- Author:
- David Nickerson <nickerso@users.sourceforge.net>
- Date:
- 2012-09-25 14:48:06+12:00
- Desc:
- updates with more information from the presentation
- Permanent Source URI:
- https://models.fieldml.org/w/andre/VPH-MIP/rawfile/1f279bed1a35a70dcac0f000174185f827c5cc91/components/voltage-clamp.xml
<?xml version="1.0" encoding="iso-8859-1"?>
<model xmlns="http://www.cellml.org/cellml/1.1#" xmlns:cellml="http://www.cellml.org/cellml/1.1#" xmlns:cmeta="http://www.cellml.org/metadata/1.0#" xmlns:xlink="http://www.w3.org/1999/xlink" name="voltage_clamp" cmeta:id="voltage_clamp_model">
<import xlink:href="units.xml">
<units name="mV" units_ref="mV"/>
<units name="ms" units_ref="ms"/>
<units name="K" units_ref="K"/>
<units name="uA_per_cmsq" units_ref="uA_per_cmsq"/>
<units name="mS_per_cmsq" units_ref="mS_per_cmsq"/>
<units name="uF_per_cmsq" units_ref="uF_per_cmsq"/>
</import>
<import xlink:href="INa.xml">
<component name="INa" component_ref="INa"/>
</import>
<import xlink:href="IK.xml">
<component name="IK" component_ref="IK"/>
</import>
<import xlink:href="Ileak.xml">
<component name="Ileak" component_ref="Ileak"/>
</import>
<component name="voltage_clamp" cmeta:id="voltage_clamp_component">
<variable cmeta:id="V_initial" name="V_initial" public_interface="in" private_interface="out" units="mV"/>
<variable cmeta:id="n_initial" name="n_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable cmeta:id="m_initial" name="m_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable cmeta:id="h_initial" name="h_initial" public_interface="in" private_interface="out" units="dimensionless"/>
<variable cmeta:id="INa" name="INa" public_interface="out" private_interface="in" units="uA_per_cmsq"/>
<variable cmeta:id="IK" name="IK" public_interface="out" private_interface="in" units="uA_per_cmsq"/>
<variable cmeta:id="Ileak" name="Ileak" public_interface="out" private_interface="in" units="uA_per_cmsq"/>
<variable cmeta:id="VNa" name="VNa" public_interface="in" private_interface="out" units="mV"/>
<variable cmeta:id="VK" name="VK" public_interface="in" private_interface="out" units="mV"/>
<variable cmeta:id="Vleak" name="Vleak" public_interface="in" private_interface="out" units="mV"/>
<variable cmeta:id="gNa_max" name="gNa_max" public_interface="in" private_interface="out" units="mS_per_cmsq"/>
<variable cmeta:id="gK_max" name="gK_max" public_interface="in" private_interface="out" units="mS_per_cmsq"/>
<variable cmeta:id="gleak_max" name="gleak_max" public_interface="in" private_interface="out" units="mS_per_cmsq"/>
<variable cmeta:id="Tref_rates" name="Tref_rates" public_interface="in" private_interface="out" units="K"/>
<variable cmeta:id="T" name="T" public_interface="in" private_interface="out" units="K"/>
<variable cmeta:id="Q10_rates" name="Q10_rates" public_interface="in" private_interface="out" units="dimensionless"/>
<variable cmeta:id="time" name="time" public_interface="in" private_interface="out" units="ms"/>
<variable cmeta:id="V" name="V" public_interface="out" private_interface="out" units="mV"/>
<variable cmeta:id="Vnew" name="Vnew" public_interface="in" private_interface="out" units="mV"/>
<variable cmeta:id="I" name="I" public_interface="out" private_interface="out" units="uA_per_cmsq"/>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="I_calculation"><eq/>
<ci>I</ci>
<apply><plus/>
<ci>INa</ci>
<ci>IK</ci>
<ci>Ileak</ci>
</apply>
</apply>
</math>
<math xmlns="http://www.w3.org/1998/Math/MathML">
<apply id="V_calculation"><eq/>
<ci>V</ci>
<piecewise>
<piece>
<ci>Vnew</ci>
<apply><gt/>
<ci>time</ci>
<cn cellml:units="ms">0.0</cn>
</apply>
</piece>
<otherwise>
<ci>V_initial</ci>
</otherwise>
</piecewise>
</apply>
</math>
</component>
<group>
<relationship_ref relationship="encapsulation"/>
<component_ref component="voltage_clamp">
<component_ref component="INa"/>
<component_ref component="IK"/>
<component_ref component="Ileak"/>
</component_ref>
</group>
<connection>
<map_components component_1="voltage_clamp" component_2="INa"/>
<map_variables variable_1="INa" variable_2="INa"/>
<map_variables variable_1="m_initial" variable_2="m_initial"/>
<map_variables variable_1="h_initial" variable_2="h_initial"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Tref_rates" variable_2="Tref"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10_rates" variable_2="Q10"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="VNa" variable_2="VNa"/>
<map_variables variable_1="gNa_max" variable_2="gNa_max"/>
</connection>
<connection>
<map_components component_1="voltage_clamp" component_2="IK"/>
<map_variables variable_1="IK" variable_2="IK"/>
<map_variables variable_1="n_initial" variable_2="n_initial"/>
<map_variables variable_1="time" variable_2="time"/>
<map_variables variable_1="Tref_rates" variable_2="Tref"/>
<map_variables variable_1="T" variable_2="T"/>
<map_variables variable_1="Q10_rates" variable_2="Q10"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="VK" variable_2="VK"/>
<map_variables variable_1="gK_max" variable_2="gK_max"/>
</connection>
<connection>
<map_components component_1="voltage_clamp" component_2="Ileak"/>
<map_variables variable_1="Ileak" variable_2="Ileak"/>
<map_variables variable_1="V" variable_2="V"/>
<map_variables variable_1="Vleak" variable_2="Vleak"/>
<map_variables variable_1="gleak_max" variable_2="gleak_max"/>
</connection>
</model>
