divide/>
<ci>K1Alpha</ci>
<apply>
<plus/>
<ci>K1Alpha</ci>
<ci>K1Beta</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_14' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>IK1</ci>
<apply>
<times/>
<ci>G_K1</ci>
<ci>K1_inf</ci>
<ci>V_E_K</ci>
</apply>
</apply>
</math>
<math id='math_15' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>INab</ci>
<apply>
<times/>
<ci>G_Nab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Na</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_16' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>IKp</ci>
<apply>
<times/>
<ci>G_Kp</ci>
<apply>
<divide/>
<ci>V_E_K</ci>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="TODO">7.488</cn>
<ci>V</ci>
</apply>
<ci>inv_5p98</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_17' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ICamax</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>Pca_4En3</ci>
<apply>
<minus/>
<ci>exp2VFRT</ci>
<ci>Cao_341</ci>
</apply>
<apply>
<minus/>
<cn cellml:units="TODO">0.5</cn>
<apply>
<times/>
<cn cellml:units="TODO">0.02</cn>
<ci>V</ci>
</apply>
</apply>
</apply>
<apply><lt/>
<apply><abs/>
<ci>V</ci>
</apply>
<ci>LHospitalThreshold</ci>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>Pca_4En3</ci>
<ci>VFsq_over_RT</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>exp2VFRT</ci>
<ci>Cao_341</ci>
</apply>
<apply>
<minus/>
<ci>exp2VFRT</ci>
<cn cellml:units="TODO">1.0</cn>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
<math id='math_18' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ICaK</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>PKFe3</ci>
<apply>
<plus/>
<ci>Open</ci>
<ci>OCa</ci>
</apply>
<ci>yCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<ci>exp2VFRT</ci>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<divide/>
<apply>
<minus/>
<cn cellml:units="TODO">0.5</cn>
<apply>
<times/>
<cn cellml:units="TODO">0.02</cn>
<ci>V</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>ICamax</ci>
<ci>inv_ICahalf</ci>
</apply>
</apply>
</apply>
</apply>
<apply><lt/>
<apply><abs/>
<ci>V</ci>
</apply>
<ci>LHospitalThreshold</ci>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<ci>PKFe3</ci>
<apply>
<plus/>
<ci>Open</ci>
<ci>OCa</ci>
</apply>
<ci>yCa</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<ci>exp2VFRT</ci>
</apply>
<ci>Ko</ci>
</apply>
<apply>
<divide/>
<ci>VF_over_RT</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>exp2VFRT</ci>
<cn cellml:units="TODO">1.0</cn>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>ICamax</ci>
<ci>inv_ICahalf</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
<math id='math_19' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ICa</ci>
<apply>
<times/>
<cn cellml:units="TODO">6.0</cn>
<ci>ICamax</ci>
<ci>yCa</ci>
<ci>Open</ci>
</apply>
</apply>
</math>
<math id='math_20' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>NaiP1p5</ci>
<apply>
<root/>
<apply>
<times/>
<ci>Nai</ci>
<ci>Nai</ci>
<ci>Nai</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_21' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>INaK</ci>
<apply>
<times/>
<ci>INaKmax_Ko_Ko_KmKo</ci>
<apply>
<divide/>
<ci>NaiP1p5</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>NaiP1p5</ci>
<apply><root/>
<apply><times/>
<ci>KmNai</ci>
<ci>KmNai</ci>
<ci>KmNai</ci>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<cn cellml:units="TODO">0.1245</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="TODO">-0.1</cn>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
<apply>
<divide/>
<ci>sigma</ci>
<ci>exp_VF_over_RT</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<apply>
<times/>
<ci>Km1AT_NaK</ci>
<ci>inv_ATPi</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>ADP</ci>
<ci>inv_Ki1AD_NaK</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_22' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>exp_eta_VF_over_RT</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>eta</ci>
<ci>VF_over_RT</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_23' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>exp_eta1_VF_over_RT</ci>
<apply>
<divide/>
<ci>exp_eta_VF_over_RT</ci>
<ci>exp_VF_over_RT</ci>
</apply>
</apply>
</math>
<math id='math_24' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>INaCa</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>exp_eta_VF_over_RT</ci>
<ci>Nai</ci>
<ci>Nai</ci>
<ci>Nai</ci>
</apply>
<apply>
<times/>
<ci>exp_eta1_VF_over_RT</ci>
<ci>Nao_p3</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>KmCa_Cao</ci>
<apply>
<times/>
<ci>KmCa_Cao_ksat</ci>
<ci>exp_eta1_VF_over_RT</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_25' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ICab</ci>
<apply>
<times/>
<ci>G_Cab</ci>
<apply>
<minus/>
<ci>V</ci>
<ci>E_Ca</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_26' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>IpCa</ci>
<apply>
<times/>
<ci>IpCamax</ci>
<apply>
<divide/>
<ci>Cai</ci>
<apply>
<plus/>
<ci>KmpCa</ci>
<ci>Cai</ci>
</apply>
</apply>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<apply>
<times/>
<ci>Km1ATP_CaP</ci>
<ci>inv_ATPi</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>ADP</ci>
<ci>inv_KiADP_CaP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<divide/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>Km2ATP_CaP</ci>
<ci>inv_ATPi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_27' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CaiP3</ci>
<apply>
<times/>
<ci>Cai</ci>
<ci>Cai</ci>
<ci>Cai</ci>
</apply>
</apply>
</math>
<math id='math_28' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>common</ci>
<piecewise>
<piece>
<apply>
<times/>
<cn type='real'>0.75</cn>
<ci>CaiP3</ci>
<apply>
<divide/>
<apply>
<minus/>
<cn type='real'>1.0</cn>
<apply>
<times/>
<cn type='real'>0.02</cn>
<ci>V</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>CaiP3</ci>
<ci>KmnsCa_p3</ci>
</apply>
</apply>
</apply>
<apply><lt/>
<apply><abs/>
<ci>V</ci>
</apply>
<ci>LHospitalThreshold</ci>
</apply>
</piece>
<otherwise>
<apply>
<times/>
<cn cellml:units="TODO">0.75</cn>
<ci>CaiP3</ci>
<apply>
<divide/>
<ci>VFsq_over_RT</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>exp_VF_over_RT</ci>
<cn cellml:units="TODO">1.0</cn>
</apply>
<apply>
<plus/>
<ci>CaiP3</ci>
<ci>KmnsCa_p3</ci>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
<math id='math_29' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>InsNa</ci>
<apply>
<times/>
<ci>PnsNa</ci>
<ci>common</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Nai</ci>
