/* There are a total of 13 entries in the algebraic variable array. There are a total of 6 entries in each of the rate and state variable arrays. There are a total of 21 entries in the constant variable array. */ /* * VOI is t in component environment (second). * CONSTANTS[0] is C_m in component environment (fF). * ALGEBRAIC[7] is v_RyR in component RyR (fmol_per_sec). * CONSTANTS[1] is F in component constants (C_per_mol). * STATES[0] is q_Ca_SR in component environment (fmol). * STATES[1] is q_Ca_D in component environment (fmol). * STATES[2] is q_C_RyR in component environment (fmol). * STATES[3] is q_CI_RyR in component environment (fmol). * STATES[4] is q_I_RyR in component environment (fmol). * STATES[5] is q_O_RyR in component environment (fmol). * ALGEBRAIC[12] is v_RyRgate_Ca_D in component RyR (fmol_per_sec). * CONSTANTS[2] is kappa_RyR in component RyR_parameters (fmol_per_sec). * CONSTANTS[3] is kappa_OC in component RyR_parameters (fmol_per_sec). * CONSTANTS[4] is kappa_CCI in component RyR_parameters (fmol_per_sec). * CONSTANTS[5] is kappa_CII in component RyR_parameters (fmol_per_sec). * CONSTANTS[6] is kappa_IO in component RyR_parameters (fmol_per_sec). * CONSTANTS[7] is K_Ca_SR in component RyR_parameters (per_fmol). * CONSTANTS[8] is K_Ca_D in component RyR_parameters (per_fmol). * CONSTANTS[9] is K_C_RyR in component RyR_parameters (per_fmol). * CONSTANTS[10] is K_CI_RyR in component RyR_parameters (per_fmol). * CONSTANTS[11] is K_I_RyR in component RyR_parameters (per_fmol). * CONSTANTS[12] is K_O_RyR in component RyR_parameters (per_fmol). * CONSTANTS[13] is R in component constants (J_per_K_per_mol). * CONSTANTS[14] is T in component constants (kelvin). * CONSTANTS[15] is nCa_1 in component RyR (dimensionless). * CONSTANTS[16] is nCa_2 in component RyR (dimensionless). * ALGEBRAIC[0] is mu_Ca_SR in component RyR (J_per_mol). * ALGEBRAIC[2] is mu_Ca_D in component RyR (J_per_mol). * ALGEBRAIC[1] is q_Ca_gate_complexes in component RyR (fmol). * ALGEBRAIC[3] is mu_C_RyR in component RyR (J_per_mol). * ALGEBRAIC[4] is mu_CI_RyR in component RyR (J_per_mol). * ALGEBRAIC[5] is mu_I_RyR in component RyR (J_per_mol). * ALGEBRAIC[6] is mu_O_RyR in component RyR (J_per_mol). * ALGEBRAIC[8] is v_OC in component RyR (fmol_per_sec). * ALGEBRAIC[9] is v_CCI in component RyR (fmol_per_sec). * ALGEBRAIC[10] is v_CII in component RyR (fmol_per_sec). * ALGEBRAIC[11] is v_IO in component RyR (fmol_per_sec). * CONSTANTS[17] is zNa in component ion_valences (dimensionless). * CONSTANTS[18] is zCl in component ion_valences (dimensionless). * CONSTANTS[19] is zK in component ion_valences (dimensionless). * CONSTANTS[20] is zCa in component ion_valences (dimensionless). * RATES[0] is d/dt q_Ca_SR in component environment (fmol). * RATES[1] is d/dt q_Ca_D in component environment (fmol). * RATES[5] is d/dt q_O_RyR in component environment (fmol). * RATES[2] is d/dt q_C_RyR in component environment (fmol). * RATES[3] is d/dt q_CI_RyR in component environment (fmol). * RATES[4] is d/dt q_I_RyR in component environment (fmol). */ void initConsts(double* CONSTANTS, double* RATES, double *STATES) { CONSTANTS[0] = 1.381e5; CONSTANTS[1] = 96485; STATES[0] = 6.41e-1; STATES[1] = 3.68876E-07; STATES[2] = 2.9682830E-06; STATES[3] = 2.9682830E-06; STATES[4] = 2.9682830E-06; STATES[5] = 2.9682830E-06; CONSTANTS[2] = 498020; CONSTANTS[3] = 5.01701; CONSTANTS[4] = 6.61466; CONSTANTS[5] = 5.43605; CONSTANTS[6] = 0.453004; CONSTANTS[7] = 102.047; CONSTANTS[8] = 66.2643; CONSTANTS[9] = 0.819033; CONSTANTS[10] = 0.755897; CONSTANTS[11] = 