Fig10_Ca.rst

About this model

Original publication:
 Kernik et al. (2019): "A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources" J Physiol. 2019 Sep 1; 597(17): 4533-4564.
DOI:https://dx.doi.org/10.1113%2FJP277724

Figure 10

Calcium handling in the iPSC-CM model

Channels.cellml is the main CellML file which incorporates the handling of calcium within the cell. Its associated SED-ML file contains all the simulation settings.

To execute the code, all the files related to this channel need to be downloaded in a same folder:

  1. fig10_Ca.py
  2. Channels.cellml
  3. Channels.sedml
  4. parameter.cellml
  5. unit.cellml

To reproduce Figure 10, save all the files to the same folder and execute the following script from the command line:

$ cd [PathToThisFile]

$ [PathToOpenCOR]/pythonshell fig10_Ca.py

figures/Figure10_Ca.png

A, baseline model the calcium transient. B, relative contribution of calcium from ISERCA, INCX and IPMCA to the calcium transient during a single AP in the baseline mode. (Blue: 62% SERCA, Red: 31% NCX, Yellow: 7% non-NCX (SL-pump))