<ci>exp_VF_over_RT</ci>
</apply>
<ci>Nao</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_30' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>InsK</ci>
<apply>
<times/>
<ci>PnsK</ci>
<ci>common</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Ki</ci>
<ci>exp_VF_over_RT</ci>
</apply>
<ci>Ko</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_31' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>InsCa</ci>
<apply>
<plus/>
<ci>InsNa</ci>
<ci>InsK</ci>
</apply>
</apply>
</math>
<math id='math_32' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>V_AM</ci>
<apply>
<times/>
<ci>V_AM_scaler_max_1_f_01_12_23</ci>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<times/>
<ci>f_01</ci>
<ci>P0</ci>
</apply>
<apply>
<times/>
<ci>f_12</ci>
<ci>P1</ci>
</apply>
<apply>
<times/>
<ci>f_23</ci>
<ci>P2</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>inv_ATPi</ci>
<apply>
<plus/>
<ci>KmATP_AM</ci>
<apply>
<times/>
<ci>KmATP_AM_Ki_AM</ci>
<ci>ADP</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_33' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ATPm</ci>
<apply>
<minus/>
<ci>Cm</ci>
<ci>ADPm</ci>
</apply>
</apply>
</math>
<math id='math_34' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>DmuH</ci>
<apply>
<plus/>
<ci>DmuH_Constant</ci>
<ci>Dpsi</ci>
</apply>
</apply>
</math>
<math id='math_35' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>NAD</ci>
<apply>
<minus/>
<ci>CPN</ci>
<ci>NADH</ci>
</apply>
</apply>
</math>
<math id='math_36' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>KmIDNAD_NAD</ci>
<apply>
<divide/>
<ci>KmIDNAD</ci>
<ci>NAD</ci>
</apply>
</apply>
</math>
<math id='math_37' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>exp_FRT_6_g_DmuH</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FRT_6_g</ci>
<ci>DmuH</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_38' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>FRT2_Dpsi</ci>
<apply>
<times/>
<ci>FRT2</ci>
<apply>
<minus/>
<ci>Dpsi</ci>
<cn cellml:units="TODO">91.0</cn>
</apply>
</apply>
</apply>
</math>
<math id='math_39' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VCS</ci>
<apply>
<times/>
<ci>VCS_C1</ci>
<apply>
<divide/>
<ci>Oaa</ci>
<apply>
<plus/>
<ci>Oaa</ci>
<ci>KmOaa</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_40' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VACO</ci>
<apply>
<times/>
<ci>kfACO</ci>
<apply>
<minus/>
<ci>CIK</ci>
<apply><plus/>
<ci>AKG</ci>
<ci>SCoA</ci>
<ci>Succ</ci>
<ci>FUM</ci>
<ci>MAL</ci>
<ci>Oaa</ci>
<apply>
<times/>
<ci>ISOC</ci>
<ci>one_inv_KACOeq</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_41' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Fa</ci>
<apply>
<divide/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>ADPm</ci>
<ci>inv_KADP</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>Cam</ci>
<ci>inv_KaCa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_42' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Fi</ci>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>NADH</ci>
<ci>inv_KidhNADH</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_43' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VIDH</ci>
<apply>
<divide/>
<ci>kIDH_EtID</ci>
<apply>
<plus/>
<ci>VIDH_Constant</ci>
<apply>
<times/>
<ci>KmIDNAD_NAD</ci>
<ci>Fi</ci>
</apply>
<apply>
<times/>
<apply>
<power/>
<apply>
<divide/>
<ci>Kmiso</ci>
<ci>ISOC</ci>
</apply>
<ci>nID</ci>
</apply>
<ci>Fa</ci>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>KmIDNAD_NAD</ci>
<ci>Fi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_44' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>a__1</ci>
<apply>
<plus/>
<ci>Mg_Kmg_1</ci>
<apply>
<times/>
<ci>Mg_Kmg_1_Kca</ci>
<ci>Cam</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_45' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VKGDH</ci>
<apply>
<times/>
<ci>kKGDH_EtKG</ci>
<apply>
<divide/>
<ci>a__1</ci>
<apply>
<plus/>
<ci>a__1</ci>
<apply>
<power/>
<apply>
<divide/>
<ci>KmKG</ci>
<ci>AKG</ci>
</apply>
<ci>nKG</ci>
</apply>
<apply>
<times/>
<ci>KmKGNAD_KmIDNAD</ci>
<ci>KmIDNAD_NAD</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_46' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VSL</ci>
<apply>
<times/>
<ci>kfSL</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>SCoA</ci>
<ci>ADPm</ci>
</apply>
<apply>
<times/>
<ci>CoA_KSLeq</ci>
<ci>Succ</ci>
<ci>ATPm</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_47' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VSDH</ci>
<apply>
<times/>
<ci>kSDH_EtSDH</ci>
<apply>
<divide/>
<ci>Succ</ci>
<apply>
<plus/>
<ci>Succ</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>KmSucc</ci>
<apply>
<times/>
<ci>KmSucc_KiFUM</ci>
<ci>FUM</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>inv_KiOxaa</ci>
<ci>Oaa</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_48' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VFH</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>kfFH</ci>
<ci>FUM</ci>
</apply>
<apply>
<times/>
<ci>kfFH_KFHeq</ci>
<ci>MAL</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_49' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VMDH</ci>
<apply>
<times/>
<ci>kMDH_Fh_EtMD</ci>
<ci>MAL</ci>
<apply>
<divide/>
<ci>NAD</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>MAL</ci>
<ci>Kmal</ci>
<apply>
<times/>
<ci>Oaa</ci>
<ci>Kmal_Kioaa</ci>
</apply>
</apply>
<apply>
<plus/>
<ci>KmmNAD</ci>
<ci>NAD</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_50' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VAAT</ci>
<apply>
<times/>
<ci>VAAT_Constant</ci>
<apply>
<divide/>
<ci>Oaa</ci>
<apply>
<plus/>
<ci>kcnsASP_KAATeq_kfAAT</ci>
<ci>AKG</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_51' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>AREN</ci>
<apply>
<root/>
<apply>
<times/>
<ci>NADH</ci>
<ci>kres_sq_KmIDNAD</ci>
<ci>KmIDNAD_NAD</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_52' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>denominator1</ci>
<apply>
<divide/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<plus/>
<apply>
<plus/>
<ci>exp_6_FRT_Dpsio</ci>
<apply>
<times/>
<ci>r1_exp_6_FRT_Dpsio</ci>
<ci>AREN</ci>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>r2</ci>
<apply>
<times/>
<ci>r3</ci>
<ci>AREN</ci>
</apply>
</apply>
<ci>exp_FRT_6_g_DmuH</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_53' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VNO</ci>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci>rhoREN_ra_rc1_exp_6_FRT_Dpsio</ci>
<apply>
<times/>
<ci>rhoREN_rc2</ci>