11.0374; CONSTANTS[12] = 11.9593; CONSTANTS[13] = 8.31; CONSTANTS[14] = 310; CONSTANTS[15] = 1; CONSTANTS[16] = 2; CONSTANTS[17] = 1; CONSTANTS[18] = -1; CONSTANTS[19] = 1; CONSTANTS[20] = 2; } void computeRates(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[7]*STATES[0]); ALGEBRAIC[2] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[8]*STATES[1]); ALGEBRAIC[6] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[12]*STATES[5]); ALGEBRAIC[7] = CONSTANTS[2]*exp(ALGEBRAIC[6]/( CONSTANTS[13]*CONSTANTS[14]))*(exp(ALGEBRAIC[0]/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[2]/( CONSTANTS[13]*CONSTANTS[14]))); RATES[0] = - ALGEBRAIC[7]; ALGEBRAIC[3] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[9]*STATES[2]); ALGEBRAIC[8] = CONSTANTS[3]*(exp(ALGEBRAIC[6]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[3]+ CONSTANTS[16]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[4] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[10]*STATES[3]); ALGEBRAIC[9] = CONSTANTS[4]*(exp((ALGEBRAIC[3]+ CONSTANTS[15]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[4]/( CONSTANTS[13]*CONSTANTS[14]))); RATES[2] = ALGEBRAIC[8] - ALGEBRAIC[9]; ALGEBRAIC[5] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[11]*STATES[4]); ALGEBRAIC[10] = CONSTANTS[5]*(exp((ALGEBRAIC[4]+ CONSTANTS[16]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[5]/( CONSTANTS[13]*CONSTANTS[14]))); RATES[3] = ALGEBRAIC[9] - ALGEBRAIC[10]; ALGEBRAIC[11] = CONSTANTS[6]*(exp(ALGEBRAIC[5]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[6]+ CONSTANTS[15]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14]))); RATES[5] = ALGEBRAIC[11] - ALGEBRAIC[8]; RATES[4] = ALGEBRAIC[10] - ALGEBRAIC[11]; ALGEBRAIC[12] = (( CONSTANTS[16]*ALGEBRAIC[8] - CONSTANTS[15]*ALGEBRAIC[9]) - CONSTANTS[16]*ALGEBRAIC[10])+ CONSTANTS[15]*ALGEBRAIC[11]; RATES[1] = ALGEBRAIC[7]+ALGEBRAIC[12]; } void computeVariables(double VOI, double* CONSTANTS, double* RATES, double* STATES, double* ALGEBRAIC) { ALGEBRAIC[0] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[7]*STATES[0]); ALGEBRAIC[2] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[8]*STATES[1]); ALGEBRAIC[6] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[12]*STATES[5]); ALGEBRAIC[7] = CONSTANTS[2]*exp(ALGEBRAIC[6]/( CONSTANTS[13]*CONSTANTS[14]))*(exp(ALGEBRAIC[0]/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[2]/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[3] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[9]*STATES[2]); ALGEBRAIC[8] = CONSTANTS[3]*(exp(ALGEBRAIC[6]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[3]+ CONSTANTS[16]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[4] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[10]*STATES[3]); ALGEBRAIC[9] = CONSTANTS[4]*(exp((ALGEBRAIC[3]+ CONSTANTS[15]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[4]/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[5] = CONSTANTS[13]*CONSTANTS[14]*log( CONSTANTS[11]*STATES[4]); ALGEBRAIC[10] = CONSTANTS[5]*(exp((ALGEBRAIC[4]+ CONSTANTS[16]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14])) - exp(ALGEBRAIC[5]/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[11] = CONSTANTS[6]*(exp(ALGEBRAIC[5]/( CONSTANTS[13]*CONSTANTS[14])) - exp((ALGEBRAIC[6]+ CONSTANTS[15]*ALGEBRAIC[2])/( CONSTANTS[13]*CONSTANTS[14]))); ALGEBRAIC[12] = (( CONSTANTS[16]*ALGEBRAIC[8] - CONSTANTS[15]*ALGEBRAIC[9]) - CONSTANTS[16]*ALGEBRAIC[10])+ CONSTANTS[15]*ALGEBRAIC[11]; ALGEBRAIC[1] = CONSTANTS[16]*STATES[5]+ CONSTANTS[15]*STATES[3]+ (CONSTANTS[15]+CONSTANTS[16])*STATES[4]; }