function [VOI, STATES, ALGEBRAIC, CONSTANTS] = mainFunction() % This is the "main function". In Matlab, things work best if you rename this function to match the filename. [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel(); end function [algebraicVariableCount] = getAlgebraicVariableCount() % Used later when setting a global variable with the number of algebraic variables. % Note: This is not the "main method". algebraicVariableCount =19; end % There are a total of 7 entries in each of the rate and state variable arrays. % There are a total of 17 entries in the constant variable array. % function [VOI, STATES, ALGEBRAIC, CONSTANTS] = solveModel() % Create ALGEBRAIC of correct size global algebraicVariableCount; algebraicVariableCount = getAlgebraicVariableCount(); % Initialise constants and state variables [INIT_STATES, CONSTANTS] = initConsts; % Set timespan to solve over tspan = [0, 10]; % Set numerical accuracy options for ODE solver options = odeset('RelTol', 1e-06, 'AbsTol', 1e-06, 'MaxStep', 1); % Solve model with ODE solver [VOI, STATES] = ode15s(@(VOI, STATES)computeRates(VOI, STATES, CONSTANTS), tspan, INIT_STATES, options); % Compute algebraic variables [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS); ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI); % Plot state variables against variable of integration [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends(); figure(); plot(VOI, STATES); xlabel(LEGEND_VOI); l = legend(LEGEND_STATES); set(l,'Interpreter','none'); end function [LEGEND_STATES, LEGEND_ALGEBRAIC, LEGEND_VOI, LEGEND_CONSTANTS] = createLegends() LEGEND_STATES = ''; LEGEND_ALGEBRAIC = ''; LEGEND_VOI = ''; LEGEND_CONSTANTS = ''; LEGEND_VOI = strpad('time in component environment (second)'); LEGEND_CONSTANTS(:,1) = strpad('C_m in component environment (fF)'); LEGEND_STATES(:,1) = strpad('q_K_o in component environment (fmol)'); LEGEND_STATES(:,2) = strpad('q_K_i in component environment (fmol)'); LEGEND_STATES(:,3) = strpad('q_Na_o in component environment (fmol)'); LEGEND_STATES(:,4) = strpad('q_Na_i in component environment (fmol)'); LEGEND_STATES(:,5) = strpad('q_x0_funny in component environment (fmol)'); LEGEND_STATES(:,6) = strpad('q_x1_funny in component environment (fmol)'); LEGEND_STATES(:,7) = strpad('q_mem in component environment (fC)'); LEGEND_CONSTANTS(:,2) = strpad('R in component environment (J_per_K_per_mol)'); LEGEND_CONSTANTS(:,3) = strpad('T in component environment (kelvin)'); LEGEND_CONSTANTS(:,4) = strpad('F in component environment (C_per_mol)'); LEGEND_ALGEBRAIC(:,14) = strpad('v_funny_K in component funny (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,15) = strpad('v_funny_Na in component funny (fmol_per_sec)'); LEGEND_ALGEBRAIC(:,19) = strpad('I_mem_funny in component funny (fA)'); LEGEND_CONSTANTS(:,5) = strpad('kappa_funny_Na in component funny_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,6) = strpad('kappa_funny_K in component funny_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,7) = strpad('kappa_R_xf in component funny_parameters (fmol_per_sec)'); LEGEND_CONSTANTS(:,8) = strpad('K_Na_i in component funny_parameters (per_fmol)'); LEGEND_CONSTANTS(:,9) = strpad('K_Na_o in component funny_parameters (per_fmol)'); LEGEND_CONSTANTS(:,10) = strpad('K_K_i in component funny_parameters (per_fmol)'); LEGEND_CONSTANTS(:,11) = strpad('K_K_o in component funny_parameters (per_fmol)'); LEGEND_CONSTANTS(:,12) = strpad('K_x0_funny in component funny_parameters (per_fmol)'); LEGEND_CONSTANTS(:,13) = strpad('K_x1_funny in component funny_parameters (per_fmol)'); LEGEND_CONSTANTS(:,14) = strpad('zNa in component funny_parameters (dimensionless)'); LEGEND_CONSTANTS(:,15) = strpad('zK in component funny_parameters (dimensionless)'); LEGEND_CONSTANTS(:,16) = strpad('z_xff in component funny_parameters (dimensionless)'); LEGEND_CONSTANTS(:,17) = strpad('z_xfr in component funny_parameters (dimensionless)'); LEGEND_ALGEBRAIC(:,1) = strpad('mu_K_i in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,2) = strpad('mu_K_o in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,3) = strpad('mu_Na_i in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,4) = strpad('mu_Na_o in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,5) = strpad('V_mem in component funny (J_per_C)'); LEGEND_ALGEBRAIC(:,7) = strpad('Am_Na in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,6) = strpad('Am_K in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,10) = strpad('Af_K in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,11) = strpad('Ar_K in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,12) = strpad('Af_Na in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,13) = strpad('Ar_Na in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,8) = strpad('mu_x0_funny in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,9) = strpad('mu_x1_funny in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,16) = strpad('Af_R_xf in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,17) = strpad('Ar_R_xf in component funny (J_per_mol)'); LEGEND_ALGEBRAIC(:,18) = strpad('v_xf in component funny (fmol_per_sec)'); LEGEND_RATES(:,2) = strpad('d/dt q_K_i in component environment (fmol)'); LEGEND_RATES(:,1) = strpad('d/dt q_K_o in component environment (fmol)'); LEGEND_RATES(:,4) = strpad('d/dt q_Na_i in component environment (fmol)'); LEGEND_RATES(:,3) = strpad('d/dt q_Na_o in component environment (fmol)'); LEGEND_RATES(:,7) = strpad('d/dt q_mem in component environment (fC)'); LEGEND_RATES(:,5) = strpad('d/dt q_x0_funny in component environment (fmol)'); LEGEND_RATES(:,6) = strpad('d/dt q_x1_funny in component environment (fmol)'); LEGEND_STATES = LEGEND_STATES'; LEGEND_ALGEBRAIC = LEGEND_ALGEBRAIC'; LEGEND_RATES = LEGEND_RATES'; LEGEND_CONSTANTS = LEGEND_CONSTANTS'; end function [STATES, CONSTANTS] = initConsts() VOI = 0; CONSTANTS = []; STATES = []; ALGEBRAIC = []; CONSTANTS(:,1) = 153400; STATES(:,1) = 27.9828; STATES(:,2) = 5510; STATES(:,3) = 9.3276; STATES(:,4) = 0.00456; STATES(:,5) = 5.4799070E-06; STATES(:,6) = 5.4799070E-06; STATES(:,7) = -8.5e4; CONSTANTS(:,2) = 8.31; CONSTANTS(:,3) = 310; CONSTANTS(:,4) = 96500; CONSTANTS(:,5) = 45.0247; CONSTANTS(:,6) = 91.4974; CONSTANTS(:,7) = 0.188833; CONSTANTS(:,8) = 1.80864; CONSTANTS(:,9) = 13.2633; CONSTANTS(:,10) = 2.57828; CONSTANTS(:,11) = 18.9074; CONSTANTS(:,12) = 0.00306604; CONSTANTS(:,13) = 61.5887; CONSTANTS(:,14) = 1; CONSTANTS(:,15) = 