<ci>exp_FRT_6_g_DmuH</ci>
</apply>
</apply>
<ci>AREN</ci>
</apply>
<apply>
<times/>
<ci>rhoREN_ra</ci>
<ci>exp_FRT_6_g_DmuH</ci>
</apply>
</apply>
<ci>denominator1</ci>
</apply>
</apply>
</math>
<math id='math_54' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VHNe</ci>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<ci>rhoRen_6_ra</ci>
<ci>AREN</ci>
</apply>
<apply>
<times/>
<ci>rhoRen_6_ra_rb</ci>
<ci>exp_FRT_6_g_DmuH</ci>
</apply>
</apply>
<ci>denominator1</ci>
</apply>
</apply>
</math>
<math id='math_55' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>denominator2</ci>
<apply>
<divide/>
<ci>rhoREF</ci>
<apply>
<plus/>
<ci>VFO_VHFe_C1</ci>
<apply>
<times/>
<ci>r2_r3_exp_AREF_FRT</ci>
<ci>exp_FRT_6_g_DmuH</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_56' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VHFe</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>ra_exp_AREF_FRT</ci>
<apply>
<times/>
<ci>ra_rb</ci>
<ci>exp_FRT_6_g_DmuH</ci>
</apply>
</apply>
<ci>denominator2</ci>
</apply>
</apply>
</math>
<math id='math_57' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>exp_3FRT_DmuH</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>FRT_3</ci>
<ci>DmuH</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_58' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>AF1</ci>
<apply>
<times/>
<ci>kf1_Pi</ci>
<apply>
<divide/>
<ci>ATPm</ci>
<ci>ADPm</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_59' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>denominator3</ci>
<apply>
<minus/>
<apply>
<divide/>
<ci>rhoF1</ci>
<apply>
<plus/>
<ci>exp_3_FRT_Dpsio</ci>
<apply>
<times/>
<ci>p1_exp_3_FRT_Dpsio</ci>
<ci>AF1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>p2</ci>
<apply>
<times/>
<ci>p3</ci>
<ci>AF1</ci>
</apply>
</apply>
<ci>exp_3FRT_DmuH</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_60' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VATPase</ci>
<apply>
<times/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci>VATPase_C1</ci>
<apply>
<times/>
<ci>pc2</ci>
<ci>exp_3FRT_DmuH</ci>
</apply>
</apply>
<ci>AF1</ci>
</apply>
<apply>
<times/>
<ci>pa</ci>
<ci>exp_3FRT_DmuH</ci>
</apply>
</apply>
<ci>denominator3</ci>
</apply>
</apply>
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<math id='math_61' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Vhu</ci>
<apply>
<times/>
<apply>
<plus/>
<ci>pa_300</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>pa_300</ci>
<ci>AF1</ci>
</apply>
<apply>
<times/>
<ci>pa_pb_3</ci>
<ci>exp_3FRT_DmuH</ci>
</apply>
</apply>
</apply>
<ci>denominator3</ci>
</apply>
</apply>
</math>
<math id='math_62' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ATPi_ADP</ci>
<apply>
<divide/>
<ci>ATPi</ci>
<ci>ADP</ci>
</apply>
</apply>
</math>
<math id='math_63' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>ADPm_ATPm</ci>
<apply>
<divide/>
<ci>ADPm</ci>
<ci>ATPm</ci>
</apply>
</apply>
</math>
<math id='math_64' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VANT</ci>
<apply>
<divide/>
<apply>
<minus/>
<ci>VmDT_75</ci>
<apply>
<times/>
<ci>VmDT_20</ci>
<ci>ATPi_ADP</ci>
<ci>ADPm_ATPm</ci>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<times/>
<ci>F_over_RT</ci>
<ci>Dpsi</ci>
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</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<apply><divide/>
<cn cellml:units="TODO">10.0</cn>
<cn cellml:units="TODO">9.0</cn>
</apply>
<ci>ATPi_ADP</ci>
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<exp/>
<apply>
<minus/>
<apply>
<times/>
<ci>hm_F_over_RT</ci>
<ci>Dpsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<cn cellml:units="TODO">18.0</cn>
<ci>ADPm_ATPm</ci>
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</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_65' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Vhleak</ci>
<apply>
<times/>
<ci>gh</ci>
<ci>DmuH</ci>
</apply>
</apply>
</math>
<math id='math_66' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>MAlpha</ci>
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<piece>
<cn cellml:units="TODO">3.2</cn>
<apply><eq/>
<ci>V</ci>
<cn cellml:units="mV">-47.13</cn>
</apply>
</piece>
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<apply>
<times/>
<cn cellml:units="TODO">0.32</cn>
<apply>
<divide/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="TODO">47.13</cn>
</apply>
<apply>
<minus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="TODO">-0.1</cn>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="TODO">47.13</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</otherwise>
</piecewise>
</apply>
</math>
<math id='math_67' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>MBeta</ci>
<apply>
<times/>
<cn cellml:units="TODO">0.08</cn>
<apply>
<exp/>
<apply>
<minus/>
<apply>
<times/>
<ci>V</ci>
<apply><divide/>
<cn cellml:units="TODO">1.0</cn>
<cn cellml:units="TODO">11.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_68' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>inv_MBeta_MAlpha</ci>
<apply>
<divide/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<plus/>
<ci>MBeta</ci>
<ci>MAlpha</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_69' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>tmNa</ci>
<piecewise>
<piece>
<apply>
<times/>
<ci>MAlpha</ci>
<ci>inv_MBeta_MAlpha</ci>
</apply>
<apply><lt/>
<ci>inv_MBeta_MAlpha</ci>
<cn cellml:units="TODO">0.03</cn>
</apply>
</piece>
<otherwise>
<ci>mNa</ci>
</otherwise>
</piecewise>
</apply>
</math>
<math id='math_70' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>HAlpha</ci>
<piecewise>
<piece>
<apply>
<times/>
<apply><times/>
<cn cellml:units="TODO">0.135</cn>
<apply><exp/>
<apply><divide/>
<cn cellml:units="TODO">-80.0</cn>
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<eq/>
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<piece>
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<plus/>
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<times/>
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<times/>
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<ci>V</ci>
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<ci>V</ci>
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<ci>V</ci>
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<eq/>
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<piece>
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<times/>
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<ci>V</ci>
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<times/>
