/* There are a total of 30 entries in the algebraic variable array. There are a total of 7 entries in each of the rate and state variable arrays. There are a total of 22 entries in the constant variable array. */ /* * VOI is t in component environment (second). * CONSTANTS[0] is C_m in component environment (fF). * STATES[0] is q_K_o in component environment (fmol). * STATES[1] is q_K_i in component environment (fmol). * STATES[2] is q_Sa in component environment (fmol). * STATES[3] is q_Sb in component environment (fmol). * STATES[4] is q_Sc in component environment (fmol). * STATES[5] is q_Sd in component environment (fmol). * STATES[6] is q_mem in component environment (fC). * CONSTANTS[1] is R in component environment (J_per_K_per_mol). * CONSTANTS[2] is T in component environment (kelvin). * CONSTANTS[3] is F in component environment (C_per_mol). * ALGEBRAIC[21] is v_Kr in component Kr (fmol_per_sec). * ALGEBRAIC[27] is I_mem_Kr in component Kr (fA). * ALGEBRAIC[1] is I_stim in component environment (fA). * CONSTANTS[4] is stimPeriod in component environment (second). * CONSTANTS[5] is stimDuration in component environment (second). * ALGEBRAIC[0] is tPeriod in component environment (second). * CONSTANTS[6] is kappa_Kr in component Kr_parameters (fmol_per_sec). * CONSTANTS[7] is kappa_xr10 in component Kr_parameters (fmol_per_sec). * CONSTANTS[8] is kappa_xr11 in component Kr_parameters (fmol_per_sec). * CONSTANTS[9] is kappa_xr20 in component Kr_parameters (fmol_per_sec). * CONSTANTS[10] is kappa_xr21 in component Kr_parameters (fmol_per_sec). * CONSTANTS[11] is K_K_i in component Kr_parameters (per_fmol). * CONSTANTS[12] is K_K_o in component Kr_parameters (per_fmol). * CONSTANTS[13] is K_Sa_Kr in component Kr_parameters (per_fmol). * CONSTANTS[14] is K_Sb_Kr in component Kr_parameters (per_fmol). * CONSTANTS[15] is K_Sc_Kr in component Kr_parameters (per_fmol). * CONSTANTS[16] is K_Sd_Kr in component Kr_parameters (per_fmol). * CONSTANTS[17] is zK in component Kr_parameters (dimensionless). * CONSTANTS[18] is z_xr1_f in component Kr_parameters (dimensionless). * CONSTANTS[19] is z_xr1_r in component Kr_parameters (dimensionless). * CONSTANTS[20] is z_xr2_f in component Kr_parameters (dimensionless). * CONSTANTS[21] is z_xr2_r in component Kr_parameters (dimensionless). * ALGEBRAIC[2] is u_K_i in component Kr (J_per_mol). * ALGEBRAIC[3] is u_K_o in component Kr (J_per_mol). * ALGEBRAIC[4] is V_mem in component Kr (J_per_C). * ALGEBRAIC[5] is Am_Kr in component Kr (J_per_mol). * ALGEBRAIC[19] is Af_Kr in component Kr (J_per_mol). * ALGEBRAIC[20] is Ar_Kr in component Kr (J_per_mol). * ALGEBRAIC[17] is v_Sa in component Kr (fmol_per_sec). * ALGEBRAIC[28] is v_Sb in component Kr (fmol_per_sec). * ALGEBRAIC[26] is v_Sc in component Kr (fmol_per_sec). * ALGEBRAIC[29] is v_Sd in component Kr (fmol_per_sec). * ALGEBRAIC[12] is v_x10 in component Kr (fmol_per_sec). * ALGEBRAIC[24] is v_x11 in component Kr (fmol_per_sec). * ALGEBRAIC[16] is v_x20 in component Kr (fmol_per_sec). * ALGEBRAIC[25] is v_x21 in component Kr (fmol_per_sec). * ALGEBRAIC[6] is mu_Sa in component Kr (J_per_mol). * ALGEBRAIC[9] is mu_Sb in component Kr (J_per_mol). * ALGEBRAIC[13] is mu_Sc in component Kr (J_per_mol). * ALGEBRAIC[18] is mu_Sd in component Kr (J_per_mol). * ALGEBRAIC[7] is Af_x10 in component Kr (J_per_mol). * ALGEBRAIC[10] is Ar_x10 in component Kr (J_per_mol). * ALGEBRAIC[14] is Af_x11 in component Kr (J_per_mol). * ALGEBRAIC[22] is Ar_x11 in component Kr (J_per_mol). * ALGEBRAIC[8] is Af_x20 in component Kr (J_per_mol). * ALGEBRAIC[15] is Ar_x20 in component Kr (J_per_mol). * ALGEBRAIC[11] is Af_x21 in component Kr (J_per_mol). * ALGEBRAIC[23] is Ar_x21 in component Kr (J_per_mol). * RATES[1] is d/dt q_K_i in component environment (fmol). * RATES[0] is d/dt q_K_o in component environment (fmol). * RATES[6] is d/dt q_mem in component environment (fC). * RATES[2] is d/dt q_Sa in component environment (fmol). * RATES[3] is d/dt q_Sb in component environment (fmol). * RATES[4] is d/dt q_Sc in component environment (fmol). * RATES[5] is d/dt q_Sd in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 60000; STATES[0] = 20.0448; STATES[1] = 388.832; STATES[2] = 1.598306E-07; STATES[3] = 1.598306E-07; STATES[4] = 1.598306E-07; STATES[5] = 1.598306E-07; STATES[6] = -13039; CONSTANTS[1] = 8.31; CONSTANTS[2] = 310; CONSTANTS[3] = 96500; CONSTANTS[4] = 1; CONSTANTS[5] = 0.0001; CONSTANTS[6] = 175.029; CONSTANTS[7] = 0.0794844; CONSTANTS[8] = 0.00212813; CONSTANTS[9] = 0.267259; CONSTANTS[10] = 2.18134; CONSTANTS[11] = 12.9706; CONSTANTS[12] = 95.1175; CONSTANTS[13] = 0.0465841; CONSTANTS[14] = 0.00570751; CONSTANTS[15] = 1.73989; CONSTANTS[16] = 0.213172; CONSTANTS[17] = 1; CONSTANTS[18] = 1.6149028778859738; CONSTANTS[19] = -1.3218634652232777; CONSTANTS[20] = -1.0273976425216251; CONSTANTS[21] = -0.18153135376657775; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[4] = STATES[6]/CONSTANTS[0]; ALGEBRAIC[6] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[13]*STATES[2]); ALGEBRAIC[7] = ALGEBRAIC[6]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[9] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[14]*STATES[3]); ALGEBRAIC[10] = ALGEBRAIC[9]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[12] = CONSTANTS[7]*(exp(ALGEBRAIC[7]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[10]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[8] = ALGEBRAIC[6]+ CONSTANTS[20]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[13] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[15]*STATES[4]); ALGEBRAIC[15] = ALGEBRAIC[13]+ CONSTANTS[21]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[16] = CONSTANTS[9]*(exp(ALGEBRAIC[8]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[15]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[17] = - ALGEBRAIC[12] - ALGEBRAIC[16]; RATES[2] = ALGEBRAIC[17]; ALGEBRAIC[5] = CONSTANTS[17]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[2] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[11]*STATES[1]); ALGEBRAIC[18] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[16]*STATES[5]); ALGEBRAIC[19] = ALGEBRAIC[18]+ALGEBRAIC[2]+ALGEBRAIC[5]; ALGEBRAIC[3] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[12]*STATES[0]); ALGEBRAIC[20] = ALGEBRAIC[18]+ALGEBRAIC[3]; ALGEBRAIC[21] = (ALGEBRAIC[5]==0.00000 ? 1.00000*CONSTANTS[6]*(exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[20]/( CONSTANTS[1]*CONSTANTS[2]))) : ((( 1.00000*CONSTANTS[6]*ALGEBRAIC[5])/( CONSTANTS[1]*CONSTANTS[2]))/(exp(ALGEBRAIC[5]/( CONSTANTS[1]*CONSTANTS[2])) - 1.00000))*(exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[20]/( CONSTANTS[1]*CONSTANTS[2])))); RATES[1] = - ALGEBRAIC[21]; RATES[0] = ALGEBRAIC[21]; ALGEBRAIC[14] = ALGEBRAIC[13]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[22] = ALGEBRAIC[18]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[24] = CONSTANTS[8]*(exp(ALGEBRAIC[14]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[22]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[26] = ALGEBRAIC[16] - ALGEBRAIC[24]; RATES[4] = ALGEBRAIC[26]; ALGEBRAIC[11] = ALGEBRAIC[9]+ CONSTANTS[20]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[23] = ALGEBRAIC[18]+ CONSTANTS[21]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[25] = CONSTANTS[10]*(exp(ALGEBRAIC[11]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[23]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[27] = CONSTANTS[3]*( - CONSTANTS[17]*ALGEBRAIC[21]+ ALGEBRAIC[12]*(CONSTANTS[19] - CONSTANTS[18])+ ALGEBRAIC[24]*(CONSTANTS[19] - CONSTANTS[19])+ ALGEBRAIC[16]*(CONSTANTS[21] - CONSTANTS[20])+ ALGEBRAIC[25]*(CONSTANTS[21] - CONSTANTS[20])); ALGEBRAIC[0] = VOI - floor(VOI/CONSTANTS[4])*CONSTANTS[4]; ALGEBRAIC[1] = (ALGEBRAIC[0]>=0.300000&&ALGEBRAIC[0]<=0.300000+CONSTANTS[5] ? ( 0.0750000*CONSTANTS[0])/CONSTANTS[5] : 0.00000); RATES[6] = ALGEBRAIC[27]+ALGEBRAIC[1]; ALGEBRAIC[28] = ALGEBRAIC[12] - ALGEBRAIC[25]; RATES[3] = ALGEBRAIC[28]; ALGEBRAIC[29] = ALGEBRAIC[24]+ALGEBRAIC[25]; RATES[5] = ALGEBRAIC[29]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[4] = STATES[6]/CONSTANTS[0]; ALGEBRAIC[6] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[13]*STATES[2]); ALGEBRAIC[7] = ALGEBRAIC[6]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[9] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[14]*STATES[3]); ALGEBRAIC[10] = ALGEBRAIC[9]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[12] = CONSTANTS[7]*(exp(ALGEBRAIC[7]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[10]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[8] = ALGEBRAIC[6]+ CONSTANTS[20]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[13] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[15]*STATES[4]); ALGEBRAIC[15] = ALGEBRAIC[13]+ CONSTANTS[21]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[16] = CONSTANTS[9]*(exp(ALGEBRAIC[8]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[15]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[17] = - ALGEBRAIC[12] - ALGEBRAIC[16]; ALGEBRAIC[5] = CONSTANTS[17]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[2] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[11]*STATES[1]); ALGEBRAIC[18] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[16]*STATES[5]); ALGEBRAIC[19] = ALGEBRAIC[18]+ALGEBRAIC[2]+ALGEBRAIC[5]; ALGEBRAIC[3] = CONSTANTS[1]*CONSTANTS[2]*log( CONSTANTS[12]*STATES[0]); ALGEBRAIC[20] = ALGEBRAIC[18]+ALGEBRAIC[3]; ALGEBRAIC[21] = (ALGEBRAIC[5]==0.00000 ? 1.00000*CONSTANTS[6]*(exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[20]/( CONSTANTS[1]*CONSTANTS[2]))) : ((( 1.00000*CONSTANTS[6]*ALGEBRAIC[5])/( CONSTANTS[1]*CONSTANTS[2]))/(exp(ALGEBRAIC[5]/( CONSTANTS[1]*CONSTANTS[2])) - 1.00000))*(exp(ALGEBRAIC[19]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[20]/( CONSTANTS[1]*CONSTANTS[2])))); ALGEBRAIC[14] = ALGEBRAIC[13]+ CONSTANTS[18]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[22] = ALGEBRAIC[18]+ CONSTANTS[19]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[24] = CONSTANTS[8]*(exp(ALGEBRAIC[14]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[22]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[26] = ALGEBRAIC[16] - ALGEBRAIC[24]; ALGEBRAIC[11] = ALGEBRAIC[9]+ CONSTANTS[20]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[23] = ALGEBRAIC[18]+ CONSTANTS[21]*CONSTANTS[3]*ALGEBRAIC[4]; ALGEBRAIC[25] = CONSTANTS[10]*(exp(ALGEBRAIC[11]/( CONSTANTS[1]*CONSTANTS[2])) - exp(ALGEBRAIC[23]/( CONSTANTS[1]*CONSTANTS[2]))); ALGEBRAIC[27] = CONSTANTS[3]*( - CONSTANTS[17]*ALGEBRAIC[21]+ ALGEBRAIC[12]*(CONSTANTS[19] - CONSTANTS[18])+ ALGEBRAIC[24]*(CONSTANTS[19] - CONSTANTS[19])+ ALGEBRAIC[16]*(CONSTANTS[21] - CONSTANTS[20])+ ALGEBRAIC[25]*(CONSTANTS[21] - CONSTANTS[20])); ALGEBRAIC[0] = VOI - floor(VOI/CONSTANTS[4])*CONSTANTS[4]; ALGEBRAIC[1] = (ALGEBRAIC[0]>=0.300000&&ALGEBRAIC[0]<=0.300000+CONSTANTS[5] ? ( 0.0750000*CONSTANTS[0])/CONSTANTS[5] : 0.00000); ALGEBRAIC[28] = ALGEBRAIC[12] - ALGEBRAIC[25]; ALGEBRAIC[29] = ALGEBRAIC[24]+ALGEBRAIC[25]; }