CaB protein knowledge page

About

Landing page for the proteins constituting the background calcium current (CaB).

This current was introduced by Luo and Rudy in order to make their model of the cardiomyocyte maintain calcium homeostasis, by counterbalancing the extrusion of calcium from the cytosol through the NCX.

In reality, little is known of such channels. They may be some variant of the transient receptor potential (TRP) channel, which exist on the plasma membrane (among other places) and show permeability to calcium.

Other name for this current: Ca-leak

Literature

For further reading
Title	Author
A Capacitative Calcium Current in Cultured Skeletal Muscle Cells Is Mediated by the Calcium-specific Leak Channel and Inhibited by Dihydropyridine Compounds	Hopf et al.
How Calcium Influx through Calcium Leak Channels Is Responsible for the Elevated Levels of Calcium-dependent Proteolysis in Dystrophic Myotubes	Alderton and Steinhardt

Existing models

Link to other PMR workspaces or exposures
Title	Author
BG_CaB	S Fong
A dynamic model of the cardiac ventricular action potential. I. Simulations of ionic currents and concentration changes*^	Luo and Rudy

Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.