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<eq/>
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<piece>
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<times/>
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<divide/>
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<ci>V</ci>
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<plus/>
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<apply><lt/>
<ci>V</ci>
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<divide/>
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<exp/>
<apply>
<times/>
<cn cellml:units="TODO">-2.535e-7</cn>
<ci>V</ci>
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<plus/>
<cn cellml:units="TODO">1.0</cn>
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<exp/>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="TODO">-0.1</cn>
<ci>V</ci>
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<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>mNa</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>MAlpha</ci>
<apply>
<minus/>
<cn cellml:units="TODO">1.0</cn>
<ci>tmNa</ci>
</apply>
</apply>
<apply>
<times/>
<ci>MBeta</ci>
<ci>tmNa</ci>
</apply>
</apply>
</apply>
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<math id='math_75' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>hNa</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>HAlpha</ci>
<apply>
<minus/>
<cn cellml:units="TODO">1.0</cn>
<ci>hNa</ci>
</apply>
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<apply>
<times/>
<ci>HBeta</ci>
<ci>hNa</ci>
</apply>
</apply>
</apply>
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<math id='math_76' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>jNa</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>JAlpha</ci>
<apply>
<minus/>
<cn cellml:units="TODO">1.0</cn>
<ci>jNa</ci>
</apply>
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<apply>
<times/>
<ci>JBeta</ci>
<ci>jNa</ci>
</apply>
</apply>
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<math id='math_77' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>xKs</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="TODO">7.19e-5</cn>
<apply>
<divide/>
<ci>V_30</ci>
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<minus/>
<cn cellml:units="TODO">1.0</cn>
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<exp/>
<apply>
<times/>
<cn cellml:units="TODO">-0.148</cn>
<ci>V_30</ci>
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<apply>
<minus/>
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<ci>xKs</ci>
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<times/>
<cn cellml:units="TODO">1.31e-4</cn>
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<divide/>
<ci>V_30</ci>
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<minus/>
<apply>
<exp/>
<apply>
<times/>
<cn cellml:units="TODO">0.0687</cn>
<ci>V_30</ci>
</apply>
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<cn cellml:units="TODO">1.0</cn>
</apply>
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<ci>xKs</ci>
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</apply>
</apply>
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<math id='math_78' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>fb</ci>
<apply>
<power/>
<apply>
<times/>
<ci>Cai</ci>
<ci>inv_Kfb</ci>
</apply>
<ci>Nfb</ci>
</apply>
</apply>
</math>
<math id='math_79' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>rb</ci>
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<power/>
<apply>
<times/>
<ci>CaNSR</ci>
<ci>inv_Krb</ci>
</apply>
<ci>Nrb</ci>
</apply>
</apply>
</math>
<math id='math_80' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Jup</ci>
<apply>
<times/>
<ci>KSR</ci>
<apply>
<divide/>
<apply>
<minus/>
<apply>
<times/>
<ci>vmaxf</ci>
<ci>fb</ci>
</apply>
<apply>
<times/>
<ci>vmaxr</ci>
<ci>rb</ci>
</apply>
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<times/>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<ci>fb</ci>
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<apply>
<plus/>
<apply>
<times/>
<ci>inv_ATPi</ci>
<apply>
<plus/>
<ci>KmATP_SR</ci>
<apply>
<times/>
<ci>ADP</ci>
<ci>KmATP_SR_Ki_SR</ci>
</apply>
</apply>
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<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>ADP</ci>
<ci>inv_Ki_prime_SR</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_81' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Jrel</ci>
<apply>
<times/>
<ci>v1</ci>
<apply>
<plus/>
<ci>O1_RyR</ci>
<ci>O2_RyR</ci>
</apply>
<apply>
<minus/>
<ci>CaJSR</ci>
<ci>CaSS</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_82' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Jtr</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>CaNSR</ci>
<ci>CaJSR</ci>
</apply>
<ci>inv_tautr</ci>
</apply>
</apply>
</math>
<math id='math_83' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Jxfer</ci>
<apply>
<times/>
<apply>
<minus/>
<ci>CaSS</ci>
<ci>Cai</ci>
</apply>
<ci>inv_tauxfer</ci>
</apply>
</apply>
</math>
<math id='math_84' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>P1_N1_P2_P3</ci>
<apply>
<plus/>
<ci>P1</ci>
<ci>N1</ci>
<ci>P2</ci>
<ci>P3</ci>
</apply>
</apply>
</math>
<math id='math_85' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>FN_Ca</ci>
<apply>
<times/>
<ci>alpha_SL_fnormmax2</ci>
<ci>P1_N1_P2_P3</ci>
</apply>
</apply>
</math>
<math id='math_86' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<ci>force_norm</ci>
<apply>
<times/>
<ci>alpha_SL_fnormmax</ci>
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<plus/>
<ci>P1_N1_P2_P3</ci>
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<ci>P3</ci>
<ci>P3</ci>
</apply>
</apply>
</apply>
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<math id='math_87' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<ci>force</ci>
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<times/>
<ci>zeta_alpha_SL_fnormmax</ci>
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<plus/>
<ci>P1_N1_P2_P3</ci>
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<ci>P3</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_88' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<ci>kTrop_np</ci>
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<times/>
<ci>kTrop_pn</ci>
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<power/>
<apply>
<times/>
<ci>LTRPNCa</ci>
<ci>inv_LTRPNtot_Ktrop_half</ci>
</apply>
<ci>Ntrop</ci>
</apply>
</apply>
</apply>
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<math id='math_89' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>P0</ci>
