Ryanodine receptor knowledge page
About
Landing page for the ryanodine receptor (Ryr).
Its major function is to create calcium-induced calcium release (CICR): the channel mediates the release of calcium from the sarcoplasmic reticulum into the cytosol, leading to the triggering of muscle contraction following depolarization of T-tubules in the same cell.
Pictures
Fig. 1. Visualisation of the Ryr2 protein (PDB)
Subfamilies
The following list contains the known isoforms of Ryr.
| Channel name | Organ | Gene | Structure |
|---|---|---|---|
| RYR1 | Skeletal | Uniprot 1 | PDB 1 |
| RYR2 | Cardiac | Uniprot 2 | PDB 2 |
| RYR3 | Brain | Uniprot 3 | PDB 3 |
Column 'Organ' refers to the site where the isoform primarily exists.
Literature
| Title | Author |
|---|---|
| Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors | Stern et al. |
| Cardiac Ca2+ Dynamics: The Roles of Ryanodine Receptor Adaptation and Sarcoplasmic Reticulum Load | Jafri et al. |
Existing models
| Title | Author |
|---|---|
| BG_Ryr | S Fong |
| Local Control Models of Cardiac Excitation-Contraction Coupling A Possible Role for Allosteric Interactions between Ryanodine Receptors* | Stern et al. |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.