1; CONSTANTS(:,16) = -1.8309039; CONSTANTS(:,17) = 0.787348905; if (isempty(STATES)), warning('Initial values for states not set');, end end function [RATES, ALGEBRAIC] = computeRates(VOI, STATES, CONSTANTS) global algebraicVariableCount; statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; ALGEBRAIC = zeros(1, algebraicVariableCount); utilOnes = 1; else statesRowCount = statesSize(1); ALGEBRAIC = zeros(statesRowCount, algebraicVariableCount); RATES = zeros(statesRowCount, statesColumnCount); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,5) = STATES(:,7)./CONSTANTS(:,1); ALGEBRAIC(:,6) = CONSTANTS(:,15).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,1) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,10).*STATES(:,2)); ALGEBRAIC(:,9) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,13).*STATES(:,6)); ALGEBRAIC(:,10) = ALGEBRAIC(:,9)+ALGEBRAIC(:,1)+ALGEBRAIC(:,6); ALGEBRAIC(:,2) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,11).*STATES(:,1)); ALGEBRAIC(:,11) = ALGEBRAIC(:,9)+ALGEBRAIC(:,2); ALGEBRAIC(:,14) = piecewise({ALGEBRAIC(:,6)==0.00000, 1.00000.*CONSTANTS(:,6).*(exp(ALGEBRAIC(:,10)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,11)./( CONSTANTS(:,2).*CONSTANTS(:,3)))) }, ((( 1.00000.*CONSTANTS(:,6).*ALGEBRAIC(:,6))./( CONSTANTS(:,2).*CONSTANTS(:,3)))./(exp(ALGEBRAIC(:,6)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - 1.00000)).*(exp(ALGEBRAIC(:,10)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,11)./( CONSTANTS(:,2).*CONSTANTS(:,3))))); RATES(:,2) = - ALGEBRAIC(:,14); RATES(:,1) = ALGEBRAIC(:,14); ALGEBRAIC(:,7) = CONSTANTS(:,14).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,3) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,8).*STATES(:,4)); ALGEBRAIC(:,12) = ALGEBRAIC(:,9)+ALGEBRAIC(:,3)+ALGEBRAIC(:,7); ALGEBRAIC(:,4) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,9).*STATES(:,3)); ALGEBRAIC(:,13) = ALGEBRAIC(:,9)+ALGEBRAIC(:,4); ALGEBRAIC(:,15) = piecewise({ALGEBRAIC(:,7)==0.00000, 1.00000.*CONSTANTS(:,5).*(exp(ALGEBRAIC(:,12)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,13)./( CONSTANTS(:,2).*CONSTANTS(:,3)))) }, ((( 1.00000.*CONSTANTS(:,5).*ALGEBRAIC(:,7))./( CONSTANTS(:,2).*CONSTANTS(:,3)))./(exp(ALGEBRAIC(:,7)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - 1.00000)).*(exp(ALGEBRAIC(:,12)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,13)./( CONSTANTS(:,2).*CONSTANTS(:,3))))); RATES(:,4) = - ALGEBRAIC(:,15); RATES(:,3) = ALGEBRAIC(:,15); ALGEBRAIC(:,8) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,12).*STATES(:,5)); ALGEBRAIC(:,16) = ALGEBRAIC(:,8)+ CONSTANTS(:,16).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,17) = ALGEBRAIC(:,9)+ CONSTANTS(:,17).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,18) = CONSTANTS(:,7).*(exp(ALGEBRAIC(:,16)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,17)./( CONSTANTS(:,2).*CONSTANTS(:,3)))); RATES(:,5) = - ALGEBRAIC(:,18); RATES(:,6) = ALGEBRAIC(:,18); ALGEBRAIC(:,19) = CONSTANTS(:,4).*(( - CONSTANTS(:,15).*ALGEBRAIC(:,14)+ CONSTANTS(:,14).*ALGEBRAIC(:,15)+ CONSTANTS(:,17).*ALGEBRAIC(:,18)) - CONSTANTS(:,16).