</apply>
<ci>P0_differential</ci>
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<ci>P0_differential</ci>
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<plus/>
<apply>
<times/>
<ci>kTrop_pn_f_01</ci>
<ci>P0</ci>
</apply>
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<times/>
<ci>kTrop_np</ci>
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</apply>
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<times/>
<ci>g_01_mod</ci>
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</apply>
</apply>
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<math id='math_90' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>P1</ci>
</apply>
<ci>P1_differential</ci>
</apply>
<apply><eq/>
<ci>P1_differential</ci>
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<plus/>
<apply>
<times/>
<ci>kTrop_pn_f_12_g_01_mod</ci>
<ci>P1</ci>
</apply>
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<times/>
<ci>kTrop_np</ci>
<ci>N1</ci>
</apply>
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<times/>
<ci>f_01</ci>
<ci>P0</ci>
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<times/>
<ci>g_12_mod</ci>
<ci>P2</ci>
</apply>
</apply>
</apply>
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<math id='math_91' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>P2</ci>
</apply>
<ci>P2_differential</ci>
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<ci>P2_differential</ci>
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<plus/>
<apply>
<times/>
<ci>f_23_g_12_mod</ci>
<ci>P2</ci>
</apply>
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<times/>
<ci>f_12</ci>
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<times/>
<ci>g_23_mod</ci>
<ci>P3</ci>
</apply>
</apply>
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<math id='math_92' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>P3</ci>
</apply>
<ci>P3_differential</ci>
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<ci>P3_differential</ci>
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<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>g_23_mod</ci>
<ci>P3</ci>
</apply>
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<times/>
<ci>f_23</ci>
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</apply>
</apply>
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<math id='math_93' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
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<ci>N1_differential</ci>
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<apply><eq/>
<ci>N1_differential</ci>
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<minus/>
<apply>
<times/>
<ci>kTrop_pn</ci>
<ci>P1</ci>
</apply>
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<times/>
<apply>
<plus/>
<ci>kTrop_np</ci>
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<ci>N1</ci>
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<math id='math_94' xmlns='http://www.w3.org/1998/Math/MathML'>
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<eq/>
<apply><diff/>
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<minus/>
<apply>
<minus/>
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<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
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<ci>LTRPNCa_differential</ci>
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<minus/>
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<times/>
<ci>kltrpn_plus</ci>
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<minus/>
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<times/>
<apply>
<times/>
<ci>kltrpn_minus</ci>
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<minus/>
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<times/>
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<eq/>
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<ci>HTRPNCa_differential</ci>
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<minus/>
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<times/>
<ci>khtrpn_plus</ci>
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<minus/>
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<times/>
<ci>khtrpn_minus</ci>
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<eq/>
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<plus/>
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<eq/>
<ci>beta_SS</ci>
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<divide/>
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<plus/>
<cn cellml:units="TODO">1.0</cn>
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<times/>
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<plus/>
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<eq/>
<ci>beta_JSR</ci>
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<plus/>
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<times/>
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<eq/>
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<plus/>
<cn cellml:units="TODO">1.0</cn>
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<eq/>
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<plus/>
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<times/>
<ci>Cai</ci>
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<eq/>
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<times/>
<ci>Cai_ktrans_plus1</ci>
<ci>Cai_ktrans_plus1</ci>
<ci>Cai_ktrans_plus1</ci>
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<eq/>
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<ci>Vmuni_ktrans</ci>
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<apply>
<divide/>
<ci>Cai_ktrans_plus1_p3</ci>
<apply>
<times/>
<apply>
<plus/>
<apply>
<times/>
<ci>Cai_ktrans_plus1_p3</ci>
<ci>Cai_ktrans_plus1</ci>
</apply>
<apply>
<divide/>
<ci>L</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<times/>
<ci>Cai</ci>
<ci>inv_kact</ci>
</apply>
</apply>
<ci>na</ci>
</apply>
</apply>
</apply>
<apply>
<minus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<minus/>
<ci>FRT2_Dpsi</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_104' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VnaCa</ci>
<apply>
<times/>
<ci>VmNC</ci>
<apply>
<exp/>
<apply>
<times/>
<ci>b_05</ci>
<ci>FRT2_Dpsi</ci>
</apply>
</apply>
<apply>
<divide/>
<ci>Cam</ci>
<apply>
<times/>
<ci>Cai</ci>
<apply>
<power/>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<divide/>
<ci>Kna</ci>
<ci>Nai</ci>
</apply>
</apply>
<ci>n</ci>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<divide/>
<ci>Knca</ci>
