- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2012-10-05 15:20:03+13:00
- Desc:
- updating documentation to better reflect the VPH-MIP slides and mention how to reproduce the simulation results; adding plot of gating variables added to the SED-ML
- Permanent Source URI:
- https://models.fieldml.org/w/andre/VPH-MIP/rawfile/58e44de10bed7fbc87fd1d437f3001c7b653a738/components/INa.xml
<?xml version="1.0" encoding="iso-8859-1"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:xlink="http://www.w3.org/1999/xlink" name="INa">
<import xlink:href="units.xml">
<units name="ms" units_ref="ms"/>
<units name="mV" units_ref="mV"/>
<units name="per_ms" units_ref="per_ms"/>
<units name="per_ms_mV" units_ref="per_ms_mV"/>
<units name="uA_per_cmsq" units_ref="uA_per_cmsq"/>
<units name="mS_per_cmsq" units_ref="mS_per_cmsq"/>
</import>
<import xlink:href="gating-variable.xml">
<component name="m_gate" component_ref="hh_gating_variable"/>
</import>
<import xlink:href="gating-variable.xml">
<component name="h_gate" component_ref="hh_gating_variable"/>
</import>
<import xlink:href="INa-gating-rates.xml">
<component name="alpha_m" component_ref="alpha_m"/>
<component name="beta_m" component_ref="beta_m"/>
<component name="alpha_h" component_ref="alpha_h"/>
<component name="beta_h" component_ref="beta_h"/>
</import>
<component name="INa">
<variable name="INa" public_interface="out" private_interface="out" units="uA_per_cmsq"/>
<variable name="m_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="m" public_interface="out" private_interface="in" units="dimensionless"/>
<variable name="h_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable name="h" public_interface="out" private_interface="in" units="dimensionless"/>
<variable name="time" public_interface="in" private_interface="out" units="ms"/>
<variable name="V" public_interface="in" private_interface="out" units="mV"/>
<variable name="VNa" public_interface="in" private_interface="out" units="mV"/>
<variable name="gNa" public_interface="out" private_interface="out" units="mS_per_cmsq"/>
<variable name="gNa_max" public_interface="in" private_interface="out" units="mS_per_cmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="INa_calculation"><eq/>
<ci>INa</ci>
<apply><times/>
<ci>gNa</ci>
<apply><minus/>
<ci>V</ci>
<ci>VNa</ci>
</apply>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="gNa_calculation"><eq/>
<ci>gNa</ci>
<apply><times/>
<ci>gNa_max</ci>
<apply><power/>
<ci>m</ci>
<cn cellml:units="dimensionless">3.0</cn>
</apply>
<ci>h</ci>
</apply>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="INa">
<component_ref component="alpha_m"/>
<component_ref component="beta_m"/>
<component_ref component="alpha_h"/>
<component_ref component="beta_h"/>
<component_ref component="m_gate"/>
<component_ref component="h_gate"/>
</component_ref>
</group>
<connection>
<map_components component_1="INa" component_2="m_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="m_initial" variable_2="X_initial"/>
<map_variables variable_1="m" variable_2="X"/>
</connection>
<connection>
<map_components component_1="INa" component_2="h_gate"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="h_initial" variable_2="X_initial"/>
<map_variables variable_1="h" variable_2="X"/>
</connection>
<connection>
<map_components component_1="INa" component_2="alpha_m"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="beta_m"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="alpha_h"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="INa" component_2="beta_h"/>
<map_variables variable_1="V" variable_2="V"/>
</connection>
<connection>
<map_components component_1="m_gate" component_2="alpha_m"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="m_gate" component_2="beta_m"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
<connection>
<map_components component_1="h_gate" component_2="alpha_h"/>
<map_variables variable_1="alpha_X" variable_2="alpha"/>
</connection>
<connection>
<map_components component_1="h_gate" component_2="beta_h"/>
<map_variables variable_1="beta_X" variable_2="beta"/>
</connection>
</model>