*ALGEBRAIC(:,18)); RATES(:,7) = ALGEBRAIC(:,19); RATES = RATES'; end % Calculate algebraic variables function ALGEBRAIC = computeAlgebraic(ALGEBRAIC, CONSTANTS, STATES, VOI) statesSize = size(STATES); statesColumnCount = statesSize(2); if ( statesColumnCount == 1) STATES = STATES'; utilOnes = 1; else statesRowCount = statesSize(1); utilOnes = ones(statesRowCount, 1); end ALGEBRAIC(:,5) = STATES(:,7)./CONSTANTS(:,1); ALGEBRAIC(:,6) = CONSTANTS(:,15).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,1) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,10).*STATES(:,2)); ALGEBRAIC(:,9) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,13).*STATES(:,6)); ALGEBRAIC(:,10) = ALGEBRAIC(:,9)+ALGEBRAIC(:,1)+ALGEBRAIC(:,6); ALGEBRAIC(:,2) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,11).*STATES(:,1)); ALGEBRAIC(:,11) = ALGEBRAIC(:,9)+ALGEBRAIC(:,2); ALGEBRAIC(:,14) = piecewise({ALGEBRAIC(:,6)==0.00000, 1.00000.*CONSTANTS(:,6).*(exp(ALGEBRAIC(:,10)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,11)./( CONSTANTS(:,2).*CONSTANTS(:,3)))) }, ((( 1.00000.*CONSTANTS(:,6).*ALGEBRAIC(:,6))./( CONSTANTS(:,2).*CONSTANTS(:,3)))./(exp(ALGEBRAIC(:,6)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - 1.00000)).*(exp(ALGEBRAIC(:,10)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,11)./( CONSTANTS(:,2).*CONSTANTS(:,3))))); ALGEBRAIC(:,7) = CONSTANTS(:,14).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,3) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,8).*STATES(:,4)); ALGEBRAIC(:,12) = ALGEBRAIC(:,9)+ALGEBRAIC(:,3)+ALGEBRAIC(:,7); ALGEBRAIC(:,4) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,9).*STATES(:,3)); ALGEBRAIC(:,13) = ALGEBRAIC(:,9)+ALGEBRAIC(:,4); ALGEBRAIC(:,15) = piecewise({ALGEBRAIC(:,7)==0.00000, 1.00000.*CONSTANTS(:,5).*(exp(ALGEBRAIC(:,12)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,13)./( CONSTANTS(:,2).*CONSTANTS(:,3)))) }, ((( 1.00000.*CONSTANTS(:,5).*ALGEBRAIC(:,7))./( CONSTANTS(:,2).*CONSTANTS(:,3)))./(exp(ALGEBRAIC(:,7)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - 1.00000)).*(exp(ALGEBRAIC(:,12)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,13)./( CONSTANTS(:,2).*CONSTANTS(:,3))))); ALGEBRAIC(:,8) = CONSTANTS(:,2).*CONSTANTS(:,3).*log( CONSTANTS(:,12).*STATES(:,5)); ALGEBRAIC(:,16) = ALGEBRAIC(:,8)+ CONSTANTS(:,16).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,17) = ALGEBRAIC(:,9)+ CONSTANTS(:,17).*CONSTANTS(:,4).*ALGEBRAIC(:,5); ALGEBRAIC(:,18) = CONSTANTS(:,7).*(exp(ALGEBRAIC(:,16)./( CONSTANTS(:,2).*CONSTANTS(:,3))) - exp(ALGEBRAIC(:,17)./( CONSTANTS(:,2).*CONSTANTS(:,3)))); ALGEBRAIC(:,19) = CONSTANTS(:,4).*(( - CONSTANTS(:,15).*ALGEBRAIC(:,14)+ CONSTANTS(:,14).*ALGEBRAIC(:,15)+ CONSTANTS(:,17).*ALGEBRAIC(:,18)) - CONSTANTS(:,16).*ALGEBRAIC(:,18)); end % Compute result of a piecewise function function x = piecewise(cases, default) set = [0]; for i = 1:2:length(cases) if (length(cases{i+1}) == 1) x(cases{i} & ~set,:) = cases{i+1}; else x(cases{i} & ~set,:) = cases{i+1}(cases{i} & ~set); end set = set | cases{i}; if(set), break, end end if (length(default) == 1) x(~set,:) = default; else x(~set,:) = default(~set); end end % Pad out or shorten strings to a set length function strout = strpad(strin) req_length = 160; insize = size(strin,2); if insize > req_length strout = strin(1:req_length); else strout = [strin, blanks(req_length - insize)]; end end