<ci>Cam</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_105' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Nai</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci>INa</ci>
<ci>INab</ci>
<ci>InsNa</ci>
<apply>
<times/>
<cn cellml:units="TODO">3.0</cn>
<apply>
<plus/>
<ci>INaCa</ci>
<ci>INaK</ci>
</apply>
</apply>
</apply>
<ci>Acap_Vmyo_F</ci>
</apply>
</apply>
<apply>
<times/>
<ci>VnaCa</ci>
<cn cellml:units="TODO">0.615</cn>
</apply>
</apply>
</apply>
</math>
<math id='math_106' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Ki</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<ci>InsK</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>IKp</ci>
<ci>ICaK</ci>
<apply>
<minus/>
<ci>Istim</ci>
<apply>
<times/>
<cn cellml:units="TODO">2.0</cn>
<ci>INaK</ci>
</apply>
</apply>
</apply>
<ci>Acap_Vmyo_F</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_107' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Cai</ci>
</apply>
<apply>
<times/>
<ci>beta_i</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>Jxfer</ci>
<apply><plus/>
<ci>Jup</ci>
<ci>Jtrpn</ci>
<apply>
<times/>
<cn cellml:units="TODO">0.25</cn>
<ci>Acap_Vmyo_F</ci>
<apply>
<plus/>
<apply>
<minus/>
<ci>ICab</ci>
<apply>
<times/>
<cn cellml:units="TODO">2.0</cn>
<ci>INaCa</ci>
</apply>
</apply>
<ci>IpCa</ci>
</apply>
</apply>
</apply>
</apply>
<apply>
<times/>
<apply>
<minus/>
<ci>VnaCa</ci>
<ci>Vuni</ci>
</apply>
<cn cellml:units="TODO">0.615</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_108' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CaSS</ci>
</apply>
<apply>
<times/>
<ci>beta_SS</ci>
<apply>
<minus/>
<apply>
<times/>
<ci>Jrel</ci>
<ci>VJSR_VSS</ci>
</apply>
<apply><plus/>
<apply>
<times/>
<ci>Jxfer</ci>
<ci>Vmyo_VSS</ci>
</apply>
<apply>
<times/>
<ci>ICa</ci>
<ci>Acap_VSS_F</ci>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_109' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CaJSR</ci>
</apply>
<apply>
<times/>
<ci>beta_JSR</ci>
<apply>
<minus/>
<ci>Jtr</ci>
<ci>Jrel</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_110' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CaNSR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>Jup</ci>
<ci>Vmyo_VNSR</ci>
</apply>
<apply>
<times/>
<ci>Jtr</ci>
<ci>VJSR_VNSR</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_111' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>V</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>inv_C_m</ci>
<apply>
<plus/>
<ci>INa</ci>
<ci>ICa</ci>
<ci>ICaK</ci>
<ci>IKs</ci>
<ci>IK1</ci>
<ci>IKp</ci>
<ci>INaCa</ci>
<ci>INaK</ci>
<ci>InsCa</ci>
<ci>IpCa</ci>
<ci>ICab</ci>
<ci>INab</ci>
<ci>Istim</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_112' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>C1_RyR</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<times/>
<ci>kaplus</ci>
<apply>
<power/>
<ci>CaSS</ci>
<ci>ncoop</ci>
</apply>
<ci>C1_RyR</ci>
</apply>
</apply>
<apply>
<times/>
<ci>kaminus</ci>
<ci>O1_RyR</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_113' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>O2_RyR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kbplus</ci>
<apply>
<power/>
<ci>CaSS</ci>
<ci>mcoop</ci>
</apply>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kbminus</ci>
<ci>O2_RyR</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_114' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>C2_RyR</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>kcplus</ci>
<ci>O1_RyR</ci>
</apply>
<apply>
<times/>
<ci>kcminus</ci>
<ci>C2_RyR</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_115' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>alpha</ci>
<apply>
<times/>
<cn cellml:units="TODO">0.4</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="TODO">2.0</cn>
</apply>
<cn cellml:units="TODO">0.1</cn>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_116' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>beta</ci>
<apply>
<times/>
<cn cellml:units="TODO">0.05</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="TODO">2.0</cn>
</apply>
<apply><divide/>
<cn cellml:units="TODO">-1.0</cn>
<cn cellml:units="TODO">13.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_117' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>alpha_prime</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>alpha</ci>
</apply>
</apply>
</math>
<math id='math_118' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>beta_prime</ci>
<apply>
<times/>
<ci>beta</ci>
<ci>inv_bL</ci>
</apply>
</apply>
</math>
<math id='math_119' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C0_to_C1</ci>
<apply>
<times/>
<cn cellml:units="TODO">4.0</cn>
<ci>alpha</ci>
</apply>
</apply>
</math>
<math id='math_120' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C1_to_C2</ci>
<apply>
<times/>
<cn cellml:units="TODO">3.0</cn>
<ci>alpha</ci>
</apply>
</apply>
</math>
<math id='math_121' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C2_to_C3</ci>
<apply>
<times/>
<cn cellml:units="TODO">2.0</cn>
<ci>alpha</ci>
</apply>
</apply>
</math>
<math id='math_122' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C3_to_C4</ci>
<ci>alpha</ci>
</apply>
</math>
<math id='math_123' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa0_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="TODO">4.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
</math>
<math id='math_124' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa1_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="TODO">3.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
</math>
<math id='math_125' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa2_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="TODO">2.0</cn>
<ci>alpha_prime</ci>
</apply>
</apply>
</math>
<math id='math_126' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa3_to_CCa4</ci>
<ci>alpha_prime</ci>
</apply>
</math>
<math id='math_127' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C1_to_C0</ci>
<ci>beta</ci>
</apply>
</math>
<math id='math_128' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C2_to_C1</ci>
<apply>
<times/>
<cn cellml:units="TODO">2.0</cn>
<ci>beta</ci>
</apply>
</apply>
</math>
<math id='math_129' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C3_to_C2</ci>
<apply>
<times/>
<cn cellml:units="TODO">3.0</cn>
<ci>beta</ci>
</apply>
</apply>
</math>
<math id='math_130' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C4_to_C3</ci>
<apply>
<times/>
<cn cellml:units="TODO">4.0</cn>
<ci>beta</ci>
</apply>
</apply>
</math>
<math id='math_131' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa1_to_CCa0</ci>
