SERCA protein knowledge page
About
Landing page for the sarcoplasmic/endoplasmic calcium ATPase (SERCA).
Its major function is to transport calcium from the cytosol into the sarcoplasmic reticulum in muscle cells. This action is coupled with the hydrolysis of ATP.
Pictures
Fig. 1. Structure of the ATP2A1 protein, rendered from PDB structure
Subfamilies
The following list contains the known subfamilies of SERCA pump.
| Channel name | Alias | Gene | Structure |
|---|---|---|---|
| SERCA1 | ATP2A1 | Uniprot 1 | SMR 1 |
| SERCA2 | ATP2A2 | Uniprot 2 | PDB 2 |
| SERCA3 | ATP2A3 | Uniprot 3 | SMR 3 |
Literature
| Title | Author |
|---|---|
| A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources | Kernik et al. |
| A thermodynamic framework for modelling membrane transporters | Pan et al. |
Existing models
| Title | Author |
|---|---|
| BG_SERCA | S Fong |
| Transporter_thermodynamics^ | Pan et al. |
| Bond graph modelling of the cardiac action potential: Implications for drift and non-unique steady states | M Pan et al. |
| A Thermodynamic Model of the Cardiac Sarcoplasmic/Endoplasmic Ca(2+) (SERCA) Pump: the three-state SERCA model* | Tran et al. |
Models denoted by [*] are not in bond graph form. Models denoted by [^] are part of a whole cell model.