C C There are a total of 13 entries in the algebraic variable array. C There are a total of 6 entries in each of the rate and state variable arrays. C There are a total of 21 entries in the constant variable array. C C C VOI is t in component environment (second). C CONSTS(1) is C_m in component environment (fF). C ALGBRC(8) is v_RyR in component RyR (fmol_per_sec). C CONSTS(2) is F in component constants (C_per_mol). C STATES(1) is q_Ca_SR in component environment (fmol). C STATES(2) is q_Ca_D in component environment (fmol). C STATES(3) is q_C_RyR in component environment (fmol). C STATES(4) is q_CI_RyR in component environment (fmol). C STATES(5) is q_I_RyR in component environment (fmol). C STATES(6) is q_O_RyR in component environment (fmol). C ALGBRC(13) is v_RyRgate_Ca_D in component RyR (fmol_per_sec). C CONSTS(3) is kappa_RyR in component RyR_parameters (fmol_per_sec). C CONSTS(4) is kappa_OC in component RyR_parameters (fmol_per_sec). C CONSTS(5) is kappa_CCI in component RyR_parameters (fmol_per_sec). C CONSTS(6) is kappa_CII in component RyR_parameters (fmol_per_sec). C CONSTS(7) is kappa_IO in component RyR_parameters (fmol_per_sec). C CONSTS(8) is K_Ca_SR in component RyR_parameters (per_fmol). C CONSTS(9) is K_Ca_D in component RyR_parameters (per_fmol). C CONSTS(10) is K_C_RyR in component RyR_parameters (per_fmol). C CONSTS(11) is K_CI_RyR in component RyR_parameters (per_fmol). C CONSTS(12) is K_I_RyR in component RyR_parameters (per_fmol). C CONSTS(13) is K_O_RyR in component RyR_parameters (per_fmol). C CONSTS(14) is R in component constants (J_per_K_per_mol). C CONSTS(15) is T in component constants (kelvin). C CONSTS(16) is nCa_1 in component RyR (dimensionless). C CONSTS(17) is nCa_2 in component RyR (dimensionless). C ALGBRC(1) is mu_Ca_SR in component RyR (J_per_mol). C ALGBRC(3) is mu_Ca_D in component RyR (J_per_mol). C ALGBRC(2) is q_Ca_gate_complexes in component RyR (fmol). C ALGBRC(4) is mu_C_RyR in component RyR (J_per_mol). C ALGBRC(5) is mu_CI_RyR in component RyR (J_per_mol). C ALGBRC(6) is mu_I_RyR in component RyR (J_per_mol). C ALGBRC(7) is mu_O_RyR in component RyR (J_per_mol). C ALGBRC(9) is v_OC in component RyR (fmol_per_sec). C ALGBRC(10) is v_CCI in component RyR (fmol_per_sec). C ALGBRC(11) is v_CII in component RyR (fmol_per_sec). C ALGBRC(12) is v_IO in component RyR (fmol_per_sec). C CONSTS(18) is zNa in component ion_valences (dimensionless). C CONSTS(19) is zCl in component ion_valences (dimensionless). C CONSTS(20) is zK in component ion_valences (dimensionless). C CONSTS(21) is zCa in component ion_valences (dimensionless). C RATES(1) is d/dt q_Ca_SR in component environment (fmol). C RATES(2) is d/dt q_Ca_D in component environment (fmol). C RATES(6) is d/dt q_O_RyR in component environment (fmol). C RATES(3) is d/dt q_C_RyR in component environment (fmol). C RATES(4) is d/dt q_CI_RyR in component environment (fmol). C RATES(5) is d/dt q_I_RyR in component environment (fmol). C SUBROUTINE initConsts(CONSTS, RATES, STATES) REAL CONSTS(*), RATES(*), STATES(*) CONSTS(1) = 1.381e5 CONSTS(2) = 96485 STATES(1) = 6.41e-1 STATES(2) = 3.68876E-07 STATES(3) = 2.9682830E-06 STATES(4) = 2.9682830E-06 STATES(5) = 2.9682830E-06 STATES(6) = 2.9682830E-06 