<ci>beta_prime</ci>
</apply>
</math>
<math id='math_132' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa2_to_CCa1</ci>
<apply>
<times/>
<cn cellml:units="TODO">2.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
</math>
<math id='math_133' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa3_to_CCa2</ci>
<apply>
<times/>
<cn cellml:units="TODO">3.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
</math>
<math id='math_134' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa4_to_CCa3</ci>
<apply>
<times/>
<cn cellml:units="TODO">4.0</cn>
<ci>beta_prime</ci>
</apply>
</apply>
</math>
<math id='math_135' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>gamma</ci>
<apply>
<times/>
<cn cellml:units="TODO">0.1875</cn>
<ci>CaSS</ci>
</apply>
</apply>
</math>
<math id='math_136' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C0_to_CCa0</ci>
<ci>gamma</ci>
</apply>
</math>
<math id='math_137' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C1_to_CCa1</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C0_to_CCa0</ci>
</apply>
</apply>
</math>
<math id='math_138' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C2_to_CCa2</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C1_to_CCa1</ci>
</apply>
</apply>
</math>
<math id='math_139' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C3_to_CCa3</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C2_to_CCa2</ci>
</apply>
</apply>
</math>
<math id='math_140' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>C4_to_CCa4</ci>
<apply>
<times/>
<ci>aL</ci>
<ci>C3_to_CCa3</ci>
</apply>
</apply>
</math>
<math id='math_141' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa0_to_C0</ci>
<ci>omega</ci>
</apply>
</math>
<math id='math_142' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa1_to_C1</ci>
<apply>
<times/>
<ci>CCa0_to_C0</ci>
<ci>inv_bL</ci>
</apply>
</apply>
</math>
<math id='math_143' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa2_to_C2</ci>
<apply>
<times/>
<ci>CCa1_to_C1</ci>
<ci>inv_bL</ci>
</apply>
</apply>
</math>
<math id='math_144' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa3_to_C3</ci>
<apply>
<times/>
<ci>CCa2_to_C2</ci>
<ci>inv_bL</ci>
</apply>
</apply>
</math>
<math id='math_145' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>CCa4_to_C4</ci>
<apply>
<times/>
<ci>CCa3_to_C3</ci>
<ci>inv_bL</ci>
</apply>
</apply>
</math>
<math id='math_146' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>C0</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C0</ci>
<ci>C1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>CCa0_to_C0</ci>
<ci>CCa0</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>C0_to_C1</ci>
<ci>C0_to_CCa0</ci>
</apply>
<ci>C0</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_147' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>C1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>C0_to_C1</ci>
<ci>C0</ci>
</apply>
<apply>
<times/>
<ci>C2_to_C1</ci>
<ci>C2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>CCa1_to_C1</ci>
<ci>CCa1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>C1_to_C0</ci>
<ci>C1_to_C2</ci>
<ci>C1_to_CCa1</ci>
</apply>
<ci>C1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_148' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>C2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>C1_to_C2</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<ci>C3_to_C2</ci>
<ci>C3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>CCa2_to_C2</ci>
<ci>CCa2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>C2_to_C1</ci>
<ci>C2_to_C3</ci>
<ci>C2_to_CCa2</ci>
</apply>
<ci>C2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_149' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>C3</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>C2_to_C3</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<ci>C4_to_C3</ci>
<ci>C4</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>CCa3_to_C3</ci>
<ci>CCa3</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>C3_to_C2</ci>
<ci>C3_to_C4</ci>
<ci>C3_to_CCa3</ci>
</apply>
<ci>C3</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_150' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>C4</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>C3_to_C4</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<ci>gL</ci>
<ci>Open</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>CCa4_to_C4</ci>
<ci>CCa4</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>C4_to_C3</ci>
<ci>fL</ci>
<ci>C4_to_CCa4</ci>
</apply>
<ci>C4</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_151' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Open</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>fL</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<ci>gL</ci>
<ci>Open</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_152' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CCa0</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa1_to_CCa0</ci>
<ci>CCa1</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>C0_to_CCa0</ci>
<ci>C0</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa0_to_CCa1</ci>
<ci>CCa0_to_C0</ci>
</apply>
<ci>CCa0</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_153' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CCa1</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa0_to_CCa1</ci>
<ci>CCa0</ci>
</apply>
<apply>
<times/>
<ci>CCa2_to_CCa1</ci>
<ci>CCa2</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>C1_to_CCa1</ci>
<ci>C1</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa1_to_CCa0</ci>
<ci>CCa1_to_CCa2</ci>
<ci>CCa1_to_C1</ci>
</apply>
<ci>CCa1</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_154' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CCa2</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa1_to_CCa2</ci>
<ci>CCa1</ci>
</apply>
<apply>
<times/>
<ci>CCa3_to_CCa2</ci>
<ci>CCa3</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>C2_to_CCa2</ci>
<ci>C2</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa2_to_CCa1</ci>
<ci>CCa2_to_CCa3</ci>
<ci>CCa2_to_C2</ci>
</apply>
<ci>CCa2</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_155' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CCa3</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa2_to_CCa3</ci>
<ci>CCa2</ci>
</apply>
<apply>
<times/>
<ci>CCa4_to_CCa3</ci>
<ci>CCa4</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>C3_to_CCa3</ci>
<ci>C3</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa3_to_CCa2</ci>
<ci>CCa3_to_CCa4</ci>
<ci>CCa3_to_C3</ci>
</apply>
<ci>CCa3</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_156' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CCa4</ci>
</apply>
<apply>
<plus/>
<apply>
<times/>
<ci>CCa3_to_CCa4</ci>
<ci>CCa3</ci>
</apply>
<apply>
<times/>
<ci>gprime</ci>
<ci>OCa</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>C4_to_CCa4</ci>
<ci>C4</ci>
</apply>
<apply>
<times/>
<apply>
<plus/>
<ci>CCa4_to_CCa3</ci>
<ci>fprime</ci>
<ci>CCa4_to_C4</ci>
</apply>
<ci>CCa4</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_157' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>yCa</ci>
</apply>
<apply>
<divide/>
<apply>
<plus/>
<apply>
<divide/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="TODO">55.0</cn>
</apply>
<apply><divide/>
<cn cellml:units="TODO">1.0</cn>
<cn cellml:units="TODO">7.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<apply>
<minus/>
<apply>
<divide/>
<cn cellml:units="TODO">0.5</cn>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<minus/>
<cn cellml:units="TODO">21.0</cn>
<ci>V</ci>
</apply>
<apply><divide/>
<cn cellml:units="TODO">1.0</cn>
<cn cellml:units="TODO">6.0</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
<ci>yCa</ci>
</apply>
</apply>
<apply>
<plus/>
<cn cellml:units="TODO">20.0</cn>
<apply>
<divide/>
<cn cellml:units="TODO">600.0</cn>
<apply>
<plus/>
<cn cellml:units="TODO">1.0</cn>
<apply>
<exp/>
<apply>
<times/>
<apply>
<plus/>
<ci>V</ci>
<cn cellml:units="TODO">30.0</cn>
</apply>
<apply><divide/>
<cn cellml:units="TODO">1.0</cn>
<cn cellml:units="TODO">9.5</cn>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_158' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>OCa</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<ci>fprime</ci>
<ci>CCa4</ci>
</apply>
<apply>
<times/>
<ci>gprime</ci>
<ci>OCa</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_159' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>Vt_CRP2</ci>
<apply>
<times/>
<ci>kt_2</ci>
<apply>
<minus/>
<ci>CrPi_mito</ci>
<ci>CrPi_cyto</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_160' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VCK_cyto</ci>
<apply>
<times/>
<ci>kf_2</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>CRT_cyto</ci>
<ci>CrPi_cyto</ci>
</apply>
<ci>ATPi_cyto</ci>
</apply>
<apply>
<times/>
<ci>CrPi_cyto</ci>
<apply>
<minus/>
<cn cellml:units="TODO">8.0</cn>
<ci>ATPi_cyto</ci>
</apply>
<ci>inv_keq</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_161' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<ci>VCK_mito</ci>
<apply>
<times/>
<ci>kf_3</ci>
<apply>
<minus/>
<apply>
<times/>
<apply>
<minus/>
<ci>CRT_mito</ci>
<ci>CrPi_mito</ci>
</apply>
<ci>ATPi</ci>
</apply>
<apply>
<times/>
<ci>CrPi_mito</ci>
<ci>ADP</ci>
<ci>inv_keq</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_162' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CrPi_mito</ci>
</apply>
<apply>
<minus/>
<ci>VCK_mito</ci>
<ci>Vt_CRP2</ci>
</apply>
</apply>
</math>
<math id='math_163' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>CrPi_cyto</ci>
</apply>
<apply>
<plus/>
<ci>Vt_CRP2</ci>
<ci>VCK_cyto</ci>
</apply>
</apply>
</math>
<math id='math_164' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>ATPi</ci>
</apply>
<apply><times/>
<apply><minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>clamp_ATPi</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<cn cellml:units="TODO">0.615</cn>
<ci>VANT</ci>
</apply>
<apply><plus/>
<ci>V_AM</ci>
<apply>
<times/>
<cn cellml:units="TODO">0.5</cn>
<ci>Jup</ci>
</apply>
<apply>
<times/>
<cn cellml:units="TODO">6.371e-5</cn>
<apply>
<plus/>
<ci>INaK</ci>
<ci>IpCa</ci>
</apply>
</apply>
<ci>VCK_mito</ci>
</apply>
</apply>
</apply>
</apply>
</math>
<math id='math_165' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>ATPi_cyto</ci>
</apply>
<apply><times/>
<apply><minus/>
<cn cellml:units="dimensionless">1.0</cn>
<ci>clamp_ATPi_cyto</ci>
</apply>
<apply>
<minus/>
<apply>
<minus/>
<ci>VCK_cyto</ci>
</apply>
<ci>VATPase_cyto</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_166' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Cam</ci>
</apply>
<apply>
<times/>
<ci>fm</ci>
<apply>
<minus/>
<ci>Vuni</ci>
<ci>VnaCa</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_167' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>ADPm</ci>
</apply>
<apply>
<minus/>
<ci>VANT</ci>
<apply><plus/>
<ci>VATPase</ci>
<ci>VSL</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_168' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Dpsi</ci>
</apply>
<apply>
<minus/>
<apply>
<times/>
<apply>
<plus/>
<apply>
<minus/>
<apply>
<minus/>
<ci>VHNe</ci>
</apply>
<ci>VHFe</ci>
</apply>
<ci>Vhu</ci>
<ci>VANT</ci>
<ci>Vhleak</ci>
<apply>
<times/>
<ci>two_b</ci>
<ci>VnaCa</ci>
</apply>
<apply>
<times/>
<cn cellml:units="TODO">2.0</cn>
<ci>Vuni</ci>
</apply>
</apply>
<ci>inv_Cmito</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_169' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>NADH</ci>
</apply>
<apply>
<plus/>
<apply>
<minus/>
<ci>VNO</ci>
</apply>
<ci>VIDH</ci>
<ci>VKGDH</ci>
<ci>VMDH</ci>
</apply>
</apply>
</math>
<math id='math_170' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>ISOC</ci>
</apply>
<apply>
<minus/>
<ci>VACO</ci>
<ci>VIDH</ci>
</apply>
</apply>
</math>
<math id='math_171' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>AKG</ci>
</apply>
<apply>
<plus/>
<ci>VIDH</ci>
<apply>
<minus/>
<ci>VAAT</ci>
<ci>VKGDH</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_172' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>SCoA</ci>
</apply>
<apply>
<minus/>
<ci>VKGDH</ci>
<ci>VSL</ci>
</apply>
</apply>
</math>
<math id='math_173' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Succ</ci>
</apply>
<apply>
<minus/>
<ci>VSL</ci>
<ci>VSDH</ci>
</apply>
</apply>
</math>
<math id='math_174' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>FUM</ci>
</apply>
<apply>
<minus/>
<ci>VSDH</ci>
<ci>VFH</ci>
</apply>
</apply>
</math>
<math id='math_175' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>MAL</ci>
</apply>
<apply>
<minus/>
<ci>VFH</ci>
<ci>VMDH</ci>
</apply>
</apply>
</math>
<math id='math_176' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>Oaa</ci>
</apply>
<apply>
<minus/>
<ci>VMDH</ci>
<apply><plus/>
<ci>VCS</ci>
<ci>VAAT</ci>
</apply>
</apply>
</apply>
</math>
<math id='math_177' xmlns='http://www.w3.org/1998/Math/MathML'>
<apply>
<eq/>
<apply><diff/>
<bvar><ci>time</ci></bvar>
<ci>ASP</ci>
</apply>
<apply>
<minus/>
<ci>VAAT</ci>
<apply>
<times/>
<ci>kcnsASP</ci>
<ci>ASP</ci>
</apply>
</apply>
</apply>
</math>
</component>
</model>