CONSTS(3) = 498020 CONSTS(4) = 5.01701 CONSTS(5) = 6.61466 CONSTS(6) = 5.43605 CONSTS(7) = 0.453004 CONSTS(8) = 102.047 CONSTS(9) = 66.2643 CONSTS(10) = 0.819033 CONSTS(11) = 0.755897 CONSTS(12) = 11.0374 CONSTS(13) = 11.9593 CONSTS(14) = 8.31 CONSTS(15) = 310 CONSTS(16) = 1 CONSTS(17) = 2 CONSTS(18) = 1 CONSTS(19) = -1 CONSTS(20) = 1 CONSTS(21) = 2 RETURN END SUBROUTINE computeRates(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(14)*CONSTS(15)*log( CONSTS(8)*STATES(1)) ALGBRC(3) = CONSTS(14)*CONSTS(15)*log( CONSTS(9)*STATES(2)) ALGBRC(7) = CONSTS(14)*CONSTS(15)*log( CONSTS(13)*STATES(6)) ALGBRC(8) = CONSTS(3)*EXP(ALGBRC(7)/( CONSTS(14)*CONSTS(15)))*(EXP(ALGBRC(1)/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(3)/( CONSTS(14)*CONSTS(15)))) RATES(1) = - ALGBRC(8) ALGBRC(4) = CONSTS(14)*CONSTS(15)*log( CONSTS(10)*STATES(3)) ALGBRC(9) = CONSTS(4)*(EXP(ALGBRC(7)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(4)+ CONSTS(17)*ALGBRC(3))/( CONSTS(14)*CONSTS(15)))) ALGBRC(5) = CONSTS(14)*CONSTS(15)*log( CONSTS(11)*STATES(4)) ALGBRC(10) = CONSTS(5)*(EXP((ALGBRC(4)+ CONSTS(16)*ALGBRC(3))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(5)/( CONSTS(14)*CONSTS(15)))) RATES(3) = ALGBRC(9) - ALGBRC(10) ALGBRC(6) = CONSTS(14)*CONSTS(15)*log( CONSTS(12)*STATES(5)) ALGBRC(11) = CONSTS(6)*(EXP((ALGBRC(5)+ CONSTS(17)*ALGBRC(3))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(6)/( CONSTS(14)*CONSTS(15)))) RATES(4) = ALGBRC(10) - ALGBRC(11) ALGBRC(12) = CONSTS(7)*(EXP(ALGBRC(6)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(7)+ CONSTS(16)*ALGBRC(3))/( CONSTS(14)*CONSTS(15)))) RATES(6) = ALGBRC(12) - ALGBRC(9) RATES(5) = ALGBRC(11) - ALGBRC(12) ALGBRC(13) = (( CONSTS(17)*ALGBRC(9) - CONSTS(16)*ALGBRC(10)) - CONSTS(17)*ALGBRC(11))+ CONSTS(16)*ALGBRC(12) RATES(2) = ALGBRC(8)+ALGBRC(13) RETURN END SUBROUTINE computeVariables(VOI, CONSTS, RATES, STATES, ALGBRC) REAL VOI, CONSTS(*), RATES(*), STATES(*), ALGBRC(*) ALGBRC(1) = CONSTS(14)*CONSTS(15)*log( CONSTS(8)*STATES(1)) ALGBRC(3) = CONSTS(14)*CONSTS(15)*log( CONSTS(9)*STATES(2)) ALGBRC(7) = CONSTS(14)*CONSTS(15)*log( CONSTS(13)*STATES(6)) ALGBRC(8) = CONSTS(3)*EXP(ALGBRC(7)/( CONSTS(14)*CONSTS(15)))*(EXP(ALGBRC(1)/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(3)/( CONSTS(14)*CONSTS(15)))) ALGBRC(4) = CONSTS(14)*CONSTS(15)*log( CONSTS(10)*STATES(3)) ALGBRC(9) = CONSTS(4)*(EXP(ALGBRC(7)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(4)+ CONSTS(17)*ALGBRC(3))/( CONSTS(14)*CONSTS(15)))) ALGBRC(5) = CONSTS(14)*CONSTS(15)*log( CONSTS(11)*STATES(4)) ALGBRC(10) = CONSTS(5)*(EXP((ALGBRC(4)+ CONSTS(16)*ALGBRC(3))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(5)/( CONSTS(14)*CONSTS(15)))) ALGBRC(6) = CONSTS(14)*CONSTS(15)*log( CONSTS(12)*STATES(5)) ALGBRC(11) = CONSTS(6)*(EXP((ALGBRC(5)+ CONSTS(17)*ALGBRC(3))/( CONSTS(14)*CONSTS(15))) - EXP(ALGBRC(6)/( CONSTS(14)*CONSTS(15)))) ALGBRC(12) = CONSTS(7)*(EXP(ALGBRC(6)/( CONSTS(14)*CONSTS(15))) - EXP((ALGBRC(7)+ CONSTS(16)*ALGBRC(3))/( CONSTS(14)*CONSTS(15)))) ALGBRC(13) = (( CONSTS(17)*ALGBRC(9) - CONSTS(16)*ALGBRC(10)) - CONSTS(17)*ALGBRC(11))+ CONSTS(16)*ALGBRC(12) ALGBRC(2) = CONSTS(17)*STATES(6)+ CONSTS(16)*STATES(4)+ (CONSTS(16)+CONSTS(17))*STATES(5) RETURN END